ライフサイエンスコーパス: annexin A5

1 used a siRNA-mediated approach to knock down annexin A5.

2 d to the peripheral membrane-binding protein annexin a5.

3 This binding could be efficiently blocked by annexin A5.

4 To modulate the pharmacokinetics of annexin A5, a 36-kDa protein that binds specifically wit

5 Annexins A5, A2, and A6 (Anx-A5, -A2, and -A6) are quant

6 Annexin A5 (A5) forms 2-dimensional crystals over phosph

7 The trimer-forming annexin A5 and B12 group had the following Ca(2+)-depend

8 PL mAbs reduced the anti-coagulant effect of annexin A5 and promoted thrombin generation.

9 tional (99m)Tc-labeled hydrazinonicotinamide annexin A5 and the plain CCPM control exhibited signific

10 proaches confirmed the well-known ability of annexins A5 and B12 to form trimers, but neither method

11 tablished that autoantibodies to troponin I, annexin-A5, and beta 1-adrenegic receptor best discrimin

12 The aPL antibody-mediated disruption of the annexin A5 anticoagulant shield may be an important prot

13 Annexin A5 (AnxA5) is a potent anticoagulant protein tha

14 The phospholipid- and Ca(2+)-binding protein annexin A5 (ANXA5) is the most abundant membrane-associa

15 As an example, we chose annexin A5 (AnxA5), a recombinant 35-kD protein extensiv

16 -phosphate-lipid complexes (CPLX), and (iii) annexin A5 (AnxA5), the principal lipid-dependent Ca(2+)

17 These effects of annexin A5 are mediated by its ability to inhibit lipopo

18 Annexin A5 belongs to a large family of calcium-binding

19 e hypothesis that aPL antibodies can disrupt annexin A5 binding to phospholipid membranes and permit

20 We find that annexin a5 binds Ca(2)(+) in solution according to a sim

21 Annexin A5 blocked platelet internalization and HepG2 pr

22 We found that annexin a5 can induce formation of large PS domains, coi

23 Annexin A5-CCPM allowed visualization of tumor apoptosis

24 In mice, annexin A5-CCPM displayed a mean elimination half-life o

25 In cell-based studies, annexin A5-CCPM exhibited strongly specific binding to a

26 o evaluate the specificity of the binding of annexin A5-CCPM to apoptotic cells, both fluorescence mi

27 blood was 22.4% of the injected dose/mL, and annexin A5-CCPM was mainly distributed in the central bl

28 ls to evaluate the potential applications of annexin A5-CCPM.

29 ptake in the tumors of the treated mice than annexin A5-CCPM.

30 ed with varying degrees of disruption to the annexin A5 crystallization pattern over the bilayer.

31 Annexin A5 depletion by siRNA led to decreased annexin A

32 Importantly, annexin A5 dose-dependently inhibited lipopolysaccharide

33 Radiolabeled annexin A5 has been successfully used to noninvasively i

34 imaging studies, only (18)F-FDG and (99m)Tc-annexin-A5 have been recently used in the settings of ac

35 We evaluated the feasibility of annexin A5 imaging in transgenic apoE(-/-) and LDLR(-/-)

36 To understand the functional significance of annexin A5 in renal cell death, we used a siRNA-mediated

37 is study, we aimed to verify the function of annexin A5 in the apoptosis of renal epithelial cells.

38 imaging of atherosclerosis with radiolabeled annexin A5 in transgenic mouse models of human atheroscl

39 cavenging hemopexin and by the PS antagonist annexin-a5, in vitro and in vivo.

40 e evidence that substoichiometric amounts of annexin A5 inhibit h-IAPP and alpha-synuclein misfolding

41 Treatment with annexin A5 inhibited myocardial mitogen-activated protei

42 cisplatin strongly induced translocation of annexin A5 into mitochondria.

43 Annexin A5 is a 35-kDa protein with high affinity bindin

44 Annexin A5 is a potent anticoagulant protein, expressed

45 We find that annexin A5 is coexpressed in human beta-cells and that e

46 There is increasing evidence that annexin A5 is related to cytotoxicity, but the precise f

47 Intravenously injected biotinylated annexin A5 localized in apoptotic and nonapoptotic macro

48 Our study suggests that annexin A5 may have therapeutic potential in the treatme

49 Taken together, our data suggest that annexin A5 may play a crucial role in cisplatin-induced

50 We conclude that annexin A5 might act as a molecular safeguard against th

51 Our aim was to study the effects of annexin A5 on myocardial tumor necrosis factor-alpha exp

52 onoclonal antibody to Del-1 (P=0.027) and by annexin A5 (P=0.027), abciximab (P=0.027), a monoclonal

53 In this study, we show that annexin A5 plays a role in interacting with and reducing

54 We discuss how weak membrane association of annexin a5 prior to Ca(2)(+) influx is the basis for the

55 determined that in the presence of calcium, annexin A5 reduced the level of baseline leakage from ve

56 ynuclein in Caenorhabditis elegans show that annexin A5 reduces alpha-synuclein inclusions in vivo.

57 essed in human beta-cells and that exogenous annexin A5 reduces the level of h-IAPP-induced apoptosis

58 This "annexin A5 resistance" identifies a novel mechanism for

59 h as that achieved by technetium-99m labeled Annexin-A5 scintigraphy.

60 ody-mediated disruption of the anticoagulant annexin A5 shield could be a thrombogenic mechanism in t

61 ence analysis, showed that the expression of annexin A5 significantly increased in the presence of ci

62 Annexin A5 siRNA also increased cell viability compared

63 viously used to study the crystallization of annexin A5, to image the effects of monoclonal human aPL

64 is the basis for the cooperative response of annexin a5 toward Ca(2)(+), and the role of membrane org

65 nexin A5 depletion by siRNA led to decreased annexin A5 translocation into mitochondria and significa

66 Furthermore, annexin A5-treated animals showed significant reductions

67 dotoxemia with and without recombinant human annexin A5 treatment (5 or 10 mug/kg, i.v.).

68 d by either an immediate or a 4-hour delayed annexin A5 treatment after lipopolysaccharide challenge.

69 Annexin A5 treatment decreases cytokine expression and i

70 binds specifically with phosphatidylserine, annexin A5 was conjugated to polyethylene glycol-coated,

71 The quantitative uptake of annexin A5 was highest in the cholesterol-fed apoE(-/-)

72 Moreover, expression of annexin A5 was induced by other nephrotoxicants such as

73 (99m)Tc-annexin A5 was injected in 31 animals for noninvasive im

74 of precise target localization, biotinylated annexin A5 was injected in the remaining 2 normally fed

75 ites of elevated metabolic activity; (99m)Tc-annexin A5, which reveals regions of enhanced apoptosis