ライフサイエンスコーパス: anterior pituitary

1 but not in AtT-20 cells (derived from mouse anterior pituitary).

2 um and Rathke's pouch - the precursor of the anterior pituitary.

3 stimulating hormone (TSH) secretion from the anterior pituitary.

4 pressed primarily in the gonadotropes of the anterior pituitary.

5 ndant role in postnatal proliferation of the anterior pituitary.

6 nd subfornical organ (SFO), but unchanged in anterior pituitary.

7 lastic lesions of the pituitary occur in the anterior pituitary.

8 1 lineage within the ventral and caudomedial anterior pituitary.

9 lineage expansion and differentiation in the anterior pituitary.

10 fected cells and their colocalization in the anterior pituitary.

11 everal organs, including the lung, limb, and anterior pituitary.

12 parathyroid glands, endocrine pancreas, and anterior pituitary.

13 d progression in many tissues, including the anterior pituitary.

14 onstrated in abundance in choroid plexus and anterior pituitary.

15 in somatotropes and lactosomatotropes of the anterior pituitary.

16 omatotrope and lactosomatotrope cells of the anterior pituitary.

17 and potentiates the release of ACTH from the anterior pituitary.

18 enteropancreatic endocrine tissues, and the anterior pituitary.

19 one (CRH) to stimulate ACTH release from the anterior pituitary.

20 d responsiveness of one dominant side of the anterior pituitary.

21 the pituitary and in scattered cells of the anterior pituitary.

22 vailable to produce all cell lineages of the anterior pituitary.

23 stimulating the HPA axis at the level of the anterior pituitary.

24 alized capillary network for delivery to the anterior pituitary.

25 mors of the parathyroid, enteropancreas, and anterior pituitary.

26 arising from the ACTH-secreting cells in the anterior pituitary.

27 , inferring rapid feedback inhibition at the anterior pituitary.

28 esulting in the loss of mature miRNAs in the anterior pituitary.

29 for regulating gonadotropin release from the anterior pituitary.

30 otropes, lactotropes, and thyrotropes of the anterior pituitary.

31 intermediate pituitary and with ACTH in the anterior pituitary.

32 mones in vitro, adenosine was incubated with anterior pituitaries.

33 In GalTase-null mice, the anterior pituitary acquired a normal secretory phenotype

34 nd/or CRH-R1 gene expression observed in the anterior pituitary after chronic 'binge' cocaine.

35 which have macrophage-type functions in the anterior pituitary, also expressed Gal-3.

36 is initiated by hypothalamic control of the anterior pituitary and adrenal cortex.

37 lays a key role in the central regulation of anterior pituitary and appetitive functions.

38 ases DNA damage locally in the forebrain and anterior pituitary and causes tissue attrition and other

39 These findings suggest sensitization of the anterior pituitary and counterregulative adaptation of t

40 prolactin secreting cell type) in the rodent anterior pituitary and in the median eminence and parave

41 opment, Hlf expression was restricted to the anterior pituitary and meninges.

42 hypophyseal placode, the source of endocrine anterior pituitary and neurosecretory hypothalamic cells

43 hyroids, gastro-intestinal endocrine tissue, anterior pituitary and other tissues.

44 In anterior pituitary and pancreatic beta cell lines, howev

45 ular localization of this receptor in normal anterior pituitary and pituitary adenomas, GHRH-R mRNA w

46 retinal axon guidance, yot mutations disrupt anterior pituitary and ventral forebrain differentiation

47 ells in the perilumenal region of the mature anterior pituitary and, using genetic inducible fate map

48 ids, enteropancreatic neuroendocrine system, anterior pituitary, and other tissues.

49 minant disorder that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrin

50 erited syndrome that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrin

51 evel comparable with the level of PC1 in the anterior pituitary, and pro-NPY processing was markedly

52 While cell specification in the anterior pituitary appears normal, patterning in the ven

53 cretory granules, the endocrine cells of the anterior pituitary are highly specialized for the produc

54 al arcuate nucleus and AT1B receptors in the anterior pituitary are regulated inversely by estrogen/p

55 er ear, the cranial sensory ganglia, and the anterior pituitary arise from a common pool of progenito

56 e propose that IL-1ra may be secreted by the anterior pituitary as a systemic anti-inflammatory hormo

57 known as GAP-43, F1, B-50, and p57) in mouse anterior pituitary AtT-20 cells enhances depolarization-

58 43 in evoked secretion, we transfected mouse anterior pituitary AtT-20 cells with the rat GAP-43 cDNA

59 traumatic brain injury in whom at least one anterior pituitary axis was assessed.

