ライフサイエンスコーパス: antagonistic

1 The interaction ranged from synergetic to antagonistic.

2 dividual effects) rather than synergistic or antagonistic.

3 ethal, vital for development and/or sexually antagonistic.

4 strates, the effects of these stimuli can be antagonistic.

5 o and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-term

6 FLO1 transcription is regulated via the antagonistic activities of the Tup1-Cyc8 co-repressor an

7 loping tissues is strongly influenced by the antagonistic activities of two protein kinases: SUC-NON-

8 lysis revealed that the p.A39E mutant showed antagonistic activity against galanin receptor 1 (GalR1)

9 nonpeptidic ligands with different modes of antagonistic activity against the CXCR4-CXCL12 axis have

10 r prevention and treatment of RSV due to its antagonistic activity against the innate immune system.

11 The CXCR4-specific i-bodies show antagonistic activity in a range of in vitro and in vivo

12 mmunocompetent primates due to its decreased antagonistic activity in the mammal IFN system.

13 ings therefore suggest a mechanism involving antagonistic activity of XIST and XACT in controlling X

14 hese noncarboxylic acids also showed partial antagonistic activity on FFA1.

15 at SCCRO family members have overlapping and antagonistic activity that regulates neddylation and cel

16 y of novel 1,4-substituted triazoles with AR antagonistic activity.

17 These findings suggest novel roles for antagonistic AgRP and POMC neurons in the regulation of

18 me is fueled by the accumulation of sexually antagonistic alleles in close linkage to the sex determi

19 rical evidence for the existence of sexually antagonistic alleles is scarce.

20 n on male function, accumulation of sexually antagonistic alleles that benefit hermaphrodites and har

21 Conversely, antagonistic alpha7nAChR stimulation potentiates the pro

22 This indicates an association between an antagonistic and a generalist strategy.

23 beta-Carotene experienced both antagonistic and additive relationships whereas lycopene

24 In contrast, sequential treatment was antagonistic and had a minimal tumor inhibitory effect c

25 In nature, the balance between antagonistic and synergistic interactions has evolved to

26 cent studies have revealed that more complex antagonistic and synergistic relationships exist within

27 by the intracellular Mtb are often mutually antagonistic and, as a consequence, can result in impair

28 ombinations for synergistic effects, two for antagonistic, and five for additive when at least eight

29 An antagonistic anti-CCR4 antibody had antitumor activity i

30 Moreover, addition of an antagonistic anti-PD-1 antibody increased cell death in

31 ition of Ang1 and Ang2 signaling (through an antagonistic anti-Tie2 antibody) was not more efficaciou

32 e peripheral neutralization of Tweak through antagonistic anti-Tweak antibody ameliorates muscle path

33 binations, allowing the combined use of even antagonistic antibiotic pairs that are typically not fav

34 Although antagonistic antibodies against many of the growth facto

35 s suggest that pIgR-mediated transcytosis of antagonistic antibodies in dIgA format can be exploited

36 tation to prevent GVHD and to develop potent antagonistic antibodies later after transplant to facili

37 Antagonistic antibodies targeting coinhibitory receptors

38 ation of TNFR2 by ATROSAB, a TNFR1-selective antagonistic antibody, and EHD2-scTNFR2, an agonistic TN

39 Understanding the antagonistic antimicrobial activities of the innate immu

40 seases has led to the development of various antagonistic approaches targeting IL-15.

41 nations of gamma-radiation and Cd seem to be antagonistic at lower doses, but synergistic at the high

42 undreds of target genes and are functionally antagonistic at these loci: whereas TERRA activates, ATR

43 ators span multiple processes, including the antagonistic autophagy and methionine biosynthesis pathw

44 nthine A2BAR ligands was identified, and its antagonistic behavior confirmed through functional exper

45 of functional cAMP experiments confirmed the antagonistic behavior of representative ligands.

