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1 ngle 5 (K5) of human plasminogen is a potent angiogenesis inhibitor.
2 id solenopsin, and found that it is a potent angiogenesis inhibitor.
3 oliferating hemangioma, are stimulated by an angiogenesis inhibitor.
4 ilin-2 (NRP2), a novel mechanism for a tumor angiogenesis inhibitor.
5 fumagillin derivative and a well-established angiogenesis inhibitor.
6 -kDa fragment of collagen XVIII, is a potent angiogenesis inhibitor.
7 lecule isocoumarin, is a recently discovered angiogenesis inhibitor.
8 and vascular tone, is a naturally occurring angiogenesis inhibitor.
9 ic administration of TNP-470, a conventional angiogenesis inhibitor.
10 point and the effectiveness of TNP-470 as an angiogenesis inhibitor.
11 e metastatic site and not from a circulating angiogenesis inhibitor.
12 in three tumour types treated with a potent angiogenesis inhibitor.
13 nts to a role for protein S as an endogenous angiogenesis inhibitor.
14 Maspin has been identified as a potent angiogenesis inhibitor.
15 C-terminal domain of perlecan, is a powerful angiogenesis inhibitor.
16 matrix protein, thrombospondin 1 (TSP1), an angiogenesis inhibitor.
17 teinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor.
18 es of endothelial cells after treatment with angiogenesis inhibitors.
19 provide biomarkers for treatment efficacy of angiogenesis inhibitors.
20 ranol may serve as a lead for a new class of angiogenesis inhibitors.
21 ise a major source of small molecular weight angiogenesis inhibitors.
22 nding of the downstream molecular targets of angiogenesis inhibitors.
23 esting novel approaches to the generation of angiogenesis inhibitors.
24 c system may function as naturally occurring angiogenesis inhibitors.
25 epresent a new target for the development of angiogenesis inhibitors.
26 ions of anticancer drugs coadministered with angiogenesis inhibitors.
27 e IV may represent an important new class of angiogenesis inhibitors.
28 nhibit this interaction are a novel class of angiogenesis inhibitors.
29 he mechanisms of tumor growth suppression by angiogenesis inhibitors.
30 r proteins that are themselves not active as angiogenesis inhibitors.
31 impact as a noninvasive method for assessing angiogenesis inhibitors.
32 tions involved in the acquired resistance to angiogenesis inhibitors.
33 enic mediators and a concomitant decrease in angiogenesis inhibitors.
34 ially useful tool for assessing responses to angiogenesis inhibitors.
35 endent transduction of signals by endogenous angiogenesis inhibitors.
36 ficant toxicities associated with the use of angiogenesis inhibitors.
37 is among the most potent and broad-spectrum angiogenesis inhibitors.
38 prospectively assessed in clinical trials of angiogenesis inhibitors.
39 as potential targets for the development of angiogenesis inhibitors.
42 emonstrated that mice lacking brain-specific angiogenesis inhibitor 1 (BAI1) have severe deficits in
43 ssessed the expression and function of brain angiogenesis inhibitor 1 (BAI1) in the engulfment of apo
49 olves the phagocytic receptor brain-specific angiogenesis inhibitor 1 (BAI1), which recognizes phosph
51 ult ADHD and the gene BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), even aft
54 of nintedanib (BIBF 1120), a small molecule angiogenesis inhibitor, 10 weeks post-injection suppress
56 dometriosis-associated angiogenesis, and the angiogenesis inhibitor 2-methoxyestradiol may be a poten
58 ql1 specifically binds to the brain-specific angiogenesis inhibitor 3 (Bai3), which is a member of th
59 s, anginex shares with several physiological angiogenesis inhibitors a dependence on plasma adhesion
60 o target vessel wall neovascularization with angiogenesis inhibitors, a therapeutic approach that has
61 eolytic fragment of plasminogen, is a potent angiogenesis inhibitor able to suppress tumor growth and
63 ture, but there are only limited data on how angiogenesis inhibitors affect the tumor uptake of these
64 Mice were treated with a combination of the angiogenesis inhibitor AGM-1470 (TNP-470), the antibioti
66 wo-thirds hepatectomy, or treatment with the angiogenesis inhibitor, AGM-1470,O-chloroacetyl-carbamoy