60 adrenocorticotropic hormone (ACTH) from the anterior pituitary both in vitro and in vivo, suggesting

61 les in regulating hormone secretion from the anterior pituitary, but it also provides strong inputs t

62 titutive expression of Prop1 interferes with anterior pituitary cell differentiation and increases th

63 d in the regulation of normal and neoplastic anterior pituitary cell function.

64 ux through L- and T-type Ca2+ channels in an anterior pituitary cell line (GH3, up to 500 nM); and Ba

65 This study demonstrates that rodent anterior pituitary cell lines produce extracellular aden

66 l-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification.

67 The differentiation of three anterior pituitary cell types is regulated by the tissue

68 cification and complete failure of all other anterior pituitary cell types to differentiate.

69 abnormalities of two ventral and one dorsal anterior pituitary cell types, presumably on the basis o

70 fferent adipokines on the functioning of all anterior-pituitary cell-types.

71 inase C (PKC) was investigated in clonal rat anterior pituitary cells (GH4C1), which were voltage cla

72 association with secretory granules of human anterior pituitary cells and human pituitary tumors.

73 sin XVA was expressed in all types of normal anterior pituitary cells and pituitary tumors and in oth

74 HD protein Pit-1 control the development of anterior pituitary cells and regulate the expression of

75 sfected muscle cells to cultured pig primary anterior pituitary cells elicits GH release.

76 Anterior pituitary cells express gamma-aminobutyric acid

77 Anterior pituitary cells express nucleotide-gated G prot

78 Pro-opiomelanocortin anterior pituitary cells express significant growth horm

79 Anterior pituitary cells fire action potentials and rele

80 isms that control the emergence of different anterior pituitary cells from a common stem cell populat

81 we addressed these questions using cultured anterior pituitary cells from postpubertal female rats a

82 ctifying K+ current (IK(IR)) in cultured rat anterior pituitary cells highly enriched in corticotrope

83 sitive Ca2+ currents when expressed in AtT20 anterior pituitary cells in culture.

84 e release from the LbetaT2 cell line and rat anterior pituitary cells in primary culture in a concent

85 sf-CD is produced by primary rat anterior pituitary cells in response to secretogogue, su

86 novel hypothesis that a critical subgroup of anterior pituitary cells might function as glucose senso

87 expression is activated specifically in the anterior pituitary cells that express the genes for thyr

88 /adrenocorticotropin and growth hormone from anterior pituitary cells were investigated in Cpefat mic

89 immunocytochemistry in approximately 20% of anterior pituitary cells, and some of these cells coloca

90 th hormone (GH) from primary cultures of rat anterior pituitary cells, as well as by their binding af

91 he ubiquitin/proteasome pathway is active in anterior pituitary cells, that this pathway targets both

92 d that it is expressed in a subpopulation of anterior pituitary cells, the gonadotropes.

93 Isolated as a product of murine anterior pituitary cells, this peptide was sequenced and

94 Gi-coupled P2Y12R, were identified in mixed anterior pituitary cells.

95 n specification and expansion of specialized anterior pituitary cells.

96 TC) (10(-10)-10(-7) M) to a subpopulation of anterior pituitary cells.

97 Myosin XVA is also highly expressed in human anterior pituitary cells.

98 le-stimulating hormone secretion by cultured anterior pituitary cells.

99 0 and causes the secretion of prolactin from anterior pituitary cells.

100 cellular Ca(2+) in the control of sGC in rat anterior pituitary cells.

101 ity to stimulate cAMP production in cultured anterior pituitary cells.

102 crine role of PACAP in normal and neoplastic anterior pituitary cells.

103 cells, it is readily detected in primary rat anterior pituitary cells.

104 93T cells and ACTH release from cultured rat anterior pituitary cells.

