ライフサイエンスコーパス: anterograde

1 on MTL structures, except to the extent that anterograde amnesia affects performance.

2 immunotherapy but may be left with permanent anterograde amnesia.

3 I, R, RT, RTp, and STGr using retrograde and anterograde anatomical tracers.

4 Since early prion spread is anterograde and endosome-lysosomal movement within axons

5 such distribution is associated with reduced anterograde and increased retrograde transport of axonal

6 ane affinity, the ability to undergo dynamic anterograde and internalization cycles appear to determi

7 Of interest, anterograde and retrograde axonal transport appear to be

8 ly, MB's effects bolster the conclusion that anterograde and retrograde axonal transport are not nece

9 irus particles in primary neurons to measure anterograde and retrograde axonal transport, demonstrati

10 nd imaging (SPAIM) to show that DCVs undergo anterograde and retrograde capture as they circulate thr

11 ytOx) modules in visual area V2, we injected anterograde and retrograde cholera toxin subunit B (CTb)

12 m a thoracic inflammatory process results in anterograde and retrograde degeneration of axons, leadin

13 idly transported along linear tracks in both anterograde and retrograde directions.

14 All ALS-FUS variants impaired anterograde and retrograde FAT in squid axoplasm, wherea

15 on of an actin-dependent retrograde flow and anterograde and retrograde microtubule-dependent transpo

16 activities in vivo, and they uncovered that anterograde and retrograde sorting paths may serve discr

17 test this hypothesis, we performed bilateral anterograde and retrograde tectal tracing combined with

18 To address this issue, anterograde and retrograde tracers were placed, respecti

19 In cases in which anterograde and retrograde tracers were placed, respecti

20 In other experiments, anterograde and retrograde tracers were separately injec

21 l magnetic resonance imaging screen, we used anterograde and retrograde tracers, optogenetic and DREA

22 established by simultaneous co-injection of anterograde and retrograde tracers.

23 Postmortem anterograde and retrograde tracing combined with immunof

24 Anterograde and retrograde tracing experiments revealed

25 Anterograde and retrograde tracing identified the cortic

26 rtical connections as the claustrum, we used anterograde and retrograde tracing techniques to elucida

27 edial, and ventromedial) by a combination of anterograde and retrograde tracing.

28 ave used viral, transgenic, and conventional anterograde and retrograde tract-tracing methods to bett

29 ance in sensory neurons between the rates of anterograde and retrograde trafficking of cargo destined

30 microfluidic neuronal cultures suggest both anterograde and retrograde trans-synaptic spreading of T

31 control and regulation must exist for proper anterograde and retrograde transport of vital proteins,

32 arry cargo via kinesin and dynein motors for anterograde and retrograde transport, respectively.

33 e through Drosophila motoneuron terminals by anterograde and retrograde transport.

34 The anterograde and retrograde tubular carriers are both lar

35 phila neurons, which in turn influences both anterograde and retrograde vesicle transport.

36 de AP conduction in 6 patients and transient anterograde AP conduction in 8 patients.

37 eview we summarize the literature supporting anterograde (axon to cell) spread of viral infection, de

38 Anterograde axonal tracing from the septum revealed exte

39 vous system to body surfaces, referred to as anterograde axonal trafficking.

40 umber in these terminals occurs with similar anterograde axonal transport and DCV half-lives.

41 ic chamber system showed both a reduction in anterograde axonal transport and spread from axons to no

42 ore, the basic domain of pUS9 contributes to anterograde axonal transport and spread of HSV-1 from ne

43 in pUS9 has been shown to play a role in the anterograde axonal transport of herpes simplex virus 1 (

44 Here we demonstrate deficits in anterograde axonal transport of mitochondria in primary

45 om infected neurons to epithelial cells: (i) anterograde axonal transport of virus particles from neu

46 odimeric glycoprotein gE/gI is important for anterograde axonal transport, and gE/gI cytoplasmic doma

47 oteins gE/gI and US9 initiate the process of anterograde axonal transport, ensuring that virus partic

48 d mice, indicating that paclitaxel inhibited anterograde axonal transport, whereas eribulin did not.

