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1 es enzyme activity of chloroplastic carbonic anhydrase.
2 that the pH gradient is created by carbonic anhydrase.
3 ted to H2S by the ubiquitous enzyme carbonic anhydrase.
4 l function for Cd, an unusual Cd/Zn carbonic anhydrase.
5 man serum albumin, beta-casein, and carbonic anhydrase.
6 phosphate carboxylase/oxygenase and carbonic anhydrase.
7 t converting it to CO2 via external carbonic anhydrase.
8 competitive with the native enzyme, carbonic anhydrase.
9 hannel, UreI; and periplasmic alpha-carbonic anhydrase.
10 for proton transfer in catalysis by carbonic anhydrase.
11 f the urease gene cluster and alpha-carbonic anhydrase.
12 e1 and pendrin, and two isoforms of carbonic anhydrase.
13 gh the action of a shell-associated carbonic anhydrase.
14 hich is rapidly converted to H2S by carbonic anhydrase.
15 arboxylase/oxygenase (RuBisCO) with carbonic anhydrase.
16 t previously observed in alpha-type carbonic anhydrases.
17 -controlled stomatal development by carbonic anhydrases.
19 polipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon treatment
20 markers FoxF1, Pax-1, keratin-8/18, carbonic anhydrase-12, and NC markers brachyury, galectin-3 and C
21 (8.6 kDa), myoglobin (17 kDa), and carbonic anhydrase (29 kDa) upon higher energy collisional dissoc
22 a creatine kinase M-type (CK-M) and carbonic anhydrase 3 (CA-3) in the blood, more than 90% of which
23 alivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PS
24 alivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP).
28 poxia-regulated genes (for example, carbonic anhydrase 9 (CA9) and vascular endothelial growth factor
32 hotosynthetic attributes along with carbonic anhydrase activity whereas its higher concentrations pro
33 rapid and simple quantification of carbonic anhydrase activity which is very important to prevent th
34 uration constants for CO2 fixation, carbonic anhydrase activity, CO2 /HCO3 (-) uptake, delta(13) Corg
35 deficiency, probably due to reduced carbonic anhydrase activity, validated by quantitative proteomics
38 ined system of protein and ligands--carbonic anhydrase and a series of structurally homologous hetero
41 ent on H(+) V-ATPase, together with carbonic anhydrase and five further transporters or channels that
44 into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous microcompartm
45 er than any small molecule model of carbonic anhydrase and with an efficiency within 1400-fold of the
47 f inorganic carbon transporters and carbonic anhydrases (and other supporting components) that culmin
48 aper describes a synthetic dimer of carbonic anhydrase, and a series of bivalent sulfonamide ligands
50 ction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation reactions.
52 luding: green fluorescent proteins, carbonic anhydrase, and oxidative stress proteins; and functional
53 rganic carbon transport components, carbonic anhydrases, and aggregation of Rubisco in the chloroplas
55 as the folding modulators and human carbonic anhydrase as a model protein, we demonstrate that PFAR i
56 We demonstrate this system using carbonic anhydrase as the target and a library of 144,000 proprie
58 tudy examined the effects of bovine carbonic anhydrase (BCA) and CO2-rich gas streams on the carbonat
59 ng the affinity of unlabeled bovine carbonic anhydrase (BCA) for a variety of ligands (most of which
60 clease (Rnase) A, myoglobin, bovine carbonic anhydrase (BCA) II, hemoglobin (Hb), and the hemoglobin-
66 ctions of these inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlighting the rel
68 ar pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor production
72 y inhibitors are reported for human carbonic anhydrase (CA) enzymes, few may be considered useful as
73 hibition of cancer-associated human carbonic anhydrase (CA) enzymes, specifically CA IX and XII, has
76 maltose binding protein (MBP), and carbonic anhydrase (CA) in the presence of hundreds of non-binder
77 t] Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate across all
79 possibility of developing selective carbonic anhydrase (CA) inhibitors, interactions between 17 benze
82 ry DNAs encoding four distinct beta-carbonic anhydrase (CA) isoforms were characterized from leaf tis
84 ns: (1) generation by extracellular carbonic anhydrase (CA), (2) release from acidic synaptic vesicle
85 carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an engineered protein cage based on l
87 ncement was completely abolished in carbonic anhydrase (CA)-deficient antisense lines of both C3 and
90 y ~100-fold less than that of human carbonic anhydrase (CA)II and at least 550-fold better than compa
92 urified, and characterized an alpha-carbonic anhydrase (CA, EC 4.2.1.1) from the human pathogenic bac
94 three established aminosulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor pharmacophores, cou
95 the underexposed sulfamate class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors was generated that
96 condary amines and COS as potential carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, using the dithioc
102 btained, which showed an increasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action with the in
103 tivity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and XII are r
104 hagas disease, encodes for an alpha-carbonic anhydrase (CA, EC 4.2.1.1) possessing high catalytic act
109 the immunohistochemical analysis of carbonic anhydrases (CA) IX and XII expression in thyroid cancer.