105 are known to control hormone secretion from anterior pituitary cells.

106 ) exclusively in normal ACTH-secreting human anterior pituitary cells: PPAR-gamma was abundantly expr

107 The exon was found in RNA from pancreas, anterior pituitary, cerebellum, and hippocampus.

108 -Fos expression in gastrointestinal tissues, anterior pituitary, cerebellum, and hippocampus.

109 atic CRFR1 oppose the activation of CRFR1 on anterior pituitary corticotropes, leading to the release

110 Anterior pituitary corticotroph cells are a central comp

111 Anterior pituitary corticotroph cells are a central comp

112 as investigated in AtT20 D16:16 clonal mouse anterior pituitary corticotroph cells.

113 The anterior pituitary corticotroph is a major control point

114 hanced secretagogue-induced ACTH output from anterior pituitary corticotrophs and may also involve in

115 y of D2 expression in the thyrotrophs of the anterior pituitary coupled with the requirement for loca

116 In anterior pituitary, CRF-BP immunoreactivity (ir) was det

117 ssed in corticotrope tumor cells and primary anterior pituitary cultures, the same virally encoded pr

118 In male rats, blockade of anterior pituitary DA receptors with haloperidol (1 mg/k

119 Anterior pituitary deficits are common after CRT.

120 of CPD was examined in AtT-20 cells, a mouse anterior pituitary-derived corticotroph.

121 ing circumstantial evidence that one or more anterior pituitary-derived products, or factors induced

122 The secrets of anterior pituitary development and cell lineage determin

123 Here we show that ZBTB20 is essential for anterior pituitary development and lactotrope specificat

124 s point to ZBTB20 as a critical regulator of anterior pituitary development and lactotrope specificat

125 demonstrates that microRNAs are critical for anterior pituitary development and that miR-26b regulate

126 system that reproduces the earliest steps of anterior pituitary development.

127 ke's pouch, the epithelial primordium of the anterior pituitary, differentiates in close topographica

128 ouse embryos is also an efficient inducer of anterior pituitary differentiation in chick embryonic la

129 accessibility by IGFBP-5 may play a role in anterior pituitary differentiation, survival, and/or pro

130 1%; 27 studies) of patients had at least one anterior pituitary disorder.

131 umatic brain injury patients have persistent anterior pituitary disorder.

132 are warranted to better define the burden of anterior pituitary disorders and to identify high-risk p

133 Anterior pituitary disorders were associated with a tren

134 injury severity, and skull fractures predict anterior pituitary disorders, which in turn may be assoc

135 3; 95% CI, 1.03-2.91; six studies) predicted anterior pituitary disorders.

136 but only 1 of 39 (2.6%) nbTBI controls, had anterior pituitary dysfunction (p = 0.004).

137 We reveal a high prevalence of anterior pituitary dysfunction in soldiers suffering mod

138 icking of three membrane proteins in primary anterior pituitary endocrine cells.

139 Over 35% of the PAM-1 in anterior pituitary extracts aggregates at pH 5.5, wherea

140 um) whose primary features include defective anterior pituitary formation and pan-hypopituitarism, wi

141 entiated loci that play a role in growth and anterior pituitary function and are associated with heig

142 Irs1-/- female mice also displayed normal anterior pituitary function, distinguishing them from lo

143 ing nursing, oxytocin has been implicated in anterior pituitary function, paracrine effects in the te

144 abundant in hypothalamic nuclei controlling anterior pituitary function.

145 hat participate in neuroendocrine control of anterior pituitary function.

146 at it is an important paracrine regulator of anterior pituitary function.

147 The neurosecretory anterior pituitary GH(4)C(1) cells exhibit the high volt

148 a permeabilized cell system derived from rat anterior pituitary GH3 cells expressing prosomatostatin

149 Rat anterior pituitary GH3 cells, which secrete growth hormo

150 tion and growth in vivo and/or interact with anterior pituitary GHRH receptors in vitro.

151 The anterior pituitary gland (adenohypophysis) comprises ant

152 je cell layer of the cerebellum, and rostral anterior pituitary gland (location of corticotropes).

