ライフサイエンスコーパス: anhedonia

1 impact of lateral hypothalamic stimulation (anhedonia).

2 tology common across these conditions (e.g., anhedonia).

3 this area correlates with depressed mood and anhedonia.

4 ficantly with clinical ratings for avolition/anhedonia.

5 ic antidepressants to reverse stress-induced anhedonia.

6 ecreases in sucrose preference, a measure of anhedonia.

7 ard learning compared with patients with low anhedonia.

8 ating symptoms that include hopelessness and anhedonia.

9 the novel object location task and increased anhedonia.

10 ed by the EPDS: depressed mood, anxiety, and anhedonia.

11 ide a new psychological conceptualization of anhedonia.

12 in relation to this new conceptualization of anhedonia.

13 in multiple animal models of depression and anhedonia.

14 nt MDD and, more specifically, in those with anhedonia.

15 e reward learning, an important component of anhedonia.

16 ility to stress-induced social avoidance and anhedonia.

17 d decreased sucrose preference, a measure of anhedonia.

18 er implicated the fronto-striatal network in anhedonia.

19 ch pointed to the symptomatic equivalence of anhedonia.

20 buting to the generation of symptoms such as anhedonia.

21 ockout mice were resilient to stress-induced anhedonia.

22 duced striatal volume prospectively predicts anhedonia.

23 -related motivation, and questionnaire rated anhedonia.

24 wed depression-like behavior but no signs of anhedonia.

25 s in association with reduced motivation and anhedonia.

26 mal responses to behavioural challenges, and anhedonia.

27 e hippocampus protects rats from CUS-induced anhedonia.

28 ced reward-contingency learning with greater anhedonia.

29 depression-associated dendritic atrophy and anhedonia.

30 erence in the two-bottle free-choice test of anhedonia.

31 rs to a 10 day CSDS regimen known to produce anhedonia (a depressive-like effect) and social avoidanc

32 havior is hypothesized to be associated with anhedonia, a core feature and potential trait marker of

33 e uptake in the PFC is sufficient to produce anhedonia, a core symptom of depression.

34 Anhedonia, a core symptom of major depressive disorder (

35 were negatively associated with symptoms of anhedonia across both groups.

36 , have complicated our understanding of what anhedonia actually reflects in this patient population.

37 ria1 (-/-) mice provide a potential model of anhedonia, adding converging evidence to the role of glu

38 olling for sex, age, and medical covariates, anhedonia (adjusted hazard ratio, 1.58; 95% confidence i

39 distortions, cognitive disorganization, and anhedonia (all p < 0.02).

40 Improvement was most notable on the SANS anhedonia and alogia subscales.

41 as improvement in negative symptoms such as anhedonia and alogia.

42 LT-1 in the CEA is sufficient to induce both anhedonia and anxiety and therefore that a lack of gluta

43 blockade in the CEA would induce symptoms of anhedonia and anxiety in rats.

44 n, including dysregulated feeding behaviour, anhedonia and behavioural despair.

45 ocytic glutamate transporter (GLT-1) induces anhedonia and c-Fos expression in areas that regulate an

46 rated that central blockade of GLT-1 induces anhedonia and c-Fos expression in the PFC.

47 is study found that CSDS triggers persistent anhedonia and confirms that DeltaFosB overexpression pro

48 14.8%): 108 (24%) and 77 (17%) patients had anhedonia and depressed mood, respectively.

49 Male rats showed anhedonia and depression-like behavior after 8 weeks of

50 d the fast-acting antidepressant ketamine on anhedonia and depression-like behavior, spine density, a

51 ilar to that caused by treatments that cause anhedonia and dysphoria (prodepressive effects) in rats

52 induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dy

53 and reducing depressive-like states such as anhedonia and dysphoria.

54 authors reviewed the empirical literature on anhedonia and emotional experience in schizophrenia thro

55 e mechanisms underlying the PTSD symptoms of anhedonia and emotional numbing.

