ライフサイエンスコーパス: animal model

1 otype of Dravet syndrome and are an accepted animal model.

2 is 100-fold lower than that required in the animal model.

3 resistance both in vitro and in an infected animal model.

4 ously been analysed for renal function in an animal model.

5 d microvessel sprouting from an angiogenesis animal model.

6 d acute lung eosinophilia in an experimental animal model.

7 nd pathological fear behaviors in humans and animal models.

8 etards aging and increases longevity in many animal models.

9 iated with hypothalamic inflammation (HI) in animal models.

10 s ability to help quantify liver fibrosis in animal models.

11 t have been hampered by the absence of small animal models.

12 and regeneration, as revealed by studies of animal models.

13 brain tissue, as well as in tissues from HD animal models.

14 ls, consistently with biological efficacy on animal models.

15 een shown in patients with CHF as well as in animal models.

16 chenne muscular dystrophy (DMD) patients and animal models.

17 ains scarce on human development compared to animal models.

18 t infection susceptibility later in life, in animal models.

19 ed by the lack of adjuvant-free experimental animal models.

20 t target serine hydrolases in both cells and animal models.

21 various CSF routes has been demonstrated in animal models.

22 c hypertrophy in cell culture studies and in animal models.

23 ich activates autophagy in cell cultures and animal models.

24 reproductive system in humans, as it does in animal models.

25 ccessful tumor targeting was demonstrated in animal models.

26 correlated with HCC development in all three animal models.

27 ular injury, and premature death in multiple animal models.

28 NA dysregulation causes neurodegeneration in animal models.

29 utable to the lack of well-established HFpEF animal models.

30 and tumor control by DNA damage therapies in animal models.

31 via CSF has been demonstrated repeatedly in animal models.

32 criptional repressors in advanced testing in animal models.

33 siology and disease, and optimize the use of animal models.

34 dered by a paucity of tractable experimental animal models.

35 broad-based immune responses in preclinical animal models.

36 irements are often not recapitulated well in animal models.

37 l replication in vitro and severe disease in animal models.

38 f bacterial infection dynamics in laboratory animal models.

39 educes circulating IgG levels in preclinical animal models.

40 n to the fetus during pregnancy in different animal models.

41 been shown to cause diastolic dysfunction in animal models.

42 accounts of depression based on findings in animal models.

43 human neurodegenerative disease and related animal models.

44 etastases using both in vitro techniques and animal models.

45 chopulmonary dysplasia (BPD) in children and animal models.

46 is supported by neurophysiology in human and animal models.

47 n reported to directly promote thrombosis in animal models.

48 nimals and poorly reproduced in experimental animal models.

49 tection against influenza virus infection in animal models.

50 ut a question mark on the timing used in the animal models.

51 ns, making MLL-FP driven leukemias ideal for animal modeling.

52 uroscience best studied in only a handful of animal models?

53 fects of AD symptoms observed in AD/TTR(+/-) animal models after IDIF treatment and eventually for de

54 ecome standard components of the toolkit for animal model analyses of wild population data sets.

55 nipulating the local ion concentration in an animal model and altering neural behavior.

56 brane rupture in keratoconus, mimicking this animal model and highlighting the clinical relevance of

57 etection of CCR2-directed inflammation in an animal model and in human tissues as a step toward clini

58 arrhythmic potential of RDN in a postinfarct animal model and to determine whether any benefits relat

59 ted retinal degenerations; however, relevant animal models and biomarkers of progression in patients

60 striatal progenitors can be transplanted in animal models and can differentiate and integrate into t

61 phrases, allowing identification of related animal models and classification of entire assay descrip

62 This review will discuss examples of animal models and clinical studies to provide guidance a

63 ugh preclinical testing using representative animal models and clinically relevant quantitative bioma

64 Herein, we used animal models and cultured mammalian cells to demonstrat

65 has been implicated in alcohol responses in animal models and human alcoholics.

66 Successes achieved in both animal models and human clinical trials have proven ASOs

67 The data from animal models and human material provide preclinical pro

68 -infected tissues and are adaptable to other animal models and human patient samples.

69 major depression, drawing upon findings from animal models and human trials.

70 tions for interpreting disease phenotypes in animal models and humans.