153 le speculation that hormones produced in the anterior pituitary gland act as positive regulators of p

154 sociated with a pronounced hypoplasia of the anterior pituitary gland and a marked decrease in pituit

155 ion of secretory granule content proteins of anterior pituitary gland and adrenal medulla.

156 imb, as well as expression in the developing anterior pituitary gland and first branchial arch.

157 recursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.

158 prolactin (PRL)-producing lactotroph of the anterior pituitary gland and induce development of PRL-p

159 Adenosine has been identified in the anterior pituitary gland and is secreted from cultured f

160 e puerperium is usually due to tumors in the anterior pituitary gland and occurs occasionally in here

161 RL) is a polypeptide hormone produced by the anterior pituitary gland and other sites that acts both

162 ells of GnRH include the gonadotropes of the anterior pituitary gland and the cells of various hormon

163 ons of corticotropin-releasing factor in the anterior pituitary gland and the central nervous system.

164 he determination and proliferation events of anterior pituitary gland and tooth organogenesis.

165 Subsequently, the anterior pituitary gland appears bifurcated, dysmorphic

166 Prodynorphin (ProDYN) in the anterior pituitary gland appears to be processed differe

167 ary somatotrophs and other cell types of the anterior pituitary gland are not well understood at pres

168 Low levels were also detected in the anterior pituitary gland by radioimmunoassay.

169 uggest that adenosine, formed locally in the anterior pituitary gland can stimulate gap junction comm

170 of the homeobox genes Rpx, Lhx3 and Pit1 for anterior pituitary gland development.

171 station in the rat, prolactin (PRL) from the anterior pituitary gland exerts its luteotropic function

172 have demonstrated it to be released from the anterior pituitary gland in vivo.

173 The anterior pituitary gland integrates the repertoire of ho

174 The mammalian anterior pituitary gland is a compound endocrine organ t

175 hibit significantly reduced body weights and anterior pituitary gland sizes.

176 olactin is a peptide hormone produced by the anterior pituitary gland that is critical in lactation.

177 otently stimulate the release of GH from the anterior pituitary gland through the activation of a nov

178 ufficiency is indicative of a failure of the anterior pituitary gland to stimulate the target endocri

179 nistically unique, actions also occur in the anterior pituitary gland where both peptides inhibit adr

180 that are required for the development of the anterior pituitary gland, are the predominant cause of M

181 NAs for four FPR family members in the mouse anterior pituitary gland, Fpr-rs1, Fpr-rs2, Fpr-rs6, and

182 Released by various immune cells and by the anterior pituitary gland, MIF plays a critical role in t

183 also has been shown to be secreted from the anterior pituitary gland, monocytes/macrophages, and T c

184 Within the anterior pituitary gland, RXRgamma expression is limited

185 oxide (NO) release from the hypothalamus and anterior pituitary gland, we hypothesized that it also m

186 on and Rathke's pouch, the progenitor of the anterior pituitary gland.

187 r essential for development of the mammalian anterior pituitary gland.

188 ssion, including brain, skeletal muscle, and anterior pituitary gland.

189 nction of the hormone-producing cells of the anterior pituitary gland.

190 teropancreatic neuroendocrine cells, and the anterior pituitary gland.

191 t have severe defects of the limbs, lung and anterior pituitary gland.

192 nactivating a loxP-modified SF1 locus in the anterior pituitary gland.

193 on that includes the thyrotrope cells of the anterior pituitary gland.

194 ted to Rathke's pouch, the primordium of the anterior pituitary gland.

195 ely express elevated levels of CRH-BP in the anterior pituitary gland.

196 egulated growth hormone release from the rat anterior pituitary gland.

197 t analyses to be present specifically in the anterior pituitary gland.

198 ch is limited to the thyrotrope cells of the anterior pituitary gland.

199 occur primarily centrally rather than at the anterior pituitary gland.

200 e with targeted ablation of Jnk genes in the anterior pituitary gland.

201 y inhibiting gonadotropin secretion from the anterior pituitary gland.

202 e during cell specification and in the adult anterior pituitary gland.

203 pouch cells, resulting in a greatly enlarged anterior pituitary gland.

