ライフサイエンスコーパス: annulation

1 have ortho functional groups to complete the annulation.

2 ate (PIDA)-mediated intramolecular oxidative annulation.

3 ization and indole C2-H bond activation/Heck annulation.

4 n enantioselective variant of a useful [4+1] annulation.

5 butyl stannane followed by Pd-catalyzed Heck annulation.

6 1 via a symmetrical, two-directional, double annulation.

7 he alpha,beta-enone 8 by a modified Robinson annulation.

8 the hydroxy group resulting from the initial annulation.

9 ures, respectively, prepared through lateral annulation.

10 er of events in this radical-polar crossover annulation.

11 atives as the result of a dehydrative indole annulation.

12 ners, in various rhodium-catalyzed oxidative annulations.

13 acetates with an intramolecular Pauson-Khand annulation, a cycloisomerization, or a [5+2] cycloadditi

14 ile to an activated intermediate followed by annulation affords the pyrimidine product in a single st

15 This formal [3+2] annulation allowed the synthesis of diverse naphtho[2,1-

16 The controlled gold-catalyzed annulations allowed the formation of fused beta-lactams

17 one by the sigma-system as a result of benzo-annulation also appear to have no effect on the charge t

18 A Rh-catalyzed tandem annulation and (5 + 1) cycloaddition was realized.

19 l-directed metallacycle-mediated [2 + 2 + 2] annulation and an intramolecular radical cyclization cas

20 A two-directional unsymmetrical double annulation and biomimetic etherification was developed t

21 The effect of annulation and carbonylation on the electronic and ligat

22 by employing an excess of alkyne, where both annulation and hydroarylation took place regio- and ster

23 ccomplished in 13 steps using a new oxindole annulation and late-stage enamine oxidation.

24 ting operations, two are classical (Robinson annulation and Mukaiyama aldol) and two are newly devise

25 ations include hydrogenation, cycloaddition, annulation, and diverse "breaking and mending" approache

26 through an intramolecular allylation, [3+2] annulation, and Sakurai-like homodimerization.

27 This novel annulation approach also works for an aldehyde, thus pro

28 tructure have been synthesized using a pyran annulation approach as a key strategic element.

29 C-Glycosidation, dearomatization, and Hauser annulation are the key steps.

30 The procedure is amenable to (benz)annulation at both the 2,3- and 3,4-positions of the pho

31 is structure has been achieved via a [3 + 2] annulation between a terminal alkyne and a carboxamide u

32 efficient palladium-catalyzed C-H activated annulation between abundant aryl bromides and oxanorborn

33 ocyclic carbene (NHC)-catalyzed formal [4+2] annulation between alpha,beta-unsaturated aldehydes and

34 p being a chiral phosphine-catalyzed [3 + 2] annulation between an imine and an allenoate to form a p

35 An efficient MgI2-catalyzed annulation between donor-acceptor cyclopropane and N-tos

36 hosphine ligand promotes redox-neutral [4+2] annulation between N-H aromatic ketimines and internal a

37 . fumigatus Af293 and describes an oxidative annulation biosynthetic strategy likely shared among sev

38 um catalyzed direct regioselective oxidative annulation by double C-H activation is described to synt

39 ly efficient catalyst for dehydrative alkyne annulation by NH-free hydroxamic acids in water.

40 reactivity, evidence is provided to support annulation by way of regioselective alkyne-alkyne coupli

41 ed homoallylic nitrones whose intramolecular annulation can be controlled to deliver one of two disti

42 The products of the [3+2] annulation can be readily transformed into structures th

43 ly regioselective catalytic arene-norbornene annulation (CANAL) between dibromonaphthalenes and benzo

44 A branching double-annulation cascade (BDAC) strategy for diverse and compl

45 A one-pot sequential double annulation cascade (SDAC) strategy involving an opening

46 s are thus a paired set of diastereospecific annulation catalysts that act on the fumiquinazoline F s

47 sters can undergo dynamic kinetic asymmetric annulations catalyzed by (pybox)MgI(2) complexes.

48 s embrace a variant of metallacycle-mediated annulation chemistry where initial alkyne-carbonyl coupl

49 Directed by an oxime-masked alcohol, annulation chemoselectively occurs at the beta position,

50 naphthale n-2(3H)-one [(-)-8] under Robinson annulation conditions.