56 in mood and cognition, loss of interest and anhedonia and emphasized several features not in DSM inc

57 l illness was found somewhat less often, and anhedonia and functional disability were seen somewhat m

58 trate greater efficacy, with the reversal of anhedonia and improved tolerability.

59 Left, but not right, MCAo, elicited anhedonia and increased anxiety and despair.

60 Social stress induces anhedonia and increases risk of depression, although the

61 ar mechanism(s) of testosterone in mediating anhedonia and manipulated extracellular signal-regulated

62 ic disorders, and are related to symptoms of anhedonia and motor retardation.

63 ed significant relationships between CRP and anhedonia and motor slowing.

64 An understanding of anhedonia and other reward-related constructs will facil

65 is consistent with clinical observations of anhedonia and points to a neural substrate that might co

66 basal ganglia glutamate was associated with anhedonia and psychomotor slowing measured by the finger

67 nflammatory markers were assessed along with anhedonia and psychomotor speed.

68 ptors are more susceptible to stress-induced anhedonia and social avoidance compared with wild-type m

69 and circuit processes underlying CES-induced anhedonia and tested them mechanistically.

70 tomical features may confer vulnerability to anhedonia and thus, may inform early identification of i

71 sented in support of this new perspective on anhedonia and to demonstrate how cognitive impairments m

72 eward, reduced ability to experience reward (anhedonia) and aversion (dysphoria) are in high demand b

73 motivation (e.g., sense of purpose, greater anhedonia), and fewer days of intoxication.

74 maladaptive behavioral stress responsivity, anhedonia, and an increased sensitivity to selective ser

75 together with increased behavioral despair, anhedonia, and anxiety-related behavior in the novelty-i

76 sions that reflect states of depressed mood, anhedonia, and anxiety.

77 e and hypersomnia, but less so with sadness, anhedonia, and appetite loss.

78 may be related to symptoms such as anergia, anhedonia, and depression.

79 onic stress in rats resulted in weight loss, anhedonia, and hyperactivity of hypothalamic-pituitary-a

80 insufficient alleviation or even increase of anhedonia, and loss of interest.

81 sessing clinically impairing depressed mood, anhedonia, and major depressive episode (MDE).

82 anxious depression, anxious anhedonia, pure anhedonia, and resolved depression.

83 ncreased susceptibility to social aversion, "anhedonia," and learned helplessness and causes impaired

84 Depressed mood, anhedonia, anergia, and apathy were assessed at baseline

85 depressive episode (MDE), such as low mood, anhedonia, anorexia, and weight loss.

86 akups were marked by high levels of sadness, anhedonia, appetite loss, and (for romantic breakups) gu

87 Both family history of MDD and subclinical anhedonia are associated with reduced FA in the bilatera

88 Both positive psychotic symptoms and anhedonia are associated with striatal functioning, but

89 Battery, EEG markers, and fMRI correlates of anhedonia are available, further work is needed for thei

90 ed whether these alterations are specific to anhedonia as compared with low mood and whether they are

91 ubsequent social avoidance and reductions in anhedonia as measured by intracranial self-stimulation.

92 findings help elucidate neural mechanisms of anhedonia, as a step toward identifying potential biosig

93 continuous rather than categorical scale of anhedonia, as in the present study, may permit greater s

94 cognitive disorganization, grandiosity, and anhedonia, as well as parent-rated negative symptoms).

95 t than placebo on all SANS dimensions except anhedonia-asociality.

96 and experience have also been reported, with anhedonia being one of the core features.

