ライフサイエンスコーパス: animal study

1 supported by a dedicated experimental large animal study.

2 n used to identify the parameters for a live animal study.

3 Experimental animal study.

4 Interventional controlled experimental animal study.

5 Randomized animal study.

6 Prospective randomized ex vivo animal study.

7 essed this issue with a large interventional animal study.

8 0.8 V/m, the lower limit of effectiveness in animal studies.

9 proven effective at reducing fat storage in animal studies.

10 ficant difference in their effect in post-MI animal studies.

11 there is a lack of supporting evidence from animal studies.

12 t host environments can be better modeled in animal studies.

13 o ensure reproducibility in experimental and animal studies.

14 facilitate comparability of future human and animal studies.

15 Minor publication bias was observed in small animal studies.

16 nd optimization of stimulation parameters in animal studies.

17 ies and have not been reported in controlled animal studies.

18 olving concepts of NAFLD from both human and animal studies.

19 mental developmental principles learned from animal studies.

20 thus being a valid candidate for subsequent animal studies.

21 surements were made from phantom, human, and animal studies.

22 ure levels that are lower than those used in animal studies.

23 Finally, the system was successfully used in animal studies.

24 o findings from microelectrode recordings in animal studies.

25 ed the published data on PEP efficacy across animal studies.

26 ly connected to immune-mediated disorders in animal studies.

27 s reduced by deprivation, as demonstrated by animal studies.

28 be so much less invasive than they can be in animal studies.

29 fe support or hyperbaric oxygen therapy, and animal studies.

30 ere found to be compatible with results from animal studies.

31 een shown to be disrupted by cannabinoids in animal studies.

32 mph node transplant) to cover both human and animal studies.

33 l Animal Care and Use Committee approved all animal studies.

34 Most HAAs are carcinogenic in long-term animal studies.

35 lobin-based oxygen carrier (HBOC) in in vivo animal studies.

36 thropoietin promoted hepatic regeneration in animal studies.

37 lammatory effects in humans, as predicted by animal studies.

38 rs have shown promise in several preclinical animal studies.

39 It is also bioavailable and suitable for animal studies.

40 the ethical and technical reach permitted by animal studies.

41 od oral bioavailability were observed during animal studies.

42 ter tract in spatial learning, as implied by animal studies.

43 se of dose-response analyses in vitro and/or animal studies.

44 orting evidence, albeit largely derived from animal studies.

45 ip bias has not been examined in preclinical animal studies.

46 rm to atherosclerosis progression comes from animal studies.

47 n than currently modeled or measured in most animal studies.

48 ung protection seen in previous clinical and animal studies.

49 clinical trials and the other in preliminary animal studies.

50 comes has recently emerged from clinical and animal studies.

51 ed only after brain injury, causing edema in animal studies.

52 of experimental design and interpretation in animal studies.

53 issue inflammation and insulin resistance in animal studies.

54 and exceeding protective thresholds seen in animal studies.

55 onditioning and extinction in both human and animal studies.

56 its promising applications for live cell and animal studies.

57 g an experimentally tractable alternative to animal studies.

58 suggested to be embryotoxic and fetotoxic in animal studies.

59 in C-terminus are often used in cellular and animal studies.

60 l understood and rely mainly on experimental animal studies.

61 In the animal study, 12 New Zealand/Dutch Belt pigmented rabbit

62 Confirming previous animal studies, 1B6 was poor at reversing glycemia in a

63 al stromal cells (MSCs) constitute, based on animal studies, a promising interventional strategy for

64 al research, both the sex and the age of the animals studied affect disease phenotypes by modifying t

65 In animal studies, aged apoE2-TR mice also exhibited preser

66 Phenotypic effects displayed in animal studies, along with resolution of WWOX's architec

67 Data from animal studies and a ring vaccination clinical trial con

68 However, animal studies and a study in immunocompromised children

69 s limited because it is derived largely from animal studies and analysis of human mononuclear phagocy

70 onment of breast cancer in both pre-clinical animal studies and clinical applications.