51 esis of a cyclopentane nucleus by convergent annulation constitutes a significant challenge for synth

52 port a systematic study of the Larock indole annulation designed to explore the scope and define the

53 quence employs a mild fluoride-induced aryne annulation developed in our laboratories to build a key

54 The cooperative umpolung annulation eliminates mutual deactivation and leads to a

55 meta-terphenyls via a regioselective [3 + 3] annulation-elimination sequence involving Morita-Baylis-

56 A one-pot protocol for the enyne-RCM/Heck annulation featuring a sequential addition of the Ru and

57 hieved; both rely upon cyclopropane/aldehyde annulation for construction of the core tetrahydrofurans

58 intramolecular palladium(0)-mediated indole annulation for macrocyclization closure of the strained

59 f the scope and limitations of the carbamate annulation for piperidine synthesis.

60 ghly diastereo- and enantioselective [4 + 2] annulation for the assembly of the functionalized pyran

61 Ring in the new: a new annulation for the efficient synthesis of substituted fu

62 vergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has be

63 ts the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispy

64 ation to an acid, followed by Friedel-Crafts annulation, gives an indole-annulated cyclopentanone tha

65 This NHC-catalyzed annulation has been used for the total synthesis of mare

66 ding aza-Prins/intramolecular Friedel-Crafts annulations have been identified, and both reaction scop

67 to the effects the regiochemically distinct annulations have on the conformation of the chromophore.

68 onal group of the aniline derivative, and an annulation in the final step to close the quinoline ring

69 es with Schiff base formation and subsequent annulation in the presence of large N,N-dimethylamides (

70 allowing identification of the segments and annulation in the tarsus, while poorly developed thoraci

71 The proposed mechanism for this annulation includes (1) Pd(OAc)(2) reduction to the acti

72 involving an imine formation-intermolecular annulation-intramolecular iminium ion cyclization sequen

73 diates through the application of a two-step annulation involving an electrochemical ring closure bet

74 This intermolecular annulation involving tandem C-H activation, cyclization,

75 The annulation is believed to proceed via (1) oxidative addi

76 The enantioselective [3+2] annulation is catalyzed using a scandium(III)/indapybox

77 This [3 + 2]-annulation is operationally simple under metal-free reac

78 The annulation is proposed to proceed by initial formation o

79 This tandem annulation is proposed to proceed via transposition of t

80 d methoxycarbonylation, unprecedented Hauser annulation, Krohn photo-oxidation, and regioselective ge

81 sitions, carbene transfer reactions, cascade annulations, macrocyclisations or the formation of gold

82 The annulation methodology is highly efficient for the synth

83 crotylsilane reagents 9 and 10 in our [4+2]-annulation methodology.

84 In contrast with other intramolecular annulation methods, such as Friedel-Crafts acylations, t

85 The palladium-catalyzed annulation of 1,3-dienes by o-iodoacetoxycoumarins provi

86 The palladium-catalyzed annulation of 1,3-dienes by o-iodoaryl acetates provides

87 ently synthesized by the palladium-catalyzed annulation of 2,2'-diiodobiphenyls with alkynes.

88 he synthesis of dibenzofurocarbazole via bis-annulation of 2,5-bis(2-pivaloyloxymethyl)pyrrole.

89 The reaction initially proceeds through the annulation of 2-(2,2-dibromovinyl)aniline, an isocyanate

90 s protocol are easily assembled via C-X bond annulation of 2-bromo-N-protected aniline with norbornad

91 The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-form

92 Silver-mediated annulation of 2-iodo enol esters leading to 4- and 3,4-s

93 Ruthenium-catalyzed oxidative annulation of 2H-chromene-3-carboxamides with alkynes ha

94 A diastereoselective (3 + 2) dearomative annulation of 3-substituted indoles with alpha-haloketon

95 O4-mediated one-pot stereocontrolled (4 + 2) annulation of 4-alkenols and oxygenated naphthalenes pro

96 s of the synthetic sequence are the Robinson annulation of a beta-ketoester and methyl vinyl ketone a

97 The key steps include a Hauser-Kraus annulation of a cyanophthalide with a chiral enone-lacto

98 e motif of the target was then installed via annulation of a pyrrolidine ring onto the spirocycle.