69 mitogen-activated protein kinase and a known angiogenesis inhibitor, also blocked the observed VEGF-i
70 eal a novel function for angioarrestin as an angiogenesis inhibitor and indicate that the molecule ma
71 metastatic 4T1 breast tumor using SU6668, an angiogenesis inhibitor and recombinant murine (rm) B7.2-
73 ude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasc
75 ay be critical for developing biomarkers for angiogenesis inhibitors and improving combination regime
76 rogation of the changes in the expression of angiogenesis inhibitors and in situ hybridization studie
77 ood vessel growth is regulated by endogenous angiogenesis inhibitors and matrix constituents, as well
78 or (ATR) ligands, such as PA and PASSSR, are angiogenesis inhibitors and that ATRs are useful targets
79 y be an important mediator of the effects of angiogenesis inhibitors and that FILIP1L has the potenti
82 hrombotic and hemorrhagic complications from angiogenesis inhibitors and vascular disrupting agents,
83 ntrast, most localized tumors expressed this angiogenesis inhibitor, and a significant correlation be
84 ndothelial growth factor as an example of an angiogenesis inhibitor, and agents targeting the epiderm
85 ssibility for the combination of TNP-470, an angiogenesis inhibitor, and temozolomide (TMZ), a DNA-al
87 suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therap
88 ted in other tumor types), responsiveness to angiogenesis inhibitors, and resistance to both chemothe
91 eported the identification of the endogenous angiogenesis inhibitor angiostatin, a specific inhibitor
94 he crystal structure of the human Pg-derived angiogenesis inhibitor, angiostatin, complexed to VEK-30
106 tration improves the antitumoral efficacy of angiogenesis inhibitors, as compared with intermittent d
108 ), also known as soluble VEGF receptor 1, an angiogenesis inhibitor associated with preeclampsia.
109 h as site and stage, and therapies including angiogenesis inhibitors associated with higher risk of V
110 treated so as to compare the effects of four angiogenesis inhibitors at three distinct stages of dise
112 he G-protein coupled receptor brain-specific angiogenesis inhibitor (BAI3) as a cell surface protein
113 cancer patients treated with the widely used angiogenesis inhibitor bevacizumab in combination with c
114 ollagen XVIII, has been shown to be a potent angiogenesis inhibitor both in vivo and in vitro when gi
118 e tested the proposition that treatment with angiogenesis inhibitors can inhibit the progression of t
119 trix homeostasis, together with a loss of an angiogenesis inhibitor, can prime vascular beds to be mo
120 These results suggest that 3TSR, or other angiogenesis inhibitors, can be repurposed for TSP1 repl
123 fortunately, emerging evidence confirms that angiogenesis inhibitors cause cardiac complications, inc
124 vitation of lesions in clinical trials of an angiogenesis inhibitor combined with chemotherapy for no
125 rowth factor (VEGF) Trap (aflibercept) is an angiogenesis inhibitor comprising portions of the extrac
128 results reveal upregulation of an endogenous angiogenesis inhibitor during multi step tumorigenesis a
129 is are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elabor
130 ) or with cells engineered to overexpress an angiogenesis inhibitor--either tissue inhibitor of matri
131 monocyte activating polypeptide II, another angiogenesis inhibitor, elicited the same response in th
132 s study was to investigate the effect of the angiogenesis inhibitor Endostar on carotid plaque neovas
133 d treatment of allograft recipients with the angiogenesis inhibitor endostatin failed to inhibit leuk
135 assessed the effect of local delivery of the angiogenesis inhibitor endostatin on human glioma cell l
136 hanced migratory activity in response to the angiogenesis inhibitor endostatin, to determine if HemEP
137 gioma endothelial cells is stimulated by the angiogenesis inhibitor endostatin, unlike the inhibition
141 owever, the mechanism by which these diverse angiogenesis inhibitors exert their common effects remai
143 e importance of the research in the field of angiogenesis inhibitors for future oncologic therapy.
