ライフサイエンスコーパス: annexin A2

1 ine Panc-1 is dependent on the expression of annexin A2.

2 e targets, Rab14, co-immunoprecipitated with annexin A2.

3 d S100A10, a dimeric protein associated with annexin A2.

4 licit a significant conformational change in annexin A2.

5 mplexes of heparin oligosaccharides bound to annexin A2.

6 situated at the convex face of domain IV of annexin A2.

7 the calcium dependence of heparin binding to annexin A2.

8 Lys279 and Lys281, on the convex surface of annexin A2.

9 ent manner after binding of beta(2)GPI to EC annexin A2.

10 ction of tPA required its membrane receptor, annexin A2.

11 Annexin A2, a calcium-, actin-, and lipid-binding protei

12 Annexin A2, a calcium-dependent phospholipid-binding pro

13 IR requires transcriptional induction of the annexin A2 (A2) gene through the direct action of the hy

14 Annexin A2 (A2) heterotetramer (A2.p11)(2) is a key prof

15 The annexin A2 (A2) heterotetramer, consisting of two copies

16 Evidence indicates that annexin A2 (A2), a receptor for tissue plasminogen activ

17 endosomal tubules along microtubules to the Annexin A2/actin-dependent stabilization and detachment

18 (A2t) of p11 and annexin A2, but not p11 or annexin A2 alone, directly binds cPLA(2)alpha via Ser(72

19 r annexins and mu subunits demonstrated that annexin A2 also binds the mu1 subunit of the AP-1 comple

20 uired for transport (ESCRT) machinery and on Annexin A2, an RNA-binding protein involved in membrane

21 Consistently, annexin A2 and a cell-internalizing, penetratin-fused ve

22 We also identified porcine annexin A2 and a glycosyltransferase with homology to th

23 The knowledge, that annexin A2 and A5 act as ligands for C1q on apoptotic ce

24 d that the two phospholipid-binding proteins annexin A2 and A5 are, beside DNA, significant C1q ligan

25 whereas the anti-inflammatory proteins (e.g. Annexin A2 and Annexin A6) were significantly upregulate

26 rdx knockdowns in response to RSV, including annexin A2 and desmoplakin.

27 ochemical analyses confirmed localization of annexin A2 and glyceraldehyde 3-dehydrogenase (GAPDH), p

28 Annexin A2 and heparin bind to one another with high aff

29 s were made for binding interactions between annexin A2 and heparin polysaccharide in solution at pH

30 an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflam

31 Rab14 also co-localized in part with annexin A2 and lamellar bodies in alveolar type II cells

32 ells exhibit a perinuclear redistribution of annexin A2 and p11 and show increased fusion of perinucl

33 Both the annexin A2 and p11 subunits of calpactin I coimmunopreci

34 ibition of MMP-1 production with Abs against annexin A2 and S100A10, a dimeric protein associated wit

35 obtained at high resolution for uncomplexed annexin A2 and three complexes of heparin oligosaccharid

36 gnized functional link between intracellular annexin A2 and tumor cell adhesion, migration and in viv

37 in which the N-terminal and core domains of annexins A2 and A5 were swapped showed that trimer forma

38 several SNPs in bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell

39 be more important than ANG association with annexin A2, and KSHV probably uses annexin A2 to maintai

40 analyses, we observed annexin A2-ANG-LANA-1, annexin A2-ANG, and ANG-LANA-1 colocalizations.

41 In triple-staining analyses, we observed annexin A2-ANG-LANA-1, annexin A2-ANG, and ANG-LANA-1 co

42 studies suggest that LANA-1 association with annexin A2/ANG could be more important than ANG associat

43 tion, but blocked activation induced by anti-annexin A2 antibodies and F(ab')2 fragments, as well as

44 sence of beta2GPI, and demonstrate that anti-annexin A2 antibodies directly cause endothelial cell ac

45 , we show that similar to dysferlin, lack of annexin A2 (AnxA2) also results in poor myofiber repair

46 plex consisting of the lipid-binding protein annexin A2 (AnxA2) and S100A10 as such a factor.