49 rly, suggestive of a putative dysfunction of anterograde axonal transport.

50 ew mechanisms for how gE/gI and US9 initiate anterograde axonal transport.

51 Both gE-277 and gE-348 did not function in anterograde axonal transport; there were markedly reduce

52 In cortical axons, they normalized anterograde BDNF transport, restored retrograde BDNF tra

53 acting beta1-adrenergic receptor both in the anterograde, biosynthetic pathway and during postendocyt

54 Therefore, activity-dependent anterograde capture is a major determinant of presynapti

55 cells were normal both in morphology and in anterograde cargo transport.

56 microtubule-based kinesin-2 KIF3AC motor, an anterograde cargo transporter in neurons.

57 fall into two distinct classes containing 1) anterograde cargoes and clathrin clusters or 2) retrogra

58 that the coat protein I (COPI) complex sorts anterograde cargoes into these tubules in human cells.

59 Because retrograde and anterograde communication exists between the nuclear and

60 data demonstrate that IFT52 is essential for anterograde complex integrity and for the biosynthesis a

61 of IFT74, IFT81, IFT88 and ARL13B, other key anterograde complex members.

62 Chloroplast gene expression is subjected to anterograde control by a battery of nucleus-encoded prot

63 The nucleo-cytoplasmic compartment exerts anterograde control on chloroplast gene expression throu

64 k showed that Unc-104 (a kinesin-3) is a key anterograde DCV motor.

65 Milton RNA interference had no influence on anterograde DCV runs, and detailed colocalization analys

66 ort but does not directly facilitate ongoing anterograde DCV transport in the axon or nerve terminal.

67 Here we show that anterograde DCV transport requires the well-known mitoch

68 ed from basal capture by its selectivity for anterograde DCVs and its inhibition by overexpression of

69 , supplemented by the silver-impregnation of anterograde degeneration following eye removal, and comp

70 Retrograde but not anterograde degeneration was strongly blocked at the bif

71 This pole-ward drift is facilitated by anterograde delivery of secretory cargo to the cell tip

72 rrectly" oriented MTs are transported in the anterograde direction away from the soma.

73 ed gM-mCherry assemblies transporting in the anterograde direction in axons.

74 tested primarily utilize the IFT path in the anterograde direction, differences are observed in the r

75 euronal circuits in either the retrograde or anterograde direction, respectively.

76 ma, and kinesins move cargo in the opposite, anterograde direction.

77 Maintaining anterograde endosomal trafficking during pancreatitis ma

78 mnesia (TGA), an abrupt occurrence of severe anterograde episodic amnesia accompanied by repetitive q

79 Here we show that LRRK2 regulates the anterograde ER-Golgi transport through anchoring Sec16A

80 e tracing studies confirmed results from the anterograde experiments and differences in projections f

81 athway conduction during slow-fast AVNRT and anterograde fast pathway conduction during fast-slow AVN

82 turing at the tip and filopodia-guided actin anterograde flow with phagocytic cup formation, and (iii

83 stalled "tug-of-war" between retrograde and anterograde forces on the MT, providing an explanation f

84 ments cisternal maturation in explaining how anterograde Golgi transport is achieved, and that bidire

85 removal of KIF3 and IFT88, and KIF3-mediated anterograde IFT is responsible for photoreceptor transit

86 D1bLIC-GFP is transported with anterograde IFT particles to the flagellar tip, dissocia

87 ed signaling in Chlamydomonas induced rapid, anterograde IFT-independent, cytoplasmic microtubule-dep

88 Next, we used anatomic cases with anterograde injections in ACC/OFC to determine the exten

89 Using anterograde injections into this region of the mcIO, we

90 ing ARF6 activity in mature neurons restores anterograde integrin flow, allows transport into axons,

91 Anterograde intraflagellar transport (IFT) employing kin

92 Anterograde intraflagellar transport (IFT) is mediated b

93 family motors that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying car

94 IFT88, essential for anterograde intraflagellar transport (IFT), was signific

95 s in IFT52, which encodes a component of the anterograde intraflagellar transport complex.

96 Similarly, knockdown of ift22, an anterograde intraflagellar transport component, also sup

97 the motor and third coiled-coil stalk of the anterograde kinesin, KIF21A.

