ライフサイエンスコーパス: anti-apoptotic

1 cogene is suggested to largely depend on its anti-apoptotic action.

2 ondrial hyperpolarization, a bax independent anti-apoptotic action.

3 B is best known for its pro-inflammatory and anti-apoptotic actions, but in skeletal muscle, NF-kappa

4 ed potent antioxidant, anti-inflammatory and anti-apoptotic activities due to the synergistic effects

5 ve stress and exerting anti-inflammatory and anti-apoptotic activities.

6 bit IAPP misfolding which, along with direct anti-apoptotic activity and beneficial metabolic effects

7 tic function of Bcl-xL is independent of its anti-apoptotic activity and its residence in the mitocho

8 uate its free radical scavenging ability and anti-apoptotic activity in cell-free and cellular system

9 this metastatic function is dependent on its anti-apoptotic activity in the mitochondria.

10 contrast, mutation of Asp-219 abrogated the anti-apoptotic activity of GAAP but not its effects on c

11 phenotypes, and we provide evidence that the anti-apoptotic activity of Tctp is necessary for the nor

12 ective functions are generally attributed to anti-apoptotic activity, however, little is known about

13 279), which leads to modulation of GSK3alpha anti-apoptotic activity, promoting pathogen survival ear

14 ed a diffuse downregulation of proteins with anti-apoptotic activity, some of which were targets of p

15 report that BAG3, a protein with recognized anti-apoptotic activity, was expressed in 346 PDACs anal

16 sion leading to inhibition of Dnmt1-mediated anti-apoptotic activity.

17 cl-xL promotes metastasis independent of its anti-apoptotic activity.

18 ntributes to a proliferative, migratory, and anti-apoptotic AEC phenotype.

19 lphaB-Crystallin is a protein chaperone with anti-apoptotic and anti-inflammatory activity that is ap

20 rovided the first evidence that Malat1 plays anti-apoptotic and anti-inflammatory roles in brain micr

21 B-to-AP-1 switch), which compensated for the anti-apoptotic and barrier-repair functions of NF-kappaB

22 otif (TMBIM) family that also includes other anti-apoptotic and Ca(2+)-modulating membrane proteins.

23 data indicate that hyper-O-GlcNAcylation is anti-apoptotic and contributes to NF-kappaB oncogenic ac

24 alidated biomarkers, as well as PIK3C3, have anti-apoptotic and neurotrophic effects, are decreased i

25 otein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways.

26 AS of the anti-apoptotic and proliferation-associated survivin (BI

27 Here, we implicate the anti-apoptotic and survival protein, tumor necrosis fact

28 Interestingly, the in vitro anti-apoptotic and the pro-survival actions seen after m

29 TMBIM members are anti-apoptotic and were predicted to have seven-transmem

30 Possibly underlying its cytoprotective, anti-apoptotic, anti-oxidative effects, UDCA was reporte

31 TREM-1 expression in macrophages and confers anti-apoptotic attributes.NF-kappaB p65 silencing identi

32 mitochondria and modulated by virus-encoded anti-apoptotic B cell leukemia (BCL)2-like suppressors.

33 of pluripotent molecules Sox2 and Nanog and anti-apoptotic B-cell lymphoma 2 (Bcl-2), respectively.

34 ed proapoptotic Bim expression and decreased anti-apoptotic Bcl(XL) levels.

35 3 phosphorylation, induces expression of the anti-apoptotic Bcl-2 and Bcl(XL) proteins, and promotes

36 Our data suggest that cleavage of anti-apoptotic Bcl-2 and Bcl-xL contributes to the decis

37 primary mouse T cells led to the cleavage of anti-apoptotic Bcl-2 and Bcl-xL in dying cells.

38 panied by increased expression of at least 1 anti-apoptotic Bcl-2 family member.

39 Although no general pattern of individual anti-apoptotic Bcl-2 family members emerged, increased e

40 Indeed, small molecule inhibitors of the anti-apoptotic BCL-2 family members have been designed r

41 ometry to analyze the expression of pro- and anti-apoptotic Bcl-2 family members in T cells from 12 A

42 Among all the anti-apoptotic BCL-2 family members, infection preferent

43 tivating the drug efflux pump gene ABCC3 and anti-apoptotic Bcl-2 family members.