71 in subfield oxidative stress and behavior in animal models and in human patients to better manage ant

72 advantageous exposures and half-life both in animal models and in humans, and in vivo efficacy in mou

73 antigen-specific CD8 T cells is mounting in animal models and in translational studies involving sub

74 Drawing from experimental animal models and observational human studies, we propos

75 ty provide a survival benefit in preclinical animal models and prevent recurrent infections in human

76 the conceptual foundations of genetic group animal models and provide extensive, step-by-step tutori

77 to protect against C. difficile infection in animal models and reduce recurrence in humans.

78 They provide an example of how animal models and their detailed level of neurobiologica

79 d metastasis-suppressive effects in multiple animal models and to be safe in both animals and humans.

80 ies compounds with antiepileptic efficacy in animal models and, hence, it is an appealing methodology

81 perimental allergic encephalomyelitis (an MS animal model), and the disease suppression depended on f

82 variability of protein turnover rates in any animal model, and utilize activity-based protein profili

83 ve against tau-mediated neurodegeneration in animal models, and because COX- and 5-LOX-derived eicosa

84 phytocannabinoids in tissues from different animal models, and develop new cannabinoid-based medicin

85 risk of carcinogen-induced breast cancer in animal models, and higher circulating hCG concentrations

86 factor mutations, mechanistic insights from animal models, and implications for development of novel

87 oligodendrocyte precursor cells in vitro, in animal models, and in human cells.

88 unction across species, identify appropriate animal models, and it provides important translational o

89 Recent work in a wide variety of animal models, and particularly in insects, has started

90 f outcome measures, availability of relevant animal models, and robust functional rescue from gene au

91 event and reverse neurodegeneration in other animal models, and to determine if it can be provided in

92 nesis, to build next-generation cellular and animal models, and to develop precision medicine approac

93 More animal models are needed to assess the functions of thes

94 New animal models are needed to investigate CYP3A functions,

95 e is unique to humans and some primates, new animal models are needed to understand the function of A

96 e vaccine candidates more efficiently, small-animal models are needed.

97 Several animal models, based on the expression of PrPs carrying

98 Pf) sporozoites, can protect from malaria in animal models but protective humoral immunity is difficu

99 ature pigs have been used as an experimental animal model, but they are still large and require relat

100 on in Staphylococcus aureus bacteremia (SaB) animal models, but clinical data are not available.

101 ssays are used for measuring reactivation in animal models, but there have been limited comparisons b

102 recovery from tissue ischemia in preclinical animal models by still unknown mechanisms.

103 The effect seen in cell and animal models can be recapitulated in humans.

104 meeting this challenge has been the lack of animal models capable of identifying impediments limitin

105 The development of animal models, coupled with an improved understanding of

106 Evidence from human studies and animal models demonstrates the influence that both mater

107 Animal models do not reflect the biology of the human di

108 ium release but, since knocking out genes in animal models does not necessarily replicate the human p

109 kidney disease (DKD) is limited by a lack of animal models exhibiting progressive kidney disease.

110 utoimmune disease multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis

111 seases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.

112 Hamsters are an ideal animal model for a variety of biomedical research areas

113 (ENU) mutation (ClockDelta19) are used as an animal model for bipolar disorder (BD).

114 urce of stem cells when one utilizes mice as animal model for corneal research.

115 In order to develop an animal model for evaluating vaccine antigens that can be

116 ge, and they have been proposed as a natural animal model for human epilepsy.

117 acaques (RMs), which are commonly used as an animal model for human HIV-1 infections and for testing

118 (C. elegans) is a versatile and widely used animal model for in vivo studies of a broad range of hum

119 suggest that microminipigs represent a novel animal model for influenza A virus infection.

120 dy, we evaluated the microminipig as a novel animal model for influenza A virus infection.

121 t mice mimic miliaria and provide a possible animal model for its study.

122 Gl) in non-human primates (NHPs) is a common animal model for ocular drug development.

123 e (MPTP) mouse model is the most widely used animal model for Parkinson's disease (PD), it is known t

124 sor gene, and they provide a fully penetrant animal model for the study of angiosarcoma development a

125 anized mice could be a highly relevant small-animal model for the study of dengue pathogenesis and th

126 t (Mustela putorius furo) is a commonly used animal model for the study of influenza virus infection

127 nockout (DAT-KO) mouse is currently the best animal model for this syndrome, displaying functional hy

128 Thus, we developed a clinically-relevant animal model for TON using a novel ultrasonic pulse inju

129 Using animal models for autoimmune type 1 diabetes (T1D), we f

130 ment of an efficient cell culture system and animal models for HBV investigation, development of trea