111 man (h) isoforms of the zinc enzyme carbonic anhydrase, CA (EC 4.2.1.1), hCA I, II, IX, and XII, invo
112 ing 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clinically us
115 ggest that intra- and extracellular carbonic anhydrases can work in concert to ensure rapid shuttling
117 In the hippocampus, extracellular carbonic anhydrase (Car) speeds the buffering of an activity-gene
119 n different Ci species catalyzed by carbonic anhydrases (CAs) are key components in the CCM, and an a
121 s (CCMs) involving transporters and carbonic anhydrases (CAs) are well known, but the contribution of
126 rter, suggesting that inhibition of carbonic anhydrases (CAs) confers the beneficial thiazide effect.
127 etween CO2 and HCO3(-) catalyzed by carbonic anhydrases (CAs), and active inorganic carbon (Ci) uptak
128 e discovered that CPOs also inhibit carbonic anhydrases (CAs), especially the IX and XII isoforms ide
131 phate carboxylase/oxygenase and the carbonic anhydrase CcaA, whereas the C-terminal peptide is essent
137 hlamydomonas reinhardtii, a luminal carbonic anhydrase, CrCAH3, was suggested to improve proton remov
138 parison we assayed recessive ca1ca4 carbonic anhydrase double mutant plants, based on their slowed st
139 isolated Arabidopsis thaliana beta-carbonic anhydrase double mutants (ca1 ca4) exhibit an inversion
140 microalgae induce an extracellular carbonic anhydrase (eCA), associated with the cell surface, at lo
142 ium perfringens strain 13, the only carbonic anhydrase encoded in the genome, was characterized both
143 pheric CO2 elevation, including the carbonic-anhydrase-encoding genes CA1 and CA4 and the secreted pr
145 t are achieved by the activity of a carbonic anhydrase enzyme combined with the maintenance of a low
147 clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquaporin-1 for
148 lex, containing the ancestral gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-like, and
151 1, CCP2 and LCIA) and mitochondrial carbonic anhydrase genes (CAH4 and CAH5) are up regulated in ligh
152 d synteny studies suggest that both carbonic anhydrase genes form one or two independent gene lineage
154 ystem of protein and ligands--human carbonic anhydrase (HCA) and a series of benzothiazole sulfonamid
155 was synthesized and bound to human carbonic anhydrase (HCA) using a nanomolar active site ligand.
156 ng reactions and evaluated as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors against isoforms
157 harmacologically relevant human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, the cytosolic enzy
158 This study uses mutants of human carbonic anhydrase (HCAII) to examine how changes in the organiza
159 panel of metalloenzymes, including carbonic anhydrase (hCAII), several matrix metalloproteinases (MM
161 four physiologically relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, II, IX, a
162 mutation of Haemophilus influenzae carbonic anhydrase (HICA), which mimics the endogenous metal affi
165 digestion of differentially labeled carbonic anhydrase I and hemoglobin allowed the identification of
166 proteins, the strict association of carbonic anhydrase I and S100A8 with ECM was verified by western
168 was demonstrated by modification of carbonic anhydrase I with electrochemically generated reactive me
171 ual mobility in complexes of bovine carbonic anhydrase II (BCA) and para-substituted benzenesulfonami
175 lyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, respective
177 In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently catalyzes the conversion
178 d MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalytic activit
186 onding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA possesses
187 he binding of sulfonamides to human carbonic anhydrase II (hCAII) is a complex and long-debated examp
188 ion of the CD spectrum of the Human Carbonic Anhydrase II (HCAII), with main focus on the near-UV CD
189 er uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to examine th
190 We have reported previously that carbonic anhydrase II augments transport activity of MCT1 and MCT
191 conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reaction inside
192 ate-resistant acid phosphatase, and carbonic anhydrase II in bone marrow macrophages (BMMs), RANKL re
193 eprotonation of zinc-bound water in carbonic anhydrase II is the rate-limiting step in the catalysis
194 mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (acinar)(-)
196 lected scFvs was shown to recognize carbonic anhydrase II, an up-regulated enzyme involved in resorpt
198 wn genes, whereas Srpx2, Cd200, and carbonic anhydrase III (CAIII) were identified as novel markers o
200 nic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secretion and
202 of Rubisco and the thylakoid lumen carbonic anhydrase in the pyrenoid rose substantially, coincident
203 igate the repertoire of cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marinus), that
205 ensitive to Na(+)withdrawal, to the carbonic anhydrase inhibitor acetazolamide and to H2DIDS inhibiti
206 B. pertussis-infected mice with the carbonic anhydrase inhibitor acetazolamide reduced lung inflammat
213 onnection, we report a new class of carbonic anhydrase inhibitors, based on the thiopyrano-fused pyra
214 e of topical beta blockers, topical carbonic anhydrase inhibitors, daily dose of BAK, and glaucoma fi
215 laucoma medications (beta blockers, carbonic anhydrase inhibitors, parasympathomimetics, and prostagl
217 rite bioactivation, but the role of carbonic anhydrase is abrogated when physiological concentrations
218 rusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-mediated
223 inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV using acetazo
224 e human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of homology.
