ライフサイエンスコーパス: anion exchanger

1 ed between the same anion and the lipophilic anion exchanger.

2 cation exchanger and the other containing an anion exchanger.

3 rnary ammonium groups to form a "tentacular" anion exchanger.

4 ssigned to the cytoplasmic surface of native anion exchanger.

5 to the cytoplasmic domain of band 3, the RBC anion exchanger.

6 r induce a cation leak in a still functional anion exchanger.

7 ncentrated on a narrow bore (2 mm) aliphatic anion exchanger.

8 as well as the surface delivery of the AE1-4 anion exchanger.

9 minantly by CFTR or by an electrogenic SLC26 anion exchanger.

10 lectrogenic NBCs and 33-43% identical to the anion exchangers.

11 detergent insolubility by newly synthesized anion exchangers.

12 be important in other cell types expressing anion exchangers.

13 solute carrier family 26 member A6 (SLC26A6) anion exchangers.

14 ly of bicarbonate transporters that includes anion exchangers.

15 lls that express the H(+)-ATPase but not the anion exchanger 1 (AE1) and that are thought to mediate

16 Anion exchanger 1 (AE1) mediates Cl(-)/HCO3(-) exchange

17 The anion exchanger 1 (AE1), a member of bicarbonate transpo

18 Anion exchanger 1 (AE1), also known as band 3 or SLC4A1,

19 ainst the carboxy-terminal 12 amino acids of anion exchanger 1 (AE1), revealed a distribution of immu

20 reaction inside red blood cells, and band 3 [anion exchanger 1 (AE1)] provides a passage for HCO3(-)

21 Anion exchanger 1 (AE1; Band 3; SLC4A1) is the founding

22 mutation is in a gene (slc4a1) encoding the anion exchanger 1 (also called band 3 and AE1), an eryth

23 cytoplasmic domain of the human erythrocyte anion exchanger 1 (cdAE1) serves as a center of organiza

24 to a major interacting loop of the erythroid anion exchanger 1 (eAE1) with ankyrin-R, whereas the mai

25 3)(-) ions is catalyzed by human erythrocyte anion exchanger 1 (hAE1) through a ping-pong mechanism w

26 the bicarbonate/chloride transporter kidney anion exchanger 1 (kAE1), detected by yeast two-hybrid a

27 ia cells were transfected with human band 3 (anion exchanger 1 [AE1]) cDNA, using the pBabe retrovira

28 in putative transmembrane domain 8 (TMD8) of anion exchanger 1 are involved in ion translocation, and

29 The renal ammonium transporter RhBG and anion exchanger 1 kAE1 colocalize in the basolateral dom

30 s (caused by a 27- base pair deletion in the anion exchanger 1 protein gene) and protection from cere

31 NBCe1-A-TM1 was previously modeled on the anion exchanger 1 TM1 (AE1-TM1); however, our data demon

32 genes encoding carbonic anhydrase II, kidney anion exchanger 1, and different subunits of the H+-ATPa

33 ribe a mutation in human erythrocyte band 3 (anion exchanger 1; SLC4A1) causing both hereditary spher

34 Anion exchanger-1 (AE1) mediates chloride-bicarbonate ex

35 Expression of the acid-loading transporter anion exchanger 2 (AE2) (SLC4A2 product) was detected in

36 Cl(-) /HCO3- anion exchanger 2 (AE2) participates in intracellular pH

37 odium bicarbonate co-transporter (NBCe1) and anion exchanger 2 (AE2) that are both components of the

38 equate expression of the key HCO3- exporter, anion exchanger 2 (AE2), and (3) an intact cholangiocyte

39 Anion exchanger 2 (AE2), the principal bicarbonate secre

40 To regulate pH, ameloblasts express anion exchanger 2 (Ae2a,b), chloride channel Cftr, and a

41 e conductance regulator/chloride bicarbonate anion exchanger 2 (cAMP-->CFTR-->Cl(-) /HCO 3- AE2) sign

42 ane regulator (CFTR), Cl(-) /HCO3 (-) (apex) anion exchanger 2 (Cl(-) /HCO3 (-) AE2), and adenylyl cy

43 sis transmembrane regulator, Cl(-)/HCO(3)(-) anion exchanger 2 and AC8, and responded to secretin.

44 of the basolateral Cl(-) /HCO3(-) exchanger (anion exchanger 2; AE2).

45 Ameloblasts were immunostained for anion exchanger-2 (Ae2), a transmembrane pH regulator se

46 ranching ducts of cholangiocytes (expressing anion exchanger-2-AE2 and CFTR), or regulatable C-peptid

47 presence of the basolateral ion transporter anion exchanger 4.