204 In alphaT3-1 mouse anterior pituitary gonadotropes, chronic activation of g

205 2+] were determined simultaneously in single anterior pituitary gonadotrophs from ovariectomized fema

206 and it has significant extrinsic effects on anterior pituitary growth.

207 Incubation of anterior pituitary halves from adult male rats with grad

208 The anterior pituitary harbours five distinct hormone-produc

209 The pars tuberalis (PT) region of the anterior pituitary has emerged as a principal melatonin

210 etions by releasing substances which control anterior pituitary hormonal release into the portal bloo

211 underlie complex diseases featuring combined anterior pituitary hormone deficiency and, in specific c

212 t for terminal oligosaccharide sequences for anterior pituitary hormone function.

213 The anterior pituitary hormone prolactin exerts important ph

214 a, a complement-derived cytokine, stimulates anterior pituitary hormone release and activates the hyp

215 nduced changes in hypothalamic regulation of anterior pituitary hormone release, including the declin

216 action in inflammation and in the control of anterior pituitary hormone release.

217 All the men had otherwise normal anterior pituitary hormone secretion and sellar anatomy.

218 us and brainstem unrelated to the control of anterior pituitary hormone secretion.

219 tions to the median eminence for controlling anterior pituitary hormone secretion.

220 We have shown that the anterior pituitary hormone, thyroid-stimulating hormone

221 ary gland formation and specification of the anterior pituitary hormone-secreting cell types.

222 Anterior pituitary hormones are required for development

223 eptide (PACAP) stimulates release of several anterior pituitary hormones by interacting with PACAP re

224 (CPHD) have insufficient levels of multiple anterior pituitary hormones causing short stature, metab

225 Snell dwarf (dw/dw) mice are deficient in anterior pituitary hormones due to a mutation in the gen

226 ne human chorionic gonadotropin (CG) and the anterior pituitary hormones follitropin, lutropin, and t

227 whether adenosine controls the secretion of anterior pituitary hormones in vitro, adenosine was incu

228 e suggested that incomplete glycosylation of anterior pituitary hormones leads to the creation of hor

229 y stimulated (15-31%, P < 0.05), while other anterior pituitary hormones were not altered by these cy

230 is characterized by an increased release of anterior pituitary hormones, whereas altered target-orga

231 ha than adenomas that stained positively for anterior pituitary hormones.

232 rmone (GH) and one or more of the other five anterior pituitary hormones.

233 ult in compromised production of one or more anterior pituitary hormones.

234 good model to study the rapid development of anterior pituitary hyperplasia, and 2) various proteins

235 essive mutation (df) resulting in a profound anterior pituitary hypocellularity due to a general lack

236 dditional phenotype of hypopituitarism, with anterior pituitary hypoplasia and hypogonadotropic hypog

237 Lhx4 and Prop1 mutants exhibit severe anterior pituitary hypoplasia resulting from limited dif

238 DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inabilit

239 Disruption of Zbtb20 leads to anterior pituitary hypoplasia, hypopituitary dwarfism an

240 ectly inhibits gonadotropin release from the anterior pituitary in birds.

241 d ectoderm, suggesting that the mechanism of anterior pituitary induction is conserved between mammal

242 are fertile, increased FSH production by the anterior pituitary is also unlikely to contribute to the

243 Its release from the anterior pituitary is generally under tonic inhibition b

244 ill, much later, form Rathke's pouch and the anterior pituitary, is independently specified by anteri

245 In the developing anterior pituitary, it is expressed in all regions from

246 The expression of thyrostimulin in the anterior pituitary known to express TSH receptors sugges

247 this study, we demonstrate that although rat anterior pituitary lactotrophs, somatotrophs, and gonado

248 replication in the GH-producing cells in the anterior pituitary leading to decreased synthesis of GH

249 In the anterior pituitary, levels of both proopiomelanocortin (

250 ight (57-65% of wild type [WT]), and intense anterior pituitary LIF immunoreactivity.

