ライフサイエンスコーパス: angiopathy

1 of 'familial cerebellar ataxia with amyloid angiopathy'.

2 d enhancing astrocytosis or cerebral amyloid angiopathy.

3 le lobar CMBs suggestive of cerebral amyloid angiopathy.

4 rly for lobar hemorrhages related to amyloid angiopathy.

5 se gene variants on risk of cerebral amyloid angiopathy.

6 ing Alzheimer's disease and cerebral amyloid angiopathy.

7 to significantly increased cerebral amyloid angiopathy.

8 ating neuroinflammation and cerebral amyloid angiopathy.

9 ial dissection, vasculitis, or postvaricella angiopathy.

10 amyloid diseases including cerebral amyloid angiopathy.

11 ated with familial forms of cerebral amyloid angiopathy.

12 lzheimer's disease (AD) and cerebral amyloid angiopathy.

13 myloid disease known as PrP cerebral amyloid angiopathy.

14 en, and 5) led to the development of amyloid angiopathy.

15 id deposits associated with cerebral amyloid angiopathy.

16 se familial forms of AD and cerebral amyloid angiopathy.

17 eningoencephalic vessels as cerebral amyloid angiopathy.

18 wo pathways associated with cerebral amyloid angiopathy.

19 rentially mature senile plaques, and amyloid angiopathy.

20 ith Alzheimer's disease and cerebral amyloid angiopathy.

21 cored plaques, and mild or moderate amyloid angiopathy.

22 lay onset and retard progression of diabetic angiopathy.

23 yloid disease, hereditary cystatin C amyloid angiopathy.

24 d blood vessels severely affected by amyloid angiopathy.

25 ular degeneration in AD and cerebral amyloid angiopathy.

26 s causing familial forms of cerebral amyloid angiopathy.

27 logical hallmarks of AD and cerebral amyloid angiopathy.

28 morrhage is the hallmark of cerebral amyloid angiopathy.

29 o be associated with the severity of amyloid angiopathy.

30 d Alzheimer's disease despite severe amyloid angiopathy.

31 ontributes significantly to cerebral amyloid angiopathy.

32 od vessels of patients with cerebral amyloid angiopathy.

33 nic Alzheimer's disease and cerebral amyloid angiopathy.

34 t not Braak tangle stage or cerebral amyloid angiopathy.

35 th a particular emphasis on cerebral amyloid angiopathy.

36 gy of Alzheimer's disease and cerebral Abeta angiopathy.

37 Willis atherosclerosis, or cerebral amyloid angiopathy.

38 rominent Abeta38-containing cerebral amyloid angiopathy.

39 total plasma cholesterol or cerebral amyloid angiopathy.

40 Alzheimer disease but can also cause amyloid angiopathy.

41 ystem and the importance of cerebral amyloid angiopathy.

42 ry was significantly associated with amyloid angiopathy.

43 luid (100% versus 58%; P = 0.02) and amyloid angiopathy (50% versus 12%; P = 0.03).

44 nted patients with probable cerebral amyloid angiopathy (69 +/- 10 years) and 29 similar aged control

45 merging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral

46 In hereditary cystatin C amyloid angiopathy, a cystatin C variant is deposited in arteria

47 ons of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no pla

48 yperphosphorylated tau; and cerebral amyloid angiopathy, a microangiopathy affecting both cerebral co

49 th muscle cells (SMCs) isolated from amyloid-angiopathy affected brain vessels accumulate intracellul

50 ementia can be secondary to cerebral amyloid angiopathy alone.

51 of candidate treatments for cerebral amyloid angiopathy, an untreatable cause of haemorrhagic stroke

52 ding a clue to the known association between angiopathies and diabetes and implying new gene candidat

53 wild-type mice, and formed cerebral amyloid angiopathy and Abeta plaques after a 12-month period of

54 ation, wound healing, scarring, angiogenesis/angiopathy and basement membrane physiology, as well as

55 0 and Abeta42 levels and accelerates amyloid angiopathy and cerebral beta-amyloidosis by diminishing

56 -tau pathology, severity of cerebral amyloid angiopathy and cortical microhaemorrhages.

