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1 s is a systematic review of the safety of IV angiotensin II.
2 hancement, 100 picomole) in the detection of angiotensin II.
3 tion, antimembrane basal GN, and infusion of Angiotensin II.
4 ting their abdominal aorta or by infusion of angiotensin II.
5 unted pressor responses to phenylephrine and angiotensin II.
6 thout influencing the hypertensive effect of angiotensin II.
7 It is also upregulated by angiotensin II.
8 , and development of fibrosis in response to angiotensin-II.
9 SOD2(+/)(-)) mice in response to low dose of angiotensin II (0.3 mg/kg per day) compared with wild-ty
10 udies, in which 31,281 participants received angiotensin II (0.5-3,780 ng/kg/min), were selected.
11 apolipoprotein E knockout mice treated with angiotensin II (1000 ng/kg) were treated with RvD2 or ve
14 he G protein-coupled receptor (GPCR) agonist angiotensin II, a potent mitogen for these cells, induce
16 actors implicated in muscle atrophy, such as angiotensin-II, activin and Acvr2b, in SIRT6 depleted ce
18 activated in heart failure (norepinephrine, angiotensin II, aldosterone, and neprilysin) impair insu
21 ctor (HIF)-1alpha and -2alpha in response to angiotensin II and hypoxia, respectively, which drive VE
22 s receptor axis and vaccines directed toward angiotensin II and its type 1 receptor are in phase I or
23 thus studied whether SREBP-1 is activated by angiotensin II and mediates angiotensin II-induced profi
26 o, mice fed a high-fat diet and treated with angiotensin II and the vasodilator hydralazine to preven
27 received a study intervention (163 received angiotensin II, and 158 received placebo) and were inclu
28 ore age 60, blunted hypertensive response to angiotensin II, and a leftward shift in pressure natriur
29 o-HDL cholesterol ratio, C-reactive protein, angiotensin II, and albuminuria reduction and with incre
30 rofound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbi
31 lternatives such as vasopressin/selepressin, angiotensin II, and phenylephrine could have a fundament
32 scular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of a
33 nhibitor pyr3 was sufficient to inhibit both angiotensin II- and 1-oleoyl-2-acetyl-sn-glycerol-induce
34 roduction of another potent vasoconstrictor, angiotensin II; and we scored the severity of arteriolos
36 e 2 (NADPH oxidase 2 or Nox2) is enhanced by angiotensin II (Ang II) and contributes to increased hyp
37 ressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM-alph
38 K mutation in mice subjected to high salt or angiotensin II (Ang II) as models of hypertension and in
39 protected against the pro-oxidant effects of angiotensin II (Ang II) by attenuating superoxide genera
43 oconstrictor and a proinflammatory mediator, angiotensin II (Ang II) is considered a potential link b
46 Male Sprague Dawley rats were infused with angiotensin II (Ang II) to induce hypertension and orall
47 um influx, and we have previously shown that angiotensin II (Ang II) via canonical transient receptor
49 tension in endemic areas,(1) but the role of angiotensin II (Ang II), a major regulator of blood pres
51 are inhibited by vasoconstrictors, including angiotensin II (Ang II), but the mechanisms involved are
52 2) affects Ca(2+)-activated CaMKII in vitro, Angiotensin II (Ang II)-induced CaMKIIdelta signaling in
54 ms of perivascular leukocyte infiltration in angiotensin II (Ang II)-induced hypertension and their l
55 ing pathways involved in the effect of LC on angiotensin II (Ang II)-induced NADPH oxidase activation