145 presents the first demonstration of multiple angiogenesis inhibitors from a single tumor and suggests
146 ong-term, in vivo expression of a functional angiogenesis inhibitor has been established using rAAV,
148 mbospondin-1 (THBS1), a P53 and Rb regulated angiogenesis inhibitor, has been observed in some human
149 vatalanib), an orally active, multitargeted angiogenesis inhibitor, has shown tolerability and promi
152 n these findings, several clinical trials of angiogenesis inhibitors have been initiated in human mel
155 umors such as renal cell carcinoma; however, angiogenesis inhibitors have not been particularly succe
158 hat the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in
159 pproaches targeting the DNA damage response, angiogenesis inhibitors, immune checkpoint inhibitors, o
160 Many new techniques such as gene therapy, angiogenesis inhibitors, immunotherapy, and others that
164 address this issue, we screened a variety of angiogenesis inhibitors in developing zebrafish and chic
165 eview the rationale and recent experience of angiogenesis inhibitors in malignant gliomas and to high
166 ew summarizes the most important findings on angiogenesis inhibitors in NSCLC and discusses the poten
167 l trials of these agents and discuss the new angiogenesis inhibitors in preclinical development.
169 us endothelial checkpoints, and resistant to angiogenesis inhibitors independent of myeloid cells.
170 Similar increases were achieved using other angiogenesis inhibitors, indicating that increased drug
171 ibitor of metalloproteinase 2 (TIMP-2) is an angiogenesis inhibitor initially characterized for its a
176 se data demonstrate that soluble VEGFR-1, an angiogenesis inhibitor, is regulated in skeletal muscle
177 23-amino acid peptide termed kinesin-derived angiogenesis inhibitor (KAI) not only prevents interacti
178 tment of endometriosis-bearing mice with the angiogenesis inhibitor Lodamin, an oral nontoxic formula
180 fore, VEGF upregulation of ADAMTS1, a potent angiogenesis inhibitor, may represent a mechanism for fe
181 eas less-specific targeted agents, including angiogenesis inhibitors (median RR, 3.39; P < .001) and
182 and suggest that therapeutic application of angiogenesis inhibitors might potentially be associated
185 ted a potential drug interaction between the angiogenesis inhibitor O-(N-chloroacetyl-carbamoyl)-fuma
186 e have identified angiostatin, an endogenous angiogenesis inhibitor of 38 kDa which specifically bloc
188 leukemia, with an emphasis on modulators of angiogenesis, inhibitors of the ubiquitin-proteasome pat
189 herosclerosis, we investigated the effect of angiogenesis inhibitors on plaque growth in apoE -/- mic
190 angiogenesis stimulator) and endostatin (an angiogenesis inhibitor), or for thrombospondin-1 and bas
193 of the anti-angiogenic signal by the natural angiogenesis inhibitor, pigment epithelial-derived facto
196 indomethacin (2 mg/kg/day), or the specific angiogenesis inhibitor PPI-2458 (5 mg/kg every other day
198 by systemic administration of 3 doses of the angiogenesis inhibitor PPI-2458 during the acute phase.
199 strategy, we have identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma.
207 27a/b promotes angiogenesis by targeting the angiogenesis inhibitor SEMA6A, which controls repulsion
208 ally, miR-27 regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro a
210 nts for activity of thalidomide analogues as angiogenesis inhibitors, since there is only speculative
212 ly indicator of response to tyrosine kinase (angiogenesis) inhibitors such as pazopanib in ovarian ca
214 ing the pharmacological response and dose of angiogenesis inhibitors, such as PTK/ZK, for further cli
215 lidate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of
217 This explains why ovalicin and related anti-angiogenesis inhibitors target Type II human MetAP but n
220 LC) patients treated with pazopanib, an oral angiogenesis inhibitor targeting VEGFR, platelet-derived
223 m has been a significant complication of the angiogenesis inhibitors thalidomide and lenalidomide.
224 d RSI were lower in tumors overexpressing an angiogenesis inhibitor than in control tumors (all P < .
