ライフサイエンスコーパス: anion transport

1 suggested that K370 is important for organic anion transport.

2 that this amino acid is required for organic anion transport.

3 rged polymer matrix, which facilitates rapid anion transport.

4 IL-1 beta post-translational processing and anion transport.

5 thermodynamic and kinetic information about anion transport.

6 (CF), a genetic illness caused by deficient anion transport.

7 lecular architecture, sensing, catalysis and anion transport.

8 , and the cellular physiology of glucose and anion transport.

9 other disorders of sulfur metabolism and/or anion transport.

10 e domain of AE1 (mdAE1) efficiently mediated anion transport.

11 tiport agent for lipid bilayer transmembrane anion transport.

12 ) preserve nonlinear capacitance, yet negate anion transport.

13 Anion binding in solution and anion transport across lipid bilayers are found to incre

14 CFTR mediates regulated anion transport across the apical membrane of epithelial

15 sport plays a major role in blood-to-aqueous anion transport across the ciliary body epithelium.

16 Our results suggest that anion transport across the vacuolar membrane in plant ce

17 in A (GPA) enhances the expression of band 3 anion transport activity at the cell surface of Xenopus

18 ellular residues 68-70 increase the specific anion transport activity of band 3.

19 P4.2 deficiency does not affect band 3 anion transport activity, since uptake of radiolabeled s

20 r efficient supramolecular assembly and high anion transport activity.

21 ffect on growth suppression, indicating that anion transport and growth suppression are independent f

22 TR at least partially restored CFTR-mediated anion transport and improved the intestinal phenotype.

23 onductance regulator (CFTR), which regulates anion transport and mucociliary clearance in the airways

24 s expressed in the same tissue in epithelial anion transport and suggest that transport specificity i

25 egulation of membrane-skeletal interactions, anion transport and the invasion and growth of malaria p

26 ological processes, including pH regulation, anion transport and water balance.

27 omplex from the membrane, (ii) inhibition of anion transport, and (iii) rupture of the band 3-ankyrin

28 Band 3 and band 3-mediated anion transport are decreased.

29 Since increased aged band 3 and decreased anion transport are initial steps in band 3 aging, which

30 ateral and canalicular bile acid and organic anion transport are markedly impaired in endotoxemia.

31 and the relationship between fatty acids and anion transport are unknown.

32 eal/bronchial epithelia and point to loss of anion transport as key to airway epithelial dysfunction

33 Vesicle anion transport assays using ion-selective electrodes sh

34 Anion transport assays were used to determine the mechan

35 atory cytokine secretion caused by defective anion transport at the apical membrane may contribute to

36 a2+ was held constant and was blocked by the anion transport blockers, DIDS and niflumic acid.

37 sarcoplasmic reticulum and are inhibited by anion transport blockers; however, the unitary single ch

38 revented the observed age-related decline in anion transport by lymphocytes and the generation of age

39 rst demonstration that regulation of organic anion transport by mOAT is likely to be tightly controll

40 Anion transport by the colonic mucosa maintains the hydr

41 Anion transport by the human sodium-iodide symporter (hN

42 ysts secreted sulfonefluorescein, an organic anion transported by the PAH system.

43 manifested by a substantial loss of organic anion transport capacity in kidney and CP was identified

44 it is proposed that eosin is located in the anion transport channel such that it is accessible from

45 on receptors can be applied such as sensing, anion transport, control of molecular motion and gelatio

46 This key segregation of cation and anion transport could explain the extraordinary fluid tr

47 out mice manifest a profound loss of organic anion transport (e.g. para-aminohippurate) both ex vivo

48 CNTPs block anion transport, even at salinities that exceed seawater

49 gs underscore the importance of H(+)-coupled anion transport for pH(i) homeostasis.

50 ons to the observation of a reduced cellular anion transport function is discussed.