56 gate the roles of SIRT2 in aging-related and angiotensin II (Ang II)-induced pathological cardiac hyp
60 ently, the effect of metformin in regressing angiotensin II (Ang-II)-mediated atheromatous plaque for
61 ralleled in rodents following "slow-pressor" angiotensin II (AngII) administration: young male and ag
63 E knockout (ApoE-KO) mice were infused with angiotensin II (AngII) for 28 days to induce AAA formati
69 ocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glome
71 otassium (p < 0.02), but plasma aldosterone, angiotensin II (ANGII), and renin activities are unchang
73 e but Cre positive; (2) c-hNox4 Tg mice; (3) angiotensin II (AngII)-infused control mice; and (4) c-h
74 othesised that both exogenous and endogenous angiotensin-II (AngII) can decrease the partial pressure
75 upon stimulation with the endogenous ligand angiotensin-II (AngII), including the Gq/11 protein and
76 2 expression, suggesting mechanisms by which angiotensin II antagonism mediates regeneration of capil
77 sion of glomerulosclerosis can be induced by angiotensin II antagonism, but the effect of these treat
78 study (Heart Failure Endpoint evaluation of Angiotensin II Antagonist Losartan), a multinational ran
79 ated Wistar rats with those in untreated and angiotensin II antagonist-treated Munich Wistar Fromter
82 and hemodynamic responses to an infusion of angiotensin II (assessment of intrarenal renin-angiotens
83 ion, particularly because stimulating type 1 angiotensin II (AT1) receptors in the kidney or circulat
86 gression of renal diseases can be delayed by angiotensin II blockers that stabilize renal function or
87 ls consisting of polypropylene glycol (PPG), angiotensin II, bovine serum albumin, and the "thermomet
88 ts binding of the endogenous peptide agonist angiotensin II but not the beta-arrestin-biased peptide
89 where these tumor cells autocrinely produce angiotensin II by a chymase-dependent rather than an ang
90 critical role of hypoxia in producing local angiotensin II by a lactate-chymase-dependent mechanism
92 s-1 knockout mice (n = 26) were infused with angiotensin II by using subcutaneously implanted osmotic
93 biocompounds (arginine, trehalose, DPPC, and angiotensin II) by water cluster primary ion beams in co
94 REBP-1 induces glomerular sclerosis and that angiotensin II can activate SREBP-1 in tubular cells.
95 ansforming growth factor-beta, endothelin-1, angiotensin II, CCN2 (connective tissue growth factor),
96 pertension to either high salt or the second angiotensin II challenge and were protected against rena
97 echanistically, we found that Plk1 regulated angiotensin II-dependent activation of RhoA and actomyos
98 on did not affect angiotensin II production, angiotensin II-dependent BP regulation, or sodium handli
100 explore the repurposing of drugs that target angiotensin II-dependent NFkappaB signaling pathways to
101 included number of subjects, comorbidities, angiotensin II dose and duration, pressor effects, other
103 hough not required for SREBP-1 activation by angiotensin II, EGF receptor signaling was necessary for
104 YAP phosphorylation at Ser(127) and Ser(397) Angiotensin II elicited YAP phosphorylation and cytoplas
105 ractile responses elicited by phenylephrine, angiotensin II, endothelin-1, U46619, and K(+)-induced m
109 omain GPCR that when activated by its ligand angiotensin II, generates signaling events promoting vas
111 nd point was reached by more patients in the angiotensin II group (114 of 163 patients, 69.9%) than i
112 ere reported in 60.7% of the patients in the angiotensin II group and in 67.1% in the placebo group.