97 iated with symptoms of social withdrawal and anhedonia, both of which are strongly modulated by endog

98 KOR stimulation produced anhedonia but had no effect on expression or extinction

99 entral striatum activity was associated with anhedonia but not low mood; however, the combined presen

100 the HC group and correlated negatively with anhedonia but positively with the total hippocampal and

101 ted increases in behavioural measurements of anhedonia, but not increases in measurements of behaviou

102 ukocytes and behavioral responses (anorexia, anhedonia, cachexia) to simulated gram-negative bacteria

103 airment of reward perception and experience (anhedonia) can contribute to psychiatric diseases, inclu

104 ssion of active S6K1 in the mPFC blocked the anhedonia caused by chronic stress, resulting in a state

105 ajor depressive disorder is characterized by anhedonia, cognitive biases, ruminations, hopelessness a

106 Anhedonia continued to significantly predict outcomes (P

107 dent individuals experience symptoms such as anhedonia, craving, fatigue, insomnia, and dysphoria.

108 hresholds, a depressive-like sign reflecting anhedonia (decreased sensitivity to reward), whereas dis

109 ) were compared: depressed preschoolers with anhedonia, depressed preschoolers without anhedonia ("he

110 onia severity while controlling for baseline anhedonia, depression, and anxiety symptoms.

111 icipants provided self-report assessments of anhedonia, depression, and anxiety symptoms.

112 otypes seen in humans diagnosed with autism (anhedonia, depression, anxiety, and altered social inter

113 ng and olfactory-associated behavior, and an anhedonia/depression-like deficit.

114 -like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness.

115 of ketamine fails to attenuate CSDS-induced anhedonia despite reducing other depression-related beha

116 Anhedonia, disrupted reward processing, is a core sympto

117 elerate recovery from dopamine depletion and anhedonia during cocaine withdrawal.

118 ly to have experienced suicidal ideation and anhedonia during the follow-up period.

119 Anxiety and anhedonia emerged as prominent symptom dimensions with p

120 e nucleus accumbens is further decreased and anhedonia emerges.

121 other symptoms of major depressive episodes-anhedonia, feelings of worthlessness, psychomotor agitat

122 TG mice were also protected against anhedonia following both serotonin and catecholamine dep

123 RT adjustment correlated with self-reported anhedonia for both patients and controls.

124 vity during cognitively demanding tasks; and anhedonia from hypoactivation of the cuneus and posterio

125 the more reliable cognitive symptoms such as anhedonia, guilt, suicidal thinking, and hopelessness.

126 st three decades, the clinical definition of anhedonia has remained relatively unchanged, although co

127 s functional connectivity studies related to anhedonia have focused on case-control comparisons in sp

128 th anhedonia, depressed preschoolers without anhedonia ("hedonic"), a psychiatric comparison group wi

129 Anhedonia identifies risk of MACE and ACM beyond that of

130 the NAS produces multiple behavioral signs (anhedonia, impaired extinction) characteristic of experi

131 Such 'musical anhedonia' implies the existence of music-specific brain

132 These findings support the hypothesis that anhedonia in depressed patients reflects the inability t

133 The dopamine system has been linked to anhedonia in depression and both the positive and negati

134 ural prediction error signals could underlie anhedonia in depression and negative symptoms in schizop

135 together with the ventral striatum, underlie anhedonia in depression.

136 count for the persistence of amotivation and anhedonia in detoxified methamphetamine abusers.

137 K2 activity within the dentate gyrus induced anhedonia in gonadectomized rats receiving testosterone

138 It is associated with anhedonia in healthy adolescents and is a behavioral ind

139 al interactions, which predict the degree of anhedonia in individuals.

140 itionally, morphometric results suggest that anhedonia in major depression is related to caudate volu

141 s social defeat-induced social avoidance and anhedonia in mice.

142 Although 6-OHDA lesions did not induce anhedonia in our model, the dose of AMI utilized had ant

143 m affected anticipatory reward, analogous to anhedonia in patients with schizophrenia and other psych

144 the PFC alone would be sufficient to induce anhedonia in rats.

145 iation of hedonic experience may manifest as anhedonia in schizophrenia.