51 ggest that the Ser667Phe does not affect the anion transport function of band 3, but causes a traffic

52 uld occur in two ways, enhancement of band 3 anion transport function or enhancement of band 3 traffi

53 ides prompted systematic comparison of their anion transport functions in Xenopus oocytes.

54 Two inhibitors of anion transport, glyburide and ethacrynic acid, blocked

55 l chloride diarrhea and results in a loss of anion transport had no effect on growth suppression, ind

56 ance regulator (CFTR) channel for epithelial anion transport, how its expression is regulated remains

57 The results show that anion transport imposes an upper limit on mitochondrial

58 Our results demonstrate that anion transport in a HBM is best described by the solubi

59 y of Bot1 detects Na(+)-dependent polyvalent anion transport in a Nernstian manner with channel-like

60 were screened for their ability to activate anion transport in CF cells grown on permeable supports.

61 es related to metabolic pathways and organic anion transport in cKO mice compared with control litter

62 ycosylation, significantly inhibited organic anion transport in COS-7 cells expressing a mouse organi

63 and the buffering reaction, but the role of anion transport in determining mitochondrial Ca(2+) dyna

64 ifferences between ALMTs and their impact on anion transport in plants.

65 Our results demonstrate that anion transport in polyILs occurs through a mechanism in

66 s were assayed in single cells by monitoring anion transport in real time through fluorescence emissi

67 of the Schiff base counterion could initiate anion transport in the related protein, halorhodopsin, i

68 ibrosis, reflects transepithelial cation and anion transport in the respiratory epithelium.

69 We used fluorescent probes to measure H+ and anion transport in vesicles reconstituted with purified

70 tration of peptide required for half-maximal anion transport induced across Madin-Darby canine kidney

71 ional processing by a mechanism dependent on anion transport inhibition.

72 They were also inhibited by the anion transport inhibitor 100microM 2,2'-(1,2-ethenediyl

73 The anion transport inhibitor 4, 4'-diisothiocyanostilbene-2

74 The anion transport inhibitor 4,4-diisothiocyanatostilbene-2

75 followed cell injury in the presence of the anion transport inhibitor DIDS and the Cl(-) channel inh

76 We used the anion transport inhibitor DIDS to investigate other memb

77 ansport with GMP, and was susceptible to the anion transport inhibitor DIDS.

78 It is unaltered by the broad spectrum anion transport inhibitor SITS, and is not accompanied b

79 on-radioactive ALA or probenecid (an organic anion transport inhibitor) and, therefore, appears to be

80 othiocyanatostilbene-2,2'-disulfonate (DIDS; anion transport inhibitor), or with NBCe1-specific small

81 ed by cell death and requires activity of an anion transport inhibitor-sensitive component, but this

82 an inhibitor of protein kinase A or with an anion transport inhibitor.

83 Na+ and HCO3- dependent, and blocked by the anion-transport inhibitor DIDS, and conclude that it is

84 nrelated compounds, and (6) inhibited by the anion transport inhibitors 4,4'-diisothiocyanatostilbene

85 rt of [(3)H]E(2)17betaG was inhibited by the anion transport inhibitors 4,4'-diisothiocyanatostilbene

86 On the other hand, anion transport inhibitors and alkylating agents arrest

87 going apoptosis was inhibited by the organic anion transport inhibitors MK571, sulfinpyrazone, and pr

88 IL-1 beta post-translational processing, and anion transport inhibitors such as tenidap that suppress

89 roM), 4) inhibited by structural analogs and anion transport inhibitors, and 5) energy-dependent.

90 post-translational processing was blocked by anion transport inhibitors, including 4,4'-diisothiocyan

91 The transport process was inhibited by anion transport inhibitors.

92 citation medium were exposed to a battery of anion transport inhibitors.