48 ave indicated that the variant chicken AE1-4 anion exchanger accumulates in the basolateral membrane

49 Chloride uptake by basolateral anion exchanger activity (AE2) supports intracellular cA

50 Anion exchanger activity was also significantly reduced

51 ith activation of a DIDS-sensitive Cl--HCO3- anion exchanger (AE) to produce HCO3- efflux, and a DIDS

52 Anion exchanger (AE), sodium bicarbonate cotransporter (

53 Na(+)-K(+)-2Cl(-) cotransporters (NKCC1) and anion exchangers (AE), the 2 primary basolateral Cl(-) u

54 Human red cell anion exchanger AE1 (band 3) is an electroneutral Cl-HCO

55 ase II (CA II) binds to the C termini of the anion exchanger AE1 and the electrogenic Na/HCO3 cotrans

56 tif (D887ADD) in the carboxy-terminus of the anion exchanger AE1 binds to carbonic anhydrase II (CAII

57 We recently found that band 3 (the anion exchanger AE1) was present in the apical membrane

58 aemoglobin-binding cytoplasmic domain of the anion exchanger AE1.

59 tin, increased and redistributed basolateral anion exchanger AE1/2 protein, and redistributed Na-tran

60 H(+) secretion is removed by the basolateral anion-exchanger AE1.

61 used to detect immunoreactivity against the anion exchanger (AE1 or AE2).

62 an alternately spliced form of the erythroid anion exchanger (AE1, band 3), but unlike band 3 it does

63 amino acid sequence 30-35% identical to the anion exchangers (AE1-3), a superfamily of HCO3- transpo

64 sket" model for transport in the erythrocyte anion exchanger, AE1.

65 tramembrane domain of the erythrocyte band 3 anion exchanger, AE1.

66 nel AQP1, the chloride channel CFTR, and the anion exchanger AE2) that account for ion-driven water t

67 Anion exchanger AE2, CAII, and CAIV were abundant in the

68 chimeras between AE1 and the closely related anion exchanger AE2, which does not bind ankyrin, we hav

69 any change in mRNA and protein levels of the anion exchanger Ae2.

70 The mouse anion exchanger AE2/SLC4A2 Cl(-)/HCO(-)(3) exchanger is

71 ino acids, is 34% identical to the mammalian anion exchanger (AE2); approximately 50% to the electrog

72 n the cytoplasmic domain of the nonerythroid anion exchanger, AE2, that serves as an intracellular pH

73 ate cotransporter Nbce1, and the basolateral anion exchanger Ae2a,b in maturation ameloblasts suggest

74 The anion exchanger AE3, expressed in hippocampal (HC) neuro

75 ABSTRACT: The anion exchanger AE3, expressed in hippocampal (HC) neuro

76 as suggested that CA4 acts in a complex with anion exchangers (AEs) to facilitate Cl(-)-HCO(3)(-) exc

77 via a pathway that requires participation of anion exchangers (AEs).

78 capillaries were coated with 65-nm-diameter anion exchanger (AEX) latex nanoparticles that attach el

79 ing TM3-5 and TM8 that should function as an anion exchanger and a cation leak.

80 n adsorbed layer of quaternary ammonium type anion exchanger and a phenolic azo type proton chromoion

81 teractions of the repeats with the Cl/HCO(3) anion exchanger and clathrin.

82 is mediated by the downregulated in adenoma anion exchanger and is stimulated by estrogens.

83 is distinct from the erythrocyte band-3 type anion exchanger and may belong to the monocarboxylate-ty

84 raction between the two major domains of the anion exchanger and suggest a novel substrate feedback m

85 ng assay to quantify the binding affinity of anion exchangers and a recombinant fragment of ANK1, R13

86 can also recognize the cytoplasmic tails of anion exchangers and aquaporins.

87 ites are used in technology as catalysts and anion exchangers and are important sinks for environment

88 mology and predicted topology similar to the anion exchangers and NBCs.

89 ructurally homologous transporters including anion exchangers and prestin.

90 nt pool of ankyrin is complexed with the AE1 anion exchanger, and the solubility properties of this p

91 study examined whether rat Oatp2 is also an anion exchanger, and, if so, whether it is energized by

92 + mature B-cells bound with high affinity to anion exchangers, and eluted as an intact trimeric compl

93 wise conferred high affinity NF-Y binding to anion exchangers, and stabilized NF-Y interaction with C

94 adical polymerization, derivatized as strong anion exchangers, and used for lipoproteins enrichment.

95 In addition to plasma membrane staining, anion exchanger antibodies stain a perinuclear compartme

96 After delivery to the plasma membrane, anion exchangers are internalized and recycled to the Go

97 This result suggests that AE2 anion exchangers are involved in the regulation of intra

98 s, suggest that ion transporters such as the anion exchanger associate in a large central cavity form

99 allowed to reach confluence, it located the anion exchanger band 3 in the apical membrane and an H+-

100 the skate homolog of the mammalian red cell anion exchanger band 3.