71 erception that fibrotic tissue is permanent, animal studies and clinical data now demonstrate the hig

72 cs shifted from one driven by discoveries in animal studies and clinical observations (eg, oestrogen,

73 A large number of animal studies and clinical trials have indicated that o

74 Biomedical research has relied on animal studies and conventional cell cultures for decade

75 ative (ADQI) XIII was to harmonize human and animal studies and determine what is known about potenti

76 ume of literature, comprising both human and animal studies and employing both observational and expe

77 Several EDC effects have been reported in animal studies and extrapolated to human studies.

78 xample, there is growing evidence, both from animal studies and from human neuroimaging, that activit

79 Both animal studies and human clinical trials suggest that dr

80 Although animal studies and human functional neuroimaging implica

81 Larger animal studies and human studies are necessary to confir

82 urrent knowledge in these areas derived from animal studies and human trials.

83 ss the lack of reproducibility in biomedical animal studies and improve the communication of research

84 en, MeDALL included mechanistic experimental animal studies and in vitro studies in humans.

85 Experimental animal studies and limited epidemiologic evidence sugges

86 has been found to improve sepsis outcomes in animal studies and one clinical study.

87 Several animal studies and one recent human study have suggested

88 sphenol A (BPA) show reproductive effects in animal studies and potentially affect human ovulation, c

89 Animal studies and recent clinical research suggests tha

90 Both animal studies and studies using deep brain stimulation

91 lation in conditions of parental stress (one animal study and seven human studies) also reported incr

92 nociceptive processes (in line with previous animal studies); and the LC showing lateralized activity

93 e research designs and results obtained from animal studies, and compare these to the human trials.

94 ystem theory, including cross-modal studies, animal studies, and so forth.

95 Additionally, animal studies applying lasers for treating peri-implant

96 Animal studies are a foundation for defining mechanisms

97 ors, and extensive target validation through animal studies are addressed.

98 However, preclinical animal studies are not always predictive of human outcom

99 Animal studies are not amenable to the specific investig

100 is feasible and merits exploration in intact animal studies as an energy source for arrhythmia elimin

101 the pathophysiological literature, including animal studies, as well as experimental psychology and c

102 etimes show effects that are not observed in animal studies at human exposure levels that are lower t

103 h is bidirectional in nature, with human and animal studies becoming more closely integrated as techn

104 In animal studies, both seizures and interictal spikes indu

105 In animal studies, brain-derived neurotrophic factor (BDNF)

106 limus-coated balloons has been shown in few animal studies, but data from randomized clinical trials

107 -inflammatory functions in some clinical and animal studies, but the direct mechanism is not fully un

108 ics has been employed in a growing number of animal studies, but the technique has yet to be widely u

109 fied in the ES luminal epithelium, mainly in animal studies, but there has been no functional study i

110 ng and executive functions, and (4) show how animal studies can reveal population and network phenome

111 Concordant with previous animal studies, cardiovascular magnetic resonance measur

112 In animal studies, central and blood borne inflammatory cyt

113 Based on these findings and animal studies, clinical trials of recombinant human EPO

114 y 2015 under protocols approved by the local animal studies committee and institutional review board.

115 there is conflicting evidence from human and animal studies concerning the effects of THC on the dopa

116 In a randomized, nonblinded laboratory animal study conducted between January 2013 and December

117 A prospective comparative case - control animal study conducted on 56 eyes of 28 healthy new born

118 Animal studies confirm earlier anecdotal observations in

119 Thus, these cell culture and whole animal studies demonstrate a role for the retrograde dyn

120 In vitro laboratory and animal studies demonstrate a synergistic role for the co

121 Clinical and animal studies demonstrate that alcohol intoxication at

122 Animal studies demonstrate that certain monoclonal NAbs

123 Both clinical trials and experimental animal studies demonstrate that chronic hypoxia can indu

124 Human clinical studies as well as laboratory animal studies demonstrate that offspring of pregnancies

125 ss to offspring via early postnatal care, as animal studies demonstrate the importance of early mater