93 have a 7 + 7 inverted repeat structure with anion transport initiated by chloride binding at the int

94 Similarly for the AEM, currents governing anion transport into the center channel from the AEM cha

95 To test whether organic anion transport is coupled to HCO3- extrusion, we compar

96 Here anion transport is investigated both in guinea-pig outer

97 We hypothesize that this residual level of anion transport is sufficient to eliminate or postpone t

98 Anion transport kinetic assays were performed on isolate

99 ree cell lines, suggesting that promotion of anion transport may not be deleterious to cells.

100 substrate selectivity and the Na(+)-coupled anion transport mechanism by the human SLC13 family and

101 5-maleimide (EMA) is a specific inhibitor of anion transport mediated by the erythrocyte membrane pro

102 Transmembrane anion transport modality is enjoying a renewed interest

103 udies implicate a role in hepatocyte organic anion transport of a plasma membrane protein that has be

104 ential (DeltaPsim) to examine the effects of anion transport on mitochondrial Ca(2+) flux and bufferi

105 fects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo.

106 Here we directly demonstrate an anion transport pathway in lysosomes that has the defini

107 r the bile acid and the nonbile acid organic anion transport pathways, respectively.

108 A expression of hepatic transporters organic anion transporting polypeptide (Oatp) 1a1, Oatp1a4, Oatp

109 Human organic anion transporting polypeptide (OATP) 1B1 and sodium-dep

110 tive liver uptake via members of the organic anion transporting polypeptide (OATP) family.

111 Organic anion transporting polypeptide (oatp) is an integral mem

112 s were determined in wild-type (WT), organic anion transporting polypeptide (OATP) knockout mice (lac

113 Here, we investigated the role of organic anion transporting polypeptide (OATP) transporters to th

114 c transporters, such as those of the organic anion transporting polypeptide (OATP, SLC21) and multidr

115 Several members of the organic anion transporting polypeptide (OATP/Oatp) family of upt

116 on, protein mass and function of the organic anion transporting polypeptide (Oatp1), another sinusoid

117 due to the presence of T4-selective organic anion transporting polypeptide (OATP1C1).

118 Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is

119 Organic anion transporting polypeptide 2 (Oatp2) mRNA was decrea

120 he basolateral membrane transporter, organic anion transporting polypeptide 2 (Oatp2), was not affect

121 The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5) is a l

122 Human organic anion transporting polypeptide 2B1 (OATP2B1) is a membra

123 Organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is al

124 ce with a targeted disruption of the organic anion transporting polypeptide Oatp1b2.

125 Organic anion transporting polypeptide OATP1B3 is a membrane-bou

126 nion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1) are exp

127 cifically up-regulates I. scapularis organic anion transporting polypeptide, isoatp4056 and kynurenin

128 The human organic anion transporting polypeptide-C (OATP-C) (gene SLC21A6)

129 ed bile salts, a process mediated by organic anion-transporting polypeptide (OATP) 1B2.

130 Human organic anion-transporting polypeptide (OATP) 2B1 (OATP-B; SLCO2

131 The organic anion-transporting polypeptide (OATP/Oatp) superfamily i

132 the hepatic anion uptake transporter organic anion-transporting polypeptide 1A1 (Oatp1a1), the hepato

133 Organic anion-transporting polypeptide 1A2 (OATP1A2) (gene symbo

134 Organic anion-transporting polypeptide 1A2 (OATP1A2) is a drug u

135 The organic anion-transporting polypeptide 1b family (Oatp1b2 in rod

136 on of the hepatic transport proteins organic anion-transporting polypeptide 1B1 (OATP1B1) and 1B3 (OA

137 sulfotransferase 2a1 (Sult2a1), and organic anion-transporting polypeptide 2 (Oatp2) in liver in mic

138 agonist-stimulated platelets via an organic anion-transporting polypeptide and is retained in the cy

139 sistance protein (ABCC/MRP), and the organic anion-transporting polypeptide protein (SLCO/OATP) famil

140 morphism in the SLCO1B1 gene for the organic anion-transporting polypeptide that regulates statin upt

141 ressed comparable MRP and OATP/SLCO (organic anion-transporting polypeptide) mRNA levels, and MRP1 pr

142 Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are m

143 Organic anion transporting polypeptides (Oatp) are transporters

144 The hepatic organic anion transporting polypeptides (OATPs) influence the ph

145 drug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps).