57 walls was characteristic of cerebral amyloid angiopathy and did not co-localize with prion protein de

58 s, multiple system atrophy, cerebral amyloid angiopathy and elderly controls free of pathology.

59 ably increased the level of cerebral amyloid angiopathy and exacerbated cerebral amyloid angiopathy-r

60 Two persons had severe amyloid angiopathy and haemorrhagic stroke.

61 role in the pathogenesis of cerebral amyloid angiopathy and in the accumulation of Abeta in the brain

62 The severity of cerebral amyloid angiopathy and microhaemorrhages did not relate to any o

63 ears) with pathology-proven cerebral amyloid angiopathy and multiple microbleeds on in vivo clinical

64 Braak stage was five or six, amyloid angiopathy and neuritic plaques were common and more tha

65 Cerebral amyloid angiopathy and neurofibrillary tangles persist, however,

66 lationship between advanced cerebral amyloid angiopathy and neurologic dysfunction and that such larg

67 ved in an inherited form of cerebral amyloid angiopathy and readily form amyloid fibrils in vitro.

68 etween complement dysregulation and systemic angiopathy and suggest that complement activation may co

69 tter and in artery walls as cerebral amyloid angiopathy and tau protein accumulates as neurofibrillar

70 to be in part a protein elimination failure angiopathy and that this dysfunction is a feed-forward p

71 here a striking correlation between amyloid angiopathy and the location of mutation in PS-1 linked A

72 39 with clinically probable cerebral amyloid angiopathy) and 47 age-matched controls.

73 not Abeta42) levels, cerebrovascular amyloid angiopathy, and ApoE4 allele frequency were all highly c

74 ic small vessel disease and cerebral amyloid angiopathy, and determined the Braak tangle stage.

75 been linked to HF through perfusion defects, angiopathy, and inflammation, whether patients with AD p

76 t cortical amyloid plaques, cerebral amyloid angiopathy, and tauopathy.

77 ic for microhaemorrhages in cerebral amyloid angiopathy, and that increasing the resolution of magnet

78 bleeds and microinfarcts in cerebral amyloid angiopathy, and to explore the pathological burden that

79 of Alzheimer's disease and cerebral amyloid angiopathy, APOE has been studied in other neurological

80 filament formation, cerebrovascular amyloid angiopathy, apolipoprotein E (ApoE) allotype, and synapt

81 e pathophysiological level, cerebral amyloid angiopathy appears to be in part a protein elimination f

82 roimaging markers of severe cerebral amyloid angiopathy are cortical microbleeds and microinfarcts.

83 ninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as h

84 viously designated familial cerebral amyloid angiopathy-British type, is an autosomal dominant disord

85 uction of Abeta plaques and cerebral amyloid angiopathy burden and a reduction of the total brain lev

86 ls where there was a severe cerebral amyloid angiopathy burden.

87 ge, and pathologically showed severe amyloid angiopathy but only rare neuritic senile plaques and neu

88 enotype was associated with cerebral amyloid angiopathy, but not HS or arteriosclerosis.

89 yloid-beta (Abeta) plaques, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles.

90 f 190 AD subjects exhibited cerebral amyloid angiopathy (CAA) and other frequently associated lesions

91 along cerebrovasculature as cerebral amyloid angiopathy (CAA) are hallmarks of AD.

92 itis of the CNS (PACNS) and cerebral amyloid angiopathy (CAA) are unusual vasculopathies generally re

93 th pathologically diagnosed cerebral amyloid angiopathy (CAA) for evidence of an inflammatory respons

94 Although cerebral amyloid angiopathy (CAA) has important clinical implications, ou

95 Cerebral amyloid angiopathy (CAA) has never been more relevant.

96 ebral haemorrhage (ICH) and cerebral amyloid angiopathy (CAA) in a systematic review of published neu

97 n selectively induces acute cerebral amyloid angiopathy (CAA) in neonatally-injected transgenic CRND8