46 al profile of ON and OFF responses exhibited antagonistic behaviour, with the strongest ON responses

47 chromatin remodelling enzyme integrates two antagonistic calcium-dependent signalling pathways that

48 ial type VI secretion system (T6SS) mediates antagonistic cell-cell interactions between competing Gr

49 sms employed by cardiomyocytes to coordinate antagonistic cell-cycle and differentiation gene program

50 pathway, which induces pleiotropic and often antagonistic cellular responses, we identified the long

51 These interactions create antagonistic centre-surround receptive fields important

52 idant (chromanol) and prooxidant (Br-BODIPY) antagonistic chemical activities of the two-segment comp

53 CF) functions to insulate these adjacent yet antagonistic chromatin domains during embryonic stem cel

54 benefit as monotherapy, may together provide antagonistic clinical outcomes.

55 The Red Queen hypothesis posits that antagonistic co-evolution between interacting species re

56 st that, as with protein sequence evolution, antagonistic co-evolution may be key to de novo gene evo

57 Similarly, synergistic and antagonistic co-regulators modulate the DNA-bridging eff

58 The resultant antagonistic coevolution often leads to extreme adaptati

59 volution, suggesting that they may be key in antagonistic coevolution to escape host suppression.

60 proposed as a cause of perpetual intersexual antagonistic coevolution with wide-ranging evolutionary

61 f sexual conflict has contrasting effects on antagonistic coevolution: Pleiotropic constraints stabil

62 whether these cases truly represent sexually antagonistic coevolution; alternatively, ecological or n

63 teractions in bacterial communities where an antagonistic compound produced by one community member c

64 ressed by RAP2.12 overexpression, suggesting antagonistic control of auxin flux by hypoxia and ERFVII

65 a genetically defined neural circuit for the antagonistic control of emotional behaviors and memories

66 with inflammatory signaling, suggesting the antagonistic convergence of cardiac and inflammatory tra

67 Our analysis suggests global, antagonistic coregulation of splicing by the CELF and RB

68 Bifidobacteria demonstrate an antagonistic correlation with enterobacteria and enteroc

69 cterized growth-defense trade-offs stem from antagonistic crosstalk among hormones rather than an ide

70 e then address mechanisms of synergistic and antagonistic crosstalk between different CLRs and with T

71 Interestingly, during ETI, the normally antagonistic defence hormones, salicylic acid (SA) and j

72 Altogether, our data reveal the antagonistic development of nucellus and endosperm, in c

73 output neurons that project to the mutually antagonistic direct and indirect basal ganglia pathways.

74 between GA and other signaling pathways via antagonistic direct interactions with key transcription

75 ffects that differ depending on agonistic or antagonistic drug characteristics and on local 5-HT1B re

76 ther identified corresponding synergistic or antagonistic drug combinations.

77 an initial synergistic effect turned into an antagonistic effect after 4 h because of enhanced mobili

78 We postulate an antagonistic effect between SPLs and the heterogeneous M

79 This antagonistic effect diminished as the breeders grew olde

80 anner and their combination showed a similar antagonistic effect in C28/I2, L-02 and HK-2 cells.

81 We attribute this to an antagonistic effect of PVDPf-5 on the growth of PAO1, pr

82 /MIC <28, the isoniazid concentration had an antagonistic effect on culture conversion.

83 tion of both Satb1 and Satb2, owing to their antagonistic effect on the pluripotency regulator Nanog.

84 the generated 2-acetamidopyridines elicit an antagonistic effect with excellent affinity (Ki < 10 nM)

85 ptying also indicate a safe and long-lasting antagonistic effect.

86 Ergosterol (ERG) had a weak antagonistic effect.

87 1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in drug-related behaviors, and disp

88 ieve synergistic effects in therapeutics and antagonistic effects in toxicity.

89 Synergistic and antagonistic effects of binary mixtures composed of full

90 We propose that the antagonistic effects of H2A.Z and HSF1 provide a mechani

91 reactive natural products that attenuate the antagonistic effects of several synthetic and naturally

92 d reliability of predictions and potentially antagonistic effects of substitutions, only single-point

93 be constitutively active and unresponsive to antagonistic effects of the antiapoptotic BCL-2 proteins

94 Our results showed synergistic and antagonistic effects on host mortality and enzyme activi

95 cation classes for additive, synergistic, or antagonistic effects on IOP was not identified.