146 t pump (Bsep), and the expression of organic anion transporting polypeptides 1 and 2 (Oatp1 and 2) an

147 and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3.

148 The organic anion transporting polypeptides, Oatp1 (Slc21a1) and Oat

149 Organic anion-transporting polypeptides (OATP) 1B1 and 1B3 are w

150 Organic anion-transporting polypeptides (OATPs) mediate the live

151 disposition are OATP1B1 and OATP1B3 (organic anion-transporting polypeptides 1B1 and 1B3, respectivel

152 The organic anion-transporting polypeptides represent an important f

153 Facilitated anion transport potentially represents a powerful tool t

154 covery of pathologies involving anomalies in anion transport processes.

155 thiourea groups have been prepared and their anion transport properties studied.

156 library of indole-based perenosins and their anion transport properties.

157 The membrane anion transport protein (band 3 or AE1) is thought to fa

158 Although many organic anion transport protein (Oatp) family members have PDZ c

159 The mRNA for organic anion transport protein (oatp) was previously shown to b

160 protein that has been termed oatp1 (organic anion transport protein 1).

161 nsport of (99m)Tc-mebrofenin through organic anion transport protein 1a and 1b (Oatp1a/1b) and multid

162 aevis oocytes was used to isolate an organic anion transport protein from rat kidney.

163 Band 3, the major anion transport protein of human erythrocytes, forms the

164 Band 3, the anion transport protein of the erythrocyte membrane, exi

165 In summary, OATP2 is a novel organic anion transport protein that has overlapping but not ide

166 The membrane domain of the human red cell anion transport protein, band 3, is too large to be stud

167 Rat organic anion transporting protein 1a1 (oatp1a1), a hepatocyte b

168 e here a gene reporter, based on the organic anion transporting protein Oatp1a1, which mediates uptak

169 xpression and/or function of hepatic organic anion transport proteins.

170 e similarity to pendrin and related sulphate/anion transport proteins.

171 A subclass of bacterial CLC anion-transporting proteins, phylogenetically distant fr

172 ans cells with pharmacological inhibitors of anion transport provided complete or substantial protect

173 ndamental chemical trends and determine that anion transport quantitatively correlates to polarity an

174 However, aromatic anion transport resulting from PGP and PIN expression in

175 This assay reveals that anion transport selectivity for this amphiphilic bis-cat

176 ine, these membranes show neither cation nor anion transport selectivity.

177 mal assay that allows one to readily measure anion transport selectivity.

178 that a far greater number of unloaded band 3 anion transport sites face the cytoplasm than face the e

179 ed blood cells, including the outward-facing anion transport sites of band 3, an integral membrane pr

180 Anion transport studies of red cells from two affected i

181 tment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treati

182 ting that DMPS is transported by the organic anion transport system and that this transport is linked

183 have implicated at least one of the organic anion transport systems in the basolateral uptake of ino

184 nate (DIDS), an inhibitor of band 3-mediated anion transport that dissociates band 3 into dimers (inc

185 d Oat6 appear to function largely in organic anion transport, they also bind and transport some organ

186 8del-CFTR activity, as indicated by enhanced anion transport through the plasma membrane.

187 It is an anion transporting transmembrane protein, possessing nin

188 re more consistent with electrically passive anion transport via MDR-TCBD protein, but only at low [A

189 in from Halobacterium salinarum (shR) during anion transport was analyzed at the molecular level usin

190 localization of choroid plexus (CP) organic anion transport were determined in apical (or brush bord

191 ot display a dominant negative phenotype for anion transport when coexpressed with wild-type AE1.

192 thus inserts into lipid bilayers to turn on anion transport, which can then be turned off through ad