47 Human-derived H1650 SP cells over-express annexin A2 (AnxA2) and SOX2, and are resistant to conven

48 1R phosphorylated the prometastatic molecule Annexin A2 (AnxA2) at Y23 and Y333 in response to stroma

49 AIIt is composed of 2 molecules of annexin A2 (ANXA2) bound together by a dimer of the prot

50 We recently found that annexin A2 (ANXA2) co-localizes with PS-ASOs in late end

51 eport that the phospholipid-binding protein, annexin A2 (ANXA2) functions to maintain vascular integr

52 Here we reveal a role for annexin A2 (AnxA2) in host defense against infection as

53 Annexin A2 (AnxA2) is a multifunctional Ca(2+)-dependent

54 Annexin A2 (AnxA2) is a peripherally associated membrane

55 Annexin A2 (ANXA2) overexpression is required for cancer

56 Annexin A2 (ANXA2) promotes myeloma cell growth, reduces

57 Annexin A2 (AnxA2) was reported to be an extracellular e

58 ach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse sensory ne

59 Annexin A2 (AnxA2), a Ca(2+)-dependent phospholipid-bind

60 We investigated whether Annexin A2 (AnxA2), a progastrin receptor, activates NF-

61 membrane-associated, actin binding protein, annexin A2 (AnxA2), is up-regulated in migrating IECs an

62 The mRNA encoding Annexin A2 (ANXA2), one of the most abundant proteins in

63 -206 directly targets the oncogenes KRAS and annexin a2 (ANXA2), thereby acting as tumor suppressor i

64 ne peripherally associated membrane protein, annexin A2 (AnxA2), to induce the formation of phosphati

65 n the membrane phospholipid binding protein, annexin A2 (ANXA2), we observed a significant decrease i

66 We also identify the S100A10 subunit of the annexin A2 (AnxA2)-S100A10 protein complex as a novel Mu

67 ion between NKCC2 and the cytosolic protein, annexin A2 (AnxA2).

68 ve enzyme and co-localizes with cell surface annexin A2 (ANXA2).

69 orylation and extracellular translocation of annexin A2 (AnxA2).

70 Annexin A2 appeared as punctate nuclear dots in LANA-1-p

71 Identification of annexin A2 as a binding partner for TM601 is also consis

72 tif that binds to and inhibits intracellular annexin A2 as a candidate therapeutic lead for potential

73 omatography-mass spectrometry, we identified annexin A2 as a factor H binding partner.

74 , we identified the calcium-effector protein annexin A2 as a novel binding partner for ICAM-1.

75 Here, we identify annexin A2 as a novel binding partner for TM601 in multi

76 Here, we identify Annexin A2 as an autophagy modulator that regulates auto

77 We thus propose membrane exposure of annexin A2 as an oxidative stress signal for some Vdelta

78 , vimentin, actin, caldesmon, myosin IC, and annexin A2 as major proteins and was noted to exhibit co

79 creased MMP-1 synthesis by signaling through annexin A2, as demonstrated by inhibition of MMP-1 produ

80 evel, indicating that these genes are indeed annexin A2-associated targets.

81 Annexin A2 associates with CD44 in lipid rafts; therefor

82 r, the results indicate a functional role of annexin A2 binding to endosomal membranes following orga

83 At this site, annexin A2 binds up to five sugar residues from the nonr

84 howed that a heterotetramer (A2t) of p11 and annexin A2, but not p11 or annexin A2 alone, directly bi

85 Annexin A2 can contribute to AP-mediated tissue inflamma

86 phages through a signaling pathway involving annexin A2/CD11b-mediated integrin-linked kinase.

87 Annexin A2 coimmunoprecipitated with LANA-1 and ANG in T

88 Annexin A2 colocalized with several LANA-1 punctate spot

89 The annexin A2 complex (termed "A2") is the cell surface cor

90 graphy showed that cortical actin bundled by annexin A2 connected docked secretory granules to the pl

91 that the membrane curvature-inducing protein annexin A2 contributes to the formation of these vesicle

92 Accordingly, Annexin a2-deficient mice were more susceptible to A. ph

93 Lipidomic analysis of annexin A2-deficient mouse cells indicates that this pro

94 They now show that an annexin A2-deficient mouse rendered hyperhomocysteinemic

95 We determined that annexin A2 does not play an essential role in infection

96 This process is dependent on the Annexin A2 effectors ARP2 and Spire1.

97 our findings demonstrate that inhibition of annexin A2 expression in glioma cells could become a new

98 associated proteins, we silenced endogenous annexin A2 expression in rat alveolar type II cells by R

99 Annexin A2 expression increases after starvation in cell

100 t starvation-induced autophagy by regulating Annexin A2 expression levels.

