ライフサイエンスコーパス: anilino

1 The fluorescent, hydrophobic compound 8-anilino 1-naphthalene sulphonate (ANS) was used to quant

2 Competition experiments between 8-anilino-1-naphtalene sulfonic acid, which has fluorescen

3 one binding site and allows the binding of 8-anilino-1-naphtalene sulfonic acid.

4 Furthermore, 8-anilino-1-naphthalene sulfonate (ANS) binding to cCSQ cl

5 S-Methylglutathione and 8-anilino-1-naphthalene sulfonate (ANS) each yield partial

6 nium hydrochloride (GuHCl), tryptophan and 8-anilino-1-naphthalene sulfonate (ANS) fluorescence detec

7 nastellin binding to III3 was monitored by 8-anilino-1-naphthalene sulfonate (ANS) fluorescence.

8 The extrinsic fluorescence dye 8-anilino-1-naphthalene sulfonate (ANS) is widely used for

9 nilino)naphthalenesulfonic acid (bis-ANS), 8-anilino-1-naphthalene sulfonate (ANS), and 1-azidonaphth

10 8-Anilino-1-naphthalene sulfonate fluorescence enhancement

11 , fluorescent dye binding experiments with 8-anilino-1-naphthalene sulfonate revealed increased expos

12 s display much stronger signal compared to 8-anilino-1-naphthalene sulfonic acid (ANS), a commonly us

13 uorescence spectroscopy in the presence of 8-anilino-1-naphthalene sulfonic acid (ANS), we show that

14 LDH was noncovalently labeled with 8-anilino-1-naphthalene sulfonic acid (ANS).

15 8-Anilino-1-naphthalene sulfonic acid binding data showed

16 sed binding of the fluorophore bis-(5, 5')-8-anilino-1-naphthalene sulfonic acid to the chaperonin.

17 bitors but were reduced in the presence of 8-anilino-1-naphthalene-sulfonic acid (ANS) or Congo Red (

18 luorescence associated with the binding of 8-anilino-1-naphthalene-sulfonic acid to hydrophobic regio

19 vironment-sensitive fluorescent probe ANS (8-anilino-1-naphthalene-sulfonic acid) provided further ev

20 dendrimers to bind the fluorescent probe, 8-anilino-1-naphthalene-sulfonic acid.

21 Similarly, the ANS (8-anilino-1-naphthalenesulfate) binding showed generally i

22 Trp fluorescence and fluorescence-detected 8-anilino-1-naphthalenesulfonate (ANS) binding.

23 Fluorescence behavior of 8-anilino-1-naphthalenesulfonate (ANS) reflects a blue-shi

24 ular dichroism, chemical denaturation, and 8-anilino-1-naphthalenesulfonate binding.

25 d a decrease in alpha-helical content, and 8-anilino-1-naphthalenesulfonate fluorescence revealed the

26 However, the hydrophobic probe 5, 5'-bis-(8-anilino-1-naphthalenesulfonate) (bis-ANS) inhibited FtsZ

27 ANS (8-anilino-1-naphthalenesulfonate), a hydrophobic probe sim

28 cally distinct region, characterized by an 8-anilino-1-naphthalenesulfonate-positive hydrophobic sign

29 hroism (CD), one-dimensional (1)H NMR, and 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence ex

30 highest surface hydrophobicity measured by 8-anilino-1-naphthalenesulfonic acid (ANS) probe (p<0.05).

31 dissociation of CF1 during cold treatment, 8-anilino-1-naphthalenesulfonic acid (ANS) was employed.

32 Fluorescence intensity measurements of 8-anilino-1-naphthalenesulfonic acid (ANS) were monitored

33 hydrophobic and hydrophilic properties of 8-anilino-1-naphthalenesulfonic acid (ANS).