99 Annulation of a spiro-lactal unit to 5 was pursued with

100 The overall reaction is a [2 + 2 + 1] annulation of a terminal alkyne, a nitrile, and an oxyge

101 as been developed by the palladium-catalyzed annulation of a variety of internal alkynes, in which tw

102 lation sequence represents the first general annulation of alkenenitriles to assemble diverse bicycli

103 A copper-mediated intermolecular annulation of alkyl ketones and beta-nitrostyrenes has b

104 The origin of stereoselectivity in the (3+2) annulation of allenes and enones catalyzed by an amino a

105 ives through the Pd-catalyzed regioselective annulation of allenes with 3-iodo-1-alkylindole-2-carbox

106 the phosphine-catalyzed intermolecular [3+2] annulation of allenes with alkenes; however, there have

107 ly diastereoselective Mukaiyama-type [3 + 2]-annulation of allylsilane 5 with the unsaturated aldehyd

108 with the previously reported formal (3 + 3) annulation of alpha-nitro-alpha,beta-enals and 2,2-dimet

109 ple by Tong of a phosphine-catalyzed [4 + 1] annulation of an amine with an allene that furnished an

110 ic route was an efficient diastereoselective annulation of an oxolane ring onto a pyroglutamate scaff

111 eveloped via Cu(II)-catalyzed intermolecular annulation of aryl ketones with a wide range of aromatic

112 A simple and efficient one-pot annulation of arylidenones, alkynes, and nitriles in the

113 The first process involves a Pd-catalyzed annulation of arynes by 2-halobiaryls and related vinyli

114 econd process utilizes a Pd-catalyzed double annulation of arynes by simple aryl halides.

115 The palladium-catalyzed annulation of arynes by substituted o-halobenzamides pro

116 ly in good yields by the palladium-catalyzed annulation of arynes.

117 fferent processes involving the Pd-catalyzed annulation of arynes.

118 can be an effective synthetic route for the annulation of benzene rings to various aromatic systems,

119 A Robinson annulation of benzylpiperidone and resolution of the des

120 tives, to control the enantioselective [3+3] annulation of beta-(hetero)aryl-alpha-nitro-alpha,beta-e

121 The annulation of certain hindered propargylic alcohols affo

122 Robinson annulation of coprostanone (1) at the 2,3- and 3,4-posit

123 the first example of an intermolecular [4+2] annulation of cyclobutylanilines with alkynes enabled by

124 A new process for (4 + 2)-annulation of donor-acceptor cyclopropanes (DACs) with u

125 A new process for the [4 + 2] annulation of donor-acceptor cyclopropanes with acetylen

126 ented N-heterocyclic carbene (NHC)-catalyzed annulation of enals to form 3,4-disubstituted cyclopenta

127 Intermolecular annulation of enynes and propargyl esters to selectively

128 oup through the intramolecular oxidative aza-annulation of enynyl azides is reported for the first ti

129 s are readily prepared in good yields by the annulation of in situ generated arynes by 2-haloarenecar

130 ynthesized in moderate to good yields by the annulation of in situ generated arynes with 2-haloacetan

131 The palladium-catalyzed annulation of internal alkynes by N-substituted o-iodoan

132 The palladium-catalyzed annulation of internal alkynes by o-iodophenols in the p

133 Y, via palladium-catalyzed selective [3 + 2] annulation of iodopyranoquinolines and internal akynes w

134 Ruthenium-catalyzed oxidative annulation of N-quinolin-8-yl-benzamides with alkynes in

135 A visible-light-mediated annulation of N-sulfonylallylamines and olefins is repor

136 The palladium/bpy-catalyzed annulation of o-alkynylphenol with various aryl halides

137 A palladium-catalyzed tandem oxidative annulation of primary benzamides with acrylates via inte

138 ynthesis of azepines from the intermolecular annulation of propargyl esters and alpha,beta-unsaturate

139 ls 4 bearing an aldehyde side chain; and (3) annulation of ring A by intramolecular vinylogous Mukaiy

140 The Hauser-Kraus annulation of sulfonylphthalide with 3-olefinic oxindole

141 uilding block by a (4 + 2)-cycloaddition for annulation of the B ring.

142 Some model systems were investigated toward annulation of the C-ring of the natural product.

143 The annulation of the dipivalate proceeds through the interm

144 Annulation of the final ring was achieved through visibl

145 ine families are nonribosomally assembled by annulation of the indole side chain of fumiquinazoline F

146 nstruction of the carbazole framework and an annulation of the pyran ring, which is either catalyzed

147 novel key transformations, including a [4+2] annulation of thioimidates with vinyl carbodiimides and

148 A ZnBr(2)-mediated regioselective annulation of unsymmetrical 1,2-diarylmethinedipivalates

149 hly enantioselective Pd(PPh3)4/NHC-catalyzed annulation of vinyl benzoxazinanones and enals has been

