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1 gration and proliferation, and inhibited the angiogenic ability of ECs both in vitro and ex vivo In s
4 lling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1
5 tively significant antiangiogenic and slight angiogenic activities in a microvascular sprouting assay
7 d to contribute via mitogenic, survival, and angiogenic activities to HHV-8-associated Kaposi's sarco
9 down miR-126-3p from CD34Exo abolished their angiogenic activity and beneficial function both in vitr
10 ning 28 bridges endothelial inflammation and angiogenic activity by retaining expression of TNFR1 and
11 (designated EDM-TTF-1(+)) displayed an anti-angiogenic activity in the endothelial cell tube formati
14 tudy explores the fate of EETs with COX, the angiogenic activity of the primary metabolites formed, a
15 rowth factor (VEGF), characterization of its angiogenic activity, and demonstration that its expressi
17 associated with a poor response to the anti-angiogenic agent bevacizumab in patients with colorectal
18 id (SCFA), acts classically as a potent anti-angiogenic agent in tumour angiogenesis models, some aut
19 ested sunitinib and sorafenib, two oral anti-angiogenic agents that are effective in advanced renal-c
21 ve regulated and concerted expression of pro-angiogenic and angiostatic factors needed to produce fun
22 receptor 2, which has been shown to mediate angiogenic and blood vessel repair activities in mice.
23 f C/EBPalpha in the expansion as well as pro-angiogenic and immune suppressive functions in MDSCs.
27 an infiltrate into tumor tissue, secrete pro-angiogenic and pro-tumorigenic factors and thereby incre
28 on of stem cell function and may explain the angiogenic and therapeutic benefits associated with CD34
34 so, we measured a panel of 12 inflammatory, angiogenic, and oxidative stress biomarkers in plasma or
35 on whether netrin-4 acts either pro- or anti-angiogenic, angiogenesis in the retina was assessed in N
36 s significantly higher GCF concentrations of angiogenic biomarkers for approximately 2 to 4 weeks and
37 euron-specific enolase, and multiple soluble angiogenic biomarkers were determined and their impact o
39 EGF/VEGFR2 pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby pre
42 Endothelial cell responsiveness to these pro-angiogenic BMP ligands is regulated by Notch status and
43 intain a fitness advantage over noninvasive, angiogenic (C3) cells by promoting invasion and reducing
45 NFkappaB pathway, in turn triggering an anti-angiogenic cascade, might inhibit tumorigenesis and canc
47 ts signaling events and results in excessive angiogenic cell proliferation and plexus formation, lead
48 hial pulse wave velocity (bPWV), circulating angiogenic cells (CACs), and blood pressure before and 2
50 gans skin, liver, and intestines, whereas no angiogenic changes appeared due to conditioning or synge
51 ever, the Day 3 serum cultured networks were angiogenic, characterized by increased vessel density, a
54 n serum of human interleukin-8 (IL-8), a pro-angiogenic chemokine implicated in a wide range of infla
59 AML cells produce pro-inflammatory and anti-angiogenic cytokines and gradually degrade endosteal end
60 s, increased production of profibrogenic and angiogenic cytokines and related alterations of the bone
61 l markers, arterial endothelial markers, pro-angiogenic cytokines, and Notch pathway components was s
64 with wild-type bone marrow cells rescued the angiogenic defect and ameliorated left ventricular remod
68 posits new mechanisms for understanding anti-angiogenic drug resistance and presents an expanded role
69 l tumors were sensitive to the targeted anti-angiogenic drug sunitinib but resistant to cytotoxic che
71 can be treated to varying degrees with anti-angiogenic drugs, but geographic atrophy (GA) is an adva
72 derstanding angiogenesis and developing anti-angiogenic drugs, but most work only involves numerical
74 g miR-193a-3p in less proliferative and less angiogenic ECFC-derived cells will enhance their vasculo
77 ous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood.
83 fruit (TCMPs) have been shown to exert anti-angiogenic effects by inhibiting endothelial cell migrat
88 m of miR-21 mediating metformin-induced anti-angiogenic effects, providing important implications reg
92 HPMCs cultured with IL-6 and sIL-6R promoted angiogenic endothelial tube formation, which could be bl
93 e fibroblast growth factor (FGF) is a potent angiogenic factor and aberrant FGF signaling is a common
94 results demonstrate that NPNT is a paracrine angiogenic factor and may play a role in pathological os
95 tly target and repress the mRNA encoding the angiogenic factor angiopoietin 1 (ANGPT1), leading to de
96 herefore, we hypothesized that a circulating angiogenic factor could predict disease severity and sur
97 IL-32 could function as an inflammatory and angiogenic factor in human obesity and obesity-associate
99 wth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the deve
104 ted the effect of miR200-b, a potential anti-angiogenic factor, on VEGF receptor 2 (VEGFR-2) expressi
106 eatment, and then, we assessed expression of angiogenic factors and mechanotransducers (focal adhesio
107 lue light filtering affects the secretion of angiogenic factors by retinal pigmented epithelial cells
108 In the absence of prematurity, UPI increased angiogenic factors in association with reduced OIR sever
109 y mechanotransduction-mediated expression of angiogenic factors in proximal tubular cells, and it may
113 arrow microenvironment secrete cytokines and angiogenic factors that support the maintenance and rege