251 domain transcription factor, specifies three anterior pituitary lineages; governs growth hormone, pro

252 Pact(-/-) mice exhibited anterior pituitary lobe (AL) hypoplasia, which developed

253 X2-ir was observed in scattered cells of the anterior pituitary, neurons in the hypothalamic arcuate

254 halamic explants and FSH and LH release from anterior pituitaries of adult male rats in vitro and rel

255 After a preincubation period, hemi-anterior pituitaries of adult male rats were incubated w

256 In contrast, anterior pituitaries of Cdk4-null mice at postnatal 8 we

257 The anterior pituitary of fertile mice lacking Ink4c or infe

258 However, while Tef is expressed in the anterior pituitary of the adult mouse, Hlf was detected

259 h PAM in neurons but is not expressed in the anterior pituitary or AtT-20 corticotrope cells.

260 Integral membrane PAM-1 solubilized from rat anterior pituitary or from transfected AtT-20 cells aggr

261 i.e., parathyroid cells, neural cells in the anterior pituitary or hippocampus, and keratinocytes.

262 mRNA in the hypothalamus, but not in normal anterior pituitary or in pituitary adenomas, and the dif

263 ency of one or more hormones produced by the anterior pituitary or released from the posterior pituit

264 ipheral organs, including the uterus and the anterior pituitary, or the proliferation of MCF-7a breas

265 PROP1 function is essential for anterior pituitary organogenesis, and heritable mutation

266 Within the channels expressed in anterior pituitary (P2X2R, P2X3R, P2X4R, and P2X7R), the

267 stantial alterations within the hypothalamic-anterior pituitary-peripheral hormonal axes that are pro

268 We demonstrate that initial formation of the anterior pituitary placode is independent of Notch signa

269 of differences in gene expression between an anterior pituitary precursor cell line, alphaT1-1, and a

270 paraventricular nucleus (pPVN) and increased anterior pituitary pro-opiomelanocortin mRNA expression

271 To develop a model of anterior pituitary proliferation to study the pathogenes

272 ormone (CRH), arginine vasopressin (AVP) and anterior pituitary proopiomelanocortin (POMC) mRNAs and

273 The anterior pituitary regulates the function of multiple or

274 and blunts the ability of stress to increase anterior pituitary release of adrenocorticotropic hormon

275 The anterior pituitary releases six different hormones that

276 dividual hormone-secreting cell types in the anterior pituitary requires a series of sequential cell

277 JP17 rats had a reduced growth rate, lower anterior pituitary rGH contents, and a reduced amplitude

278 I levels low and IGFBP-5 concentrated in the anterior pituitary rostral tip.

279 We further demonstrate that the small anterior pituitary size reflects loss of neurofibromin e

280 lates growth hormone (GH) gene expression in anterior pituitary somatotrophs by binding to the GHRH r

281 ibits the release of growth hormone from the anterior pituitary (somatotropin release inhibitory fact

282 High level, anterior pituitary-specific expression of the rat growth

283 ved peptides may function differently in the anterior pituitary than in the brain.

284 attributed to loss of ATRX in the embryonic anterior pituitary that resulted in low circulating leve

285 ars in late-responding tissues including the anterior pituitary, the intestine, and the tail where ce

286 n of Rathke's pouch, which gives rise to the anterior pituitary, the organ responsible for the produc

287 monstrate that in contrast to the cortex and anterior pituitary, there is a persistent increase in ty

288 hibit the evoked release of ACTH from rodent anterior pituitary tissue in vitro.

289 mally in pituitary development, into typical anterior pituitary tissue.

290 dependent K+ (I(K)) and Ca++ currents in rat anterior pituitary tumor (GH3) cells were analyzed by us

291 lays a critical role in TRH signaling in the anterior pituitary via both Pit-1-dependent and -indepen

292 In contrast, in the anterior pituitary, we found limited IL-1beta gene expre

293 hyrotropin-releasing hormone receptor in the anterior pituitary, we generated phosphosite-specific po

294 the roles of ProDYN-derived peptides in the anterior pituitary, we have determined the nucleotide (n

295 ors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single in

296 Conversely, in the anterior pituitary, where local or circulating Ang II st

297 ay of stressors induce ACTH release from the anterior pituitary, with consequent stimulation of the a

298 on of p55(PIK) was limited to cerebellum and anterior pituitary, with moderate levels of p55(PIK) in

299 In anterior pituitary, ZBTB20 is highly expressed by all th