ライフサイエンスコーパス: annexin IV

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1 transcription and the physiological role of annexin IV.

2 he thickness of two layers of membrane-bound annexin IV.

3 or these studies and compared with wild-type annexin IV.

4 B4 was found to specifically recognize mouse annexin IV.

5 nd to exhibit IgM natural Abs that recognize annexin IV.

6 p has been inserted into the first intron of annexin IV.

7 Annexin IV (AIV), a Ca2+-dependent membrane-binding prot

8 Annexin IV also plays an inhibitory role in modulating g

9 Other annexins, such as annexin IV and annexin VI, do not exhibit this binding.

10 itro assays showed that unmodified wild-type annexin IV and the T6A mutant, but not PKC-phosphorylate

11 The identities of PKC, annexin I, annexin IV, annexin VI, and annexin VII were confirmed b

12 These data in toto identify annexin IV as a key ischemia-related target Ag that is r

13 In this orientation, a single layer of WT annexin IV, attached to the outer leaflet of one vesicle

14 Preinjection of recombinant annexin IV blocked IR injury in wild-type C57BL/6 mice,

15 The combination of Ins(3,4,5,6)P4 and annexin IV did not alter the in vitro activity of CaMKII

16 e to close, and in these regions there is no annexin IV expression in presumptive roof plate cells.

17 hern blot and immunoblot data indicated that annexin IV expression was eliminated in many but not all

18 hemical analysis, however, demonstrated that annexin IV expression was eliminated in some cell types,

19 of these midline structures is essential for annexin IV expression, we analyzed two strains of mutant

20 nscripts suggest that regulation of both the annexin IV gene expression and the cellular role of the

21 Annexin IV has been shown to have an inhibitory role in

22 Finally, annexin IV immunolabeling is present from the caudal spi

23 e is absent from the caudal spinal cord, and annexin IV immunopositivity disappears at the level wher

24 esent study, we explore the possible role of annexin IV in development of the CNS midline.

25 is study, we demonstrate an in vivo role for annexin IV in the development of the pronephric tubules

26 lipid vesicles in the presence of wild-type annexin IV indicated a separation distance corresponding

27 y were used to probe the structural basis of annexin IV-induced membrane aggregation and the inhibiti

28 Annexin IV is also expressed in the roof plate, but not

29 Thus, annexin IV is an excellent marker for differentiated mid

30 Previously, we demonstrated that annexin IV is an excellent marker of midline structures.

31 Subsequently, annexin IV is expressed by floor plate cells at E9.5.

32 Annexin IV is present in the notochord at embryonic day

33 In the DRG and the SC, annexin IV is primarily expressed by glial cells and at

34 ids (C2) and a previously characterized anti-annexin IV mAb (B4) were used to reconstitute and charac

35 Annexin IV modifies membrane bilayers by increasing rigi

36 All three transcripts produce an identical annexin IV protein.

37 IV revealed that, similar to annexin V, the annexin IV proteins form 2D trimer-based ordered arrays

38 n crystallographic data of wild-type and T6D annexin IV revealed that, similar to annexin V, the anne

39 Further, recombinant annexin IV significantly reduced infarct volumes in wt m

40 itope identification, we constructed an anti-annexin IV single-chain antibody (scFv) and an scFv link

41 When 2 microM annexin IV was present in the pipette solution, a concen

42 sing immunocytochemistry with an antibody to annexin IV, we have elucidated the temporal and spatial

43 , depletion of endogenous annexin V, but not annexin IV, with siRNA inhibits deltaPKC translocation f

44 at resulted in the cloning of Xenopus laevis annexin IV (Xanx-4).

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