114 Thrombospondin-1 (TSP-1) is one of the anti-angiogenic factors whose synthesis is driven by hypoxia.
115 tion resulted in decreased production of pro-angiogenic factors, CXCL1 and vascular endothelial growt
116 ctors, such as endostatin, and decreased pro-angiogenic factors, including CXC motif ligand 1 (CXCL1)
117 hile exhibiting increased expression of anti-angiogenic factors, such as endostatin, and decreased pr
118 Acute myeloid leukemia (AML) cells produce angiogenic factors, which likely contribute to this remo
128 SP-4 shRNA, we found that TSP-4 mediated pro-angiogenic functions in cultured EC and angiogenesis in
129 imus activated Smad1/5/8 and opposed the pro-angiogenic gene expression signature associated with ALK
130 nhibition was associated with a specific pro-angiogenic gene expression signature, which included a s
136 ave identified Emc10 as a previously unknown angiogenic growth factor that is produced by bone marrow
138 hese tumors do not depend entirely on either angiogenic growth factors or on neighboring endothelia t
142 analyzed for their potential target genes in angiogenic, hypoxic, and immune response-related pathway
144 ndothelial growth factor levels may imply an angiogenic imbalance that exists even after recovery and
145 tensive disorders of pregnancy often exhibit angiogenic imbalances, suggesting that the same mechanis
146 tion of C/EBPalpha in MDSCs enhanced the pro-angiogenic, immune suppressive and pro-tumorigenic behav
147 e we show that BMP6 and BMP2 ligands are pro-angiogenic in vitro and in vivo, and that lateral vessel
149 te the target genes, including cysteine-rich angiogenic inducer 61 (CYR61), connective tissue growth
154 and COX and identifies ct-8,9-E-11-HET as an angiogenic lipid, suggesting a physiological role for CO
155 r burden and expression of proliferative and angiogenic markers was decreased in the miR-24 inhibited
157 easing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM
160 effect of N6L has been observed in a highly angiogenic mouse model of pancreatic neuroendocrine tumo
161 or the experimentally observed dependency of angiogenic network evolution on growth-induced solid str
165 5/8 signalling results in both pro- and anti-angiogenic outputs, highlighting a poor understanding of
167 ms from its ability to globally downregulate angiogenic pathways in cancer cells through regulation o
169 dulating the expression of genes involved in angiogenic pathways such as VEGF (vascular endothelial g
174 d induced an inflammatory, catabolic and pro-angiogenic phenotype in bovine nucleus pulposus and cart
175 the anti-angiogenic SMC phenotype to the pro-angiogenic phenotype, which may be essential for CPEC to
177 was to assess whether ethanol, which induces angiogenic phenotypes in endothelial cells, could be emp
178 n demonstrated that physiological stimuli of angiogenic phenotypes in EV-producing cells can enhance
179 associated with declines in the survival and angiogenic potency of miPSC-ECs, and capillary and arter
182 via thermal oxidation method to enhance the angiogenic potential of human umbilical vein endothelial
183 ession of RPS15A in Huh7 cells increased the angiogenic potential of HUVEC in a paracrine fashion; co
185 r, these studies highlight a key role of pro-angiogenic potential of transplanted osteogenic cells fo
186 osteogenic progenitor cells with higher pro-angiogenic potential significantly enhance bone repair i
187 etinal endothelial cell barrier function and angiogenic potential via activation of oxidative stress.
192 al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery
194 f corneal alloimmunity, including immune and angiogenic privilege, mechanisms of allosensitization, c
195 is of choroidal neovascularization (CNV), an angiogenic process that critically contributes to vision
196 sion and migration are critical steps of the angiogenic process, whose dysfunction is associated with
198 ood vessel formation is thought to occur via angiogenic processes involving branching from existing v
199 es, which include hypoxia, also regulate the angiogenic processes within a tumour, facilitating the s
201 f ECFCs increased their in vitro and in vivo angiogenic properties in mice with hindlimb ischemia.
