ライフサイエンスコーパス: angiotensinogen

1 ensin-converting enzyme inhibitor or lacking angiotensinogen.

2 ompletely, compensate for excess circulating angiotensinogen.

3 suppressed the expression of vasoconstrictor angiotensinogen.

4 on of fat-derived peptides (PAI-1 by 4-fold, angiotensinogen 3-fold, leptin 2-fold, resistin 4-fold,

5 pression of renal renin (50 %, P < 0.01) and angiotensinogen (40 %, P < 0.05) gene expression.

6 eleased by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin fa

7 n PE at altitude than at sea level, yet PRR, angiotensinogen (AGT) and AT1R proteins were all increas

8 We examine herein angiotensinogen (AGT) as a candidate gene to help elucid

9 cific renin and glial- and neuronal-specific angiotensinogen (AGT) expression.

10 tes) with two, three, and four copies of the angiotensinogen (Agt) gene (Vpr-Agt-2, Vpr-Agt-3, and Vp

11 oid 2-related factor 2 (Nrf2) stimulation of angiotensinogen (Agt) gene expression and the developmen

12 onucleoprotein F (hnRNP F) overexpression on angiotensinogen (Agt) gene expression, hypertension, and

13 ressure, we sequenced a 6.8 kb region of the angiotensinogen (AGT) gene in 29 male Nigerians with hig

14 k factor for cardiovascular disease, and the angiotensinogen (AGT) gene locus is associated with huma

15 ugh previous studies have suggested that the angiotensinogen (AGT) gene locus is involved in human es

16 Using a transgenic mouse harboring an angiotensinogen (AGT) gene modified for Cre-mediated del

17 ork showed that TGF-beta1 potently increases angiotensinogen (AGT) gene mRNA in primary human lung fi

18 riants in the RREB1 gene, a repressor of the angiotensinogen (AGT) gene previously associated with ki

19 on among the M235T and T174M variants of the angiotensinogen (AGT) gene, plasma AGT, and hypertension

20 hisms in the 5' flanking region of the human angiotensinogen (AGT) gene, the -20 and -217 polymorphis

21 used to examine the cellular localization of angiotensinogen (AGT) in the brain.

22 In the brain, angiotensinogen (AGT) is expressed in astrocytes and in

23 iated Ang II uptake and stimulation of renal angiotensinogen (AGT) mRNA and protein expression.

24 Renal inflammation modulates angiotensinogen (AGT) production in renal proximal tubul

25 The angiotensinogen (AGT) promoter G(-6) allele lowers trans

26 ntisense oligonucleotide (ASO) that inhibits angiotensinogen (Agt) synthesis to lisinopril in adult c

27 In the pituitary, the mRNA levels for angiotensinogen (AGT) were increased by 45% following es

28 osomal regions containing genes for the ACE, angiotensinogen (AGT), and angiotensin II type 1 recepto

29 such as angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin receptor type I (

30 cluding angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and the type 1 (AT1) and type 2 (

31 The levels of immunoreactive angiotensinogen (AGT), angiotensin I (AngI), and angiote

32 ingle-nucleotide polymorphisms (SNPs) in the angiotensinogen (AGT), angiotensin receptor 1 (AGTR1), a

33 leotide polymorphisms (SNPs) at renin (REN), angiotensinogen (AGT), angiotensin-converting enzyme (AC

34 Angiotensinogen (AGT)-deficient mice die shortly after b

35 we explored the role of genetic variants of angiotensinogen (AGT, M235T), ACE (I/D), and angiotensin

36 ta, epidermal growth factor receptor [EGFR], angiotensinogen [AGT]) were tested in urine (Ur) and per

37 ine CC-4, angiotensin-converting enzyme, and angiotensinogen, although the direction of effect was re

38 or-alpha, interleukin-6, C-reactive protein, angiotensinogen and adiponectin).

39 pe results in increased tissue expression of angiotensinogen and Ang II.

40 Angiotensinogen and AngI also generated the same effect,

41 large increases in plasma concentrations of angiotensinogen and angiotensin peptides (Ang II, III, I

42 lemia was associated with increased systemic angiotensinogen and angiotensin peptides, which were red

43 tribution of mast cells, and the presence of angiotensinogen and angiotensin-converting enzyme in man

44 Inasmuch as myocardial interstitium contains angiotensinogen and angiotensin-converting enzyme, and b

45 h the findings demonstrating the presence of angiotensinogen and angiotensinogen mRNA in proximal tub

46 f p53 was associated with an accumulation of angiotensinogen and AT(1) and enhanced production of ang

47 Research on a link between angiotensinogen and essential hypertension illustrates a

48 a significant decrease in circulating human angiotensinogen and markedly blunted the pressor respons

49 ute significantly to the circulating pool of angiotensinogen and provide proof-of-principle that the

50 rting enzyme locus on chromosome 17, nor the angiotensinogen and renin loci on chromosome 1, with eit

51 blot analyses showed increased expression of angiotensinogen and renin protein at 16 to 24 hours of s

52 the angiotensin II type 1 receptor, while RV angiotensinogen and renin remained unchanged.