228 iculin inclusive of amino acids 1-180, is an angiogenesis inhibitor that exerts antitumor effects in
229 one-related peptide is a naturally occurring angiogenesis inhibitor that functions by activation of p
230 ADAMTS9 as a novel, constitutive, endogenous angiogenesis inhibitor that operates cell-autonomously i
231 is based on the discovery of angiostatin, an angiogenesis inhibitor that selectively instructs endoth
232 gs demonstrate that NM-3 is a well-tolerated angiogenesis inhibitor that significantly increases the
234 hese data suggest that the combination of an angiogenesis inhibitor that targets endothelial cells wi
237 ctly contribute to the antitumor activity of angiogenesis inhibitors that block the VEGFR2 pathway.
239 common effector molecules used by a panel of angiogenesis inhibitors that perturb the cytoskeleton to
241 umors was associated with down-regulation of angiogenesis inhibitor thrombospondin and decreased sens
242 died the expression and biologic role of the angiogenesis inhibitor thrombospondin-1 (TSP-1) during t
243 Methylation-associated inactivation of the angiogenesis inhibitor thrombospondin-1 (TSP-1) has been
248 we found that explants from mice lacking the angiogenesis inhibitor thrombospondin-1 (TSP1) exhibit e
249 d by a strong reduction in the levels of the angiogenesis inhibitor thrombospondin-1 (TSP1), but the
250 he production and delivery of the endogenous angiogenesis inhibitor thrombospondin-1 by platelets may
251 erol levels also increased the levels of the angiogenesis inhibitor thrombospondin-1 in the xenograft
252 in-specific overexpression of the endogenous angiogenesis inhibitor thrombospondin-1 were subjected t
253 ly 92 microRNA cluster and downregulates the angiogenesis inhibitor thrombospondin-1, along with othe
254 onin, unlike VEGF-A, up-regulated the potent angiogenesis inhibitor thrombospondin-1, thereby trigger
257 cidate the biological role of the endogenous angiogenesis inhibitor thrombospondin-2 (TSP-2) during m
258 investigate the biologic role of the potent angiogenesis inhibitor thrombospondin-2 (TSP-2) in the c
259 arcoma secrete relatively high levels of the angiogenesis inhibitors thrombospondin-1 and TIMP-1.
263 6 E6 and E7, expression levels of two potent angiogenesis inhibitors, thrombospondin-1 and maspin, we
264 te that expression of one of the most potent angiogenesis inhibitors, thrombospondin-1, is up-regulat
265 represses thrombospondin-1 (TSP1), a potent angiogenesis inhibitor, through epigenetic regulation.
266 (bFGF) (1 microg/g/d intraperitoneal) or the angiogenesis inhibitor TNP-470 (30 mg/kg/qod subcutaneou
267 he toxicity and pharmacokinetics (PK) of the angiogenesis inhibitor TNP-470 and secondarily to evalua
268 atment of established murine tumors with the angiogenesis inhibitor TNP-470 caused near-complete abla
270 thus a promising candidate for a therapeutic angiogenesis inhibitor to be used in the treatment of ca
273 e, there is a need for small molecule ocular angiogenesis inhibitors to complement existing therapies
274 rtant when assessing novel compounds such as angiogenesis inhibitors to optimize the dose and schedul
276 ted reduced protein, not mRNA, expression of angiogenesis inhibitors TSP-1 and thrombospondin-2 (TSP-
277 tment modalities such as metronomic therapy, angiogenesis inhibitors, vascular disrupting agents and
281 ion of the thrombospondin-1 (TSP-1) gene, an angiogenesis inhibitor, was increased in MI+ cancers (27
283 whose goal was to discover novel endogenous angiogenesis inhibitors, we have purified matrilin-1 (MA
284 , to investigate mechanisms of resistance to angiogenesis inhibitors, we transduced human glioblastom
285 decreased expression of thrombospondin-1, an angiogenesis inhibitor, were also observed in ML.delta b
286 oteinases and also basement membrane-derived angiogenesis inhibitors when compared with wild-type tum
287 etic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understa
288 stration with endostatin (ES), an endogenous angiogenesis inhibitor with antitumor effects shown to i
289 Pigment epithelial-derived factor (PEDF), an angiogenesis inhibitor with neurotrophic properties, bal
290 utic limitation can be overcome by combining angiogenesis inhibitors with chemotherapeutic agents.
291 lung metastases and suggests that combining angiogenesis inhibitors with radiation therapy may contr
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