44 BCL-XL is an anti-apoptotic BCL-2 family protein found both in the cy

45 a primed state in which the loss of a single anti-apoptotic Bcl-2 family protein is sufficient to tri

46 a BH3 domain but nevertheless binds certain anti-apoptotic Bcl-2 family proteins (Bcl-2, Bfl-1, and

47 e the interaction site of a Nur77 peptide on anti-apoptotic Bcl-2 family proteins and reveal a novel

48 Overexpression of anti-apoptotic Bcl-2 family proteins contributes to canc

49 Anti-apoptotic BCL-2 family proteins have been indicated

50 Pro-apoptotic and anti-apoptotic Bcl-2 family proteins reciprocally modula

51 A study of pro-apoptotic and anti-apoptotic Bcl-2 family proteins showed that neonata

52 (BH3)-only proteins bind and neutralize the anti-apoptotic Bcl-2 family proteins, how this neutraliz

53 ing of LSCs by small molecule antagonists of anti-apoptotic BCL-2 family proteins.

54 ammalian cells are known to express multiple anti-apoptotic Bcl-2 family proteins.

55 (p53, p21 and Bax) expression, downregulated anti-apoptotic Bcl-2 gene expression and increased p53-m

56 indicates that caspase-mediated cleavage of anti-apoptotic Bcl-2 or Bcl-xL facilitates AICD in T cel

57 Furthermore, by combining different pro- and anti-apoptotic Bcl-2 pairings together with CRISPR/Cas9-

58 We further show that anti-apoptotic BCL-2 protein expression is reduced in mu

59 Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in sev

60 Viral homologs of the anti-apoptotic Bcl-2 proteins are highly diverged from t

61 proteins, WM samples expressed both pro- and anti-apoptotic Bcl-2 proteins at low levels similar to t

62 Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor devel

63 apoptosis is known to involve degradation of anti-apoptotic Bcl-2 proteins during mitotic arrest; how

64 stance, we interrogated the contributions of anti-apoptotic BCL-2 proteins in determining the fate of

65 e data suggest that although the presence of anti-apoptotic BCL-2 proteins primarily dictates cellula

66 s the need for mechanism-guided targeting of anti-apoptotic BCL-2 proteins to effectively activate th

67 mito-priming, uses co-expression of pro- and anti-apoptotic Bcl-2 proteins to engineer Bcl-2 addictio

68 Our data suggest that inhibiting anti-apoptotic BCL-2 proteins will enhance primary respo

69 as the addition of ABT-737, an inhibitor to anti-apoptotic BCL-2 proteins, revealed massive apoptosi

70 efficiently when both Bcl-xL and Mcl-1, two anti-apoptotic Bcl-2 proteins, were inactivated or elimi

71 ollowing BH3-only-mediated neutralization of anti-apoptotic Bcl-2 proteins.

72 ro-apoptotic markers were increased, whereas anti-apoptotic Bcl-2 was decreased upon NDRG1 overexpres

73 of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-XL or MCL-1, which correlated

74 he overexpression of cytoprotective HO-1 and anti-apoptotic Bcl-2/Bcl-xL.

75 t Nut3, induces miR-203, which downregulates anti-apoptotic bcl-w and promotes cell death in a p53-de

76 hanism(s) reveals that ER stress reduces the anti-apoptotic Bcl-x(L) protein in INS-1 cells.

77 nd can be prevented by the overexpression of anti-apoptotic Bcl-X(L).

78 uce either the pro-apoptotic Bcl-x(s) or the anti-apoptotic Bcl-x(L).