34 ic spectra and extrinsic fluorescence with 8-anilino-1-naphthalenesulfonic acid and tetramethylrhodam

35 induced a relatively small enhancement in 8-anilino-1-naphthalenesulfonic acid fluorescence intensit

36 scopy and reactivity with thioflavin S and 8-anilino-1-naphthalenesulfonic acid fluorescent probes, t

37 16-(9-anthroyloxy)palmitic acid (16AP) and 8-anilino-1-naphthalenesulfonic acid is reduced.

38 Binding studies using 8-anilino-1-naphthalenesulfonic acid suggest that the E175

39 h a substantial increase in the binding of 8-anilino-1-naphthalenesulfonic acid with only modest chan

40 opthan synthase catalysis, the fluorophore 8-anilino-1-naphthalensulfonate (ANS) is used to identify

41 probe [the product of modification with N-(4-anilino-1-naphthyl)maleimide] on the alpha subunit durin

42 ANS (8-anilino-1-napthalene sulfonic acid) was used to probe th

43 reduces exposure of hydrophobic sites for 8-anilino-1-napthalenesulfonic acid binding and beta-struc

44 t expose hydrophobic surfaces that support 8-anilino-1-napthalenesulfonic acid binding.

45 Fluoropodophyllotoxin (11) and several 4beta-anilino-2-fluoro-4'-O-demethyl analogues were synthesize

46 This 4-anilino-3-quinolinecarbonitrile (SKI-606) ablates tyrosi

47 the binding of a fluorescent probe 1,1'-bis(anilino)-4-,4'-bis(naphthalene)-8,8'-disulfonate (bis-AN

48 , 4'-O-demethyl-4beta-(-)-(4' '-camphanamido-anilino)-4-desoxypodophyllotoxin (25), 4-beta-disubstitu

49 llotoxins (18-20, 26), 4-alpha-disubstituted-anilino-4'-demethyl-4-desoxypodophyllotoxin (27), 4-beta

50 xypodophyllotoxin (25), 4-beta-disubstituted-anilino-4'-demethyl-4-desoxypodophyllotoxins (18-20, 26)

51 ypodophyllotoxin (27), 4-beta-trisubstituted-anilino-4'-demethyl-desoxypodophyllotoxin (22, 23), and

52 e attachment of a single water molecule to 4-anilino-4'-nitro azobenzene on the same inert surface, t

53 )(1), where H2tBAFPh is 2-(2-trifluoromethyl)anilino-4,6-di-tert-butylphenol, were found to activate

54 nships (SARs) that led to the discovery of 2-anilino-4-(thiazol-5-yl)pyrimidine ATP-antagonistic CDK2

55 ng the recent discovery and development of 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin dependent kina

56 -demethyl-4beta-[(4' '-(benzimidazol-2' '-yl)anilino]-4-desoxypodophyllotoxin (21), 4'-O-demethyl-4be

57 evented by the guanylyl cyclase inhibitors 6-anilino-5,8-quinolinedione (5 mumol/L, n = 6) or 1H-(1,2

58 O-induced activation of PAL was blocked by 6-anilino-5,8-quinolinedione and 1H-(1,2,4)-oxadiazole[4,3

59 imilarly, the guanylate cyclase inhibitors 6-anilino-5,8-quinolinedione and 1H-[1,2,4]oxadiazolo[4,3-

60 Although 6-anilino-5,8-quinolinedione fully blocked PAL activation,

61 cGMP production was inhibited by LY 83583 (6-anilino-5,8-quinolinedione), a specific inhibitor of gua

62 Two inhibitors of sGC, 6-anilino-5,8-quinolinequinone (LY83583) and 1H-[1,2,4]oxa

63 e-2 (MetAP2), identified a potent class of 3-anilino-5-benzylthio-1,2,4-triazole compounds.

64 We report that bis-ANS (1,1'-bis(4-anilino-5-napthalenesulfonic acid), an environment sensi

65 nment-sensitive fluorescent probe 1,1'-bis(4-anilino-5-napththalenesulfonic acid (bis-ANS).