150 A diastereoselective [4 + 2]-annulation of vinyl carbodiimides with chiral N-alkyl im

151 convergent strategy involving the sequential annulation of vinyl iodide 5 with indole 6 exploits vary

152 I) complexes enabled efficient redox-neutral annulations of alkynes with readily available oximes.

153 We report formal [3 + 3] annulations of aromatic azides with aromatic imines and

154 The phosphine-mediated [3 + 3] annulations of aziridines and allenes are experimentally

155 Homoenolate annulations of beta-aryl enals catalyzed by an N-heteroc

156 Lewis acid catalyzed annulations of malonate-derived donor-acceptor cycloprop

157 lic substitution enables [3 + 2] and [4 + 2] annulations of N-acylhydrazones to afford substituted py

158 hetic efforts and to summarize the effect of annulation on the properties of expanded and isomeric po

159 opanation, cycloisomerization, and, finally, annulation or elimination.

160 theory calculations suggest that the [3 + 2]-annulation pathway is strongly preferred over the possib

161 fluorophile and desiccant to facilitate the annulation process across three different azaborininone

162 The regioselectivity of the annulation process could be rationalized based on examin

163 A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of dense

164 The utility of this triple annulation process is demonstrated in the synthesis of d

165 This annulation process is the first example of intermolecula

166 ionalized carbazole derivatives via a double annulation process that generates two C-C and two C-N bo

167 A phosphine-catalyzed novel [4+2] annulation process was devised employing allene ketones

168 offers an insight into the mechanism of the annulation process.

169 enantioselective alkylative dearomatization-annulation process.

170 IQs) in high chemoselectivity over competing annulation processes, exclusive cis-diastereoselectivity

171 se-, and palladium-catalyzed cyclization and annulation processes.

172 nistic explanation for the formation of each annulation product could be provided, which has improved

173 hotocatalyst Ru(I)(bpz)3(+), and the [3 + 2] annulation product radical cation 3(+*) are all successf

174 e high chemoselectivity for the formal [4+2] annulation product.

175 Nucleophilic substitution of the annulation products and subsequent translactamization of

176 oration of the azulenyl halide and sulfonate annulation products can be achieved by employing Heck, N

177 The annulation products can be readily transformed into benz

178 the facile preparation of a diverse array of annulation products including trisubstituted cyclopenten

179 and release" strategy was devised to convert annulation products to pipecolic acid monomers.

180 tandem reactions to generate spirocyclic or annulation products under cross-coupling conditions, rem

181 A one step formal [3+2]-annulation protocol for the synthesis of 2,3-disubstitut

182 h alpha-pyridinone and 3,4-dihydropyridinone annulation protocols, permitted completion of the synthe

183 nts not accessible via conventional Robinson annulation protocols.

184 This route was enabled by a diketene annulation reaction and an oxidative ring expansion stra

185 f PEG-400 as a green solvent for the (3 + 2) annulation reaction and multiple catalytic reactions wit

186 starting materials toward the carbonylative annulation reaction and yielded 3-arylbenzo-1,2,3-triazi

187 Examples of this metallacycle-mediated annulation reaction are provided to demonstrate that a r

188 Herein we describe a salicylaldehyde-annulation reaction as a plug and play toolkit to divers

189 The A ring pyran was assembled using a pyran annulation reaction between a C1-C8 hydroxy allylsilane

190 A cascade Friedel-Crafts/Michael annulation reaction between acryloyl chloride and 2-meth

191 The Sc(OTf)3-catalyzed [3 + 2]-annulation reaction between cyclopropenones and donor-ac

192 A regio- and enantioselective formal [4 + 3] annulation reaction between enals and in situ formed azo

193 and enables the regio- and enantioselective annulation reaction between enals and vinyl benzoxazinan

194 A dirhodium(II)-catalyzed annulation reaction between two structurally different d

195 tuted cyclohexanone derivatives in which the annulation reaction establishes four stereocenters and t

196 addition, we have further developed a novel annulation reaction for the synthesis of hydroxylated 1,

197 A tandem Michael-S(N)Ar annulation reaction has been developed for the synthesis

198 ted metallacycle-mediated hydrindane-forming annulation reaction in natural product synthesis and the

199 This formal cycloaddition reaction or annulation reaction is synthetically useful for construc

200 Pd(0) catalyzed carbonylative annulation reaction of 1-(2-iodophenyl)-3-aryltriaz-1-en

201 alladium-catalyzed one-pot stepwise coupling-annulation reaction of 2-chloroqunoline-3-carbonitriles

202 The selective annulation reaction of alkynes with substrates containin

203 mple of a dynamic kinetic asymmetric [3 + 2] annulation reaction of aminocyclopropanes with both enol

204 loped through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines.