131 ced tobacco smoking in a 4-week trial and in animal models has been shown to reduce cortical dopamine

132 Blocking RAGE signaling in cell and animal models has revealed that targeting RAGE impairs i

133 palate cultures, and genetically engineered animal models have advanced our understanding of the dev

134 More recently, animal models have been developed and implemented for th

135 Animal models have begun to elucidate how skin barrier d

136 Animal models have demonstrated that allergen-specific I

137 Experiments in animal models have demonstrated the potential benefits o

138 In addition, traditional animal models have drawbacks such as high-cost, long per

139 Importantly, these animal models have not yet contributed to our poor under

140 Experiments in animal models have produced evidence for a causal role o

141 pment of colorectal cancer, and studies from animal models have provided evidence for their roles in

142 Experimental studies in allo-HCT animal models have shown some promising results for preb

143 as related to accelerated atherosclerosis in animal models; however, contrasting findings were report

144 a is known to cause persistent alveolitis in animal models; however, little is known about the molecu

145 In animal models, IL-12 and IL-23 participate in the develo

146 ve limited the range of applications of this animal model in protein-based drug discovery programs.

147 ied at the preclinical level using different animal models in which relapse to drug seeking is assess

148 results seen in suPAR-associated proteinuric animal models, in which kidney damage is caused not by l

149 variety of acute and chronic hyperammonemia animal models, including acute liver failure and ornithi

150 Animal models indicate that chronic cocaine use enhances

151 nslation of experimental results obtained in animal models into the clinics.

152 rrhoeal disease in humans, use of a relevant animal model is essential.

153 Animal models knocked out for MTM1 show severe reduction

154 manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatri

155 cause of typhoid fever), recapitulates in an animal model many symptoms of typhoid fever.

156 These results, in a large animal model, may offer insights into the potential clin

157 in largely undefined, and there is a lack of animal models mimicking natural oral human infection lea

158 e behavioral deficits in a chronic epileptic animal model more than 6 months after treatment.

159 a CA1 of wild-type and Df(16)A(+/-) mice, an animal model of 22q11.2 deletion syndrome, one of the mo

160 noncoding RNAs, and enhancer RNAs in a large animal model of acute infarction.

161 y modulated to provide neuroprotection in an animal model of acute ischemic stroke.

162 tive deficits in APP/PS1 mice, a widely used animal model of AD.

163 In an animal model of anti-TNF-resistant intestinal inflammati

164 and PAX6, and able to recover function in an animal model of corneal epithelial dysfunction after sur

165 The lack of an appropriate small-animal model of dengue infection has greatly hindered th

166 panel of blood and urinary biomarkers in an animal model of fecal peritonitis and recovery.

167 social dominance deficits in Grn+/- mice, an animal model of frontotemporal dementia due to GRN mutat

168 of eliminating WT virus contamination in an animal model of gammaherpesvirus lethality.

169 This study describes a large animal model of gastric eosinophil in peanut-sensitized

170 y Helicobacter species may represent a novel animal model of gastric lymphomagenesis.

171 of a physiologically relevant, pre-clinical animal model of HBV infection.

172 short-term survival over REBOA in this large animal model of hemorrhage-induced traumatic cardiac arr

173 ion via rAAV.Tbeta4 in a translational large animal model of hibernating myocardium.

174 In conclusion, the FAH(-/-) pig is a large-animal model of HT1 with clinical characteristics that r

175 In conclusion, we have developed a novel animal model of HTG-AP that can mimic physiological, his

176 most tripled lifespan of Apc(Min/+) mice (an animal model of human intestinal tumorigenesis).

177 ental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS).

178 ardial tissue composition in a translational animal model of I/R by the use of state-of-the-art imagi

179 uces collagen and alpha-SMA expression in an animal model of liver fibrosis.

180 profiling of LmnaH222P/H222P mouse, a small animal model of LMNA cardiomyopathy, suggested decreased

181 gradable nanoparticles for application to an animal model of lung infection.

182 e of cortical spreading depression (CSD), an animal model of migraine aura, induces a rapid and nearl

183 mmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for t

184 ntal autoimmune encephalomyelitis (EAE), the animal model of MS, resulted in a reduced Treg increase

185 To test function of CLEC12A in an animal model of multiple sclerosis (MS), we administered

186 he experimental autoimmune encephalomyelitis animal model of multiple sclerosis was assessed.