98 Sporadic cerebral amyloid angiopathy (CAA) is a common age related cerebral small

99 Cerebral amyloid angiopathy (CAA) is a common cause of brain hemorrhage i

100 Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intrac

101 orm of neuritic plaques and cerebral amyloid angiopathy (CAA) is a key feature of Alzheimer's disease

102 Cerebral amyloid beta-protein angiopathy (CAA) is a key pathological feature of patien

103 emorrhagic stroke, advanced cerebral amyloid angiopathy (CAA) is also associated with ischemic lesion

104 Cerebral amyloid angiopathy (CAA) is an age-associated condition and a co

105 Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral

106 Cerebral amyloid angiopathy (CAA) is characteristically associated with m

107 Cerebral amyloid angiopathy (CAA) is characterized by deposition of amylo

108 Cerebral amyloid angiopathy (CAA) is characterized by the deposition of a

109 Cerebral amyloid angiopathy (CAA) is common in Alzheimer's disease (AD) a

110 Cerebral amyloid angiopathy (CAA) is common in the ageing brain and is as

111 Cerebral amyloid angiopathy (CAA) is the accumulation of amyloid-beta pep

112 Cerebral amyloid angiopathy (CAA) may play a key role in determining the

113 ajor trends in the field of cerebral amyloid angiopathy (CAA) over six decades, from 1954 to 2014, us

114 Cerebral amyloid angiopathy (CAA) results from deposition of beta-amyloid

115 but has no direct effect on cerebral amyloid angiopathy (CAA) severity, whereas APOEepsilon4 is assoc

116 ngles, neuropil threads and cerebral amyloid angiopathy (CAA) similar to unimmunized AD, but lacked p

117 pertensive arteriopathy and cerebral amyloid angiopathy (CAA)) is an important cause of spontaneous i

118 ve cerebrovascular amyloid (cerebral amyloid angiopathy (CAA), and cardiovascular risk factors increa

119 compact amyloid plaques, congophilic amyloid angiopathy (CAA), and diffuse Abeta deposits.

120 We postulated that cerebral amyloid angiopathy (CAA), characterised by cortical vascular amy

121 beta), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of pa

122 ssels, a condition known as cerebral amyloid angiopathy (CAA), is a key pathological feature of Alzhe

123 beta), a condition known as cerebral amyloid angiopathy (CAA), is a key pathological feature of Alzhe

124 lls of brain blood vessels, cerebral amyloid angiopathy (CAA), is common in patients with Alzheimer's

125 notype in hemorrhage due to cerebral amyloid angiopathy (CAA), it is unclear whether apoE genotype in

126 cerebral arteries, known as cerebral amyloid angiopathy (CAA), occurs both in the setting of Alzheime

127 w (Tg2576) mice, a model of cerebral amyloid angiopathy (CAA), suggesting a pivotal role for Bim in A

128 Cerebral amyloid angiopathy (CAA), the deposition of cerebrovascular beta

129 is increasing evidence that cerebral amyloid angiopathy (CAA), which itself can cause haemorrhage (CA

130 -9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage.

131 been reported to exacerbate cerebral amyloid angiopathy (CAA)-related microhemorrhage in a transgenic

132 arance of a core AD lesion, cerebral amyloid angiopathy (CAA).

133 e primarily associated with cerebral amyloid angiopathy (CAA).

134 al distribution in sporadic cerebral amyloid angiopathy (CAA).

135 rtex and in blood vessel as cerebral amyloid angiopathy (CAA).

136 of Alzheimer's disease and cerebral amyloid angiopathy (CAA).

137 els of soluble Abeta but no cerebral amyloid angiopathy (CAA).

138 including familial forms of cerebral amyloid angiopathy (CAA).

139 n cerebral blood vessels as cerebral amyloid angiopathy (CAA).

140 diffuse plaques and cerebrovascular amyloid angiopathy (CAA).

141 in blood vessels is called cerebral amyloid angiopathy (CAA).

142 alls of cerebral vessels as cerebral amyloid angiopathy (CAA).

143 increasingly recognised in cerebral amyloid angiopathy (CAA).

144 r inflammatory processes in cerebral amyloid angiopathy (CAA).

145 e characteristic markers of cerebral amyloid angiopathy (CAA).