225 ed by Slc26a4, Slc4a8, and Slc4a9), carbonic anhydrase isoforms, and V-type H(+)-ATPase subunits in p
227 tack" screen for inhibitors against carbonic anhydrase isozyme II is performed, in which known inhibi
235 xic tumors is possible by targeting carbonic anhydrase IX (CA IX), an enzyme overexpressed in hypoxic
239 hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth.
240 technique, using antibodies against carbonic anhydrase IX (CAIX) and copper pumps (Ctr1 and ATP7B).
247 ate the intraoperative detection of carbonic anhydrase IX (CAIX)-expressing tumor lesions with chimer
250 amics from tumor biomarkers such as carbonic anhydrase IX and topoisomerase I by immunohistochemistry
252 eric monoclonal antibody that binds carbonic anhydrase IX, a cell surface glycoprotein ubiquitously e
253 a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tumor-associ
254 2), native extra- and intracellular carbonic anhydrase-like activities, the non-CO(2)/HCO(3)(-) (intr
255 arbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-like, and 20.9-kDa subunits, had a significant
256 stem comprising synthetic dimers of carbonic anhydrase linked chemically through thiol groups of cyst
257 e find that expression of the Cd/Zn carbonic anhydrase makes no difference to the Cd isotope composit
262 stingly, transcripts of chloroplast carbonic anhydrases namely CAH6, CAH3 and LCIB are up regulated i
265 e via an aspartate-alanine shuttle, carbonic anhydrase, phosophoenolpyruvate carboxylase, alanine, an
267 ation at 750 microatm pCO2, reduced carbonic anhydrase protein activity and shell growth occurs in M.
268 We identified CAH1 as an alpha-type carbonic anhydrase, providing a biochemical role in CCM function.
269 ble intermediate associated with the nitrite anhydrase reaction in both LtHb and HbA is supported bas
271 orphosis resulting in distinct gill carbonic anhydrases reflecting the contrasting life modes and hab
272 eptibility in the murine model, and carbonic anhydrase, reflecting the blood's abnormal acid base env
273 Moreover, kinetic analysis of human carbonic anhydrase refolding showed that 6AP decreased the yield
274 ted from mouse brain, we identified carbonic anhydrase-related proteins CA10 and CA11, two homologous
275 e find dorzolamide (an inhibitor of carbonic anhydrase) results in diminished nitrite bioactivation,
276 duced expression of colonic villin, carbonic anhydrase, secretory mucin muc2, and increased basal col
277 toglobulin (five peptides), 25% for carbonic anhydrase (six peptides), and 51% for bovine serum album
278 , mannose) against matched targets (carbonic anhydrase, streptavidin, concanavalin A) to identify des
279 rbon acquisition enzymes, primarily carbonic anhydrase, stress, degradation and signaling proteins we
280 rved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A, and chit
281 lants respond to elevated CO(2) via carbonic anhydrases that mediate stomatal closing, but little is
283 imately 10(5)-10(8) M(-1) s(-1) for carbonic anhydrase, the most efficient catalyst of CO(2) fixation
285 hosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fixation in cyanobacteria
287 nnose receptor-positive, expressing carbonic anhydrase type II, but relatively low levels of cathepsi
290 small molecule mimic of the enzyme carbonic anhydrase, was evaluated under rigorous conditions resem
291 onuclease A, trypsin inhibitor, and carbonic anhydrase, where the latter had impurities of superoxide
292 ium bicarbonate co-transporters and carbonic anhydrases, which were also expressed in LAM lung tissue
294 ylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an enthalpy
298 specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by western bl
299 describe variants in CA12 encoding carbonic anhydrase XII in two pedigrees exhibiting CF-like phenot
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