66 ost potent and selective validated hits, a 2-anilino-5-phenyl-1,3,4-oxadiazole (24) and a phenylmethy

67 A series of derivatives of 2-anilino-5-phenyloxazole (5) has been identified as inhib

68 on with substituted anilines furnished the 4-anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors

69 The synthesis and SAR of a series of 4-anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors

70 o prepared for comparison, as were several 1-anilino-6,7-dimethoxyisoquinoline-4-carbonitriles.

71 Initial 4-anilino-6-aminoquinoline-3-carbonitrile leads showed poo

72 by substitution at the C-8 position of our 4-anilino-6-aminoquinoline-3-carbonitrile leads.

73 The 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles were prepared f

74 n experiments using circular dichroism and 2-anilino-6-napthaline-sulfonate (ANS) fluorescence show t

75 structure-activity relationships of these 4-anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles ar

76 Here we report that both 1-anilino-8 naphthalene sulfonate (ANS) and the covalent a

77 ns, including cooperative folding, lack of 1-anilino-8-naphthalene sulfonate binding, and limited deu

78 proach, the rotational correlation time of 1-anilino-8-naphthalene sulfonate bound to nonpolar surfac

79 Using tubulin-1-anilino-8-naphthalene sulfonate complex fluorescence, we

80 1-Anilino-8-naphthalene sulfonate fluorescence indicates t

81 The ANS- (1-anilino-8-naphthalene sulfonate) anion is strongly, domi

82 measurements with earlier measurements on 1-anilino-8-naphthalene sulfonate, thioflavin T, and dynam

83 1H-NMR features and fluorescent binding of 1-anilino-8-naphthalene sulfonate.

84 nd interactions with the hydrophobic probe 1-anilino-8-naphthalene-sulfonic acid (ANS).

85 graphy, intrinsic tryptophan fluorescence, 1-anilino-8-naphthalenesulfonate (ANS) binding, circular d

86 Further, during binding experiments with 1-anilino-8-naphthalenesulfonate (ANS), the WT and N78D mu

87 es, and proteins and the hydrophobic probe 1-anilino-8-naphthalenesulfonate (ANS).

88 g within the ECD1 as determined by NMR and 1-anilino-8-naphthalenesulfonate binding but did not preve

89 ioning, liposome floatation assay, and bis-1-anilino-8-naphthalenesulfonate binding revealed that two

90 Fluorescence assays with 1-anilino-8-naphthalenesulfonate demonstrate that a hydrop

91 Interestingly, 1-anilino-8-naphthalenesulfonate fluorescence is at a mini

92 1-Anilino-8-naphthalenesulfonate monitored the involvement

93 noncovalent labeling with thioflavin T and 1-anilino-8-naphthalenesulfonate to follow the conformatio

94 3 and room temperature, measured by using 1-anilino-8-naphthalenesulfonate, were 9.4 x 10(-5) and 3.

95 dged by its binding to a fluorescent probe 1-anilino-8-naphthalenesulfonate.

96 cU by near-ultraviolet circular dichroism, 1-anilino-8-naphthalenesulfonic acid binding, free energy

97 e C-terminal domain have been evaluated by 1-anilino-8-naphthalenesulfonic acid binding, the kinetics

98 bserved previously for the GroEL 4, 4'-bis(1-anilino-8-naphthalenesulfonic acid) complex.

99 The binding of 4, 4'-bis(1-anilino-8-naphthalenesulfonic acid) to GroEL in the pres

100 he fluorescent, hydrophobic probe 4,4'-bis(1-anilino-8-naphthalenesulfonic acid), while the fluoresce

101 its reduced binding of the fluorescent dye 1-anilino-8-naphthalenesulfonic acid.

102 ve-like secondary structure and shows strong anilino-8-naphthalenesulphonate binding due to increased

103 residual secondary structure, and shows weak anilino-8-naphthalenesulphonate binding.

104 1-Anilino-8-napthalene sulfonate (ANS) binding and size-ex

105 l characterisation of these variants using 1-anilino-8-napthalene sulphonic acid (ANS) binding, near-

106 nthryl (BAET), and 10,10'-bis(N,N-diphenyl-4-anilino)-9,9'-bianthryl (BATA) in detail, we probed thei

107 ilino azatoxin class follows the SAR of the (anilino)acridine family.

