ライフサイエンスコーパス: anion conductance

1 agreement with the existence of an uncoupled anion conductance.

2 nly capable of mediating the substrate-gated anion conductance.

3 binding pocket during the activation of the anion conductance.

4 rate of glutamate transport and an abnormal anion conductance.

5 These data reflect loss of the CFTR anion conductance.

6 ability of glutamate to further activate the anion conductance.

7 r agonists to modulate the apical membrane's anion conductance.

8 rections without affecting activation of the anion conductance.

9 EAATs exhibit a sodium- and glutamate-gated anion conductance.

10 volume regulation through a volume-regulated anion conductance.

11 may involve activation of a volume-sensitive anion conductance.

12 LC1A family members is a substrate-activated anion conductance.

13 nsporters catalyzing substrate-gated or leak anion conductances.

14 We recorded the activities of three distinct anion conductances: (a) an inwardly rectifying anion cha

15 Interestingly, the amplitude of the anion conductance activated by the acidic amino acids do

16 Part of the current was generated by an anion conductance activated when uptake occurs.

17 including the kinetics of proton binding and anion conductance activation.

18 er, such as activation of the cation-induced anion conductance and creation of a substrate binding si

19 E111 and E113 may electrostatically control anion conductance and occupancy of the binding site with

20 ly slightly altered, and the relative cation/anion conductance and permeability ratios were unchanged

21 , as is well known, but it can also regulate anion conductance and selectivity of CFTR in native epit

22 The model simulates both the anion conductance and the glutamate flux through the tra

23 he glutamate concentration dependence of the anion conductance and the kinetics of glutamate flux wer

24 DeltaF508/DeltaF508) airway epithelia lacked anion conductance, and they did not hyperabsorb Na(+).

25 rt the amplitudes of the substrate-activated anion conductances are not substantially affected indica

26 Most of these mutations lead to compromised anion conductance at the apical plasma membrane of secre

27 al cells, whereas stellate cells control the anion conductance, but by an as-yet-undefined route.

28 The results show that anion conductance by ACRs has a fundamentally different

29 Inhibition of the leak anion conductance by benzylserine requires the presence

30 aspartate was able to activate the uncoupled anion conductance by N451S, but with an almost 1000-fold

31 d that EAAT subtypes with particularly large anion conductances can directly influence the excitabili

32 otein and the appearance of a cAMP-activated anion conductance characteristic of CFTR function.

33 The leak anion conductance exhibits permeation properties that ar

34 ll numerous biological roles requiring gated anion conductance, from regulating skeletal muscle excit

35 The glutamate-gated anion conductance in cones has a reversal potential of a

36 o the mechanism by which substrates gate the anion conductance in EAATs and suggest that in EAAT1, Ar

37 ontribute significantly to inward-rectifying anion conductance in mouse choroid plexus, which must th

38 d from decalcified cells revealed a dominant anion conductance in response to membrane hyperpolarizat

39 er, zinc reduced the current mediated by the anion conductance in the cone synaptic terminal glutamat

40 ransport, zinc potentiated activation of the anion conductance in the Muller cell glutamate transport

41 Thus, the finding that the anion conductance is gated independently, rather than co

42 nsporters (EAATs), suggesting that this leak anion conductance is highly conserved within the EAAT pr

43 At pH less than 5.5, anion conductance is rapidly and reversibly activated in

44 ubstrate uptake, but not substrate-activated anion conductance, is completely inhibited in these muta

45 not pTrial10, demonstrated a cAMP-dependent anion conductance, measured by fluorescence microscopy u

46 somes to identify a novel chloride-selective anion conductance mediated by OCA2 and required for mela

47 In addition, kainate blocked a resting anion conductance observed in the absence of glutamate.

48 that are similar to the substrate-activated anion conductance of ASCT2, preferring hydrophobic anion

49 We instead explored the role of the abnormal anion conductance of the EAAT1(P>R) mutation, and to do

50 a(++), but this effect resulted from reduced anion conductance, rather than from a direct effect on t

51 ddition, DeltaFRD elicited a cAMP-stimulated anion conductance response in primary human bronchial ep

52 not Rab11a, reduced by 50% the CFTR-mediated anion conductance response.

53 Disruption of CFTR-mediated anion conductance results in defective fluid and electro

54 Glutamate transporters also display an anion conductance that is activated by the binding of Na

55 f glutamate, and they are associated with an anion conductance that is stoichiometrically uncoupled f

56 thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability.

57 thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability.

58 PepT1 did not display the substrate-gated anion conductances that have been found to be characteri

59 The leak anion conductance was increased by, but did not require

60 We found that the leak anion conductance was inhibited by the binding of the ne

61 anhydrase was inhibited and transepithelial anion conductance was limited to HCO3- revealed a sharp

62 A volume-sensitive anion conductance was observed when cell swelling was in

63 mbrane conductance regulator (Cftr)-mediated anion conductance was responsible.

64 The selectivity sequence of the SNAT2H-304A anion conductance was SCN->>NO3->I->Br->Cl->Mes-.

65 The properties of this leak anion conductance were studied by electrophysiological r

66 Volume-sensitive anion conductances were observed in both rat lacrimal gl

67 binding to the transporters induces a basal anion conductance, which is further activated by glutama

68 Interestingly, a Na(+)-dependent leak anion conductance with similar properties was previously

69 s the EC(50) for L-glutamate to activate the anion conductance, without affecting the EC(50) for the

70 to several seconds; (b) a quickly activating anion conductance (X-QUAC), important for anion efflux a

71 revailing anion; and (c) a slowly activating anion conductance (X-SLAC), activating above -100 mV.