98 o the ligation consistent with inhibition of anterograde (kinesin based) transport by paclitaxel.

99 riven) motion, constrained pauses, and brief anterograde (kinesin-driven) reversals.

100 Evidence has emerged that multiple anterograde kinesins can contribute to some transport pr

101 perior colliculus (SC) contained only sparse anterograde label.

102 examined the distribution of retrograde and anterograde labeling after injecting tracers into one or

103 rons, retrograde labeling of PL neurons, and anterograde labeling of PL.

104 aration between two major clusters which, by anterograde labeling, correspond to gustatory and somato

105 ending L5B pathway from the BC by dual-color anterograde labeling.

106 Our study reveals an anterograde link between photoreceptor-mediated signalin

107 evels, a mechanism attributed to a defect in anterograde lysosomal targeting of Abeta.

108 retrograde dynein/dynactin motor complex in anterograde mbp mRNA transport and myelination in vivo.

109 or the retrograde dynein/dynactin complex in anterograde mbp mRNA transport.

110 Disruption of anterograde membrane trafficking in the apl5Delta mutant

111 ercise (RE) improves cognition, formation of anterograde memories, and mood, alongside enhancing hipp

112 equation modeling of commensurate scores of anterograde memory from a large (N = 315), population-de

113 ves after going on tangents, suggesting that anterograde memory impairment may have interfered with n

114 Participants then undertook an anterograde memory task of alcohol impairment when intox

115 articipants on task and reduce the burden on anterograde memory.

116 engagement of wee Augmin activity to promote anterograde microtubule growth into the nascent branches

117 Anterograde mitochondrial transport is mediated by the m

118 wed that loss of APC slowed the frequency of anterograde mitochondrial transport to the membrane.

119 At later disease stages, also anterograde mitochondrial transport was affected in both

120 37W, impairs the ability of DISC1 to promote anterograde mitochondrial transport.

121 n neuronal axons DISC1 promotes specifically anterograde mitochondrial transport.

122 ptic nerve led to MRI detection of degrading anterograde Mn transport at the primary injury site and

123 bnormal Mn accumulation and gradually reduce anterograde Mn transport via specific Mn entry routes.

124 Here, we uncover a surprising role of the anterograde molecular motor UNC-104/KIF1A as a key regul

125 terestingly, reduction of HTT stimulated the anterograde motility of Rab2-containing vesicles.

126 arry a temperature-sensitive mutation in the anterograde motor for IFT.

127 Although the anterograde motor kinesin KIF1B is involved in mbp mRNA

128 al is driven by direct interactions with the anterograde motor kinesin-1.

129 teractions of cargo with a highly processive anterograde motor.

130 olding protein JIP1, which not only inhibits anterograde movement but may also promote autophagosome

131 owed that predominance of 3R tau favored the anterograde movement of APP vesicles, increasing anterog

132 sn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn

133 In Lrrk loss-of-function mutants, anterograde movement of GOPs was enhanced, whereas Lrrk

134 vated cellular pathway acting to inhibit the anterograde movement of newly synthesized rhodopsin, is

135 ns than in wild type Hsp27 neurons, although anterograde movement velocities remained normal.

136 protein (MBP), expression of which requires anterograde mRNA transport followed by local translation

137 As an anterograde neuronal tracer, recombinant adeno-associate

138 meclin is crucial for proper myelination and anterograde neuronal trafficking, two processes that are

139 elease is surprisingly similar regardless of anterograde or retrograde DCV transport into boutons, bo

140 oups was studied following administration of anterograde or retrograde tracers into the PB.

141 However, the relevance of anterograde or retrograde trafficking for SORLA activity

142 GOPs move toward dendritic ends (anterograde) or cell bodies (retrograde), whereas most o

143 ploit both routes: viruses typically use the anterograde pathway for envelope formation prior to exit

144 The anterograde pathway, from the endoplasmic reticulum thro

145 ssemble with their auxiliary subunits before anterograde plasma membrane trafficking of the protein c

146 required for distal axon degeneration via an anterograde pro-degenerative factor.