108 e subsequent conversion to an axially chiral anilino alcohol is also reported.

109 The 2-anilino and 2-(dialkylamino)alkylamino substituents as w

110 ip (SAR) profile of the nonintercalating C11 anilino azatoxin class follows the SAR of the (anilino)a

111 attractive strategy to prepare diverse gamma-anilino-beta-ketoesters in one step.

112 oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic ac

113 carbonyl ]am ino]ethyl]amino]carbonyl]methyl]anilino]carbonyl]methyl]phenyl] adenosine (p- and m-DITC

114 Reaction of resin-bound o-anilino derivative with arylisothiocyanates yielded resi

115 with tin chloride, generated a resin-bound o-anilino derivative.

116 On the basis of an anilino diaryl sulfide screening lead 1, in combination

117 series of conformationally constrained ortho-anilino diaryl ureas.

118 aluated the antinociceptive activity of five anilino enaminones E139, ethyl 4-(4'-chlorophenyl)amino-

119 scovery and optimization of a series of 8-(1-anilino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxam

120 classes of agonists in which the bridgehead anilino group from our first series was replaced with an

121 Optimization of the C-4 anilino group of 1a led to 1c, which contains a 2,4-dich

122 The anilino group of the CDK2-bound compound was essentially

123 oelectronic effect involving twisting of the anilino group out of the plane of the benzene ring that

124 the nanoparticle chemically and contains an anilino group that is located on the end of the linker m

125 For the p38-bound inhibitor, the anilino group was angled out of plane and was positioned

126 with a bulky group at the 4'-position of the anilino group were shown to be competitive with both ATP

127 2-Anilino groups with small hydrophobic groups in the meta

128 in the 2, 4-diamino-5-methyl-6-[(substituted anilino)methyl]pyrido[2, 3-d]pyrimidine series generally

129 een 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines 5-17 were synthe

130 yielded 2,4-diamino-6-bromo-5-[(substituted anilino)methyl]thieno[2,3-d]pyrimidines.

131 dependent rhodamine analogues possessing an anilino-methyl moiety was developed and shown to exhibit

132 2,4-Diamino-5-[3,5-dichloro-4-(1-pyrrolo)anilino]methyl]- 6-bromothieno[2,3-d]pyrimidine was the

133 rious substituents on the phenyl ring of the anilino moiety at the C-3 position of the 1,2,4-triazole

134 Fluorescence binding assays with 1-anilino naphthalene-8-sulfonic acid (ANS) confirm that t

135 SVNLDVK were identified earlier as 1,1'-bi(4-anilino) naphthalene-5,5'-disulfonic acid (bis-ANS)-bind

136 rystallin chaperone interacts with 1,1'-bi(4-anilino) naphthalene-5,5'-disulphonic acid (bis-ANS) and

137 oup transformation gave 1,8-bis(3'-methyl-4'-anilino)naphthalene, 16, and 1,8-bis(4'-anilino)naphthal

138 l-4'-anilino)naphthalene, 16, and 1,8-bis(4'-anilino)naphthalene, 21, in 65% and 90% overall yield, r

139 mutant showed a 2-fold increase in 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid (bis-ANS) bindi

140 rporation of the hydrophobic probe 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid (bis-ANS) into

141 1,1'-Bis(4-anilino)naphthalene-5,5'-disulfonic acid binding, an ind

142 1,1'-Bis(4-anilino)naphthalene-5,5'-disulfonic acid cross-linking t

143 The 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid fluorescence in

144 However, 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid interaction ind

145 ATP hydrolysis was analyzed using 1,1'-bis(4-anilino)naphthalene-5,5'disulfonic acid (bisANS), a hydr

146 ic and static light scattering and 1,1-bis(4-anilino)naphthalene-5,5-disulfonic acid (bis-ANS) fluore