96 Thus, MEF8 has two antagonistic effects on mitochondrial editing: stimulato

97 taminants in polar bear adipose tissue exert antagonistic effects on PPARG, but adipogenesis by a mix

98 1, which is a TGFbeta-rheostat known to have antagonistic effects on the endothelial cell and smooth

99 Retinoic acid and 1,25D3 have antagonistic effects on the expression of effector cytok

100 properties of OxPAPC are associated with its antagonistic effects on Toll-like receptors and suppress

101 and carbon incorporation by D. magna, where antagonistic effects were observed at the lower doses, w

102 On the contrary, antagonistic effects were observed for (lutein-delta-toc

103 interactions between diffusible factors with antagonistic effects, morphogenesis is not the consequen

104 ctivity, but 12 chemicals exhibited apparent antagonistic effects.

105 lular context, RAS can exert different, even antagonistic, effects, depending on its sublocalization.

106 Furthermore, to mimic the antagonistic efficacy of endothelial-derived prostacycli

107 e-Dawley rats were used to assess dosimetry, antagonistic efficacy via blood pressure measurements, a

108 cal processes or during ozonation, agonistic/antagonistic endocrine activities, mutagenic/genotoxic a

109 the knowledge of the currently characterized antagonistic endophytic fungi and their effects on nemat

110 terestingly, miR-142-3p and PKCalpha exhibit antagonistic expression during Mphi and DC differentiati

111 ic defects affect coordinated contraction of antagonistic flexor-extensor muscles in the adult, indic

112 MQC balances antagonistic forces of fusion and fission determining mi

113 ases, cleaves IL-36Ra into its highly active antagonistic form.

114 Here, we show how antagonistic frequency-dependent selection (FDS), genera

115 We then go on to demonstrate that the antagonistic functions of different plant RelA SpoT homo

116 -function alleles for 12 genes and uncovered antagonistic functions of two new Edn1 targets, follista

117 roactive flow control devices, utilizing two antagonistic functions, hydrophobic repellency versus li

118 t yielded another outcome--the generation of antagonistic functions.

119 nhibits NF-kappaB activation among its other antagonistic functions.

120 teromer can explain previous results showing antagonistic galanin-opioid interactions and offers a ne

121 ocampal neurons; however, the identity of an antagonistic GAP remains elusive.

122 ta demonstrate the participation of HvVP1 in antagonistic gene expression programs and support its ce

123 ated manner, leading to both synergistic and antagonistic gene expression.

124 oordinating MEF2 isoform-specific control of antagonistic gene programs.

125 sult from the successive linkage of sexually antagonistic genes to sex-determining genes.

126 AIBs integrating an array of synergistic and antagonistic glutamatergic inputs, from sensory neurons

127 In mutualistic pollinators and antagonistic herbivores, past experience (learning) affe

128 onsive genes, the H2A.Z histone variant, and antagonistic histone marks.

129 rochromatic silencing due to the presence of antagonistic histone post-translational modifications, i

130 through cis regulatory elements that recruit antagonistic host RNA-binding proteins.

131 provides one such scenario, but it requires antagonistic host-parasite interactions.

132 hat dissolved phosphate and carbonate had an antagonistic impact on arsenate toxicity to cucumber.

133 reported that these receptors have mutually antagonistic impacts on autophagy, which is induced by P

134 on of PRC2 with RNA or chromatin is mutually antagonistic in cells and in vitro.

135 transcription factor osr1 have functionally antagonistic influences on kidney development.

136 ng primarily of one strain, suggestive of an antagonistic interaction among nonkin strains.

137 istance to treatment, and highlights a novel antagonistic interaction between EGFRwt and EGFRvIII in

138 We investigated the antagonistic interaction between white spruce (Picea gla

139 High CO2 and high temperature have an antagonistic interaction effect on rice yield potential

140 provide novel implications of this potential antagonistic interaction in a variety of neurological co

141 The synergistic or antagonistic interaction of psychotherapies and drugs fo

142 d differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytok

143 for expanded data storage applications, when antagonistic interactions (i.e., competing ferro- and an

144 vide insight into the mechanism by which the antagonistic interactions between ABA and BRs are coordi

145 STATEMENT We present evidence for spatially antagonistic interactions between individual, spectrally

146 o, there are reports of both synergistic and antagonistic interactions between ligand-dependent EGFRw

147 e cell function and their ability to mediate antagonistic interactions between MOR and Gal1R ligands.

