ライフサイエンスコーパス: angiogenic growth factor

1 in our studies expresses high levels of this angiogenic growth factor.

2 and can be reversed by administration of an angiogenic growth factor.

3 y to treatment groups with either placebo or angiogenic growth factor.

4 endothelial cell migration in response to an angiogenic growth factor.

5 roviding direct evidence for GRO-alpha as an angiogenic growth factor.

6 r endothelial growth factor (VEGF), a potent angiogenic growth factor.

7 esses, and 2) exogenous focal delivery of an angiogenic growth factor.

8 l injury when administered in the absence of angiogenic growth factor.

9 eration of EPCs or secondary to secretion of angiogenic growth factors.

10 een linked in vivo to enhanced expression of angiogenic growth factors.

11 scular endothelium, which in turn depends on angiogenic growth factors.

12 ne kinase pathway, increasing the amounts of angiogenic growth factors.

13 likely to be associated with the release of angiogenic growth factors.

14 ivity but also stimulating the expression of angiogenic growth factors.

15 ularly considering the multifaceted roles of angiogenic growth factors.

16 round spiral arteries and secrete a range of angiogenic growth factors.

17 duced angiogenesis via modulation of several angiogenic growth factors.

18 ss osteogenic potential and produce numerous angiogenic growth factors.

19 is was driven by sphingosine 1-phosphate and angiogenic growth factors.

20 a" reveals increased levels of proliferative/angiogenic growth factors.

21 responses of the local vascular cells to the angiogenic growth factors.

22 t gliomas and linked to RNA stabilization of angiogenic growth factors.

23 C formation and also inhibited expression of angiogenic growth factors.

24 e and competing for the HS-binding domain of angiogenic growth factors.

25 eading and enhances migration in response to angiogenic growth factors.

26 xercise showed similar secretion patterns of angiogenic growth factors.

27 onplants comparable with that induced by the angiogenic growth factors.

28 omoting macrophages and direct inhibition of angiogenic growth factors.

29 was to determine whether SMOC-2 can modulate angiogenic growth factor activity and angiogenesis.

30 Thymidine phosphorylase (TP) is an angiogenic growth factor and a target for anticancer dru

31 ulation of Notch/Delta gene expression by an angiogenic growth factor and insight into the critical r

32 there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation.

33 proliferative neoplasm strictly dependent on angiogenic growth factors and cytokines and invariably a

34 ells, namely, macrophages, induces potential angiogenic growth factors and cytokines which contribute

35 potently inhibited heparanase and HS-binding angiogenic growth factors and displayed improved antitum

36 dothelial hyporesponsiveness to prototypical angiogenic growth factors and eNOS agonists, underlies v

37 Pro-angiogenic growth factors and enzymes up-regulated durin

38 hains of proteoglycan and releasing HS-bound angiogenic growth factors and facilitates tumor invasion

39 , extracted from a mouse sarcoma, is rich in angiogenic growth factors and has been shown to support

40 The 3DFC contains viable cells that secrete angiogenic growth factors and has previously been shown

41 teriogenesis and increased the expression of angiogenic growth factors and hypoxia-inducible factor-1

42 tained expression of labile genes, including angiogenic growth factors and immunosuppressive cytokine

43 with subsequently reduced concentrations of angiogenic growth factors and increased placental debris

44 agenesis involves the paracrine secretion of angiogenic growth factors and proinflammatory molecules

45 angiogenic phenotype that expressed multiple angiogenic growth factors and proteinases, such as macro

46 is by controlling the expression of multiple angiogenic growth factors and that adenovirus-mediated e

47 crovessels and that disordered expression of angiogenic growth factors and their receptors may contri

48 Angiogenic growth factors and their receptors, such as b

49 Allogeneic stimulation induces angiogenic growth factors and TSP-1 in T cells.

50 est a potential negative interaction between angiogenic growth factors and vascular cells; their use

51 tein tyrosine phosphorylation, production of angiogenic growth factors, and activation of signal prot

52 EMPs), circulating endothelial cells (CECs), angiogenic growth factors, and endothelial progenitor ce

53 nes are up-regulated in response to hypoxia, angiogenic growth factors, and signals regulating capill

54 tyrosine phosphorylation, the production of angiogenic growth factors, and the activation of signal

55 The angiogenic growth factor angiopoietin 2 (Ang2) destabili

56 GF-2), as well as smaller increases in other angiogenic growth factors (angiopoietin-2, thrombopoieti

57 Many angiogenic growth factors are regulated by hypoxia-induc

58 also detected in perinecrotic areas in which angiogenic growth factors are up-regulated.

