ライフサイエンスコーパス: anthranilic acid

1 eavage of l-kynurenine to give l-alanine and anthranilic acid.

2 dent as was that of a downstream metabolite, anthranilic acid.

3 nt than CI-1040, the cyanoquinoline, and the anthranilic acid.

4 r the light (d(0)) or heavy (d(4)) form of 2-anthranilic acid (2-AA).

5 Anthranilic acid (2-aminobenzoic acid, 2-AA) has the rem

6 The procedure uses the fluorescent compound anthranilic acid (2-aminobenzoic acid; 2-AA) to label ol

7 ith the matrixes 6-aza-2-thiothymine and 80% anthranilic acid/20% nicotinic acid but not with 3-hydro

8 N-(3,4,-Dimethoxycinnamoyl) anthranilic acid (3,4-DAA), an orally active synthetic d

9 3,4,-Dimethoxycinnamoyl anthranilic acid (3,4-DAA), an orally active synthetic d

10 nhibitors, the high-throughput screening hit anthranilic acid 4, the known benzofuran analogue 5, and

11 ns was made possible by the virtue of unique anthranilic acid (AA, 2-aminobenzoic acid [2AA]) chemist

12 itive fluorescent label 2-aminobenzoic acid (anthranilic acid, AA) for characterization of carbohydra

13 Gase F and labeled with 2-aminobenzoic acid (anthranilic acid, AA).

14 We found that N-(p-amylcinnamoyl) anthranilic acid (ACA) and 2-(p-amylcinnamoyl) amino-4-c

15 acid derivatives such as N-(p-amylcinnamoyl)anthranilic acid (ACA), which act as slow inhibitors.

16 ptophan precursors (14)C-, (13)C-, and (15)N-anthranilic acid and (14)C- and (13)C-ribose.

17 y amide (CI-1040), two CI-1040 analogues (an anthranilic acid and an N-alkyl amide), and a cyanoquino

18 s the hydrolytic cleavage of l-kynurenine to anthranilic acid and l-alanine.

19 e report that simple, commercially available anthranilic acids and aminobenzoic acids act as superior

20 xtension of this protocol to the coupling of anthranilic acids and isocyanides leading to medicinally

21 e:tryptophan ratio, and C-reactive protein), anthranilic acid, and 3-hydroxykynurenine were positivel

22 ith N-glycanase F, reductively aminated with anthranilic acid, and fractionated by normal phase high-

23 acid fragment as a suitable isostere for the anthranilic acid appendage of 4, which led to the discov

24 order CI-1040 approximately cyanoquinoline < anthranilic acid approximately U-0126 < alkyl amide.

25 A series of potent anthranilic acid-based inhibitors of the hepatitis C NS5

26 etic derivative of the tryptophan metabolite anthranilic acid, but not l-kynurenine, enhanced product

27 azone ligation were observed when polyvalent anthranilic acid catalysts operating on polyvalent aldeh

28 We conclude that ACA and other anthranilic acid derivatives are effective allosteric in

29 We here report the SAR of anthranilic acid derivatives as FXR modulators and devel

30 The favorable effects of anthranilic acid derivatives in atherosclerosis indicate

31 otection and produces a wide range of N-aryl anthranilic acid derivatives in up to 99% yield.

32 d protection and produces N-aryl and N-alkyl anthranilic acid derivatives in up to 99% yield.

33 Crystallographic analysis of seven anthranilic acid derivatives showed formation of two dis

34 of the family are sensitive to inhibition by anthranilic acid derivatives such as N-(p-amylcinnamoyl)

35 nds related in structure to flufenamate, all anthranilic acid derivatives, as potential inhibitors of

36 enolic kynurenine catabolites kynurenine and anthranilic acid did not reduce either metal.

37 rticularly promising set of analogues is the anthranilic acid esters 63-66 in which the phenyl ring i

38 , followed by N-(9-fluorenylmethoxycarbonyl)-anthranilic acid (Fmoc-anthranilic acid) with an IC(50)

39 sosome-related organelles (gut granules), as anthranilic acid glucosyl esters--not, as previously sur

40 N-(1-Pyrene)anthranilic acid has been employed in metal ion-selectiv

41 f ortho-C-H bonds in anilides to form N-acyl anthranilic acids has been developed.

42 somerism of appropriately substituted N-aryl anthranilic acids has been investigated in the solid sta

43 enzyne intermediates by the diazotization of anthranilic acids in the presence of Barton esters.

44 The structure-based design of novel anthranilic acid inhibitors of AcpS, a potential antibac

45 Anthranilic acid is a competitive inhibitor with benzoic

46 Anthranilic acid is derived from tryptophan by action of

47 oceed in 14 steps from protected tryptophan, anthranilic acid, leucine, and alanine in 7% overall yie

48 r X-ray complex structures of representative anthranilic acid ligands bound to AcpS are described in

49 ence of BBA5 were synthesized to include the anthranilic acid/nitrotyrosine fluorescence quenching pa

50 stered tranilast, N-(3,4-dimethoxycinnamoyl) anthranilic acid, on histologic and histomorphometric ch

51 een the indole-nitrogen of tryptophan and an anthranilic acid residue, and a high yielding macrolacta

52 e synthetic derivative of the Trp metabolite anthranilic acid, reversed paralysis in mice with experi

53 are also important interaction sites for the anthranilic acid S0100176 (N-benzyl-N-pyridin-3-ylmethyl

54 An anthranilic acid series of allosteric thumb pocket 2 HCV

55 rally active class of MetAP2 inhibitors, the anthranilic acid sulfonamides exemplified by A-800141, w

56 reversible inhibitors of MetAP2, a series of anthranilic acid sulfonamides with micromolar affinities

57 econd step (microwave-assisted reaction with anthranilic acid) takes approximately 14 h in total to c

58 We find that anthranilic acid, the product of the PhnAB synthase, is

59 QF) with a 6-6-6 tricyclic core derived from anthranilic acid, tryptophan, and alanine.

60 serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methyl

61 s can be reacted with commercially available anthranilic acids under microwave irradiation conditions

62 MurA inhibitors, derivatives of 5-sulfonoxy-anthranilic acid, using high-throughput screening.

63 oxyanthranilic acid, and 3-hydroxykynurenine:anthranilic acid were significant discriminating variabl

64 Higher concentrations of nicotinamide and anthranilic acid were, however, associated with a lower

65 metabolites: kynurenine, kynurenic acid, and anthranilic acid, were substantially, but differentially

66 also inhibited by ACA, ONO-RS-082, and Fmoc-anthranilic acid, whereas the Na(+)/citrate transporter

67 which is synthesized by the condensation of anthranilic acid with a 3-keto-fatty acid.

68 renylmethoxycarbonyl)-anthranilic acid (Fmoc-anthranilic acid) with an IC(50) value of approximately

69 ng PLP, kynurenine, HK, kynurenic acid (KA), anthranilic acid, xanthurenic acid (XA), and 3-hydroxyan