148 derstanding of the nature of friendly versus antagonistic interactions between P. aeruginosa and S. a

149 We propose that antagonistic interactions between Sirt1 and Sirt7 are pi

150 Due to the antagonistic interactions between the salicylic acid (SA

151 auxin gradients, implies that the well known antagonistic interactions between the two hormone groups

152 will potentially cause both synergistic and antagonistic interactions between vaccination and the us

153 rther, this effort highlights the utility of antagonistic interactions both in high-throughput screen

154 ling connections between cellular processes, antagonistic interactions can also have tremendous value

155 cid (ABA) and brassinosteroids (BRs) exhibit antagonistic interactions during many plant development

156 nd refined olive oil-bound antioxidants, and antagonistic interactions for protein and extra virgin o

157 Results revealed antagonistic interactions for Trolox with all macromolec

158 We also tested whether antagonistic interactions with conspecifics would affect

159 gative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic a

160 rapidly and adaptively, presumably driven by antagonistic interactions with pathogens [1-4].

161 ffects) were more common than synergistic or antagonistic interactions, (iv) C:N:P stoichiometry of s

162 e duplication provides a potential source of antagonistic interactions, an important component of gen

163 In antagonistic interactions, faster evolution by any means

164 properties, antibiotic susceptibilities, and antagonistic interactions.

165 Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by

166 Thus, our observations reveal an unexpected antagonistic interplay between two repressive pathways i

167 ng factor RBM5 regulates the balance between antagonistic isoforms of the apoptosis-control genes FAS

168 Min proteins and FtsZ-mts in droplets yields antagonistic localization, thus demonstrating that dropl

169 studies reveal that SHW1 and HY5 work in an antagonistic manner to regulate photomorphogenic growth.

170 L control the expression of some genes in an antagonistic manner.

171 in single-molecule trajectories suggests an antagonistic mechanism between HsRAD51 binding and rewra

172 Antagonistic microorganisms produce antimicrobials to in

173 erythropoietin and a series of agonistic or antagonistic mimetic peptides free in solution.

174 h fenarimol, testosterone, and ecdysone were antagonistic, mixtures of juvenoids showed additive effe

175 inding protein downstream regulatory element antagonistic modulator (DREAM) binds to regulatory eleme

176 Antagonistic modules also regulate the responses of deet

177 space and nutrients as well as by secreting antagonistic molecules and triggering local inflammatory

178 rapeutical approaches are emerging including antagonistic monoclonal antibodies and agonistic fusion

179 common tremor input is always shared by the antagonistic motoneuron pools, in agreement with the sim

180 Myosin V and VI are antagonistic motors that cohabit membrane vesicles in ce

181 Resistance from antagonistic muscle groups might be a crucial factor red

182 utant mice exhibit aberrant co-activation of antagonistic muscle pairs and skilled grasping deficits

183 postnatal reorganization of CS circuitry for antagonistic muscle pairs.

184 dings were obtained from electromyography on antagonistic muscles (right flexor digitorum and extenso

185 e expression for proprioceptors that control antagonistic muscles at a single hindlimb joint.

186 e as avoiding inappropriate co-excitation of antagonistic muscles?

187 Synergistic and antagonistic mutation responses of human MCL-5 cells to

188 The antagonistic nature of the different mechanisms of HDT o

189 Particularly, little is understood about how antagonistic (negative) and mutualistic (positive) inter

190 uggest that sex determination operates as an antagonistic network with the emergent property of bista

191 n changes the activity of these functionally antagonistic neurons in opposite ways, increasing the ac

192 oximately 70.0%) relative to synergistic and antagonistic ones.

193 oevolutionary change in response to sexually antagonistic or congruent selection.

194 der balancing selection from either sexually antagonistic or spatially varying selection.

195 bination in order to evaluate their possible antagonistic or synergic effect on predicted glycaemic r

196 ps encompass different lifestyles, including antagonistic (or pathogenic, the most well-studied lifes

197 uman gonad commit to one of the two mutually antagonistic organogenetic fates, the testis or the ovar

198 d proliferation are usually considered to be antagonistic partners in development.

199 Pr4 and Endochitinase A also trigger the antagonistic pathogen defense pathway in maize and suppr

200 d behaviors by coordinated activation of two antagonistic pathways.