147 ission of acrylodan and 2-(4'-(iodoacetamido)anilino)naphthalene-6-sulfonic acid (IAANS) attached to

148 tive fluorescent probe, 2-(4'-(iodoacetamido)anilino)naphthalene-6-sulfonic acid (IAANS), to yield a

149 ents that showed IAANS (2-(4'-(iodoacetamido)anilino)naphthalene-6-sulfonic acid) coupled to Cys 35 c

150 the fluorescence probe, 2-((4'-iodoacetamido)anilino)naphthalene-6-sulfonic acid; and the labeled Pg

151 rescence of the hydrophobic probe 1,1'-bis(4-anilino)-naphthalene-5,5'-disulfonic acid.

152 methods (circular dichroism, aromatic and 8-anilino-naphthalene-1-sulfonic acid fluorescence, visibl

153 negligible binding of the hydrophobic dye 1-anilino-naphthalene-8-sulfonate (ANS) between pH 7 to 5.

154 on of a hydrophobic core as detected using 1-anilino-naphthalene-8-sulfonate fluorescence.

155 c pH levels, IEk binds the fluorescent dye 1-anilino-naphthalene-8-sulfonic acid (ANS), a probe for e

156 the fluorescent probe 2-[(4'-(iodoacetamido)anilino]naphthalene-6-sulfonic acid (IAANS) at Cys-35.

157 the fluorescent probe 2(-)[4'-(iodoacetamido)anilino]naphthalene-6-sulfonic acid.

158 evaluated using fluorescent probes 1,1'-bi(4-anilino)naphthalenesulfonic acid (bis-ANS), 8-anilino-1-

159 valuated using a fluorescent probe 1,1'-bi(4-anilino)naphthalenesulfonic acid (bis-ANS).

160 The peptides contained either the acetamido-anilino-naphthyl sulfonic acid (AANS), acrylodan, or dan

161 eptides was detected by measuring 1,1'-bis(4-anilino)napthalene-5,5'-disulfonic acid (bisANS) fluores

162 Hydrophilic substituents on the anilino nitrogen abolish agonist activity or produce ant

163 ant removal of the benzyl ether yields the o-anilino, o-phenolic polyaryls.

164 al database screening strategy has led to 7-[anilino(phenyl)methyl]-2-methyl-8-quinolinol (4, NSC 668

165 strong intramolecular hydrogen bonds between anilino protons and pyridyl and azo nitrogen atoms are r

166 recalculated with methyl groups in place of anilino protons, the barrier to isomerization disappears

167 lic ligand efficiency (LLE) in a series of 2-anilino-pyrimidine IGF-1R kinase inhibitors led to the i

168 Here, we describe the optimization of the 2-anilino quinazoline class as antimalarial agents.

169 Here, we show that BIBW2992, an anilino-quinazoline designed to irreversibly bind EGFR a

170 -donating groups at the para-position of the anilino ring enhance or maintain in vitro and in vivo ag

171 communicated that an ortho acyl group on the anilino ring enhanced oral absorption in this category o

172 itional substituent at the 6-position of the anilino ring further increases the potency of this serie

173 roduction of a meta hydroxyl group on the C4 anilino ring was computed to be particularly favorable.

174 is less electrophilic than the extended bis(anilino)squaraine analogue, but it is still susceptible

175 l encapsulation of fluorescent, deep-red bis(anilino)squaraine dyes inside Leigh-type tetralactam mac

176 the two domains of the protein and with the anilino substituent projecting into a hydrophobic pocket

177 yrylium dyes were prepared with one or two 4-anilino substituents at the 2- and 6-positions and with

178 In an attempt to find optimal anilino substituents for pol IIIC binding and optimal 3-

179 nificant drawback of our original bridgehead anilino-substituted series.

180 The influence of 4-anilino substitution on pan-erbB inhibitory potency was

181 s on inhibitor potency by methylation of the anilino-triazole nitrogens, as well as the X-ray crystal