146 which has been linked to abstinence-induced anhedonia in smokers and may play a critical role in smo

147 forced swim test and was sufficient to cause anhedonia in the absence of chronic stress exposure.

148 Ketamine did not block CSDS-induced anhedonia in the ICSS test.

149 TT, normalized PDE4 activity and ameliorated anhedonia in the R6/2 mice.

150 also relevant in other symptoms like social anhedonia in the schizophrenia disorder spectrum.

151 pain and depression, as well as in rats with anhedonia induced by chronic social stress.

152 Anhedonia is a core symptom of major depressive disorder

153 Anhedonia is a transdiagnostic risk factor implicated in

154 -sectional research in adults has shown that anhedonia is associated with reduced dorsal striatal vol

155 tor and indicate that greater stress-induced anhedonia is associated with resistance to antidepressan

156 ce pleasure, evidence is mixed as to whether anhedonia is caused by a reduction in hedonic capacity.

157 Anhedonia is central to multiple psychiatric disorders a

158 An alternative explanation is that anhedonia is due to the inability to sustain positive af

159 Loss of the capacity to experience pleasure (anhedonia) is a core clinical feature of schizophrenia.

160 In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affe

161 ating and nest-building deficits, as well as anhedonia-like and anxiety-like behaviors.

162 Anhedonia-like behavior (sucrose consumption) was assess

163 uces striatal DA release in association with anhedonia-like behavior in nonhuman primates.

164 Exposure to SPS increased anhedonia-like behaviors and decreased the rewarding pro

165 cation of cocaine "bingeing" relative to the anhedonia-like deterioration of reward processes during

166 , neither Per3(-/-) nor WT mice exhibited an anhedonia-like phenotype, and neither genotypes exhibite

167 D3 protein (Per3(-/-)) exhibited a transient anhedonia-like phenotype, observed as reduced sucrose pr

168 Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response elem

169 epressant treatment were CREB-dependent, the anhedonia-like symptoms were not mediated by CREB in NAc

170 nct biological correlates-depressed mood and anhedonia (loss of pleasure or interest).

171 ing depressed mood, decreased concentration, anhedonia, loss of interest, and feelings of worthlessne

172 ponses were compared across adolescents with anhedonia, low mood, or both symptoms, cross-sectionally

173 We have previously identified anhedonia, manifest as decreased sucrose preference and

174 Correlates of anhedonia may add to the understanding of the link betwe

175 s, our results suggest that specific musical anhedonia may be associated with a reduction in the inte

176 y of these individuals with specific musical anhedonia may be crucial to understand better the neural

177 easant stimuli correlated negatively with an anhedonia measure.

178 and reward that could also contribute to the anhedonia often observed in depressed patients.

179 The authors examined the effect of anhedonia on reward expectancy (expected outcome value)

180 DD were categorized based on the presence of anhedonia, only anhedonic patients had decreased GABA/w

181 tion-like behavior could not be explained by anhedonia or behavioral despair.

182 using on symptoms of depressed mood, apathy, anhedonia, or anergia.

183 ipants included mothers with depressed mood, anhedonia, or depression history but who were not in a c

184 Anhedonia, or diminished interest or pleasure in rewardi

185 Anhedonia, or markedly diminished interest or pleasure,

186 to unfavourable circumstances, and that the anhedonia, pessimism and fatigue that often accompany it

187 ession, moderate anxious depression, anxious anhedonia, pure anhedonia, and resolved depression.

188 05), which in turn correlated with increased anhedonia (R=-0.47, P=0.001).

189 r a positive family history of MDD (FH+) and anhedonia (reduced capacity for pleasure) were associate

190 cts of CSDS on sensitivity to reward because anhedonia (reduced sensitivity to reward) is a defining

191 While theorists have argued that anhedonia reflects a reduced capacity to experience plea

192 Rather, anhedonia reflects a set of beliefs related to low pleas

193 but the extent to which this is specific to anhedonia remains poorly understood.