53 eed, they express renin, the renin receptor, angiotensinogen, and angiotensin-converting enzyme by mR

54 ("visceral white"), including the resistin, angiotensinogen, and chemerin genes, in addition to indu

55 Increased intracellular levels of Ang II, angiotensinogen, and renin were observed by confocal mic

56 sequence (St domain) in the promoter of the angiotensinogen (ANG) gene and consequently upregulate t

57 Angiotensinogen (ANG) is the specific substrate of the r

58 ding region to produce a nonsecreted form of angiotensinogen [Ang(-S)Exp].

59 53 was characterized by upregulation of Bax, angiotensinogen, Ang type 1 (AT(1)) receptors, and Ang I

60 dietary salt and increased plasma levels of angiotensinogen, angiotensin II, and aldosterone.

61 wn to stimulate expression of the endogenous angiotensinogen, angiotensin-converting enzyme, and endo

62 We have used RT-PCR to identify mRNA for angiotensinogen, angiotensin-converting enzyme, and the

63 Angiotensinogen-, angiotensin-converting enzyme-, and an

64 ma and liver protein using a polyclonal anti-angiotensinogen antibody demonstrated two specific immun

65 ure or plasma angiotensin II (AII), renin or angiotensinogen (Ao) concentrations.

66 p53 modulates transcription of angiotensinogen (Aogen) and AT(1) receptors in myocytes,

67 pression of p53-dependent genes; quantity of angiotensinogen (Aogen), AT(1), and Bax decreased, where

68 Additionally, p53 DNA binding to angiotensinogen (Aogen), AT1 receptor, and Bax was marke

69 On this basis, p53 DNA binding activity to angiotensinogen (Aogen), bax, and the AT1 receptor was d

70 ance, and renal mRNA levels of its precursor angiotensinogen are increased 2-fold in B-129/Sv-4A11(+/

71 tions of AngII, as well as angiotensin I and angiotensinogen, are much greater than can be explained

72 p53 binding to the promoter of angiotensinogen, AT1 receptor, and Bax also increased.

73 Expression of angiotensinogen, AT1 receptor, p53, and Bax increased an

74 Angiotensin I (Ang I) was generated from angiotensinogen by cathepsin D in the presence of normal

75 II derived from local synthesis of renin and angiotensinogen can cause an elevation in blood pressure

76 tensin II (Ang II) receptors, we mutated the angiotensinogen cDNA by removing the signal sequence-enc

77 WT-p90RSK-Tg mice, suggesting an increase of angiotensinogen cleavage and subsequent RAS activation i

78 Although HG did not affect the rate of angiotensinogen conversion, it decreased expression of a

79 otype is virtually identical to that seen in angiotensinogen-deficient (Agt-/-) and angiotensin-conve

80 Wild-type (Agt+/+) and homozygous angiotensinogen deletion mutant (Agt-/-) littermates wer

81 es demonstrate that extra-hepatic sources of angiotensinogen do not contribute significantly to the c

82 ssociated with preeclampsia, we investigated angiotensinogen expression in the first trimester uterus

83 further show that repression of resistin and angiotensinogen expression involves recruitment of CtBP1

84 paralleled by incrementally increased liver angiotensinogen expression.

85 five genetically determined levels of mouse angiotensinogen gene (Agt) expression covering the range

86 nked to differential expression of the human angiotensinogen gene (AGT) gene and hypertension, but th

87 o determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angioten

88 having zero to four functional copies of the angiotensinogen gene (Agt).

89 hose found in mutant mice homozygous for the angiotensinogen gene (Agt-/-), indicating that major bio

90 rrying a gene-targeted deletion of the mouse angiotensinogen gene (mAgt).

91 e- and cell-specific expression of the human angiotensinogen gene and normally produce and process th

92 reduction on renin release, renal renin and angiotensinogen gene expression and the role played by a

93 We conclude that increased NF-kappaB and angiotensinogen gene expression are associated with R-FS

94 Intra-graft angiotensinogen gene expression was significantly elevat

95 t suppressed basal levels of renal renin and angiotensinogen gene expression; (b) acute reduction of

96 generated transgenic mice containing a human angiotensinogen gene flanked by loxP sites (hAGT(flox)).