113 occurred in 75 of 163 patients (46%) in the angiotensin II group and in 85 of 158 patients (54%) in
114 more severe dysfunction) was greater in the angiotensin II group than in the placebo group (-1.75 vs
115 ffect size sequence of adenosine = 20-HETE > angiotensin II > thromboxane = superoxide > renal nerves
116 s systematic review supports the notion that angiotensin II has an acceptable safety profile for use
117 was fatal in 55 of 115 patients treated with angiotensin II in case studies, cohort studies, and one
119 hanism and highlight the importance of local angiotensin II in regulating radioresistance of hypoxic
122 Treatment of young PAI-1(-/-) mice with Angiotensin II induced extensive hypertrophy and fibroti
123 , we determined that loss of LNK exacerbates angiotensin II-induced (Ang II-induced) hypertension and
124 ngly reduced in rodent AAA models, including angiotensin II-induced AAA and elastase perfusion-stimul
125 ersus male (XY) sex chromosome complement on angiotensin II-induced AAA formation and rupture in phen
129 is required for the formation and rupture of Angiotensin II-induced aortic aneurysms, through effects
133 xidative stress also plays a central role in angiotensin II-induced gap junction remodeling and arrhy
134 a separate study, the alphaAnalogue reversed angiotensin II-induced hypertension and associated vascu
135 othelial cells are hypotensive, resistant to angiotensin II-induced hypertension and have preserved e
141 In animal models of nitrate tolerance and angiotensin II-induced hypertension, decreased vasodilat
143 loid-specific Nox2 deletion had no effect on angiotensin II-induced hypertension, which, however, was
146 the hypoxia-inducible factor complex, during angiotensin II-induced hypertensive nephropathy provided
148 emic delivery of locked nucleic acid rescued angiotensin II-induced perivascular and interstitial fib
150 This response is disease-specific, because angiotensin II-induced pressure overload does not trigge
151 is activated by angiotensin II and mediates angiotensin II-induced profibrogenic responses in primar
152 low shear stress and thrombogenicity through angiotensin II-induced redox-sensitive activation of mit
154 lasmic reticulum stress or SREBP-1 prevented angiotensin II-induced SREBP-1 binding to the TGF-beta p
155 of the SREBP inhibitor fatostatin prevented angiotensin II-induced TGF-beta upregulation and matrix
156 igher in animals with AAA when compared with angiotensin II-infused animals without AAA or control an
159 pendent effects were induced in glomeruli of angiotensin II-infused mice, and administration of the S
160 rt failure, we studied a guinea-pig model of angiotensin II infusion (400 ng kg(-1) min(-1) ) over 12
165 sporadic AAD induced by a high-fat diet and angiotensin II infusion, ADAMTS-4 deficiency (Adamts-4-/
166 al blood pressures and elevated responses to angiotensin II infusion, but that Micu2(-/-) mice exhibi
169 e subjected to pressure overload by means of angiotensin-II infusion or transversal aortic constricti
171 t vascular endothelial growth factor (VEGF), angiotensin-II, interleukin-1beta, and tumor necrosis fa
172 dentified ACE2 as the main enzyme converting angiotensin II into angiotensin-(1-7) in human cerebrosp
180 nced in denervated kidneys, not explained by angiotensin II levels or expression of angiotensin type-
183 unappreciated roles for Micu2 in regulating angiotensin II-mediated hypertensive responses that are
186 rginine-containing peptide receptor ligands (angiotensin II, neurotensin(8-13), an analogue of the C-
187 antibody reduced the deleterious effects of angiotensin II on islet inflammation, restored insulin s
188 protein-coupled receptor agonists, including angiotensin II or bombesin, induced rapid and persistent
190 n of the cardiac myocytes with isoprenaline, angiotensin II, or exposure to hypoxia/reoxygenation add
192 we found that MMP14 activity is increased by angiotensin II, phenylephrine, GTP, and guanosine 5'-O-[
196 n of the AT1 R occurs independently of local angiotensin II production and the type 2 angiotensin rec
197 on-specific Atp6ap2 depletion did not affect angiotensin II production, angiotensin II-dependent BP r
198 the balance to Ace2 expression with enhanced angiotensin II production, leading to cardiac hypertroph
200 andesartan, an inverse agonist of the type 1 angiotensin II receptor (AT1 R), causes a concentration-
203 J6, we identified telmisartan, a widely used angiotensin II receptor antagonist, as a potent inhibito
204 o-OSA), all patients began treatment with an angiotensin II receptor antagonist, losartan, 50 mg dail
208 hly mean rate of 100 adverse events for 1000 angiotensin II receptor blocker users before and after g
209 n angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker were newly prescribed H-
210 imed to determine the effect of losartan, an angiotensin II receptor blocker, on subpulmonary RV dysf
212 giotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARB), beta-blockers an