146 nchymal amyloid plaques and cerebral amyloid angiopathy (CAA).

147 y might be early markers of cerebral amyloid angiopathy (CAA).

148 e cerebrovasculature [i.e., cerebral amyloid angiopathy (CAA)] and a heightened risk of micro-hemorrh

149 n the cerebral vasculature [cerebral amyloid angiopathy (CAA)] in the majority of patients.

150 ascular amyloid deposition (cerebral amyloid angiopathy [CAA]) but not in patients with high parenchy

151 deposition of beta-amyloid (cerebral amyloid angiopathy [CAA]) is a major cause of hemorrhagic stroke

152 ar beta-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds

153 tential outcome markers for cerebral amyloid angiopathy can be measured against the ideal criteria of

154 e wall of cerebral vessels (cerebral amyloid angiopathy), can lead to weakness and rupture of the ves

155 In cerebral amyloid angiopathy cohorts, cortical superficial siderosis is as

156 Cerebral angiopathy contributes to cognitive decline and dementia

157 olipoprotein E subtypes and cerebral amyloid angiopathy; deep intracerebral hemorrhage and the potent

158 has on reducing the rate of cerebral amyloid angiopathy deposition and restoring cerebral vascular he

159 ates atherosclerotic progression, peripheral angiopathy development, and arterial hypertension, all o

160 eimer's disease and related cerebral amyloid angiopathy disorders.

161 isease and related familial cerebral amyloid angiopathy disorders.

162 , several familial forms of cerebral amyloid angiopathy exist including the Dutch (E22Q) and Iowa (D2

163 Familial British dementia with amyloid angiopathy (FBD) is an autosomal dominant condition char

164 A PrP cerebral amyloid angiopathy has not been reported in diseases caused by P

165 (CADASIL)and some forms of cerebral amyloid angiopathy have a genetic basis.

166 CMBs related to symptomatic cerebral amyloid angiopathy have abnormal vascular reactivity and cerebra

167 hanism, microembolism and pulmonary vascular angiopathy have been noted in rats.

168 P23-144, associated with a heritable amyloid angiopathy, have previously been shown to contain a comp

169 s include severe widespread cerebral amyloid angiopathy, hippocampal plaques, and neurofibrillary tan

170 alysis to definite/probable cerebral amyloid angiopathy ICH uncovered a stronger effect.

171 Cerebral amyloid angiopathy in Alzheimer's disease is characterized by de

172 ontributes significantly to cerebral amyloid angiopathy in Alzheimer's disease.

173 sence of severe or moderately severe amyloid angiopathy in five family members with clinical dementia

174 ffuse and focal plaques and cerebral amyloid angiopathy in humans and nonhuman primates, whereas it i

175 issue from a patient with TBI showed amyloid angiopathy in meningeal vessels.

176 ase in the number of new plaques and amyloid angiopathy in the area immediately surrounding the infar

177 Autopsy revealed cerebral amyloid angiopathy in the complete absence of amyloid plaques or

178 e and ADan (Danish Amyloid) cerebral amyloid angiopathy in the mouse model of FDD.

179 xtent of leptomeningeal and cortical amyloid angiopathy in the normal aged subjects and in the AD pat

180 rphologic features and the role of choroidal angiopathy in various disease states that, in the future

181 ypertensive arteriopathy or cerebral amyloid angiopathy) in a multicentre, cross-sectional study.

182 ial Alzheimer's disease and cerebral amyloid angiopathy, in which patients develop neuritic plaques a

183 r Abeta plaques versus cerebral beta-amyloid angiopathy, indicating that different amyloid types and

184 Cerebral amyloid angiopathy is a common form of small-vessel disease and

185 Cerebral amyloid angiopathy is a common neuropathological finding in the

186 Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel diseas

187 lts suggest that underlying cerebral amyloid angiopathy is a contributing factor to the occurrence of

188 As cerebral amyloid angiopathy is an almost invariable pathological finding

189 Hereditary cystatin C amyloid angiopathy is an autosomal dominant disorder in which a

190 consequences; for example, cerebral amyloid angiopathy is an important cause of haemorrhagic stroke.