147 -survival Bcl-xL and Bcl-w and initiates the anterograde pro-degenerative program, highlighting the r

148 results uncover a novel function of CRK1 in anterograde protein trafficking and elucidate the mechan

149 dent kinase in Trypanosoma brucei, regulates anterograde protein trafficking by phosphorylating Sec31

150 ed in plant PIP2s, was shown to regulate its anterograde routing along the secretory pathway, particu

151 rograde movement of APP vesicles, increasing anterograde run lengths and reducing retrograde runs and

152 Khc mutations had specific effects on anterograde run parameters, neuron-specific inhibition o

153 idirectional capture by activity dependence, anterograde selectivity, and Fmr1 sensitivity.

154 limbing fibers (CFs) and serves as a crucial anterograde signal to determine and maintain the single-

155 In the Drosophila visual system, anterograde signals numerically match R1-R6 photorecepto

156 AIS), controls retrograde (axon-to-soma) and anterograde (soma-to-axon) traffic of Tau.

157 This study demonstrates anterograde spread of prions within nerve fibers prior t

158 stem (SS) inflow from BAT to brain using the anterograde SS-specific transneuronal viral tract tracer

159 The anterograde task did not reveal significant differences

160 in p14 sorting into AP1-coated vesicles for anterograde TGN-plasma membrane transport.

161 ty, VZV reactivates from ganglia and travels anterograde to the skin to cause zoster, which is often

162 rs were reconstructed and measured following anterograde tracer (dextran) injections.

163 Anterograde tracer also colocalized with GAD-67-positive

164 has actions equivalent to those of BDA as an anterograde tracer and is suitable for analysis of neura

165 ) was systematically compared with BDA as an anterograde tracer by injecting both tracers into three

166 target areas in the brain visualized by the anterograde tracer cholera toxin subunit B (CtB) in comb

167 Anterograde tracer deposits into the dLPFC (A9 and A46,

168 zing descending fibers from injections of an anterograde tracer in the rat ACC and OFC.

169 Injections of an anterograde tracer in the rPH confirmed these connection

170 Anterograde tracer injections in DEn revealed labeled te

171 As revealed by anterograde tracer injections into the insular cortex, c

172 To investigate this question, we injected anterograde tracer into the mPFC of rats and rabbits to

173 a mesoscale structural connectome (i.e., an anterograde tracer mapping of axonal projections across

174 the RMTg, we first placed injections of the anterograde tracer Phaseolus vulgaris leucoagglutinin in

175 Rats received injections of the anterograde tracer Phaseolus vulgaris-leucoagglutinin (P

176 An anterograde tracer was injected in the IC of CBA/Ca mice

177 ing expression of a virally encoded synaptic anterograde tracer, AAV-SynaptoTag, followed by 3D recon

178 using data from 461 systematically acquired anterograde-tracer injections into the right cortical an

179 We have carried out experiments in which the anterograde tracers (3) H-amino acids, biotinylated dext

180 n the rhesus monkey by using high-resolution anterograde tracers and stereology.

181 ay by depositing a mixture of retrograde and anterograde tracers at focal sites in ZIv to reveal retr

182 d RST cervical enlargement projections using anterograde tracers between postnatal week 3 (PW3) and P

183 To determine whether different anterograde tracers can be used to identify distinct sub

184 Anterograde tracers identified complementary descending

185 this portion of the reticular formation with anterograde tracers in combination with injection of ret

186 We therefore injected retrograde and anterograde tracers in different topographical regions o

187 Thus, we placed injections of retrograde or anterograde tracers into different IP subdivisions or th

188 Injection of anterograde tracers into medial septum, or triangular se

189 this end, we injected rats aged P0-P28 with anterograde tracers into RSC.

190 describes the results of microinjections of anterograde tracers placed at different levels in VMpo,

191 Anterograde tracers were injected into the taste thalamu

192 Anterograde tracers were then injected bilaterally to as

193 parahippocampal region in rats by injecting anterograde tracers, biotinylated dextran amine (BDA) an

194 biotinylated dextranamines as retrograde and anterograde tracers, respectively.

195 ctions to the dLGN, Pv, and claustrum, using anterograde tracing and electron microscopy.