101 Furthermore, AE1 anion exchangers become detergent insoluble more rapidly

102 During recycling, some of the anion exchangers become detergent insoluble.

103 ities of apical proton pumps and basolateral anion exchangers, both of which interact with spectrin.

104 , nonmammalian prestin orthologs function as anion exchangers but are apparently nonmotile.

105 e cell-free extract was also retained by the anion exchanger, but was removed with repeated washing w

106 n added to quaternary alkylammonium chloride anion exchangers, but with a striking dependence on the

107 Furthermore, the apical anion exchanger cannot be stained by antibodies that rea

108 in the isolation of two chicken stomach AE2 anion exchanger cDNAs, AE2-1 and AE2-2.

109 Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal role

110 for the normal expression and function of Cl-anion exchanger CFEX in the proximal tubule of the mamma

111 SLC26 proteins function as anion exchangers, channels, and sensors.

112 o its effects on the human intestinal apical anion exchanger Cl(-)/OH- (HCO3-).

113 chanism of isocratic CEC for proteins on the anion-exchanger column was illustrated by the results of

114 By providing an efflux pathway for base, anion exchangers constitute a key component of the plasm

115 The association of ankyrin with the AE1 anion exchanger contributes an essential function to the

116 oration of [125I]iodine into this residue in anion exchanger could be monitored.

117 ted by mice lacking NKCC1 is associated with anion exchanger-dependent Cl(-) uptake.

118 The variant chicken kidney AE1 anion exchangers differ only at the NH(2) terminus of th

119 e report the crystal structure of the band 3 anion exchanger domain (AE1(CTD)) at 3.5 angstroms.

120 e plasma membrane expression of major apical anion exchanger DRA (SLC26A3) was considerably reduced i

121 rget genes include the Na/K-ATPase, Na/H and anion exchangers, E-cadherin, and mineralocorticoid rece

122 For anion exchangers, EOF is reversed.

123 Pendrin (SLC26A4) is a Cl(-)/anion exchanger expressed in the epithelium of inflamed

124 SLC26A6 is an anion exchanger expressed on the apical membrane in many

125 dy, we used nonporous and monolithic polymer anion exchangers for purification and demonstrated a met

126 transporter (NBC), we found that NBC and the anion exchangers form a bicarbonate transporter superfam

127 lar mass approximately 40kDa) of band 3, the anion exchanger from human erythrocyte membranes, previo

128 roximately 135 kDa that is homologous to AE2 anion exchangers from other species.

129 de YIVGR, which contains tyrosine 486 of the anion exchanger, from the products of the digestion.

130 ked with 5-microm silica beads having strong anion-exchanger functions attached to hydrophilic spacer

131 oplasmic tail derived from the chicken AE1-4 anion exchanger (G(AE)).

132 rat IMCD cells expresses two members of the anion exchanger gene family, AE1 and AE2, and both of th

133 minated by selective inactivation of the AE1 anion exchanger gene, thus allowing us to study the effe

134 ma membrane of aspartate 821 in erythrocytic anion exchanger has been determined by labeling inside-o

135 injection (FI) system with a microcolumn of anion exchanger has been used to effect rapid on-line se

136 Mice null for the AE2 anion exchanger have abnormal enamel.

137 itors, protein purification or homology with anion exchangers, have so far been unsuccessful.

138 f [35S]sulfanilic acid into aspartate 821 of anion exchanger in erythrocytes when the two preparation

139 f [35S]sulfanilic acid into aspartate 821 of anion exchanger in inside-out vesicles was at least 10-f

140 The AE2 anion exchanger in pig and rabbit gastric mucosal membra

141 Cl-/HCO3- exchange mediated by the AE1 anion exchanger in the basolateral membrane of type A in

142 Similar effects were observed with the anion exchanger inhibitor 4,4' -diisothiocyanatodihydros

143 The demonstration that erythroid anion exchangers interact with elements of the cytoskele

144 e-spanning domain convert the electroneutral anion exchanger into a Na(+) and K(+) conductance or ind

145 he substitutions convert the protein from an anion exchanger into an unregulated cation channel.

146 /HCO3- exchange activity mediated by the AE1 anion exchanger is reduced by carbonic anhydrase II (CA2

147 Physiological activity of an apical anion exchanger is weak in cultured BCECs.

148 The recycling pool of newly synthesized anion exchangers is reflected in the steady-state distri

149 two hydrophobic segments in the sequence of anion exchanger, is located on the cytoplasmic surface o

150 ess with characteristics consistent with the anion exchanger isoform AE2.

