ライフサイエンスコーパス: annexin A1

1 d override the prosurvival effect of LPS via annexin A1.

2 the structure of the N-terminally truncated annexin A1.

3 trophin-glycoprotein complex of proteins and annexin A1.

4 proresolving mediators and proteins, such as annexin A1.

5 ng required the expression of caveolin 1 and annexin A1.

6 ntly changed in the tumor stroma that lacked annexin A1.

7 partitioning defective protein 3 (PAR3) and annexin A1.

8 ; and further investigation into the role of annexin A1, a downstream mediator of glucocorticoid acti

9 ulation were associated with the cleavage of annexin A1, a powerful anti-inflammatory protein known t

10 Within seconds of membrane disruption, annexins A1, A2, A5, and A6 formed a tight repair "cap."

11 domains, studies reported herein showed that annexins A1, A2, A5, and B12 could be divided into two g

12 ctinin-1, moesin, 14-3-3 protein zeta/delta, annexin A1/A3/A4/A5/A6, clathrin heavy chain 1, glyceral

13 tumor stroma and suggested a mechanism that annexin A1 affects tumor development and metastasis thro

14 In contrast, the nontrimer-forming annexin A1 and A2 group had the following Ca(2+)-depende

15 we show that these contacts are tethered by annexin A1 and its Ca(2+)-dependent ligand, S100A11, and

16 that dysferlin normally associates with both annexins A1 and A2 in a Ca2+ and membrane injury-depende

17 lin and the Ca2+ and lipid-binding proteins, annexins A1 and A2, and define a role for dysferlin in C

18 ected as lipid mixing involved extracellular annexins A1 and A5 acting in a functionally redundant ma

19 emmal repair through increased expression of annexins A1 and A6, which mediate myofiber repair.

20 tant-associated protein C (SP-C), L-plastin, annexin A1, and haptoglobin increased, whereas transferr

21 th I3C reduced the level of SP-C, L-plastin, annexin A1, and haptoglobin to that of untreated control

22 A post-translationally modified form of annexin A1 (AnnA1) is selectively concentrated in human

23 o experiments have identified involvement of Annexin A1 (Anx A1) in both these fusion processes.

24 the release of the anti-inflammatory protein Annexin-A1 (Anx-A1) from mast cells.

25 Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preservin

26 o a decrease in the level of cell-associated annexin A1 (AnxA1) and cathelin-related antimicrobial pe

27 ncy was associated with an early increase of annexin A1 (AnxA1) and did not modify the course of neut

28 inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets fo

29 such target is the anti-inflammatory protein annexin A1 (AnxA1) and its receptor, FPR2/ALX.

30 gands, including the proresolution mediators annexin A1 (AnxA1) and lipoxin A(4), as well as the acti

31 upled with increased expression of mRNAs for annexin A1 (AnxA1) and the formyl peptide receptors [(Fp

32 he proresolving properties of lipoxin A4 and annexin A1 (AnxA1) and the proinflammatory signals elici

33 cted role for the anti-inflammatory molecule annexin A1 (AnxA1) as a critical regulator of this proce

34 tide receptor-1 (FPR1), which interacts with Annexin A1 (ANXA1) from dead cells.

35 Annexin A1 (ANXA1) has an important role in cell-cell co

36 2 decades of research, no clear function for annexin A1 (AnxA1) has been established.

37 Annexin A1 (AnxA1) is a glucocorticoid-regulated protein

38 Annexin A1 (AnxA1) is a glucocorticoid-regulated protein

39 Annexin A1 (AnxA1) is a protein involved in modulation a

40 Annexin A1 (AnxA1) is a protein that displays potent ant

41 Annexin A1 (AnxA1) is an effector of the resolution of i

42 Annexin A1 (AnxA1) is an endogenous glucocorticoid regul

43 e glucocorticoid anti-inflammatory messenger annexin A1 (ANXA1) is expressed in brain microvascular e

44 The protein annexin A1 (ANXA1) is key to the phagocytosis of apoptot

45 Annexin A1 (AnxA1) is recognized as an endogenous anti-i

46 In this work, we demonstrate that endogenous annexin A1 (ANXA1) is released as a component of extrace

47 We demonstrated high expression of annexin A1 (ANXA1) mRNA by MSCs and confirmed expression

48 Suppression of annexin A1 (ANXA1), a mediator of apoptosis and inhibito

49 Annexin A1 (ANXA1), a mediator of the anti-inflammatory

50 ion leads to cell surface externalization of Annexin A1 (AnxA1), an effector of endogenous anti-infla

51 Annexin A1 (ANXA1), an inflammation modulator, is a pote

52 at is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, whi

53 ALX/FPR2, which is activated by the protein annexin A1 (ANXA1), found in high abundance in inflammat

54 of the endogenous anti-inflammatory protein Annexin A1 (AnxA1), we investigated further this possibl

55 rtain anti-inflammatory molecules, including annexin A1 (ANXA1), which is an important mediator of gl

56 In this article, we engineered novel Annexin A1 (AnxA1)-based peptides, AnxA1(2-50), that dis

57 Annexin A1 (ANXA1, formerly termed lipocortin 1 or macro

58 In these studies, we have identified Annexin-A1 (ANXA1) as a novel regulator of TLR-induced I

59 activation of the p38/MAPKAP kinase-2/LIMK1/annexin-A1 (ANXA1) signaling axis.