196 We used cell-type-specific anterograde tracing and optogenetic methods to selective

197 Finally, retrograde and anterograde tracing experiments identified the basilar p

198 Anterograde tracing experiments show that parasubicular

199 Anterograde tracing from the vagus with CTb or IB4 was c

200 subthalamic projections using the lentivirus anterograde tracing method in the rat: 1) whether cortic

201 Cell-specific anterograde tracing revealed that CCK(NTS) neurons provi

202 ointestinal (GI) tract, there have been many anterograde tracing studies of vagal afferent endings, b

203 In the present study, retrograde and anterograde tracing studies revealed a previously undesc

204 We used an anterograde tracing technique developed in our laborator

205 Here we use various retrograde and anterograde tracing techniques both in vivo and in vitro

206 nd aVTA, pVTA, and RMTg using retrograde and anterograde tracing techniques in the rat.

207 In vivo anterograde tracing using manganese-enhanced MRI suggest

208 We performed conditional anterograde tracing using mice that express Cre recombin

209 Here we have used anterograde tracing with adeno-associated virus-mediated

210 Prior anterograde tracing work identified somatotopically orga

211 yed viral-vector-mediated cell-type-specific anterograde tracing, classical retrograde tracing, and i

212 We used anterograde tracing, viral-mediated gene silencing, func

213 ippocampal region in the rat with the use of anterograde tracing.

214 ns above the injury site was demonstrated by anterograde tracing.

215 cally guided iontophoretic injections of the anterograde tract tracer biocytin.

216 ical and subcortical areas, as determined by anterograde tract tracing.

217 component analysis were applied in mouse to anterograde tract-tracing experiments available from the

218 tion of SLD from dDpMe was studied utilizing anterograde tract-tracing with biotinylated dextranamine

219 o-ANP-SG, parallel to their participation in anterograde traffic, in an isoform-specific fashion.

220 d LTCC endocytosis; promotion of Cavalpha1.2 anterograde trafficking by blocking Kir/Gem-dependent se

221 osomal proteins Rab5/D52/EEA1, which control anterograde trafficking in the constitutive-like secreto

222 Our data also show that rapid beta1 subunit anterograde trafficking is the primary mechanism by whic

223 pendent pathways stimulated rapid (</=1 min) anterograde trafficking of beta1 subunit-containing recy

224 Molecular mechanisms governing the anterograde trafficking of nascent G protein-coupled rec

225 We propose a model in which CaVbeta promotes anterograde trafficking of the L-type channels by anchor

226 usion attachment protein receptor)-dependent anterograde trafficking pathway that requires multiple p

227 To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transpor

228 MYO5A participated in anterograde trafficking, whereas MYO5B regulated postend

229 ces pronounced alterations in retrograde and anterograde trafficking, which correlate with dramatic f

230 and deformable bilayers in order to promote anterograde trafficking.

231 lecules directly or with cargo receptors for anterograde trafficking.

232 embrane receptor cargo by the COPII coat for anterograde trafficking.

233 Anterograde trains split apart and IFT complexes mix wit

234 o the tip by kinesin-II as inactive cargo on anterograde trains.

235 Anterograde trans-synaptic degeneration across the later

236 ed by the absence of a genetically tractable anterograde transfer system.

237 local gene transcription and translation or anterograde transmission from cortical regions.

238 eloped and characterized a novel conditional anterograde transneuronal viral tracing system based on

239 growth cone during axon extension relies on anterograde transport by kinesin motors.

240 ed evidence of destabilization of additional anterograde transport complex components.

241 ce of IFT81 in the skeleton, its role in the anterograde transport complex, and expand the number of

242 ased P-Akt(S473) in response to PDGF-AA upon anterograde transport disruption.

243 evelopment, the mechanisms of cargo-specific anterograde transport during axon extension are only sta

244 KLHL20 E3 ubiquitin ligase regulates protein anterograde transport from the trans-Golgi network (TGN)

245 Herpes simplex virus (HSV) anterograde transport in neuronal axons is vital, allowi

246 ore SVs arrive at the apex of A. nidulans by anterograde transport involving cooperation of kinesin-1

247 Anterograde transport is driven by kinesin, whereas retr

248 We also show that enhancement of the anterograde transport mechanism is the cause of the seiz

249 Anterograde transport mutants display low platelet-deriv

250 se findings, there was a marked reduction in anterograde transport of BDNF in BACHD cortical neurons.