151 on the oligomeric states of the AE1 (band 3) anion exchanger, little is known about the physiological

152 for the actin cytoskeleton in regulating AE1 anion exchanger localization and stability in this epith

153 was based on the isolation of FPP using the anion exchanger Macro Prep High Q and conversion of FPP

154 deletion in mice of solute carrier family 4 anion exchanger member 2 (Slc4a2) results in osteopetros

155 f oocytes with the solute carrier family 26 (anion exchanger)-member 9 (SLC26A9) cRNA, promoted WNK4

156 chloride exchanger, solute carrier family 4, anion exchanger, member 2 (SLC4A2), is up-regulated duri

157 Use of an anion-exchanger membrane doped with the tetraalkylphosph

158 mpatible and nonpolarizable Donnan exclusion anion-exchanger membrane reference/counter electrode.

159 on-selective electrodes (ISEs) with fluorous anion-exchanger membranes for the potentiometric detecti

160 71% to mouse NCBE; and 47% to a Na(+)-driven anion exchanger (NDAE1) from Drosophila.

161 ur functional data suggest this Na(+) driven anion exchanger (NDAE1) is responsible for the Na(+)-dep

162 he cytoskeletal association of the recycling anion exchangers occurs after release from the compartme

163 More dramatically, the anion exchanger of a clonal cell line of intercalated ce

164 lasma membrane of tyrosine 486 in the native anion exchanger of human erythrocytes has been determine

165 The widely expressed anion exchanger polypeptide AE2/SLC4A2 is acutely inhibi

166 ing technique was used to immunolocalize AE2 anion exchanger polypeptide to basolateral plasma membra

167 e inhibitory effects of ammonium chloride on anion exchanger processing are rapidly reversible.

168 The anion exchanger protein 1 (AE1; band 3) is an abundant e

169 Targeted mutagenesis of the anion exchanger protein band 3 in mice has demonstrated

170 minant red blood cell (RBC) autoantigen, the anion exchanger protein Band 3, to the development of NZ

171 Chicken erythroid AE1 anion exchangers receive endoglycosidase F (endo F)-sens

172 Normal pH sensitivity of the SLC4A2/AE2 anion exchanger requires transmembrane domain (TMD) amin

173 As a strategy to identify one or more anion exchangers responsible for mediating Cl(-) reabsor

174 OH(-), membranes containing the alternative anion exchanger (Rf6(CH2)3)3PN(+)P((CH2)3Rf6)3 with a bi

175 We conclude that the anion exchanger SLC26A6 has a major constitutive role in

176 Band 3 (also known as the anion exchanger, SLCA1, AE1) constitutes the major attac

177 It follows that the polypeptide of anion exchanger spans the membrane three times before it

178 These values are greater than current anion exchangers such as the resins Amberlite IRA-400 (2

179 ic for Na+/HCO3- cotransporters, but not for anion exchangers, suggesting that the sea urchin protein

180 of transporters, rat Oatp1, functions as an anion exchanger that is driven in part by the glutathion

181 n integral membrane protein and facilitative anion exchanger that mediates delivery of 5-methyltetrah

182 Erythroid band 3 (AE1) is one of three anion exchangers that are encoded by separate genes.

183 e carrier (Slc) family 26A encodes different anion exchangers that exchange Cl(-)/HCO3 (-), including

184 These variant transcripts encode AE1 anion exchangers that possess alternative N-terminal cyt

185 pid fraction, employing an organic polymeric anion exchanger through the enrichment of lipoproteins/p

186 oride uptake and bicarbonate extrusion by an anion exchanger to provide Cl(-) permissive for apical a

187 whereas the trafficking of a Cl(-)/HCO(3)(-) anion exchanger to the plasma membrane is not altered in

188 by adding a calculated amount of lipophilic anion exchanger to the polymer film.

189 ions into a polymeric film that contains the anion exchanger tridodecylmethylammonium chloride, a lip

190 f interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin

191 trifugation, the modified polypeptide of the anion exchanger was isolated from each sample and digest

192 rt of a protein that is related to the known anion exchangers was identified in the GenBankTM express

193 gp330, aquaporin-2, H+ ATPase, and the AE1 anion exchanger were all relocated into numerous vesicle

194 ion exchangers and strong base and weak base anion exchangers were evaluated as stationary phases for

195 sporters, apart from Cl- -HCO3- exchangers ('anion exchangers'), whose complementary DNAs were cloned

196 ility correlates with the association of the anion exchanger with cytoskeletal ankyrin.

197 RFC1 is an anion exchanger with seven conserved positively charged

198 oproteins are enriched by the interaction of anion exchanger with the phosphate groups and eluted at