79 HO-1 induced the expression of anti-apoptotic Bcl-xL and decreased the expression of au

80 This sensitivity occurs in part through low anti-apoptotic BCL-xL expression, high pro-apoptotic NOX

81 of NF-kappaB activation led to inhibition of anti-apoptotic (Bcl-2, Bcl-xL, survivin, and cIAP-1), pr

82 etic cell lines is oligomerized and bound to anti-apoptotic BCL2 family members in the absence of exo

83 (high) cells increased the expression of the anti-apoptotic BCL2 gene, enhances the proliferative act

84 Likewise, the level of the anti-apoptotic Bcl2 protein was decreased in residual pr

85 The anti-apoptotic BH3 family gene BCL-XL emerged as a top h

86 1 decreases the expression of STAT-regulated anti-apoptotic BH3 family members MCL1 and BCL-XL sensit

87 function as pro-apoptotic (c-FLIPL only) or anti-apoptotic (c-FLIPL/c-FLIPS) regulators of procaspas

88 plice variants, pro-apoptotic caspase-9a and anti-apoptotic caspase-9b, which are regulated by RNA tr

89 human pathogens that encode homologs of the anti-apoptotic cellular Bcl-2 proteins, which are critic

90 vating pro-apoptotic effectors or inhibiting anti-apoptotic components and by promoting MOM permeabil

91 uce the degradation of Mcl-1 and Bcl-XL, the anti-apoptotic counterparts of Bim.

92 The anti-apoptotic cytoplasmic CLU was decreased, while the

93 activation of drug efflux pumps, anti-apoptotic defense mechanisms, etc.

94 Ectopic expression of miR-1180 has an anti-apoptotic effect in HCC, while miR-1180 inhibition

95 Knockdown of PAR2 with siRNA eliminated the anti-apoptotic effect of 2f-LI and increased the sensiti

96 Consistent with an anti-apoptotic effect of autophagy, rapamycin-induced ap

97 g the release of nitrate, does not block the anti-apoptotic effect of MN10021 and derived octapeptide

98 Dasatinib also abrogated the anti-apoptotic effect of prolonged CXCL12 stimulation on

99 or and exerts an additional BDNF-independent anti-apoptotic effect, both of which contribute to NB ch

100 In addition, 3K3A-APC exerted modest anti-apoptotic effects during neuronal production.

101 tion of Akt1, suggesting CD40 involvement in anti-apoptotic effects observed.

102 -deficient BAD mutants demonstrated that the anti-apoptotic effects of cGMP and 17beta-estradiol requ

103 justified the role of Mcl-1 stabilization in anti-apoptotic effects of emotional stress.

104 ndividual PKG isoforms demonstrated that the anti-apoptotic effects of estradiol and cGMP were mediat

105 nhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of t

106 ed the renoprotective, anti-inflammatory and anti-apoptotic effects of octreotide after HIR.

107 Furthermore, we provide evidence that anti-apoptotic effects of PDGF-BB on serum-deprived ST88

108 n, we investigated the anti-inflammatory and anti-apoptotic effects of the H2S donor sodium hydrosulf

109 n podocytes, including anti-inflammatory and anti-apoptotic effects, is involved in actin cytoskeleto

110 Insulin and leptin have proliferative and anti-apoptotic effects.

111 as, and shows survival properties due to its anti-apoptotic effects.

112 Recently, the anti-apoptotic factor Bcl-2 has been reported to also in

113 PIM1 knockdown reduced expression of the anti-apoptotic factor BCL2, and dynamic BH3 profiling of

114 to the PRKCE-mediated down-regulation of the anti-apoptotic factor BCL2.

115 Finally, we observed upregulation of the anti-apoptotic factor BIRC7 in MiTF-high RCC tumors, sug

116 e there is little know about alpha-MSH as an anti-apoptotic factor, the effects of alpha-MSH on caspa

117 me c, demonstrating its important role as an anti-apoptotic factor.

118 ectively and downregulated the expression of anti-apoptotic factors and multidrug resistance proteins

119 eatment with navitoclax, an inhibitor of the anti-apoptotic factors BCL-xL and BCL-2 restored sensiti

120 gh increased Egr-2 expression, which induces anti-apoptotic factors like MCL-1.