60 Mechanistically, we identify annexin A1 as an endogenous inhibitor of integrin activa

61 two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies

62 how that, coincident with a resealing event, annexin A1 becomes concentrated at disruption sites.

63 ntering through a disruption locally induces annexin A1 binding to membranes, initiating emergency fu

64 that annexin A6 binds mu1 and mu2, and that annexin A1 binds only mu1.

65 Carbonylation of annexin A1 by endothelin-1 was followed by proteasome-de

66 Moreover, we show, for the first time, that annexin A1-dependent inhibition of adrenocorticotrophin

67 Radio-immunotherapy to annexin A1 destroys tumours and increases animal surviva

68 follow-up study, we report that exposure of annexin A1 during secondary necrosis coincided with prot

69 Subcellular patterning is evident as annexin A1, dysferlin, diacylglycerol, active Rho, and a

70 Deletion of FPR2 or its ligand annexin A1 enhances atherosclerotic lesion formation, ar

71 Thus, altogether our findings indicate that annexin A1 externalization and its proteolytic processin

72 trol levels, and recently we could show that annexin A1 externalization during secondary necrosis pro

73 culture supernatants of secondary necrotic, annexin A1-externalizing cells induced chemoattraction o

74 Instructing the annexin A1-FPR2 axis harbors a novel approach to target

75 Specifically, the annexin A1 fragment Ac2-26 counteracts conformational ac

76 We demonstrate here that an annexin A1 function-blocking antibody, a small peptide c

77 f these lipids as well as by peptides (e.g., annexin A1), has been shown to be one of the receptors i

78 te the role of FPR2 and its resolving ligand annexin A1 in atherogenesis.

79 sis, and the previously known properties for annexin A1 in immune cells and inflammation, this study

80 t the X-ray structure of full-length porcine annexin A1 in the presence of calcium.

81 The signaling mechanism employed by annexin A1 in this process is uncertain, although we hav

82 ious finding of pro-angiogenic functions for annexin A1 in vascular endothelial cell sprouting, wound

83 activated by IAV, which harbors its ligand, annexin A1, in its envelope.

84 eported the structure of full-length porcine annexin A1 including the N-terminal domain in the absenc

85 Annexin A1 is a cytosolic protein that, when activated b

86 d inflammation, this study hypothesized that annexin A1 is a key functional player in tumor developme

87 Annexin A1 is a multi functional molecule which is invol

88 The glucocorticoid-regulated protein annexin A1 is a potent inhibitor of hormone exocytosis i

89 Annexin A1 is an intracellular calcium/phospholipid-bind

90 en tumors from annexin A1 wild type mice and annexin A1 knockout mice and found a list of genes that

91 etastasis, angiogenesis and wound healing in annexin A1 knockout mice.

92 f an N-terminally truncated version of human annexin A1 lacking the first 32 amino acid residues (PDB

93 ing the anti-inflammatory peptide Ac2-26, an annexin A1/lipocortin 1-mimetic peptide.

94 carbonylation and subsequent degradation of annexin A1 may play a role in endothelin-mediated cell g

95 nd treatment with FPR agonists: AnxA1Ac2-26 [Annexin A1 mimetic peptide (Ac-AMVSEFLKQAWFIENEEQEYVQTVK

96 Nine genes, PDGF A, Cathepsin L, annexin A1, Mm.112139, Est2 repressor factor, NrCAM, ZNF

97 rs Mcm5 and Brd4, phosphoinositide-3-kinase, annexin A1, mucosa-associated lymphoid tissue lymphoma t

98 peptide competitor, and a dominant-negative annexin A1 mutant protein incapable of Ca2+ binding all

99 tial of 2 proresolving endogenous mediators, annexin A1 N-terminal derived peptide (AnxA1Ac2-26) and

100 t implications for the inhibitory actions of annexin A1 on exocytosis in other endocrine and immune c

101 t to characterize the mechanism of action of annexin A1 on exocytosis using the release of adrenocort

102 neither method detected self-association of annexin A1 or A2 on bilayers.

103 lease from cells expressing either wild-type annexin A1 or mutant forms, we show a critical involveme

104 n of monocytes, which was clearly reduced in annexin A1- or ADAM10-knockdown cells.

105 As such, annexin A1 promotes the engulfment of dying cells and da

106 comprises a small bioactive peptide from the annexin A1 protein grafted into a sunflower trypsin inhi

107 Annexin A1-regulated contacts function in the transfer o

108 he proapoptotic phospholipid-binding protein Annexin A1 that link early prostate development to early

109 ribution of FPR2 and its proresolving ligand annexin A1 to atherosclerotic lesion formation is largel

110 This revealed annexin A1 to be an effective regulator in tumor stroma

111 N tumor-associated self Ags (TAA) and to the Annexin A1 tumor vascular Ag, even in mice in which aner

112 ine genes that included GPCR11, cadherin 11, annexin A1, vimentin, lactate dehydrogenase B (upregulat

113 Expression of the FPR2/ALX ligand Annexin A1 was also significantly increased in sub-acute

114 Fenton reaction-dependent manner, including annexin A1, which promotes apoptosis and suppresses cell

115 ared the gene expression between tumors from annexin A1 wild type mice and annexin A1 knockout mice a

116 h for the membrane aggregation properties of annexin A1 will be discussed.