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2 tumor growth in vivo and suggest that these angiostatic activities may one day be exploited to comba
3 that the WARS mutation could potentiate the angiostatic activities of TrpRS by enhancing its interac
4 ynthetase (T2-TrpRS) has demonstrated potent angiostatic activity during retinal developmental neovas
6 ls may also use this receptor to mediate the angiostatic activity of IP-10/CXCL10, which is also expr
9 ran sulfate proteoglycan perlecan, possesses angiostatic activity via dual receptor antagonism, throu
10 IFNalpha-inducible effector, possess potent angiostatic activity, doing so in part by forming a posi
21 indings establish FBLN-3 and FBLN-5 as novel angiostatic agents capable of reducing tumor angiogenesi
24 118 is a topomimetic of galectin-1-targeting angiostatic amphipathic peptide Anginex, we had yet to p
27 tained-release devices facilitate high local angiostatic and antipermeability concentrations while mi
28 , however, investigators have focused on the angiostatic and antipermeability properties of corticost
29 erived factor (PEDF) is a 50-kD protein with angiostatic and neurotrophic activities that regulates v
31 accination-induced antisera displayed strong angiostatic and tumor-growth-inhibiting properties in a
32 ry genes; 3) late upregulated (days 7 to 14)-angiostatic, anti-inflammatory, and extracellular matrix
33 o suggest a heretofore unrecognized role for angiostatic basement membrane fragments in platelet biol
34 d on structure-activity relationships of the angiostatic beta-sheet-forming peptide anginex, we have
36 r fibrosis by therapeutic treatment with the angiostatic chemokine Cxcl9 was systematically analyzed
37 mokines such as interleukin 8 (IL-8) and for angiostatic chemokines such as interferon-inducible prot
39 ed a significant secretion of angiogenic and angiostatic chemokines, mainly across the hfRPE apical m
42 dent in part on a relative deficiency of the angiostatic CXC chemokine, IFN-gamma-inducible protein-1
44 of liver scarring, but a functional role of angiostatic CXCR3 chemokines in this process is unclear.
48 t a promising new strategy to potentiate the angiostatic effect of endorepellin and perhaps other ang
49 her define the sequences responsible for the angiostatic effect of TSP-1, we used synthetic peptides.
51 ffects at low therapeutic concentrations but angiostatic effects at high concentrations that are reve
55 211377, but pronounced anti-inflammatory and angiostatic effects were achieved by adding the EP1 anta
56 reduces synovial tissue vascularization via angiostatic effects, mediates inhibition of angiogenesis
60 creased expression of the interferon-induced angiostatic ELR- CXC chemokines is a feature of juvenile
64 ly described angiostatic factor, as a potent angiostatic factor that regulates non-small cell lung ca
65 now report that IP-10, a recently described angiostatic factor, as a potent angiostatic factor that
66 ht to determine the relationship of a potent angiostatic factor, endostatin (ES), with disease severi
68 Therefore, we hypothesized that circulating angiostatic factors could be linked to outcomes and repr
69 sity by exposure to different angiogenic and angiostatic factors demonstrated the utility of this sys
70 d concerted expression of pro-angiogenic and angiostatic factors needed to produce functional microva
71 Inhibition of angiogenesis by production of angiostatic factors should be a viable approach for canc
72 ilar natural proteolytic fragment are potent angiostatic factors that act through the vascular endoth
75 for a novel downstream signaling axis for an angiostatic fragment and for the key components involved
76 ve identified a new role for this endogenous angiostatic fragment in inducing autophagy through a VEG
78 unraveled a mechanistic explanation for the angiostatic functions attributed to ADAMTS1 and demonstr
79 t Peg3 induced the secretion of the powerful angiostatic glycoprotein Thrombospondin 1 independently
80 microvessel density in vivo and generates an angiostatic>angiogenic tumor microenvironment that retar
81 ts in the expression of angiogenic (IL-8) vs angiostatic (IFN-gamma-inducible protein (IP-10)) CXC ch
84 which a subset of inflammatory cells secrete angiostatic ligands, which then contribute to a local at
86 lar protein thrombospondin (TSP)-1, a potent angiostatic molecule and crucial activator of transformi
87 in, the C-terminal domain of perlecan, is an angiostatic molecule that acts as a potent inducer of au
88 se studies demonstrate synergism between two angiostatic molecules and that antiangiogenic therapy ca
90 demonstrate synergistic effects of combining angiostatic molecules that target distinct aspects of th
91 Tumor inhibition was presumably due to the angiostatic properties of anecortave acetate because the
92 ts ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an eff
101 epresents the first therapeutic effect of an angiostatic steroid in an animal model of neovascular re
102 tudy was designed to test the capacity of an angiostatic steroid, anecortave acetate, to inhibit reti
104 the authors' laboratory have suggested that angiostatic steroids suppress the PA activity essential
105 w medical and surgical treatments, including angiostatic steroids, nonsteroidal inflammatory agents,
108 determine the efficacy of antiangiogenic and angiostatic therapy in targeting mature vessels in retin
109 In contrast, treatment with combination angiostatic therapy significantly reduced compensatory u
110 umor vascular obliteration using combination angiostatic therapy was associated with reduced tumor ma
111 ing pathway may thus enhance the efficacy of angiostatic treatments for cancer and neovascular eye di
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