101 Moreover, bivalent anti-annexin A2 F(ab')2 fragments also caused endothelial cel

102 Annexin A2 facilitates the binding of Vamp8 to the autop

103 This suggested that annexin A2 forms a complex with LANA-1 and ANG as well a

104 Specifically, annexin A2, found in a heterotetrameric complex with S10

105 Annexin A2 functions in angiogenesis by binding to tissu

106 onation, confocal analysis of endogenous and annexin A2-GFP transfected cells, and immunogold labelli

107 rinsic actin-bundling activity of endogenous annexin A2 had the opposite effects.

108 Annexin A2 has been shown to play roles in cell prolifer

109 asmon resonance analysis showed that A2t and annexin A2 has modest selectivity for PtdIns(4,5)P2 over

110 We show that S100A11 in a complex with Annexin A2 helps reseal the plasma membrane by facilitat

111 through a recently identified receptor, the annexin A2 heterotetramer (A2t).

112 The protein complex annexin A2 heterotetramer (AIIt) is an important plasmin

113 a newly identified L2-specific receptor, the annexin A2 heterotetramer.

114 n-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex.

115 Recombinant annexin A2 impaired complement regulation by factor H an

116 Silencing annexin A2 in BCBL-1 cells resulted in significant cell

117 Knockdown of annexin A2 in glioma cells decreased tumor size and slow

118 , we report that the levels of expression of annexin A2 in human glioma samples correlate with their

119 a membrane repair in general and S100A11 and Annexin A2 in particular as new targets for the therapy

120 er, our analyses highlight the importance of annexin A2 in vesiculation of a population of Atg16L-pos

121 ic distribution in normal tissue (prohibitin/annexin A2 in white adipose tissue) or cancer (RAGE/leuk

122 protein) and endogenous genes (lamin A/C and annexin A2) in alveolar type II cells, but not other lun

123 a glycoprotein (gD), and a cellular protein (annexin A2) in the primary enveloped virion preparation.

124 mococcal otitis media, the administration of annexin A2 increased AP-mediated bacterial opsonization

125 Thus, annexin A2-induced actin bundling is apparently essentia

126 Furthermore, binding of inactive plasmin to annexin A2 inhibited plasmin induction of MMP-1, suggest

127 ICAM-1 clustering promotes the ICAM-1-annexin A2 interaction and induces translocation of ICAM

128 Annexin A2 is a phospholipid-binding protein that forms

129 A higher level of annexin A2 is expressed in KSHV+ but not in Epstein-Barr

130 It has been reported that annexin A2 is involved in binding to phosphatidylinosito

131 Because annexin A2 is not a transmembrane protein, the mechanism

132 Annexin A2 is overexpressed in many cancers and correlat

133 Annexin A2 knockdown abrogates starvation-induced autoph

134 as well as stable clones transfected with an annexin A2 knockdown construct.

135 We find that the annexin A2 knockdown decreased glioma cell migration in

136 creased apoptosis in the tumor tissue of the annexin A2 knockdown group.

137 In conclusion, our data show that annexin A2 limits neutrophil transendothelial migration

138 results provide clear evidence that CD44 and annexin A2 mediate the C5a chemotactic cofactor function

139 reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the pathophysiolo

140 l cell activation occurs via dimerization of annexin A2 molecules on the cell surface.

141 When an annexin A2 mutant with impaired actin filament-bundling

142 1 production is seen in dendritic cells from annexin A2-null mice, following exposure to polyethylene

143 S TX binds to human surfactant protein A and annexin A2 on airway epithelial cells and is internalize

144 ed that beta2GPI binds with high affinity to annexin A2 on the endothelial surface, though the releva

145 initiated by cross-linking or clustering of annexin A2 on the endothelial surface.