205 tions involved in the intermolecular [3 + 2] annulation reaction of N-cyclopropylaniline (CPA, 1) and

206 ed from the dehydrative C-H alkenylation and annulation reaction of phenols with 1,2-diols.

207 s catalysts for the enantioselective [4 + 1] annulation reaction of vinyl benzoxazinones and sulfur y

208 -aldehyde cyclization, and a newly developed annulation reaction that allows efficient coupling of a

209 to intermediate 7, which was used for a key annulation reaction that introduced the tricyclic nucleu

210 An asymmetric [3+2] annulation reaction to form 3-pyrroline products is repo

211 and ynals undergo a highly enantioselective annulation reaction to form enantiomerically enriched di

212 fruitfully participated in the one-pot ipso-annulation reaction to provide the corresponding 3-iodo

213 An Fe(III)-promoted oxidative annulation reaction was developed for the synthesis of 1

214 The regioselectivity of the second annulation reaction was rationalized computationally on

215 In addition to defining the basic annulation reaction we have discovered a surprising stab

216 highly enantioselective NHC-catalyzed [3+2] annulation reaction with alpha,beta-alkynals and alpha-k

217 o support the chain mechanism in the [3 + 2] annulation reaction.

218 was derived from a stereoselective aza-[3+3] annulation reaction.

219 of dihydronaphthofurans via AgTFA-catalyzed annulation reaction.

220 d from the resulting regioselectivity of the annulation reactions and DFT studies indicates that a me

221 anometallic aryl-Co(III) compounds in alkyne annulation reactions are also disclosed.

222 sis on ring-closing metathesis reactions and annulation reactions based on C-H activation.

223 oloindolines by means of (3 + 2) dearomative annulation reactions between 3-substituted indoles and h

224 Here, we have realized metallacycle-mediated annulation reactions for the assembly of angularly subst

225 of alkoxide-directed Ti-mediated [2 + 2 + 2] annulation reactions have been discovered for the synthe

226 The present procedure describes annulation reactions in one or two steps starting from 5

227 results on potassium tert-butoxide promoted annulation reactions of 2-alkynylphenyl propargyl ethers

228 xy-gamma-lactams, which are available by the annulation reactions of allylic silanes.

229 ructure: See text] Double asymmetric [3 + 2]-annulation reactions of chiral beta-silyloxyallylsilanes

230 carried out by sequential coupling-imination-annulation reactions of ortho-bromoarylaldehydes and ter

231 Annulation reactions via insertion of alkynes into both

232 rticipate with carbenoid reagents in [4 + 1] annulation reactions was investigated.

233 etrahydroisoquinoline undergo regiodivergent annulation reactions with 4-nitrobutyraldehydes.

234 oxamic acid-directed Rh(III)-catalyzed (4+2) annulation reactions with alkynes was investigated compu

235 polymers using efficient palladium catalyzed annulation reactions with low catalyst loading (1 mol %)

236 oxide-directed titanium-mediated [2 + 2 + 2] annulation reactions).

237 e intermediates in the course of [2 + 2 + 2] annulation reactions.

238 rve as efficient surrogates for enals in the annulation reactions.

239 of the double-stereodifferentiating [3 + 2]-annulation reactions.

240 dium-catalyzed regioselective [3 + 2] alkyne annulation/ring-opening followed by intramolecular aldol

241 d 38, prepared by a ring transformation/ring annulation sequence of 2-amino-3-cyano-4-alkyl furans to

242 Collectively, the rearrangement-annulation sequence represents the first general annulat

243 ive dearomatization/acid-mediated adamantane annulation sequence that allows facile access to type A

244 ere a deracemizing imine alkylation/Robinson annulation sequence, a selective "redox ketalization", a

245 e precursors in high yields in an alkylation/annulation sequence.

246 Here, we describe (4 + 3) and (3 + 2) indole annulation strategies that quickly generate complex indo

247 wise manner because of the lack of efficient annulation strategies.

248 An asymmetric organocatalytic [3 + 3] annulation strategy based on a Michael addition/intramol

249 A general and high yielding annulation strategy for the synthesis of various carbo-

250 An efficient annulation strategy involving the reaction of phenolic a

251 ne alkaloids via an intramolecular aza-[3+3] annulation strategy is described here.