202 ndothelial cell proliferation, migration and angiogenic properties in vitro, increased postnatal reti
204 aged RPE also elicits elevated levels of pro-angiogenic proteins that promote ex vivo choroidal vesse
205 mination and to develop enzyme inhibitors as angiogenic regulators to treat metastasis and tumour gro
206 or example, both inflammation and inadequate angiogenic remodeling can drive fibrosis, which can in t
209 a and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Mat
210 ) expression and to determine the underlying angiogenic response in mouse endothelial cells, and in r
211 ure in vivo studies to direct or pattern the angiogenic response in regenerating tissues to encourage
212 miR-424 ortholog) and miR-503 have augmented angiogenic response to LPS in a Matrigel plug assay.
218 A siRNA knockdown of HSP70-1 suppressed angiogenic responses and eNOS phosphorylation induced by
219 IL-10 expressing NK cells markedly enhanced angiogenic responses and placental development in DC exp
220 ing of IL-5 to IL-5Ralpha receptors enhances angiogenic responses by stimulating the expression of HS
224 The result suggests that IL-37 induces pro-angiogenic responses through TGF-beta, which may act as
225 tyrosine kinase 2 (Pyk2) in endothelial cell angiogenic responses, its role in pathological retinal a
233 ces were observed between the TIF and plasma angiogenic secretomes in triple negative MDA-MB-231 brea
234 ing of EC metabolism, how it intersects with angiogenic signal transduction, and how alterations in m
235 mor compartment whose volume depends on the "angiogenic signal" produced when VEGF binds to its recep
236 herapy may be driven by restoration of renal angiogenic signaling and attenuated fibrogenic activity,
240 Here, in a striking parallel to tumor pro-angiogenic signaling, we identify angiopoietin-2 (ANG-2)
241 Besides an increase in the production of pro-angiogenic signals such as vascular endothelial growth f
244 e a potent stimulator for switching the anti-angiogenic SMC phenotype to the pro-angiogenic phenotype
245 concept that synthetic SMC exhibits an anti-angiogenic SMC phenotype, whereas contractile SMC shows
246 small interfering RNAs or GapmeRs inhibited angiogenic sprouting and alignment of endothelial cells
247 ic device to study chemokine gradient-driven angiogenic sprouting and find that matrix degradability
248 amily 14 member A (CLEC14A) display enhanced angiogenic sprouting and hemorrhage as well as enlarged
249 We analyzed the data collected in-situ from angiogenic sprouting experiments and identified the diff
250 angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants, and retina
251 y delayed healing of skin wounds and reduced angiogenic sprouting in subcutaneous matrigel plugs.
255 leukocytes extravasated from limbal vessels, angiogenic stalks, and growing tip vessels and migrated
256 ecretion of VEGF downstream of the two major angiogenic stimuli occurring during pressure overload br
258 acity, having osteogenic potential (PC-O) or angiogenic support function (PC-M), while lacking adipog
260 proangiogenic function, which inhibited the angiogenic switch necessary for malignant progression of
261 -17-92 cluster expression contributes to the angiogenic switch of ECs and participates in the regulat
263 tate stroma is critical for activation of an angiogenic switch that fuels exponential tumor growth.
264 xis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogen
266 knockout results in an additive reduction in angiogenic switching, whereas at late stages, several tu
267 onuclear ZO-1 pattern was significantly more angiogenic that that without detectable cytonuclear ZO-1
268 The model is then utilized to simulate anti-angiogenic therapeutic interventions targeting VEGFR2-ER
270 kely contribute to this remodeling, but anti-angiogenic therapies do not improve AML patient outcomes
272 ovide strong implications for designing anti-angiogenic therapies that may differentially target endo
274 low molecular weight heparin (LMWH) in anti-angiogenic therapy has been tempered by poor in vivo del
276 t is likely that acquired resistance to anti-angiogenic therapy will involve alterations of the tumor
283 ith either full-length TSP1 or 3TSR, an anti-angiogenic TSP1 fragment, suppresses heightened vascular
284 0 mumin zebrafish and significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic
285 ivity in vessels of patient-derived FVMs and angiogenic tufts in the retina of mice with oxygen-induc
286 cale, in-silico model of dynamically coupled angiogenic tumour growth is specified to in-vivo and in-
287 estimates and inverse correlation with anti-angiogenic tyrosine-kinase inhibition in comparison to p
293 ons of angiogenic (VEGF-A, Ang1, Ang2), anti-angiogenic (VEGF-A165b ) and lymphangiogenic (VEGF-C) fa
294 inflammatory (IL-1beta and TNFalpha) and pro-angiogenic (VEGFA) genes expressed by mast cells, and mi
297 leukocytes accumulated in a higher number in angiogenic vessels, but extravasated less toward the imp
298 itates the homing of targeted NPs to adipose angiogenic vessels, thereby amplifying their delivery.
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