201 an neutrophils via VLA-3 was inhibited by an antagonistic peptide (LXY2).

202 Finally, selective cytokine blockade with antagonistic peptides might be applicable to multiple ot

203 and peroxidase activities should be mutually antagonistic, peroxidatic electron donors (PxEDs) enhanc

204 d expiration simply prevents activity in the antagonistic phase, we instead propose a model whereby i

205 Superconductivity and ferromagnetism are two antagonistic phenomena that combined can lead to a rich

206 Chk2(Cds1) then expels the Cdk1-cyclin B antagonistic phosphatase Flp1/Clp1 from the SPB.

207 The antagonistic pleiotropic characteristics of ARF as both

208 Both antagonistic pleiotropy and genetic variation in the rat

209 that may arise naturally in situations with antagonistic pleiotropy and seasonal changes in the rela

210 e-causing alleles could be identified, or if antagonistic pleiotropy could be broken, the effects of

211 We show that the trade-off is mediated by antagonistic pleiotropy through mutations that affect ne

212 hus, ANK3/unc-44 may represent an example of antagonistic pleiotropy, in which low-expression level i

213 to specific instances of both agonistic and antagonistic pleiotropy.

214 t both alleles are maintained as a result of antagonistic pleiotropy.

215 Wip1) responsible for oscillations, and two antagonistic positive feedback loops (regulated by phosp

216 ytis cinerea BOT genes, although their total antagonistic potential against phytopathogenic fungi was

217 the extent to which birds and ants engage in antagonistic predator-predator interactions and the cons

218 Strict regulation of the antagonistic processes of adhesion and motility, mediate

219 MRTFs for SRF determines the balance between antagonistic proliferative and contractile programs of g

220 e molecule that is suitable to measure these antagonistic properties of DOM.

221 ncarb, and tolylfluanid showed remarkable GR antagonistic properties with RIC20 values lower than 10(

222 set hypertension, finerenone displays strict antagonistic properties.

223 s how evolutionarily divergent and seemingly antagonistic proteins cooperate to protect and chaperone

224 is controlled by a system of three mutually antagonistic proteins, MinC, MinD, and MinE.

225 in the presence or absence of two viral IFN antagonistic proteins.

226 tients with SAR, healthy subjects exhibit an antagonistic proteomic response across seasons, which mi

227 Our results suggest that greater antagonistic push-pull interaction between synchronizing

228 these hypotheses are predicated on mutually antagonistic Rac-Rho signaling, Rac-mediated protrusion

229 wever, the effect of NusA in this context is antagonistic rather than stimulatory.

230 he effects of local and global stressors are antagonistic, rather than synergistic as widely assumed.

231 quantum dots in a living plant via a mutual antagonistic reaction.

232 How cells integrate antagonistic receptor signaling events is enigmatic.

233 ap transition of tooth morphogenesis through antagonistic regulation of expression of secreted Wnt an

234 arget PD to aid infection, which would infer antagonistic regulation of PD by host and pathogen.

235 of LRL genes accompanied the evolution of an antagonistic regulatory element controlling root hair de

236 nflammatory responses through synergistic or antagonistic (regulatory) interactions.

237 Our findings revealed an antagonistic relationship between Atg9 and TOR signaling

238 s are the first to demonstrate a dynamic and antagonistic relationship between different filamin isof

239 Previously, we reported an antagonistic relationship between Streptococcus cristatu

240 of the Dicer-like proteins that indicate an antagonistic relationship between the Dicer-like protein

241 This mutually antagonistic relationship between the HSR and immune act

242 Our results reveal the antagonistic relationship of HPF and HflX and uncover th

243 Our findings define an antagonistic relationship of miR-214 and miR-148b in det

244 ria determines their cooperative rather than antagonistic relationship.

245 aeruginosa have a bidirectional and largely antagonistic relationship.

246 Although antagonistic relationships are thought to lead to coevol

247 is was employed to elucidate synergistic and antagonistic relationships between Microcystis and other

248 cascade theory, which is based primarily on antagonistic relationships.

249 ignificant shift from increased intensity to antagonistic responses, respectively.