251 spinal cord extracts, we determined that the anterograde transport of cytoskeleton components, metabo

252 rus particles in the cytoplasm, which blocks anterograde transport of enveloped particles.

253 fruit bat, Carollia perspicillata, using the anterograde transport of eye-injected cholera toxin B su

254 hat the expression of GFP-Rab43 arrested the anterograde transport of G(AE) in a Rab43-positive media

255 retion is partly dependent on Rab8a-mediated anterograde transport of Gpr177 (wntless), a Wnt-specifi

256 Anterograde transport of HSV requires two membrane prote

257 iligand sorting receptor responsible for the anterograde transport of lysosomal enzymes and substrate

258 By using anterograde transport of neuronal tracers, we found that

259 novel role for the Kif1B-KBP complex in the anterograde transport of SCG10, which is necessary for p

260 that this defect results from disruption of anterograde transport of SCG10.

261 that KinA is the major kinesin mediating the anterograde transport of SVs.

262 )-dependent neuronal differentiation through anterograde transport of the NGF receptor TRKA.

263 Depletion of CRK1 abolished anterograde transport of the secretory protein and disru

264 nal cytoplasm, which can explain the reduced anterograde transport of unenveloped capsids and envelop

265 pesviruses, functions in both retrograde and anterograde transport of virion capsids, and plays criti

266 olgi membranes, as well as in retrograde and anterograde transport of virion capsids.

267 ptic vesicle transport polarity by promoting anterograde transport processivity.

268 zation, membrane association efficiency, and anterograde transport routes.

269 Anterograde transport supplies distal axons with newly s

270 Anterograde transport through the Golgi has been explain

271 This spread involves at least two steps: (i) anterograde transport to axon tips followed by (ii) exoc

272 Reduced microtubule spacing limits anterograde transport velocities of mitochondria and syn

273 and ixabepilone significantly inhibited the anterograde transport velocity of mitochondria in neuron

274 In contrast, photobleaching anterograde transport vesicles entering a bouton inhibit

275 transport) or from cell bodies to axon tips (anterograde transport).

276 Motor-dependent anterograde transport, a process that moves cytoplasmic

277 ctively increases capture of DCVs undergoing anterograde transport.

278 reased retrograde transport but no effect on anterograde transport.

279 ent cisternae biochemically mature to ensure anterograde transport.

280 nd that pk2 knockdown larvae show a delay in anterograde transport.

281 prevented TRKB degradation, and promoted its anterograde transport.

282 osphomimetic JIP1-S421D aberrantly activates anterograde transport.

283 ere cisternae biochemically mature to ensure anterograde transport.

284 sal body, depleting kinesin-II available for anterograde transport.

285 component of the IFT-B complex essential for anterograde transport.

286 nd selectively abolishes retrograde, but not anterograde, transport in the axon and the nerve termina

287 re highly expressed in the CNS and the major anterograde transporters of cargos, such as mitochondria

288 ere we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulati

289 o-associated viruses (AAV1 and AAV9) exhibit anterograde transsynaptic spread properties.

290 ith an intersectional approach, AAV-mediated anterograde transsynaptic tagging can categorize neurons

291 tic neurons of transduced neurons, analogous anterograde transsynaptic tools for tagging postsynaptic

292 s in the somatosensory system, is subject to anterograde transsynaptic transfer from primary sensory

293 Anterograde transsynaptic transfer is a feature shared b

294 etrograde bias by a significant reduction of anterograde velocities.

295 QR11 dispersed Golgi organelles and impaired anterograde vesicle transport to the plasma membrane as

296 f two Kinesin motor proteins responsible for anterograde vesicle transport.

297 in was also shown to be required for optimal anterograde vesicular trafficking to the plasma membrane

298 igated with adeno-associated virus (AAV), an anterograde viral tracer.

299 Using anterograde viral tracing, we show that innervation of c

300 Using anterograde viral tract-tracing data provided by the All