194 link between the core subjective symptom of anhedonia, replicated neuropsychological deficits, elect

195 These results establish that stress-elicited anhedonia requires a neuropeptide-triggered, cell-type-s

196 e amygdala in anhedonic rats, and tested for anhedonia reversal in the same animals.

197 e to unsuppressed voxel tissue water (w) and anhedonia scores expressed as a continuous variable.

198 ABA/w levels were negatively correlated with anhedonia scores for the whole MDD group (r = -0.50; P =

199 Stress produced anhedonia selectively in SL rats and this was prevented

200 vestigated whether striatal volume predicted anhedonia severity in adolescents.

201 -related motivation, which in turn predicted anhedonia severity in schizophrenia.

202 A dimensional conceptualization posits that anhedonia severity is related to a transdiagnostic conti

203 , and in depressed individuals only, greater anhedonia severity was associated with a reduced reward

204 teral putamen volume prospectively predicted anhedonia severity while controlling for baseline anhedo

205 e response to peer rejection, contributed to anhedonia severity, but only among youth with smaller pu

206 bens and midbrain correlating with increased anhedonia severity.

207 us accumbens volume was inversely related to anhedonia severity.

208 The authors conclude that anhedonia should no longer be considered an experiential

209 Moreover, patients with high anhedonia showed diminished reward learning compared wit

210 mple of 28 participants with elevated social anhedonia (SocAnh) and 38 healthy controls from a popula

211 s; (b) people with extremely elevated social anhedonia (SocAnh; n=22); and (c) controls (n=20).

212 ings were confirmed using depressed mood and anhedonia subscores from the Beck Depression Inventory i

213 ermine whether neuroadaptations that produce anhedonia subsequently affect vulnerability to stress-in

214 als and a moderation of this relationship by anhedonia, suggesting reduced reward-contingency learnin

215 onresponders showed markedly higher baseline anhedonia symptomatology (including pessimism, loss of p

216 g of prediction error signals contributes to anhedonia symptoms in depression.

217 DD patients had severe suicidal ideation and anhedonia symptoms.

218 e the disabling cognitive and negative (i.e. anhedonia) symptoms of patients with schizophrenia.

219 ic (anxious arousal) or depression-specific (anhedonia) symptoms.

220 review the neural bases of the construct of anhedonia that reflects deficits in hedonic capacity and

221 Anhedonia, the diminished ability to experience pleasure

222 Anhedonia, the loss of pleasure or interest in previousl

223 tors (mGlu2 and mGlu3) reduce stress-induced anhedonia through actions in the PFC, but the mechanisms

224 symptoms of major depressive disorder, from anhedonia to altered cognitive performance.

225 ignificantly more likely to have evidence of anhedonia, to live in large urban communities, to have p

226 omain-specific deficit in people with social anhedonia towards social affective information, and sugg

227 ying mechanisms of learning facilitation and anhedonia treatment.

228 (IL)-1 receptor antagonist before stress on anhedonia was also determined.

229 -nucleotide polymorphisms (SNPs) with social anhedonia was also observed.

230 exacerbated in SD-OBx hamsters; LPS-induced anhedonia was exacerbated in LD-OBx hamsters; and photop

231 n animal model of depression associated with anhedonia, was used to examine nucleus accumbens (NAc) a

232 ed and sustained improvements in anxiety and anhedonia were also noted.

233 lterations with the presence and severity of anhedonia were explored.

234 medically ill (hopelessness, depression, or anhedonia were used as the qualifying affective symptoms

235 immobility in the tail suspension test, and anhedonia) were assessed 4 hours, 24 hours, 72 hours, 7

236 NAc produces depression-like signs including anhedonia, whereas disruption of CREB activity by expres

237 od, we found strong increases in anxiety and anhedonia which lead to decreases in specific cognitive

238 nucleus of the amygdala reversed CES-induced anhedonia without influencing other emotional measures.