59 Angiogenic growth factor assays revealed a distinct incr

60 f these fragments exceeded that of the known angiogenic growth factor, basic fibroblast growth factor

61 VEGF is unique among angiogenic growth factors because it disrupts endothelia

62 s produced placenta growth factor (PlGF), an angiogenic growth factor belonging to the vascular endot

63 The angiogenic growth factor bFGF can be incorporated into d

64 001) in response to the administration of an angiogenic growth factor but not to placebo.

65 onuclear cells and the secretion of multiple angiogenic growth factors by CACs was determined.

66 c allografts may alter vascular responses to angiogenic growth factors by inhibiting angiogenesis and

67 Preclinical studies have indicated that angiogenic growth factors can stimulate the development

68 ellular matrix (FDM) is a novel platform for angiogenic growth factor delivery and that FDM-mediated

69 h has long been considered to be dictated by angiogenic growth factors (eg, vascular endothelial grow

70 of hypoxia-inducible factor-1alpha but lower angiogenic growth factor expression, higher expression o

71 arization by a mechanism involving increased angiogenic growth factor expression.

72 ion, suggesting its potential involvement in angiogenic growth factor expression.

73 Ges function is sufficient to substitute for angiogenic growth factor/extracellular matrix (ECM) sign

74 esis is in part mediated by the secretion of angiogenic growth factors from myocytes in response to h

75 o suggest that ocular pathology is a risk of angiogenic growth factor gene transfer.

76 proliferation were measured with or without angiogenic growth factors (GFs).

77 ers of the VEGF and Angiopoietin families of angiogenic growth factors has been linked to haemorrhagi

78 Although the effects of overexpressing angiogenic growth factors have been studied in inducing

79 ompetent to respond to an available level of angiogenic growth factors, however, may potentially limi

80 the ischemic myocardium using genes encoding angiogenic growth factors; however, randomized, double-b

81 These results indicate that the angiogenic growth factor, IGF-1, can regulate RUNX2 DNA

82 odermal tumors and described as an essential angiogenic growth factor in choriocarcinoma and melanoma

83 owever, there was no change in the levels of angiogenic growth factors in comparison to tumors grown

84 nd clinical benefits with gene therapy using angiogenic growth factors in myocardial ischaemia.

85 y that new blood vessel formation induced by angiogenic growth factors in onplants placed on the chor

86 ympathetic nerves regulate the expression of angiogenic growth factors in rat retina.

87 ogical process to control bioavailability of angiogenic growth factors in the cornea.

88 Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neo

89 the hypothesis that there is an increase in angiogenic growth factors in the pulp of orthodontically

90 Despite the expression of angiogenic growth factors in transplanted hearts, neoves

91 neovascularization and on the expression of angiogenic growth factors in vascular endothelial cells.

92 ll-cell adhesion, inflammatory cytokine- and angiogenic growth factor-induced signals impinge on the

93 We recently described how miR-132, an angiogenic growth factor inducible microRNA in the endot

94 The alteration in balance of angiogenic growth factors is mediated by both macrophage

95 bFGF, an angiogenic growth factor, is currently the subject of a

96 Angiogenin, a 14-kDa multifunctional pro-angiogenic growth factor, is upregulated in several type

97 cular endothelial growth factor (VEGF) is an angiogenic growth factor known to be up-regulated in isc

98 The response to serum/angiogenic growth factors mapped to a 38-bp region of th

99 lso some evidence that biochemical assays of angiogenic growth factors may offer similar potential as

100 K1/2 when ECs were stimulated with other pro-angiogenic growth factors, namely fibroblast growth fact

101 Alterations in angiogenic growth factors occur in cardiovascular diseas

102 his study indicates that DNAzymes, targeting angiogenic growth factors of tumors, show promise as ant

103 Injection of angiogenic growth factors often produces unstable and ab

104 To evaluate the effect of angiopoietin-1, an angiogenic growth factor, on lung capillary leakage and

105 om nonpregnant myometrium were cultured with angiogenic growth factors or conditioned medium (CM) fro

106 hese tumors do not depend entirely on either angiogenic growth factors or on neighboring endothelia t

107 utic revascularization with either exogenous angiogenic growth factors or vascular cells has yet to d

108 upport the notion that the administration of angiogenic growth factors, per se, is sufficient to stim

109 We previously reported that the angiogenic growth factor pleiotrophin (PTN) coaxes monoc

110 ith a regulatable expression of the secreted angiogenic growth factor PR39 in cardiomyocytes.