146 show that siRNA-mediated knockdown of either annexin a2 or p11 protein significantly inhibits C-1-P-d

147 Although the annexin a2-p11 heterotetramer constituents do not bind t

148 actions between ceramide 1-phosphate and the annexin a2-p11 heterotetramer constituents.

149 ular C-1-P, acting through the extracellular annexin a2-p11 heterotetrameric protein, can mediate vas

150 hat 30% of Atg16L-positive vesicles are also annexin A2-positive.

151 n turn, enhances the trans-activation of the Annexin A2 promoter.

152 To understand how annexin A2 promotes this membrane remodeling, the involv

153 Annexin A2 recruitment to damaged organelles is shown by

154 ments, using fluorescent liposomes, confirms annexin A2 recruitment to endosomes containing phagocyto

155 Absence of annexin A2 reduces both vesicle formation and homotypic

156 Further experiments showed that annexin A2 reduces the binding of factor H to cell surfa

157 To identify annexin A2-regulated or associated proteins, we silenced

158 The loss of annexin A2 resulted in the change of 61 genes.

159 Interaction of plasmin with annexin A2 resulted in the stimulation of ERK1/2 and p38

160 g and undergoing cytoskeleton remodeling via annexin A2, S100A10, transgelin, and myosin.

161 sma phagocytophilum Macrophages deficient in annexin A2 secreted significantly smaller amounts of int

162 rescued by overexpressing EGFP-tagged human annexin A2, six of seven selected targets returned to th

163 ses the amount of the ternary complex of p11/annexin A2/SMARCA3.

164 peripheral blood mononuclear cells and other annexin A2-specific Vdelta2(neg) gammadelta T-cell clone

165 We reported previously that soluble annexin A2 tetramer (A2t) activates human monocyte-deriv

166 activation by posttranslationally modifying annexin A2, the coreceptor for plasminogen and tissue pl

167 apable of binding to target proteins such as annexin A2, the tumor-suppressor protein p53 and myosin

168 ling complex on the EC surface that includes annexin A2, TLR4, calreticulin, and nucleolin.

169 different lengths were co-crystallized with annexin A2 to elucidate the structural basis of the inte

170 tion with annexin A2, and KSHV probably uses annexin A2 to maintain the viability and cell cycle regu

171 l support to our findings, better binding of annexin A2 to sialostatin L2 in sera from 21 out of 23 i

172 the cell triggers recruitment of S100A11 and Annexin A2 to the site of injury.

173 raldehyde 3-phosphate dehydrogenase (G3PDH), annexin A2, triose phosphate isomerase, and ubiquitin B

174 Depletion of endothelial annexin A2 using RNA interference enhances ICAM-1 membra

175 cium, and to be functional in the sense that annexin A2 was able to recruit the mu2 to immobilized li

176 Moreover, purified annexin A2 was able to stimulate the proliferation of a

177 The interaction between mu2 and full-length annexin A2 was demonstrated in vitro to be direct, to re

178 In LANA-1-negative TIVE-LTC cells, annexin A2 was detected predominately in the cytoplasm,

179 The host cellular protein annexin A2 was identified as a binding partner of the LC

180 ication and mass spectrometry, intracellular annexin A2 was identified as the corresponding binding p

181 entify antigenic ligands of gammadelta TCRs, annexin A2 was identified as the direct ligand of Vgamma

182 When the loss of rat annexin A2 was rescued by overexpressing EGFP-tagged hum

183 nd ANG interaction with one of the proteins, annexin A2, was validated.

184 that interact with the N-terminal domain of annexin A2 we identified the mu2 subunit of the clathrin

185 Notably, caveolin-1, caveolin-2, and annexin A2, which are proteins associated with lipid raf

186 ut not nonphosphorylated PS1, interacts with Annexin A2, which, in turn, interacts with the lysosomal

187 etermined the membrane binding properties of annexin A2 wild type and mutants both as monomer and as

188 ogen activation through its interaction with annexin A2 with concomitant reduced plasmin generation b

189 A induced the aggregation and interaction of annexin A2 with integrin CD11b, and ablation of CD11b or

190 In conclusion, the local production of annexin A2 within tissues suppresses regulation of the A