215 l studies are needed to assess the effect of angiotensin II receptor blockers in preclinical hypertro
216 sed case-control study indicates that use of angiotensin II receptor blockers might be associated wit
217 studies have suggested beneficial effects of angiotensin II receptor blockers on left ventricular hyp
219 dings challenge the generally held view that angiotensin II receptor blockers reduce cardiac hypertro
220 reatitis and 61,637 controls, current use of angiotensin II receptor blockers was followed by a decre
221 titis, by degree of severity, among users of angiotensin II receptor blockers, as compared to non-use
222 angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, beta-blockers, thiazid
223 e of angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers, lactates, renal replac
227 g-term beta-arrestin 2-biased agonism of the angiotensin II receptor may be a viable approach to the
228 d type, P = 7.8 x 10(-40)), which suppresses angiotensin II receptor signaling via allosteric transin
229 data analysis identified one important gene, angiotensin II receptor type 1 (AGTR1), in the Ca2+/AT-I
230 Substantial evidence indicates that the angiotensin II receptor type 1 (AT1 R) is inherently mec
231 027, a beta-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), stimulates acute
233 induced sympathoexcitation is independent of angiotensin II receptor type 1, oxytocin, ionotropic glu
235 ), transforming growth factor beta (47%) and angiotensin II receptor type 2 (132%), 27% less elastin
236 cation of Telmisartan (an antagonist for the angiotensin II receptor) through copper-mediated C-H ami
237 0067, a beta-arrestin 2-biased ligand of the angiotensin II receptor, or losartan, an angiotensin II
243 use model of cerebral malaria, modulation of angiotensin II receptors produced similar effects, leadi
246 expression of sFlt1 in pregnant mice induced angiotensin II sensitivity and hypertension by impairing
247 ing, reversed sFlt1-induced hypertension and angiotensin II sensitivity in the preeclampsia mouse mod
248 he interrelation of the beta-catenin and the angiotensin II signaling pathways opens immediate host-t
249 eprilysin inhibitors (ARNi), beyond blocking angiotensin II signaling, augment natriuretic peptides b
250 ding and the internalization kinetics of the angiotensin II-stimulated AT1-R differed from those stim
253 Activation of either AT1 Ra or AT1 Rb with angiotensin II stimulates TRPM4 currents in cerebral art
256 in the heart, leading to a net production of angiotensin II that promotes cardiac hypertrophy and fib
257 of a high salt intake and administration of angiotensin II, the AngII-salt model, are inconsistent w
258 nsors by allowing the short cationic peptide angiotensin II to be electrophoretically driven through
260 lood-brain barrier permeability that allowed angiotensin II to enter the perivascular space and activ
262 treatment in hypertrophy samples, including angiotensin II-treated adult cardiac fibroblasts and ren
263 tration of small-molecule Plk1 inhibitors to angiotensin II-treated mice led to reduced arterial fitn
264 nscriptome analysis of ventricular RNA after Angiotensin II treatment confirmed that PAI-1 deficiency
265 lecular species-two peptides, bradykinin and angiotensin II; two lipids, phosphatidylcholine and sphi
266 (AGT), angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1), and aldosterone
275 track activation and internalization of the angiotensin II type 1 receptor and the beta2 adrenocepto
276 aintained despite RVLM pretreatment with the angiotensin II type 1 receptor antagonist losartan, the
277 cortex homogenate from patients treated with angiotensin II type 1 receptor antagonists (n=6) or angi
278 tics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and an
281 VLM of normotensive rats is not mediated via angiotensin II type 1 receptor, oxytocin, ionotropic glu
282 occurs selectively on neurons, and neuronal angiotensin II type 1 receptors are indispensable to thi
284 system and ADAM17, we generated mice lacking angiotensin II type 1 receptors specifically on neurons.
288 on of SREBP-1 required signaling through the angiotensin II type I receptor and activation of PI3K/Ak
291 0 to 4 of 2009 with known HLA DSA status for angiotensin II type-1 receptor and endothelin-1 type A r
293 cated in this process revealed that VEGF and angiotensin-II upregulate Adamts-1 expression via activa
294 healthy subject died after a pressor dose of angiotensin II was infused continuously for 6 days.
295 velopment of cardiac fibrosis in response to angiotensin-II was mediated by myeloid precursors and co
298 Studies in which human subjects received IV angiotensin II were selected whether or not safety was d
299 all, of the signalling cascades activated by angiotensin II, which could have therapeutic implication
300 inhibit non-G protein-coupled signalling of angiotensin II, without altering the classical G protein
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