126 Detailed cell culture and animal studies demonstrated that IFIT1 is not a dominant

127 The xenograft animal study demonstrated MART-10 could effectively repr

128 arize data from a diverse array of human and animal studies demonstrating that the vmPFC is a key nod

129 In animal studies, dietary choline or TMAO significantly ac

130 Recently, the first animal studies emerged that present examples of early-li

131 However, these same animal studies failed to accurately predict many of the

132 continued basic science, translational, and animal studies for providing mechanisms to explain causa

133 However, our recent small animal studies found large numbers of recipient stem cel

134 common to see contradictions of outcomes in animal studies from different research groups, leading t

135 Within the limitations of this DM animal study, gaseous ozone application accelerates xeno

136 Results from animal studies have consistently suggested that lignans

137 Human and animal studies have converged to suggest that caffeine c

138 In contrast, though numerous animal studies have demonstrated that helminth infection

139 onnectivity between these brain regions, and animal studies have demonstrated that the vmPFC modulate

140 ney and cardiovascular injury in humans, and animal studies have described a causative link.

141 Several animal studies have emphasized the role of gut microbiot

142 Recent in vitro and animal studies have found the proton pump inhibitor (PPI

143 Animal studies have further shown the importance of TREM

144 Human and animal studies have identified an especially critical ro

145 Animal studies have identified place cells and grid cell

146 Previous human and animal studies have implicated XRCC5 in alcohol sensitiv

147 icacy results from both in-vitro and in-vivo animal studies have led to their steady progression thro

148 Animal studies have long shown that olfactory oscillator

149 Animal studies have provided compelling evidence demonst

150 Both human and animal studies have provided evidence supporting these p

151 Animal studies have revealed potential mechanisms, but h

152 Nonhuman animal studies have robustly demonstrated that mothers p

153 patients with differing outcomes and use of animal studies have shed some light on this issue, but m

154 G toxicity have not been published, however, animal studies have shown FG or Geniposide can cause hep

155 Multiple animal studies have shown PBDEs to be thyroid hormone (T

156 Animal studies have shown that a high intake of galactos

157 Animal studies have shown that carbon dioxide-mediated f

158 Preclinical animal studies have shown that choline, which is an esse

159 Animal studies have shown that electromagnetic field exp

160 Although animal studies have shown that exposure to glyphosate (a

161 In vivo animal studies have shown that MWCNT cause biomechanical

162 Animal studies have shown that substantia nigra (SN) dop

163 While animal studies have suggested causal involvement of the

164 of the post-translational modifications, and animal studies have suggested the involvement of IgG gly

165 Recent animal studies have underscored the importance of hepati

166 Preclinical animal studies have used short-term paradigms, typically

167 of cannabis exposure, for which experimental animal studies have validated causal relationships betwe

168 Animal studies identified rhesus macaques but not hamste

169 dala is well established [4], both human and animal studies implicate other brain regions in learning

170 im of making remaining material derived from animal studies in biomedical research more visible and a

171 is notion has been supported by in-vitro and animal studies in bone, cartilage, tendon, and muscle.

172 e the importance of validating findings from animal studies in human brain tissue, and advocate for N

173 s orchestrate such timing as demonstrated by animal studies in vitro [3, 4] and in vivo [5, 6], sugge

174 this hypothesis is primarily on the basis of animal studies, in which the gene is inactivated simulta

175 rmacokinetic parameters suitable for in vivo animal studies, including low clearances and decent oral

176 t will enhance translation between human and animal studies, including the identification of intermed

177 Both human and animal studies indicate a role for ANP as a regulator of

178 However, animal studies indicate that PAG analgesia is mediated l

179 Substantial evidence from animal studies indicates that the gonadal hormone 17beta

180 diphenyl ethers (PBDEs) are limited despite animal studies indicating PBDEs' potential role as an ob

181 6 levels: in vitro characterization, in vivo animal studies, initial human studies, impact on clinica

182 e, and thus far the transfer of results from animal studies into successful clinical trials has been

183 ue in depth by conducting a meta-analysis of animal studies investigating the efficacy of the clinica

184 es by mimicking recent findings from in vivo animal studies involving intrastriatal administration of

185 A unique possibility to validate these animal studies is provided by a surgical therapeutic app

186 , evidence from recent human and preclinical animal studies is reviewed, indicating that SPMs are phy

187 The aim of this animal study is to analyze bone remodeling around platfo

188 could be utilized both in human studies and animal studies, is needed to integrate the field truly.