97 ogic consequences of tissue-specific loss of angiotensinogen gene function in vivo, we constructed an

98 The human angiotensinogen gene has a C/A polymorphism located at -

99 -I reduces the basal expression of the human angiotensinogen gene in liver cells.

100 renin-angiotensin system of mice having one angiotensinogen gene inactivated.

101 tion in the mice having only one copy of the angiotensinogen gene is greater than twice wild-type.

102 They are hypertensive, and expression of the angiotensinogen gene is increased in their subcutaneous

103 his transgenic mouse model is that the human angiotensinogen gene is inserted into the mouse genome a

104 Angiotensinogen gene is primarily expressed in the liver

105 Therefore, we investigated whether the angiotensinogen gene might be similarly implicated in th

106 vity of reporter constructs containing human angiotensinogen gene promoter (with nucleoside A at -20)

107 sion of reporter constructs containing human angiotensinogen gene promoter.

108 ods) revealed no evidence for linkage of the angiotensinogen gene to hypertension.

109 r alpha (TNFalpha), is a potent activator of angiotensinogen gene transcription in hepatocytes by act

110 mouse model generated by targeting the human angiotensinogen gene upstream of the mouse HPRT locus by

111 S (ACE gene, Angiotensin II receptor 1 gene, Angiotensinogen gene) in 233 liver transplant recipients

112 gen genes can functionally replace the mouse angiotensinogen gene, and provides proof in principle th

113 evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive ho

114 Previously, the angiotensinogen gene, which encodes the key substrate fo

115 d in tissue-specific expression of the human angiotensinogen gene.

116 ed to single-nucleotide polymorphisms in the angiotensinogen gene.

117 ransgenic for both the human renin and human angiotensinogen genes (RA+) exhibit appropriate tissue-

118 e studies establish that the human renin and angiotensinogen genes can functionally replace the mouse

119 consisting of both the human renin and human angiotensinogen genes to study further the role played b

120 ice containing a PAC transgene and the human angiotensinogen (hAGT) gene (P+/A+) are moderately hyper

121 The human angiotensinogen (hAGT) gene has polymorphisms in its 2.5

122 ating the acute-phase induction of the human Angiotensinogen (hAGT) gene in hepatocytes.

123 ting acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes.

124 ed protein (KAP) promoter fused to the human angiotensinogen (HAGT) gene with the goal of specificall

125 containing the human renin (HREN) and human angiotensinogen (HAGT) genes were bred to mice heterozyg

126 EN) and bred them with mice expressing human angiotensinogen (hAGT) under the control of the same pro

127 Although angiotensinogen has long been regarded as a passive subs

128 Furthermore, male and female mice lacking angiotensinogen have normal fertility, indicating that a

129 lpha, nuclear factor-kappaB (NF-kappaB), and angiotensinogen in 60 biopsies from 27 pediatric renal t

130 tion may not affect intracellular sorting of angiotensinogen in a qualitative manner, it leads to a q

131 The expression of angiotensinogen in liver increased fivefold 3 hours afte

132 y defined, but include enhanced formation of angiotensinogen, increased sodium reabsorption, and incr

133 nogen upregulation and remodeling of cardiac angiotensinogen interaction networks in P21 Kcne2(-/-) m

134 In human decidua, angiotensinogen is expressed only in spiral artery smoot

135 e we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near

136 Angiotensinogen is the glycoprotein precursor of one of

137 th R-30P showed a tendency to lowered plasma angiotensinogen level (1563 ng of ANG I/ml (range 1129-1

138 ing that chronic overexpression of renin and angiotensinogen locally in the brain can result in hyper

139 The angiotensinogen M235T polymorphism in humans is linked t

140 lity that increases in circulating or tissue angiotensinogen may cause an increase in blood pressure

141 ed to determine whether augmented intrarenal angiotensinogen may contribute to the enhanced renal ang

142 Toll-like receptor 4 (TLR4) and angiotensinogen messenger ribonucleic acid (mRNA) were m

143 ssociated with a common molecular variant of angiotensinogen (Met235Thr).

