ライフサイエンスコーパス: annexin 2

1 ly and forms a heterotetrameric complex with annexin 2.

2 larly, the cell type-dependent enrichment of annexins 2, 5 or 6 in calcifying EVs posits one of sever

3 Here, we show that endothelial cell annexin 2, a protein that lacks a typical signal peptide

4 Annexin 2 (A2) is a profibrinolytic endothelial cell sur

5 We show here that annexin 2 acts as a receptor for factor Xa on the surfac

6 In this report, we show that DPP binds to annexin 2 and 6 present in a rat ureteric bud cell line

7 Immunofluorescence studies show that annexin 2 and DPP colocalize in these cells.

8 dose-dependent manner by displacing it from Annexin 2 and making it accessible to ubiquitin-dependen

9 ndothelial sprouting responses observed with annexin 2 and VE-cadherin knockdown.

10 not only cell-cell complex molecules such as annexin-2 and claudin-1, but also focal adhesion compone

11 viously characterized Plg-Rs (alpha-enolase, annexin 2, and p11) and a recently identified Plg-R (his

12 Plg-Rs include histone 2B, alpha-enolase, annexin 2, and p11, all proteins which lack signal seque

13 Akap12, gelsolin, myosin light chain kinase, annexin-2, and Hsp70, manifested altered translation rat

14 roteins, including myosin non-muscle form A, annexin 2, annexin A6, and Hsp47 were regulated in relat

15 In this study we defined annexin 2 (Anx2) as a novel HIV Gag binding partner in m

16 Annexin 2 (Anx2) binds PtdIns(4,5)P2 and is recruited to

17 The cellular protein annexin 2 (Anx2) is incorporated into HIV-1 particles, a

18 In this study, we identified annexin 2 as a regulator of endothelial morphogenesis us

19 d markers such as cytokeratins 18 and 19 and annexin 2, as determined both by immunostaining and by r

20 11 (S100A10) and tyrosine phosphorylation of annexin 2 because annexin 2 release is completely elimin

21 Cells co-expressing annexin 2-CFP and actin-YFP exhibit Ca(2+)-dependent flu

22 In addition, DPP and annexin 2 colocalize in the ureteric bud branches of emb

23 since overexpression of a dominant-negative Annexin 2 construct abolished the formation of these str

24 Overexpression of TF abolishes annexin 2 dependence on factor Xa signaling and diminish

25 athesis reflective of excessive cell surface annexin 2-dependent generation of plasmin.

26 In addition, annexin 2 depletion attenuated Akt activation, which was

27 In addition, mice completely deficient in annexin 2 display fibrin accumulation within blood vesse

28 osis, but little is known of the dynamics of Annexin 2 distribution in live cells during these proces

29 nterfering RNA (siRNA)-mediated knockdown of annexin 2 expression in Caco-2 epithelial cells resulted

30 an umbilical vein endothelial cells and that annexin 2 facilitates factor Xa activation of PAR-1 but

31 ereas selectively abolishing TF promotes the annexin 2/factor Xa interaction.

32 Annexin 2, we found that DLC1 competed with Annexin 2 for interaction with S100A10.

33 in exocytosis, we observed an enrichment of Annexin 2-GFP in actin tails propeling macropinosomes.

34 ve used evanescent field microscopy to image Annexin 2-GFP in live, secreting rat basophilic leukemia

35 ocketing macropinosomes was specific because Annexin 2-GFP was absent from the actin tails of rocketi

36 The association of Annexin 2-GFP with rocketing macropinosomes was specific

37 These results show that annexin 2 has an essential role in maintaining the plast

38 Because annexin 2 has been shown to influences actin cytoskeleta

39 In human subjects, overexpression of annexin 2 in acute promyelocytic leukemia leads to a ble

40 Rho colocalized with annexin 2 in lamellipodia and along the cytoplasmic face

41 s a detergent-resistant protein complex with Annexin-2 in enterocytes that can be disrupted by the ch

42 d expression of an actin regulatory protein, annexin 2, in migrating intestinal epithelial cells.

43 Although we found no evidence of Annexin 2 involvement in exocytosis, we observed an enri

44 Annexin 2 is a Ca(2+) binding protein that binds to and

45 Annexin 2 is a profibrinolytic co-receptor for plasminog

46 Annexin 2 is a ubiquitous Ca(2+)-binding protein that is

47 , we show that in spontaneously motile cells annexin 2 is concentrated in dynamic actin-rich protrusi

48 Annexin 2 is necessary for the formation of macropinocyt

49 n and activation status of Rho GTPases after annexin 2 knockdown.

50 ane ruffles and protrusions, suggesting that annexin 2 may directly interact with actin.

51 exhibiting approximately 40% similarity with annexin-2, named pemphaxin (PX).

52 ce display normal mRNA and protein levels of Annexin-2 or the putative cholesterol transport protein

53 These findings suggest that annexin 2 plays a role in targeting Rho to cellular memb

54 y biochemical studies, in which we show that annexin 2 reduces the polymerisation rate of actin monom

55 Collectively, we report that annexin 2 regulates endothelial morphogenesis through an

56 yrosine phosphorylation of annexin 2 because annexin 2 release is completely eliminated on depletion

57 We propose that annexin 2 serves to regulate factor Xa signaling specifi

58 mbranes and decreased Rho activity following annexin 2 siRNA transfection.

59 ition of cell spreading and wound closure in annexin 2 siRNA-transfected cells was prevented by expre

60 which were statistically different, include annexin 2, SMAD, PLA2G2A, and TGFbeta1.

61 ted-end cappers, we further demonstrate that annexin 2 specifically inhibits filament elongation at t

62 These results show that recruitment of Annexin 2 to nascent macropinosome membranes 16656is an

63 Translocation of annexin 2 to the cell surface dramatically increases tis

64 erved that sphingosine 1-phosphate triggered annexin 2 translocation from the cytosol to the plasma m

65 Temperature stress-induced annexin 2 translocation is dependent on both expression

66 ctin-rich protrusions, and that depletion of annexin 2 using siRNA leads to the accumulation of stres

67 In addition, annexin 2 was observed to co-immunoprecipitate with endo

68 me S100A10 sequence also mediates binding to Annexin 2, we found that DLC1 competed with Annexin 2 fo

69 aling and diminishes binding to cell surface annexin 2, whereas selectively abolishing TF promotes th

70 his finding suggests that the association of Annexin 2 with macropinocytic rockets requires native pi