191 Cerebral amyloid angiopathy is characterized by accumulation of the short

192 sgenic mouse model of human cerebral amyloid angiopathy is characterized by age-dependent cerebrovasc

193 From a clinical standpoint, cerebral amyloid angiopathy is characterized by individual focal lesions

194 Cerebral amyloid angiopathy is common among elderly patients, and is asso

195 Cerebral amyloid angiopathy is commonly associated with normal aging and

196 Prominent cerebral amyloid angiopathy is often observed in the brains of elderly in

197 the presence and burden of cerebral amyloid angiopathy is particularly important when planning to st

198 , its involvement in AD and cerebral amyloid angiopathy is poorly understood.

199 rebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overl

200 ) deposition, also known as cerebral amyloid angiopathy, is a common pathological feature of Alzheime

201 ature, a condition known as cerebral amyloid angiopathy, is increasingly recognized as an important c

202 eal, cortical and capillary cerebral amyloid angiopathy, large infarcts, lacunar infarcts, microhaemo

203 pathologies-leptomeningeal cerebral amyloid angiopathy, large infarcts, lacunar infarcts, microinfar

204 , arteriolar sclerosis, and cerebral amyloid angiopathy), Lewy bodies, transactive response DNA-bindi

205 ques, gross infarcts, microinfarcts, amyloid angiopathy, Lewy bodies, APOE epsilon4 presence, and cli

206 rovascular abnormalities of cerebral amyloid angiopathy (lobar structures) and hypertensive vasculopa

207 in locations suggestive of cerebral amyloid angiopathy (lobar with or without cerebellar microbleeds

208 Evidence suggests that choroidal angiopathy may coexist with retinal vascular damage.

209 ere small vessel disease or cerebral amyloid angiopathy may contribute in some cases, abnormal vascul

210 without adversely affecting cerebral amyloid angiopathy, microhemorrhages, myelination, or neuromuscu

211 re occipital leptomeningeal cerebral amyloid angiopathy, moderate/severe arteriolosclerosis in occipi

212 in in an age-dependent manner, forms amyloid angiopathy morphologically similar to that seen in the h

213 sized that in patients with cerebral amyloid angiopathy, multiple small spatially distributed lesions

214 ere small vessel disease or cerebral amyloid angiopathy, neither VEGF nor MAG:PLP1 correlated signifi

215 ephaly, small vessel disease, and hereditary angiopathy, nephropathy, aneurysms, and cramps (HANAC) s

216 the brain and give rise to cerebral amyloid angiopathy, neuronal dysfunction, and cellular toxicity.

217 Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and ne

218 ic lesions neither halted progression of the angiopathy nor provided appreciable benefit at the 24-mo

219 The term 'cerebral amyloid angiopathy' now encompasses not only a specific cerebrov

220 is abundant in plaques and cerebral amyloid angiopathy of AD and Down syndrome patients, colocalizin

221 Benign angiopathy of the central nervous system (BACNS) is a su

222 nd in the vasculature (cerebral beta-amyloid angiopathy) of beta-amyloid precursor protein transgenic

223 of Alzheimer's disease and cerebral amyloid angiopathy on the structure of the 21-30 fragment of the

224 logy (small vessel disease, cerebral amyloid angiopathy or VWF).

225 ial Alzheimer's disease, congophilic amyloid angiopathy, or hereditary cerebral hemorrhage with amylo

226 teriovenous shunts, biopsy-proven microrenal angiopathy, or thrombocytopenia and thus were diagnosed

227 n, generally, but also to facilitate amyloid angiopathy particularly in cases in which the mutation l

228 tion of fibrinogen lessened cerebral amyloid angiopathy pathology and reduced cognitive impairment in

229 ntrast, atherosclerosis and cerebral amyloid angiopathy pathology were associated with a lower level

230 protein deposits in human cystatin C amyloid angiopathy patients have also been found in tissues outs

231 t not Braak tangle stage or cerebral amyloid angiopathy predicted (11)C-Pittsburgh compound B standar

232 (PRNP), associated with PrP cerebral amyloid angiopathy (PrP-CAA) and Gerstmann-Straussler-Scheinker

233 to name this phenotype PrP cerebral amyloid angiopathy (PrP-CAA).