189 Based on animal studies, it has been proposed that central sensit

190 and control patients confirmed results from animal studies (mean CNR for NASH vs control patients, 2

191 risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for I

192 To make animal studies more relevant to human health, research a

193 is characteristic in humans, relying also on animal studies of analogous skills.

194 Some animal studies of auditory cortical processing have sugg

195 in rats, and 89% of human studies and 70% of animal studies of early-life adversity reported increase

196 found to be pathogenic in several human and animal studies of immune-mediated diseases.

197 Systematic consideration of experimental animal studies of oral biphenyl exposure took into accou

198 As a scientific case study, preclinical animal studies of these nutrients definitively influence

199 Despite the extensive animal studies on how amblyopia emerges, we know surpris

200 cupational and accidental exposure, only few animal studies on the genotoxic effects of chronic LDR r

201 l motor control, in close collaboration with animal studies on the molecular biology of the spinal co

202 rity, thereby providing clinical validity to animal studies on the role of platelets in severe infect

203 studies that presented preclinical in vivo (animal studies) or clinical (human studies) evidence for

204 FA) and the major SFA in the HFD used in our animal study-potently enhanced LPS-induced proinflammato

205 Animal studies provide evidence that these functions are

206 The results of animal studies provide the basis for the challenging tra

207 In a randomized, nonblinded laboratory animal study, rats were randomized into a controlled man

208 number of clinical reports and some critical animal studies regarding pre-existing and treatment-indu

209 However, animal studies reported that exposure to nicotine during

210 ogy had less consistent results, with 67% of animal studies reporting increased exon 17 methylation a

211 In vivo animal studies reveal that protoporphyrin IX fluorescenc

212 Animal studies reveal that the cancer-induced bone pheno

213 ologies are becoming clearer, several recent animal studies revealed that short-term administration o

214 Previous animal studies revealed that vaccination with siderophor

215 Animal study revealed that TTT-28 enhanced the intratumo

216 Animal studies show structural changes in brain regions

217 Collectively, our animal studies show that a specific lung injury can indu

218 Animal studies show that chronic pancreatic inflammation

219 Epidemiological and animal studies show that deleterious maternal environmen

220 Recent animal studies showed physiologically tight disynaptic c

221 In contrast with clinical results, animal studies showed significantly increased survival i

222 Cell culture and animal studies showed that tau fibrils can undergo cell-

223 t acoustic temporal fine structure (TFS) and animal studies showing minimal changes in neural coding

224 These observations were confirmed by in vivo animal studies showing preferential recruitment of APCs

225 This is supported by animal studies showing that chronic stress or glucocorti

226 These results are consistent with those from animal studies showing that exposure to PBDEs is associa

227 The findings are consistent with animal studies showing that prolonged light exposure lea

228 ntrol gene for eye development in all seeing animals studied so far.

229 Both human and animal studies strongly suggest that platelet activity i

230 Animal studies suggest an anti-fibrillatory action of th

231 Animal studies suggest that dantrolene also protects aga

232 Human epidemiological and animal studies suggest that developmental exposure to co

233 Animal studies suggest that exposure to artificial sweet

234 Animal studies suggest that kappa opioid receptor antago

235 arly correlate of disease later in life, and animal studies suggest that low birth weight is associat

236 Animal studies suggest that pancreatitis-induced acinar-

237 Previous human and animal studies suggest that patients with a susceptible

238 Previous case reports and animal studies suggest that periodontitis is associated

239 Animal studies suggest that specifically maternal dietar

240 well as propagation phase, and insights from animal studies suggest that targeting the IL-1 pathway c

