ライフサイエンスコーパス: anthelmintic

1 up 1B (PLA2g1B) as a host-derived endogenous anthelmintic.

2 understanding of the mode of action of this anthelmintic.

3 s have different selectivity for cholinergic anthelmintics.

4 s have studies on the mechanism of action of anthelmintics.

5 -based approaches have failed to yield novel anthelmintics.

6 rent sensitivities to individual cholinergic anthelmintics.

7 work for the design of effective Cry5B-based anthelmintics.

8 ported to all three commonly used classes of anthelmintics.

9 mplex secondary metabolites that show potent anthelmintic activity and are characterized by the prese

10 The in vitro anthelmintic activity of the 18 ferrocenyl PZQ derivativ

11 d to have antinociceptive, insecticidal, and anthelmintic activity.

12 hniques, we determined the MIC values of the anthelmintics against 16 C. difficile isolates of define

13 otal synthesis of paraherquamide A, a potent anthelmintic agent isolated from various Penicillium sp.

14 cently recognized to have great potential as anthelmintic agents in targeting parasitic roundworms (e

15 ies of nematotoxic lectins with potential as anthelmintic agents.

16 ere we have identified a synergy between the anthelmintic albendazole (ABZ) and drugs depleting the f

17 disulfonylmethane compounds that have shown anthelmintic and insecticidal (endectocidal) activity.

18 r inoculation, the mice were treated with an anthelmintic and then rested, reinoculated with L3s, and

19 As a result of limited classes of anthelmintics and an over-reliance on chemical control,

20 ential to lead to the informed design of new anthelmintics and control strategies.

21 argeted by the macrocyclic lactone family of anthelmintics and pesticides, making the GluCls of consi

22 ity of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have promp

23 wards fasciolosis control, reducing usage of anthelmintics and thus delaying the spread of anthelmint

24 Anthelmintics (anti-worm drugs) have historically been d

25 Few anthelmintics are available for treatment, and only one

26 Control strategies reliant on anthelmintics are unsustainable due to the emergence of

27 New anthelmintics are urgently needed, and crystal (Cry) pro

28 Among n = 37 persons who received anthelmintics as PEP, 6 persons developed trichinellosis

29 Pgp may be a candidate target for new anthelmintics, as it plays critical roles in normal cell

30 cs, prebiotics, synbiotics, antibiotics, and anthelmintics, as well as when designing treatments for

31 d on isolation of the host and the use of an anthelmintic at a certain intervention instant t0.

32 cyclic lactones, the most important group of anthelmintics available.

33 wed that piperazine, an inexpensive and safe anthelmintic, both inhibits IRK1 channels and is antiarr

34 The anthelmintics broadly inhibited C. difficile growth in v

35 ts post-movement, primarily vaccinations and anthelmintics, but very few farms reported carrying out

36 development of resistance to nematicides and anthelmintics by these parasites and reduced availabilit

37 en made in every livestock host and to every anthelmintic class.

38 y compare the in vitro efficacy of all major anthelmintic classes currently used in human therapy (be

39 d low oral bioavailability of salicylanilide anthelmintics (closantel, rafoxanide, niclosamide, oxycl

40 Our study provides a powerful means by which anthelmintic combination therapies can be examined and d

41 legans, we establish a paradigm for studying anthelmintic combinations using Cry proteins and nicotin

42 s been done to define the characteristics of anthelmintic combinations.

43 odes of ruminants is based largely on use of anthelmintics combined, where practical, with pasture ma

44 ) receptors and have recently shown that the anthelmintic compound morantel potentiates by enhancing

45 inic acetylcholine receptors (nAChRs) by the anthelmintic compound morantel.

46 Old and new veterinary anthelmintics comprise a very large field, which could n

47 on of the clinical efficacy of some of these anthelmintics could be achieved by altering the treatmen

48 Antenatal anthelmintics could be effective in reducing maternal an

49 The most extensively characterized of the anthelmintic Cry proteins is Cry5B.

50 Six analogues of the anthelmintic cyclodepsipeptide PF1022A were prepared, ea

51 1980, extraordinary success was achieved in anthelmintic development for animals.

52 /platyhelminth genomes continues to expedite anthelmintic discovery, we contend that future prioritie

53 ffective and cost-efficient model system for anthelmintic discovery.

54 nt preventive treatment for malaria, regular anthelmintic drug administration, and improved intake of

55 Niclosamide, a category B anthelmintic drug approved by the US Food and Drug Admin

56 Niclosamide is an anthelmintic drug approved by the US Food and Drug Admin

57 Anthelmintic drug efficacy (ADE) is generally estimated

58 nidazole in the intervention group, vitamins/anthelmintic drug in the control).

59 activity in CNS neurons upon exposure to the anthelmintic drug ivermectin (IVM).

60 igations pursued resistance to the nicotinic anthelmintic drug levamisole in C. elegans at a genetic

61 worm-infected hamsters were treated with the anthelmintic drug pyrantel pamoate before vaccination.