234 neurofibrillary tangle and cerebral amyloid angiopathy ratings in the whole sample and within indivi

235 tionship between markers of cerebral amyloid angiopathy-related brain injury, network efficiency, and

236 ated patients with sporadic cerebral amyloid angiopathy-related hemorrhage found no other instances o

237 ever, their contribution to cerebral amyloid angiopathy-related hemorrhage remains unclear.

238 Cerebral amyloid angiopathy-related inflammation (CAA-ri) is an important

239 Cerebral amyloid angiopathy-related inflammation (CAA-ri) is characterize

240 three times more common in cerebral amyloid angiopathy-related intracerebral haemorrhage than in oth

241 was 9/39 (23%) in probable cerebral amyloid angiopathy-related intracerebral haemorrhage versus 6/75

242 angiopathy and exacerbated cerebral amyloid angiopathy-related microhemorrhage in APP23/ABCA1-/- mic

243 e who were previously enrolled in the Bypass Angiopathy Revascularization Investigation to compare in

244 d they had a higher risk of cerebral amyloid angiopathy (RR 6.6, 1.5-29.6).

245 48; 95% CI, 1.06-5.82), and cerebral amyloid angiopathy severity (p = 0.032; OR, 4.16; 95% CI, 1.13-1

246 dense-core (senile) plaques, in the amyloid angiopathy surrounding diseased blood vessels, and in th

247 myloid-beta plaque load and cerebral amyloid angiopathy than early disease onset and tremor dominant

248 s may facilitate development of beta-amyloid angiopathy that is more frequent in varepsilon 4/ vareps

249 Fibromuscular dysplasia is an uncommon angiopathy that occurs in young to middle-aged, predomin

250 d from brain blood vessels with amyloid-beta angiopathy - the cells that were shown previously to acc

251 acerebral hemorrhage due to cerebral amyloid angiopathy, the result of beta-amyloid deposition in cer

252 uding microinfarcts, microhemorrhages, bland angiopathy, thrombotic angiopathy with platelet and fibr

253 well as neurofibrillary tangles and amyloid angiopathy throughout the cerebral cortex.

254 in network in patients with cerebral amyloid angiopathy to healthy control subjects and examined the

255 nsgenic mice with prominent cerebral amyloid angiopathy to investigate the ability of ponezumab, an a

256 the candidate outcomes for cerebral amyloid angiopathy trials are probably applicable also to other

257 essels from subjects having cerebral amyloid angiopathy was 90 degrees out of phase from that in the

258 Amyloid angiopathy was present in these cases and was readily de

259 S1 and APP/PS1/AI mice, but cerebral amyloid angiopathy was reduced in APP/PS1/AI mice.

260 s of hippocampal Abeta, and cerebral amyloid angiopathy was significantly more common compared with P

261 ffect of Apoa-I deletion on cerebral amyloid angiopathy, we measured insoluble Abeta isolated from ce

262 s, mainly according to the degree of amyloid angiopathy, were seen in the cerebellum.

263 at least partly, related to cerebral amyloid angiopathy, which belongs to the continuum of cerebral s

264 e have been associated with cerebral amyloid angiopathy, while those in the basal ganglia have been a

265 cause a hereditary form of cerebral amyloid angiopathy whilst cystatin B aggregates are found in cas

266 the proband revealed severe cerebral amyloid angiopathy, widespread neurofibrillary tangles, and unus

267 n with loss of cholinergic neurons, gliosis, angiopathy with mononuclear cell cuffing, progressive ca

268 isease, familial porencephaly and hereditary angiopathy with nephropathy aneurysm and cramps (HANAC)

269 crohemorrhages, bland angiopathy, thrombotic angiopathy with platelet and fibrin thrombi, neuronal ne

270 develop severe early-onset cerebral amyloid angiopathy with some of the related variants manifesting

271 e expected increase in prevalence of amyloid angiopathy with the ageing population, suggest that, in