111 Angiogenic growth factors promote alveolar growth and co

112 membranes were examined by Western blot for angiogenic growth factor receptor expression from 1 to 1

113 aluated for the spatiotemporal expression of angiogenic growth factor receptors on endothelial cell (

114 diac myocytes that induces the expression of angiogenic growth factors (see the related article begin

115 Angiogenic growth factor-stimulated cells exhibit substa

116 ease pellets are prepared by mixing purified angiogenic growth factors such as basic fibroblast growt

117 is-dependent, and an increased production of angiogenic growth factors such as vascular endothelial g

118 tors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial g

119 FAK is activated by angiogenic growth factors, such as insulin-like growth f

120 mediates the stimulatory actions of several angiogenic growth factors, such as pleiotrophin (PTN).

121 expression on ECs was enhanced by promotive angiogenic growth factors, such as vascular endothelial

122 the consequences of diminished signaling by angiogenic growth factors, such as VEGF and FGF.

123 ignaling controls both fiber hypertrophy and angiogenic growth factor synthesis, illustrating a mecha

124 e directions regarding bevacizumab and other angiogenic growth factor-targeted therapeutics.

125 atocyte growth factor (scatter factor) is an angiogenic growth factor that binds to its cellular tran

126 al growth factor (VEGF) is a multifunctional angiogenic growth factor that is a primary stimulant of

127 cular endothelial growth factor (VEGF) is an angiogenic growth factor that is a primary stimulant of

128 ave identified Emc10 as a previously unknown angiogenic growth factor that is produced by bone marrow

129 Angiopoietin-1 (Ang-1) is an angiogenic growth factor that promotes the chemotaxis of

130 Scatter factor (SF) is an angiogenic growth factor that stimulates motility and in

131 r angiogenesis is mediated by tumor-secreted angiogenic growth factors that interact with their surfa

132 growth factor 165 (VEGF(165)) are potent pro-angiogenic growth factors that play a pivotal role in tu

133 Here, we have shown that angiogenic growth factors that stimulate endothelial cel

134 collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is

135 The rapid development of angiogenic growth factor therapy for patients with advan

136 ization may be a generic requirement for pro-angiogenic growth factors to activate ERK1/2 signaling i

137 Controlled delivery approaches of angiogenic growth factors used adjunctively with GBR may

138 r necrosis factor-alpha to production of the angiogenic growth factor vascular endothelial growth fac

139 ignificant proliferation but did secrete the angiogenic growth factors vascular endothelial growth fa

140 jection of plasmid DNA encoding the secreted angiogenic growth factor, vascular endothelial growth fa

141 We hypothesized that the angiogenic growth factor, vascular endothelial growth fa

142 ctivity, resulting in high expression of pro-angiogenic growth factors: vascular endothelial growth f

143 of the anti-inflammatory cytokine IL-10, the angiogenic growth factor VEGF and angiogenesis were high

144 The angiogenic growth factor VEGF generated by the inflamed

145 ng are well studied and are dependent on the angiogenic growth factor VEGF, the factors involved in s

146 ear polarity and migration downstream of the angiogenic growth factors VEGF-A and Slit2.

147 e cat retina in association with increase of angiogenic growth factors (VEGF and bFGF) and activation

148 Treatment of ECV 304 cells with known angiogenic growth factors (VEGF, bFGF, or hepatocyte gro

149 constitutive and TNF-mediated expression of angiogenic growth factors (VEGF, HGF, PLGF), and SDF-1al

150 Cross-talk between the major angiogenic growth factor, VEGF, and integrin cell adhesi

151 Injection of PR39 or another angiogenic growth factor, VEGF-B, into murine hearts dur

152 though VEGF165 is one of the most potent pro-angiogenic growth factors, VEGF165 treatment for myocard

153 e of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling

154 CD13/APN in endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway.

155 d with enhanced EC migration and response to angiogenic growth factors, we characterized a specific p

156 ting EPC numbers as well as plasma levels of angiogenic growth factors were assessed.

157 1) activates transcription of genes encoding angiogenic growth factors, which are secreted by hypoxic

158 ntal gradient of oxygen generates changes in angiogenic growth factors, which may underline the patho