187 encephalomyelitis, which is the most-studied animal model of multiple sclerosis.

188 ed mushrooms extracts on high-fat diet (HFD) animal model of non-alcoholic steatohepatitis (NASH).

189 hermore, our study describes a novel in vivo animal model of noninfectious inflammation during pregna

190 In this study, we adopted an animal model of peripheral electrical stimulation that i

191 An animal model of peritoneal dissemination was used to ass

192 role of AKAP150 in cocaine reinstatement, an animal model of relapse.

193 Finally, in an animal model of sepsis, we observed that Salmonella typh

194 nated after cardiac death (DCD) in a porcine animal model of transplantation.

195 of the INSR attenuated clinical symptoms in animal models of acute graft-versus-host disease and mul

196 In animal models of acute ischaemic stroke, blocking of the

197 To examine KLF2 expression in multiple animal models of acute lung injury and further elucidate

198 However, data from animal models of addiction demonstrate that a variety of

199 mphasis on those that have been evaluated in animal models of AKI and CKD.

200 ounds have been evaluated in patients and in animal models of ALS, but have been proven disappointing

201 of natural killer (NK) cells in experimental animal models of atherosclerosis, it is not yet clear wh

202 acy of HDAC inhibitors (HDACIs) in different animal models of AUD may involve class I HDACs, we herei

203 cal self-antigen-driving disease progress in animal models of autoimmune diabetes.

204 In animal models of breast cancer, resistance to continuous

205 significantly reduces metastasis in relevant animal models of cancer.

206 ve been best studied in the tumor context in animal models of cancer.

207 In animal models of CDI, we show that when CotE is absent,

208 t a cocktail of three virulent phages in two animal models of cholera pathogenesis (infant mouse and

209 ion contributes to vascular complications in animal models of diabetes.

210 human postmortem brains, cultured cells, and animal models of disease that support the idea that alph

211 sms in the spacing effect have been found in animal models of disorders with intellectual disability,

212 Animal models of exercise-induced pain have been develop

213 Animal models of FSHD are hindered by incomplete knowled

214 In animal models of FXS and of ASD, GABA-B agonists have im

215 were recognized as key contributors in early animal models of GN, at a time when the prevailing view

216 Before a motor phenotype, animal models of HD show aberrant cortical-striatal glut

217 have been shown to control joint bleeding in animal models of hemophilia.

218 lonal bNAb proteins can confer protection in animal models of HIV infection at modest concentrations,

219 Animal models of HIV infection have a strong and well-do

220 M and MCM represent physiologically relevant animal models of HLA-E-restricted T cell immunobiology.

221 ulation of HET0016 with HPssCD and tested in animal models of human and syngeneic GBM.

222 Animal models of human disease are important for the exp

223 but demonstrated little efficacy in various animal models of human disease.

224 evidence for their efficacy in cellular and animal models of human inflammatory disease and in some

225 uses, as well as a discussion of the current animal models of infection.

226 SCFA are protective in various animal models of inflammatory disease.

227 of such processes in humans and experimental animal models of insulin-resistant diabetes.

228 de attenuate VEGF-induced retinal changes in animal models of neovascular retinal disease approximate

229 Animal models of ocular angiogenesis: from development t

230 choline receptor (nAChR) and is analgesic in animal models of pain.

231 synaptic transmission have been reported in animal models of PTEN loss; however, the full extent of

232 dies performed in human peripheral blood and animal models of PTSD, and review the human PTSD postmor

233 s both beneficial and detrimental effects in animal models of RP depending on the underlying disease

234 Current animal models of S. aureus colonisation are expensive an

235 (Nrp1(myel-KO)) mice and applied 2 stringent animal models of sepsis: cecal ligation and puncture as

236 In human TLE and in animal models of TLE, parvalbumin neurons are selectivel

237 Studies in animal models of type 2 diabetes have shown that glucago

238 the first time the immunogenicity profile in animal models of UL40, a novel HSV-2 T cell antigen that

239 the regulatory arm of the immune response in animals models of autoimmunity and Th17-skewing human ce

240 rrogation and analysis of kidney tissue from animal models or biobanked human kidney biopsies.

241 henotypes associated with gene disruption in animal models or by genetic linkage studies.