241 Animal studies suggest that the alERC may support the sp

242 Animal studies suggest that the pathological outcome of

243 Animal studies suggest that the pathophysiology and phys

244 Animal studies suggest the anti-fibrillatory effect may

245 Previous human and animal studies suggested an association between 14-3-3 d

246 D, recent evidence from human postmortem and animal studies suggests a selective vulnerability of GAB

247 Evidence from animal studies suggests maternal caffeine intake during

248 Evidence from animal studies suggests that exposure to organophosphate

249 rious ACE-Ang II-Ang II type 1 receptor arm, animal studies support the existence of protective amino

250 Animal studies support the hypothesis that in slow-wave

251 Although there are some in vitro and limited animal studies supporting these mechanisms, heme-mediate

252 Most preclinical animal studies test influenza vaccines in immunologicall

253 Future research should include animal studies that address mechanistic hypotheses and s

254 traditional 2D cell cultures and preclinical animal studies that have historically been the standard

255 Despite numerous animal studies that have illustrated the impact of addit

256 There are human and animal studies that individually report clear benefits,

257 oral, and electrophysiological findings from animal studies that provide a new understanding on how M

258 or the theory is largely drawn from nonhuman animal studies that use invasive pharmacological or elec

259 ustry did not disclose evidence of harm from animal studies that would have (1) strengthened the case

260 pite its widespread application in human and animal studies, the neurobiological basis of fear condit

261 In confirmatory animal studies, the protective effect of [Nle(4), D-Phe(

262 In the animal study, the long-interval group (IV metoprolol 25

263 Through human genetic and animal studies, there are now hundreds of known genetic

264 In animal studies, there is convincing evidence that light

265 In cell culture and animal studies, these effects alter the expression of en

266 o moving vaccine candidates from preclinical animal studies to clinical trials.

267 ransplantation has been demonstrated in many animal studies to cure experimentally induced diabetes.

268 Most animal studies to date have injected viral suspensions i

269 ; 3) the shift from reliance on high-quality animal studies to define mechanisms that established the

270 es and mood, emotion, cognition, and memory; animal studies to determine epigenetic changes that repr

271 amine H1 receptor systems have been shown in animal studies to have important roles in the reversal o

272 on has to be exercised in the translation of animal studies to human beings, our data strongly sugges

273 caution when extending similar results from animal studies to humans.

274 take this into account when designing large animal studies to most closely mimic the clinical course

275 e results to data obtained from multispecies animal studies to provide a detailed example of translat

276 way nerves is critical to the translation of animal studies to the clinical setting.

277 regarding the generalizability of controlled animal studies to the more multifaceted pattern of human

278 All animals studied to date are associated with symbiotic co

279 ss of ADARs affects neuronal function in all animals studied to date.

280 Animal studies using mice carrying orthotopic breast MDA

281 t, which has been rarely identified, even in animal studies, using electrophysiological/pharmacologic

282 In agreement with anatomical data from animal studies, we found evidence for somatosensory and

283 Consistent with animal studies, we found that in human BCa bone metastat

284 Motivated by results from animal studies, we hypothesized higher than expected rat

285 Consistent with findings from animal studies, we provide the first evidence in humans

286 For the animal study, we collected ERG parameters before and aft

287 Animal studies were approved by the Institutional Admini

288 Materials and Methods All animal studies were approved by the institutional animal

289 Animal studies were approved by the Institutional Animal

290 The animal studies were approved by the local animal ethics

291 Extensive preclinical ex vivo and animal studies were conducted with the transapical mitra

292 Animal studies were included only to support pertinent d

293 en human prospective clinical trials and two animal studies were included.

294 Materials and Methods Animal studies were performed according to institutional

295 For reconfirming the findings of the animal studies when administering 1 to healthy human vol

296 he present review attempts to link human and animal studies while proposing molecular mechanisms that

297 ses cell proliferation, both in-vitro and in animal studies, while also demonstrates additive efficac

298 rting this hypothesis from human imaging and animal studies will be discussed, and combinatorial drug

299 a promise as a myelin biomarker in human and animal studies with a particular advantage of sensitivit

300 This evidence is primarily derived from animal studies, with limited study in humans due to inac