250 y increased, and that expression of the RhoA antagonistic Rnd proteins known to activate p190RhoGAP i

251 We further discovered an antagonistic role for Ror2 in regulating canonical Wnt/b

252 his study, we show that yeast Dpb11 plays an antagonistic role in recombination control through regul

253 We further identify critical antagonistic roles for Brahma-related gene 1 (Brg1), a c

254 pletion, indicating that NatA and Naa50 play antagonistic roles in cohesion.

255 analysis revealed that DET1 and DELLAs play antagonistic roles in regulating expression of photosynt

256 3 deubiquitylase and that Asr1 and Ubp3 play antagonistic roles in setting transcription levels from

257 In addition, we identified the crucial antagonistic roles of circRNA_100338 and miR-141-3p in t

258 We propose that antagonistic roles of Nbr and Hen1 define a mechanism to

259 ) models and with deviations for synergistic/antagonistic (S/A), dose-level (DL), and dose-ratio (DR)

260 n of sex chromosomes has focused on sexually antagonistic selection among diploids, which has been sh

261 opulations with differing levels of sexually antagonistic selection for colour, we also show that sex

262 nstance by altering the strength of sexually antagonistic selection.

263 expected for genes that experience sexually antagonistic selection.

264 this Notch-dependence is established through antagonistic signaling by the pre-TCR/Notch effector, ph

265 iA and reciprocal regulation of the mutually antagonistic signaling proteins, SasA and CikA.

266 nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after e

267 This process is regulated by mutually antagonistic signals: Notch signalling and Lmx1a.

268 Here, we report an antagonistic singularity at T(c) in the spectral weight

269 ing mechanisms allowing both cooperative and antagonistic social coordination.

270 All the results demonstrate that two antagonistic soil properties controlled Ce uptake.

271 has been prepared that supports a variety of antagonistic solid state interactions alongside a distin

272 kingly, we observed profound synergistic and antagonistic solubilization patterns for the coformulati

273 Differential splicing generates antagonistic soluble IL-23R (sIL-23R) variants, which mi

274 Antagonistic spectrum of the polyphenols extracted showe

275 oprotective transcriptome profile, while the antagonistic stimulation of alpha7nAChR will achieve the

276 sk positioning evolutionary psychology as an antagonistic subdisciplinary enterprise.

277 In addition, the antagonistic surround strength and size was reduced in O

278 ateral inhibition, which imparts a spatially antagonistic surround to individual cone receptive field

279 Faster evolution is thought to be favored in antagonistic symbioses (the "Red Queen effect"), but dis

280 In antagonistic symbioses, such as host-parasite interactio

281 "essential medicine" eflornithine, which is antagonistic to another anti-HAT drug, suramin.

282 erefore, these root tropic responses must be antagonistic to gravitropism.

283 anded to signalling from plants to organisms antagonistic to pests, and to plant stress-induced, or p

284 emarkably, the rod signal in this circuit is antagonistic to that from cones.

285 d differentiation gene programs by MEF2C was antagonistic to that of MEF2A and -D.

286 ternal allele of the ICR may be a suppressor antagonistic to the active paternal allele of the ICR, s

287 , transfected synthetic RNA oligonucleotides antagonistic to the miRNA candidate significantly enhanc

288 ted heart failure hospitalization may not be antagonistic to the short-term goal of decongestion.

289 We describe two antagonistic TORC1-activating and -inhibiting activities

290 ed to population variation in the key female antagonistic trait (spine length, a defence against male

291 l coevolution in the correlated evolution of antagonistic traits among populations of Gerris incognit

292 rvations of correlated evolution in sexually antagonistic traits among populations.

293 ess, population covariation between sexually antagonistic traits remained substantial and significant

294 rsex genetic correlations for these sexually antagonistic traits.

295 astic switches of randomly fluctuating cross-antagonistic transcription factors.

296 However, this antagonistic view creates complications for our understa

297 Superinfection exclusion (SIE) is an antagonistic virus-virus interaction that prevents secon

298 Superinfection exclusion (SIE) is an antagonistic virus-virus interaction whereby initial inf

299 ass-bivalve interactions from mutualistic to antagonistic, which is important for conservation manage

300 Redundant activities of antagonistic Wnt signals, a temporal control pathway, an