242 nd, when available, validation with knockout animal models or structurally distinct ligands with affi

243 ciated with genetic values for focal traits, animal model parameter estimates can be severely biased.

244 population pedigrees can substantially bias animal model predictions of breeding values and estimate

245 ly caused by mutations in Rhodopsin; in some animal models, RD is exacerbated by light.

246 nsposon promoters, and establish a basis for animal models recreating the FSHD transcriptome.

247 es, making development of STS cell lines and animal models representative of the diverse human STS su

248 therapeutic development, particularly since animal models representing human AD are lacking.

249 of H7 HA remains unknown due to the lack of animal models reproducing the response observed in human

250 Subsequent studies in cell and animal models revealed that misfolded tau can propagate

251 Other issues include choice of animal models, selecting appropriate endpoints, ethics o

252 Recommendations include the following: (1) animal model selection, with commentary on the fidelity

253 cular features was inoculated into different animal models showing high infectivity.

254 The efficient use of this technology in animal models still presents a number of challenges, inc

255 pend on the clinical stage of AF or specific animal model studied.

256 Animal model studies highlight the role of innate-like l

257 he biomedical community for the use of large animal models such as pigs to either serve as an alterna

258 Studies in various animal models suggest an important role for pulmonary ma

259 Studies in animal models suggest that changes in the production of

260 INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphen

261 lished evidence of antiepileptic efficacy in animal models than expected by chance (P-value <0.006).

262 pies will require a physiologically relevant animal model that recapitulates HLA-E-restricted T cell

263 pertension (CTEPH) will be accelerated by an animal model that replicates the phenotype of human CTEP

264 The Cyp3a1/2 KO rats are a novel rodent animal model that will be a powerful tool for the study

265 Cell or animal models that accurately reflect the pathology of L

266 ation of fast-onset antidepressants requires animal models that can accurately predict the delay to t

267 in the advantages and disadvantages of small-animal models that have been developed to replicate vari

268 pressing need exists to identify alternative animal models that reflect human disease.

269 Combined with data from animal models, these findings show that DCC is a master

270 persistence provides a powerful new natural animal model to study RNA virus persistence in the male

271 data demonstrate that RMs are an appropriate animal model to study this phenomenon and to determine t

272 Guinea pigs were used as an animal model to understand the hematopathologic and neph

273 , questions regarding the suitability of the animal models to evaluate IFNs were raised.

274 ilent synapses and thus provided instructive animal models to examine the role of NAc silent synapse

275 The lack of animal models to experimentally study how infectious age

276 New animal models to explore these recently-identified mecha

277 icity, making it difficult to translate from animal models to humans.

278 of modern biomedical research is the use of animal models to study disease mechanisms and to develop

279 ment of macaques and pigs as immunocompetent animal models to study HBV infection in vivo, immunologi

280 monkeys, which are among the best available animal models to study RSV infection.

281 tion with sophisticated genetically modified animal models, together with biochemical and pharmacolog

282 In progressing these devices through animal models towards clinical products, understanding t

283 In animal models, tracking the fate of graft-reactive T and

284 fluorescent features in tissue from multiple animal models using refractive index matched and mismatc

285 Here we develop an animal model utilizing direct ZIKV inoculation into the

286 Surprisingly, skin abscess induction in an animal model was correlated with the amount of a major c

287 hown to influence fetal brain development in animal models was quantified serially in early, mid-, an

288 gh to insert into a vein, which, for the rat animal model we employ, entails devices less than 200 mu

289 Based on data from plant and animal models, we argue that specific RLKs could be comp

290 s phenotype, among ciliopathies and knockout animal models, we expected IS patients to have an accumu

291 Building on evidence from animal models, we propose that deprivation accelerates t

292 Genes involved in NET formation in the animal model were used to design a NET-related inflammat

293 lls and pathogenesis and transmissibility in animal models were also assessed.

294 sters, but reveals attenuated effects in the animal model where adiposity is reduced naturally indepe

295 study sought to investigate, using the same animal model, whether the reported impairment of HDL car

296 'Animal models', which utilize pedigree data to separate

297 ovel genes have not yet been investigated in animal models, which will be a key step to translating t

298 lation has been established as a widely used animal model with translational relevance for neurodevel

299 In the surgical implant infection animal model, WLBU2 decreased biofilm mass as compared t

300 ns that allows comparison of human gait with animal models would be of great value in translational r