62 rgets for ivermectin (IVM), a broad-spectrum anthelmintic drug used to treat human parasitic diseases

63 Ivermectin is a widely used anthelmintic drug whose nematocidal mechanism is incompl

64 we discovered that mebendazole, an approved anthelmintic drug, could selectively inhibit TNIK kinase

65 sis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly

66 Closantel, a known anthelmintic drug, was previously discovered as a potent

67 ementary hookworm control tools, such as new anthelmintic drugs (e.g. tribendimidine) and a recombina

68 ng candidates for further development toward anthelmintic drugs and/or highly cytotoxic metal compoun

69 or global scale-up of mass administration of anthelmintic drugs for morbidity control of schistosomia

70 We call for the efficacy of anthelmintic drugs used in MDA to be closely monitored.

71 ol strategy is to treat infected people with anthelmintic drugs, principally the safe and relatively

72 ain the stage-specific efficacy of different anthelmintic drugs.

73 The majority of anthelmintics dysregulate neuromuscular function, a fact

74 A major determinant of its anthelmintic effect is the calcium-activated potassium c

75 The salicylanilide anthelmintics exhibit desirable properties for repositio

76 The cholinergic anthelmintics had different selectivities for these rece

77 Resistance to anthelmintics has become a major problem in veterinary m

78 The increasing prevalence of resistance to anthelmintics has led to the search for alternative sust

79 Resistance to current anthelmintics has prompted the search for new drugs.

80 tional genomics of important target sites of anthelmintics have been restricted to Caenorhabditis ele

81 at the efficacy of this clinically important anthelmintic is supported by a broad, cross species poly

82 luCl) channels are the site of action of the anthelmintic ivermectin.

83 ptors is expected to inform other studies on anthelmintics (ivermectin and emodepside) that act on io

84 fish), and identify 30 structurally distinct anthelmintic lead molecules.

85 me groups of children were dewormed with the anthelmintic levamisole before the feeding period, where

86 The benzimidazole anthelmintics, mebendazole and albendazole, are commonly

87 Originally, closantel's anthelmintic mode of action was believed to rely solely

88 We have postulated that the anthelmintic morantel (Mor) positively modulates (potent

89 Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsi

90 amon bark were shown to have potent in vitro anthelmintic properties against the swine nematode Ascar

91 The structure of the unusual anthelmintic pyrrolobenzoxazine terpenoid natural produc

92 nd also to the development of compounds with anthelmintic relevance.

93 minthiases control has raised awareness that anthelmintic resistance could develop.

94 scuss whether they might also be involved in anthelmintic resistance in parasitic nematodes.

95 ed parasite epidemiology in combination with anthelmintic resistance requires the adaptation of curre

96 nthelmintics and thus delaying the spread of anthelmintic resistance.

97 trol and delay or prevent the development of anthelmintic resistance.

98 oors for elucidating subunit arrangement and anthelmintic selectivity.

99 particularly sensitive and useful model for anthelmintic studies and should be incorporated early on

100 Resistance of nematodes to anthelmintics such as avermectins has emerged as a major

101 potentially other nuclear receptors as novel anthelmintic targets.

102 isole and pyrantel are old (1965) but useful anthelmintics that selectively activate nematode acetylc

103 For this reason, anthelmintic therapy may be a potent tool for indirectly

104 In vivo, specific anthelmintic therapy resulted in decreased CD66 and CD25

105 In addition, anthelmintic therapy resulted in significantly increased

106 Anthelmintic therapy resulted in significantly increased

107 d whether this modulation is reversible upon anthelmintic therapy.

108 oides stercoralis infection before and after anthelmintic therapy.

109 er from undisturbed communities by comparing anthelmintic-treated and control hosts.

110 crease in the reproductive number of BTB for anthelmintic-treated compared with untreated buffalo.

111 amined prospectively the association between anthelmintic treatment and maternal anaemia, birthweight

112 Our results indicate that anthelmintic treatment can enhance the spread of microbi

113 Therefore, we evaluated the anthelmintic treatment effect on changes in IR.

114 Children who benefited the most from anthelmintic treatment in terms of increased hemoglobin

115 gs from previous studies have suggested that anthelmintic treatment might delay immunosuppression in

116 We calculated anthelmintic treatment needs on the basis of WHO guideli

117 Anthelmintic treatment of T. spiralis-infected rodents w

118 We evaluated the effects of anthelmintic treatment on bovine tuberculosis (BTB) acqu

119 Anthelmintic treatment reduces STH prevalence, total IgE

120 Anthelmintic treatment resulted in significant increases

121 as increasing dietary fat concentrations and anthelmintic treatment should be considered along with i

122 cently advocated policy of routine antenatal anthelmintic treatment, and the value of such a policy m

123 amma responses increased significantly after anthelmintic treatment, from 166 to 322 pg/mL (n=42; P<.

124 Anthelmintic treatment, which is recommended during preg

125 fection is reversible (for the most part) by anthelmintic treatment.

126 he disappearance or reduction of cysts after anthelmintic treatment.

127 n (HDM) and current wheeze were assessed pre-anthelmintic treatment.

128 We estimated that 126 million doses of anthelmintic treatments are required per year.

129 vealed that niclosamide, a drug approved for anthelmintic use, possessed promising activity in vitro

130 It is hoped that, ultimately, anthelmintic vaccination will be linked to deworming as

131 et should provide a basis for developing new anthelmintics, vaccines, and improved diagnostic tests a

132 ected before and after treatment with either anthelmintic were assessed for evidence of Wolbachia DNA

133 Monepantel is a recently developed anthelmintic with a novel mode of action.

134 Closantel, a veterinary anthelmintic with known proton ionophore activities, was

135 ugh the frequent 'blanket' administration of anthelmintics (wormers) has been, and remains, the corne