ライフサイエンスコーパス: annexin 1

1 tase 5 (PP5), formyl peptide receptor 2, and annexin 1.

2 rticoid-regulated anti-inflammatory mediator annexin 1.

3 ild-type but not Y21F phosphorylation mutant annexin 1.

4 er5 by TRPM7 kinase may modulate function of annexin 1.

5 in the N-terminal amphipathic alpha-helix of annexin 1.

6 tal structure of such a full-length annexin, annexin 1.

7 ng that these molecules signal downstream of annexin-1.

8 ing therapeutic potential of drugs targeting Annexin-1.

9 gnificant decrease in protein expression for annexins 1, 2, 4, 7, and 11 in hormone refractory PCa as

10 Annexins 1, 2, 4, 7, and 11 may play a role in tumor pro

11 By cDNA microarray analysis, annexins 1, 2, 4, 7, and 11 were significantly decreased

12 Deletion of annexin 1, a substrate of EGFR tyrosine kinase, abolishe

13 Annexin 1 accumulates on internal vesicles of MVB after

14 nd pertussis toxin, suggesting that secreted annexin-1 acts via formyl peptide family receptors, most

15 Recently, two studies identified annexin 1 and 7 as potential biomarkers in the developme

16 The glucocorticoid-inducible protein annexin 1 and derived peptides are effective in inhibiti

17 role for FPR in the anti-migratory effect of annexin 1 and derived peptides.

18 14-3-3 theta identified in this study, plus annexin 1 and protein gene product 9.5 proteins previous

19 amed tissues and concomitantly downregulated annexin-1 and IL-10 production.

20 RNA resulted in decreased secretion of both annexin-1 and MMP-1, confirming that annexin-1 mediates

21 position of the phospholipid-binding protein annexin-1 and then transglutaminase-mediated crosslinkin

22 dicated that CERK1 physically interacts with ANNEXIN 1 (ANN1), which was reported to form a calcium-p

23 The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in t

24 Annexin-1 (Anx-A1) has recently been shown to modulate t

25 Annexin 1 (ANX1), a calcium-binding protein, participate

26 In this study, we investigate whether annexin 1 (ANX1), a recognized second messenger of gluco

27 revious described the protection afforded by annexin 1 (ANXA1) in an experimental model of rat myocar

28 omeostatic antiinflammatory axis centered on annexin 1 (AnxA1) in cerebral microvascular dysfunction

29 Annexin 1 (AnxA1) is a multifunctional phospholipid-bind

30 ere we demonstrate that the counterregulator annexin 1 (AnxA1) is critical for controlling experiment

31 fect of the glucocorticoid inducible protein annexin 1 (ANXA1) on the process of monocytic cell migra

32 nd protein analysis showed that the level of annexin 1 (ANXA1), an anti-inflammatory protein known to

33 ipoxins (ATL) and the glucocorticoid-induced annexin 1 (ANXA1)-derived peptides that are both generat

34 I-peptide, we found that I-peptide bound to annexin 1 (Anxa1).

35 clooxygenase-2, and glucocorticoid-regulated annexin 1 appear to be important endogenous mediators of

36 Here we have identified annexin 1 as a substrate for TRPM7 kinase.

37 membranes, and therefore, phosphorylation of annexin 1 at Ser5 by TRPM7 kinase may modulate function

38 ioxidants, such as ghrelin, L-carnitine, and annexin-1 attenuate the oxidative-stress response.

39 Finally, evidence of direct annexin 1 binding to murine FPR was obtained with HEK-29

40 Phosphorylation of annexin 1 by TRPM7 kinase is stimulated by Ca2+ and is d

41 Phosphorylation of annexin 1 by TRPM7 kinase occurs at a conserved serine r

42 uced arthritis model, treatment of mice with annexin-1 during the immunization phase exacerbated sign

43 2-26 and Ac2-12, with a partial reduction in annexin 1 effects.

44 d arthritis showed a marked up-regulation of annexin-1 expression.

45 ndicated by the simultaneous upregulation of annexin-1 expression.

46 Recent interest in the annexin 1 field has come from the notion that specific G

47 TNF-alpha induced a biphasic secretion of annexin-1 from RA SF.

48 In blood leukocytes, annexin 1 gene expression was activated at 4, but not 24

49 Locally, endothelial and mast cell annexin 1 gene expression was not detectable in basal co

50 Clear induction of annexin 1 gene in response to dexamethasone treatment wa

51 time- (8-24 h) dependent manner; full-length annexin-1 had a similar effect.

52 Loss or depletion of annexin 1 has no effect on EGF degradation and causes on

53 Deletion of annexin 1 has no effect on EGF-stimulated MVB biogenesis

54 Recently, annexin-1 has also been identified as a secreted molecul

55 t the ROS-regulated Ca(2+) transport protein Annexin 1 in Arabidopsis thaliana (AtANN1) is involved i

56 We studied the role of annexin-1 in mediating MMP-1 secretion from rheumatoid a

57 ntiation of naive T cells in the presence of annexin-1 increased skewing in Th1 cells; in the collage

58 light on the receptor mechanism(s) mediating annexin 1-induced cardioprotection and shows a pivotal r

59 Annexin 1 is active in membrane aggregation and its refi

60 ed us with a wealth of evidence showing that Annexin-1 is a homeostatic endogenous anti-inflammatory

61 Together these results demonstrate that annexin-1 is a molecular "tuner" of TCR signaling and su

62 Annexin-1 is an anti-inflammatory protein that plays an

63 i-inflammatory roles, our data indicate that annexin-1 is secreted by RA SF in response to TNF-alpha

64 of both annexin-1 and MMP-1, confirming that annexin-1 mediates TNF-alpha-stimulated MMP-1 secretion.

65 ed epi-lipoxins and glucocorticoid-regulated annexin 1 might act on the same G-protein-coupled recept

66 Administration of the annexin 1 N-terminal derived peptide Ac2-26 to mice afte

67 Exogenous annexin-1 N-terminal peptide Ac2-26 stimulated MMP-1 sec

68 In annexin 1(null) mice, the peritonitis response was exagg

69 ynthesis, and mast cell degranulation in the annexin 1(null) mouse.

70 l delay in EGFR degradation, indicating that annexin 1 operates downstream of Hrs- and ESCRT-mediated

71 y, CXC chemokine KC contents, and endogenous annexin 1 protein expression) was virtually identical in

72 eceptor (TCR)-induced externalization of the annexin-1 receptor.

73 k, and NF-kappaB inhibitors had no effect on annexin-1 secretion stimulated by TNF-alpha but inhibite

74 Annexin-1 stimulation of MMP-1 secretion was inhibited b

75 The significance of annexin 1 system plasticity in the anti-inflammatory pro

76 en transglutaminase-mediated crosslinking of annexin-1 through its amino-terminal domain.

77 Binding of annexin 1 to circulating leukocytes was reduced (>50%) i

78 Although inactive by itself, addition of annexin-1 to stimulated T cells augmented anti-CD3/CD28-

79 Down-regulation of annexin-1 using small interfering RNA resulted in decrea

80 v, in contrast, the amino-terminal domain of annexin-1 was removed by proteolysis, thus preventing co

81 By contrast, membrane expression of annexin-1, which was not minimal at 30 min, was substant

82 egion plays a crucial role in interaction of annexin 1 with other proteins and membranes, and therefo