252 ccomplished using a Ru(II)-catalyzed (3 + 2) annulation strategy to construct the central pyrrole rin

253 lly enriched form, the use of a formal [3+3] annulation strategy to secure the CDE-ring system with c

254 spongian framework via a C-->ABC-->ABCD ring annulation strategy using intramolecular Diels-Alder and

255 A [4 + 3] annulation strategy was used to create the octahydroisob

256 s (DDs) were engaged in interceptive [4 + 1] annulation strategy with diazo esters (DEs).

257 A "ring expansion-annulation strategy" for the synthesis of substituted az

258 An effective [3+2] annulation tactic for the construction of diverse bicycl

259 This novel [3 + 3] annulation takes advantage of the 1,3-bielectrophilic ch

260 through the sequence of phosphine-catalyzed annulation, Tebbe reaction, Diels-Alder reaction, and in

261 elective approach to bimolecular [2 + 2 + 2] annulation that delivers products not available with oth

262 ntly Antonchick and Manna described a unique annulation that knits together three acetophenones to co

263 eloped an oxocarbenium-ion-initiated cascade annulation that provides us access to the ABCD ring stru

264 We report here a new, atom economical annulation to 2,1-benzisoxazole scaffolds via the BF3.Et

265 tched the reactivity toward a formal [4 + 1] annulation to afford functionalized pyrazoles.

266 l)aryl triflates with CsF results in [4 + 2] annulation to afford substituted acridines in good yield

267 nvolving an opening of isatoic anhydride and annulation to benzimidazole and further nickel-catalyzed

268 ategy features an intramolecular oxa-[3 + 3] annulation to construct its unique ABD-tricyclic manifol

269 motetralone 14 via enantioselective Robinson annulation to enone 13 and Suzuki carbonylative coupling

270 The reaction features an initial [3+2] annulation to form bicyclic hemiaminals, followed by rin

271 halo aldehydes, which undergo regioselective annulation to form borylated thiazoles.

272 Starting with the tricyclic core 2b, annulation to form the 13-membered western ring of sarai

273 nd bases, are suitable for the [4+2] anionic annulation to give 3-(2-alkenyl)naphthoates in regiospec

274 ne, which engaged in acid-catalyzed Robinson annulation to give the bicyclic enone.

275 n the aniline and one of the ketones, before annulation to the heterocyclic ring.

276 to seven member ring and turned on 6-exo-dig annulations to afford family of six-membered benzoxazino

277 m(III)-catalyzed, all-carbon [3+3] oxidative annulations to produce spirodialins.

278 and tetrasubstituted enones are amenable to annulation under this protocol.

279 A new methodology for [n + 1] radical annulation using sulfur dioxide as a geminal radical acc

280 A Robinson annulation, van Leusen homologation, and a desymmetrizin

281 s protocol provides a highly effective (4+2) annulation via one carbon-oxygen and one carbon-carbon b

282 An indole annulation was accomplished by a late-stage intramolecul

283 side as the vic-cis-diol moiety the chromene-annulation was based on or on the opposite side.

284 Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well

285 In addition, the scope of the [3 + 2]-annulation was evaluated and enhanced utilizing diastere

286 in the synthesis is an I2-mediated carbamate annulation, which allows for the cyclization of hydroxy-

287 t-free domino process facilitates the double annulation with a variety of scaffold building agents vi

288 d C(sp(2))-H functionalization and oxidative annulation with alkynes to give spiroindenes containing

289 catalyst, these substrates undergo oxidative annulation with alkynes to provide spiroindenes exclusiv

290 complex and its subsequent participation in annulation with an alkene.

291 The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinoli

292 mistry of one of the C-N bonds formed in the annulation with l-Ala.

293 s a 1,4-dipole synthon and undergoes [4 + 2] annulation with N-tosylimines in the presence of an orga

294 Michael acceptors, serve as acceptors in the annulation with phthalides in the presence of LDA and pr

295 cyclobutylanilines successfully undergo the annulation with terminal and internal alkynes to generat

296 anes were synthesized by peroxycarbenium ion annulations with alkenes in yields ranging from 30% to 9

297 s for N-heterocyclic carbene (NHC)-catalyzed annulations with alpha,beta-unsaturated aldehydes to aff

298 es that are easily hydrolyzed for subsequent annulations with omega-chloroalkyl Grignard reagents.

299 ed C ring aldehyde subunit in a second pyran annulation, with concomitant formation of the B ring.

300 riochlorins are modulated as a result of the annulation, with each isomer possessing a unique spectru