144 y in the transgenic alpha-myosin heavy chain-angiotensinogen mice causes prominent changes in hypertr

145 is revealed the absence of full-length human angiotensinogen mRNA and protein in the liver but not th

146 Angiotensinogen mRNA and protein levels in kidney cortex

147 that chronic AngII infusion increases renal angiotensinogen mRNA and protein levels, thus contributi

148 Human angiotensinogen mRNA has two in-phase translation initia

149 strating the presence of angiotensinogen and angiotensinogen mRNA in proximal tubule cells, the data

150 circulating AngII levels increase intrarenal angiotensinogen mRNA levels, which may contribute to the

151 espite similar increases in cardiac TLR4 and angiotensinogen mRNA over 8 to 16 h.

152 This occurs after LPS increases TLR4 and angiotensinogen mRNA, but proximal to AT(1) receptor act

153 Renal and hepatic expression of angiotensinogen mRNA, which was examined by semiquantita

154 ological block of AT1R and in the absence of angiotensinogen or TRPC6 channels.

155 induction of left ventricular hypertrophy in angiotensinogen-overexpressing transgenic mice harboring

156 a potential 20-HETE dependence of intrarenal angiotensinogen production and ANGII receptor type 1 act

157 s indicate that SHR have enhanced intrarenal angiotensinogen production that contributes to increased

158 bind to a sequence motif (St-domain) in the angiotensinogen promoter to activate its transcription i

159 inkage disequilibrium with a mutation in the angiotensinogen promoter, G(-6)A, which leads to elevate

160 Importantly, we demonstrated that angiotensinogen protein and functional angiotensin II wa

161 Although there was no detectable human angiotensinogen protein in plasma, it was evident in the

162 or 64-kD), renal (52-kD), or hepatic (52-kD) angiotensinogen protein levels; however, there was a sig

163 induction of PRECE was confirmed with serial angiotensinogen protein reduction after perfusion in WT-

164 expression of the highly glycosylated 64-kD angiotensinogen protein, of almost fourfold (densitometr

165 The level of expression of angiotensinogen, renin, ACE, and AT(1A) genes was low in

166 expression, it did not block upregulation of angiotensinogen, renin, and ACE genes by stretch.

167 ely inhibited Ang II-induced upregulation of angiotensinogen, renin, and ACE genes, as well as stretc

168 s with Ang II also upregulated expression of angiotensinogen, renin, and ACE genes, whereas it downre

169 four renin-angiotensin system gene regions (angiotensinogen, renin, angiotensin I-converting enzyme,

170 ffect of mechanical stretch on expression of angiotensinogen, renin, angiotensin-converting enzyme (A

171 of the longer and the shorter form of native angiotensinogen, respectively.

172 nal cells in culture with human prorenin and angiotensinogen resulted in increased generation of angi

173 g insulin (insulin resistance), and elevated angiotensinogen (salt retention).

174 romoter of the gene encoding its prohormone, angiotensinogen, serves as the target site for activated

175 By transplanting angiotensinogen signal peptide onto green fluorescence p

176 tation at the -30 amino acid position of the angiotensinogen signal peptide, in which an arginine is

177 lele occurs in the liver, the main tissue of angiotensinogen synthesis.

178 nvolved the genes governing the structure of angiotensinogen, the substrate in the renin reaction.

179 e loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals t

180 ive reduction in the net secretion of mature angiotensinogen through decreased translocation or incre

181 ose that this redox-responsive transition of angiotensinogen to a form that will more effectively rel

182 stem that permit intracellular processing of angiotensinogen to Ang II and that Ang II generated intr

183 ils 1) converts both human angiotensin I and angiotensinogen to angiotensin II; 2) expresses angioten

184 Activating (pro)renin for conversion of Angiotensinogen to Angiotensin makes ATP6AP2 attractive

185 ed with transgenic mice overexpressing human angiotensinogen to determine if there was a chronic comp

186 ally, we demonstrate the oxidative switch of angiotensinogen to its more active sulphydryl-bridged fo

187 We localized angiotensinogen transcription in uterine decidua using i

188 port, we describe the development of a human angiotensinogen transgenic mouse model generated by targ

189 d putative ion channel targets, namely AT1R, angiotensinogen, transient receptor potential channel 6

190 script transcriptomics, we uncovered cardiac angiotensinogen upregulation and remodeling of cardiac a

191 However, expression of renin and angiotensinogen was not increased in MHCsTNF mice compar

192 Angiotensinogen was selected because of the putative lin

193 ee system, we found that two forms of native angiotensinogen were generated by alternative initiation

194 tutively secreted proteins IgG, albumin, and angiotensinogen, when added to the assays, remain predom

195 our 4.4 A structure of the complex of human angiotensinogen with renin.