121 egulation, leading to the release of pro- or anti-apoptotic factors which mediate cell survival or de

122 thology and leads to increased expression of anti-apoptotic factors, allowing cell survival.

123 h as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic factors, including BCL2, BCL-XL, and MCL1

124 tage through upregulation of BCL-2 family of anti-apoptotic factors.

125 ation of substrates that act as pro-survival/anti-apoptotic factors.

126 f genes: mitosis and cell cycle progression, anti-apoptotic, fatty acid biosynthesis, and endoplasmic

127 vealed that monomeric vGAAP retains both its anti-apoptotic function and its effect on intracellular

128 The anti-apoptotic function and tumor-associated expression

129 cl-2 and Bcl-XL proteins exert part of their anti-apoptotic function by directly targeting Ca(2+)-tra

130 potent caspase inhibitor, best known for its anti-apoptotic function in cancer.

131 activity of GIMAP6 was not essential for its anti-apoptotic function in Huh-7 cells.

132 p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in pre

133 P(+/-) mice indicate that TCTP activates the anti-apoptotic function of Bcl-xL, in contrast to all ot

134 novel class of BH3-proteins potentiating the anti-apoptotic function of Bcl-xL.

135 Therefore, the anti-apoptotic function of miR-1180 in HCC may occur thr

136 miR-30b-5p and miR-30c-5p, essential to the anti-apoptotic function of these miRs.

137 cells, indicating that GIMAP6 might display anti-apoptotic function through NF-kappaB activation.

138 rdinated repression of molecules with shared anti-apoptotic function which precedes active cell apopt

139 The BCL-2 BH4 domain also confers anti-apoptotic functionality, but the mechanism is unkno

140 tanding of the key mechanisms underlying the anti-apoptotic functions of caspase-8 which may act as a

141 is required for hydrogen peroxide-induced SG anti-apoptotic functions.

142 tes a unique carboxyl terminus with specific anti-apoptotic functions.

143 n be partially attributed to alterations in (anti)-apoptotic gene expression.

144 H1(R132H) mutation in AML and identified the anti-apoptotic gene BCL-2.

145 n of cell survival through expression of the anti-apoptotic gene BCL2 enables EpiSCs and Sox17(+) end

146 sulted in transcriptional suppression of the anti-apoptotic gene BCL2.

147 nal response and underlies the inhibition of anti-apoptotic gene expression following DNA damage.

148 we find that the NF-kappaB target Bcl-2, an anti-apoptotic gene, is specifically expressed in ISCs i

149 nges in expression of critical pro-, but not anti-, apoptotic genes.

150 RNA-seq analysis confirmed that a set of anti-apoptotic genes (for example, BCL2, BCL-XL and DAD1

151 The expression of the pro- and anti-apoptotic genes bcl-2 and bax, respectively, was me

152 Additionally, gene expression level of anti-apoptotic genes BCL2 and BCL2L1 was downregulated a

153 SCs was associated with up-regulation of the anti-apoptotic genes Hspa1a/b, which participate in the

154 ecies, the identity of the -1 nt in critical anti-apoptotic genes is conserved such that the overall

155 tandem delivery of siRNAs that downregulate anti-apoptotic genes overexpressed in cisplatin resistan

156 hereas after 24 hours anti-proliferative and anti-apoptotic genes were upregulated.

157 creases BCL2 expression, but represses other anti-apoptotic genes, including MCL1 and BCL2A1.

158 eshold is due to drug-dependent induction of anti-apoptotic genes, predominantly in the inhibitors of

159 mage-stimulated NF-kappaB transactivation of anti-apoptotic genes.

160 nes and suppression of pro-proliferative and anti-apoptotic genes.

161 e PAR-dependent NF-kappaB transactivation of anti-apoptotic genes.

162 n Bfl-1, but not in cells dependent on other anti-apoptotic homologs.

163 ationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however w

164 GSPE also modulated pro- and anti-apoptotic markers in the pancreas of rats fed a caf

165 However, most AID+ immature B cells lacked anti-apoptotic MCL-1 and were deleted by apoptosis.

166 activation also increased the expression of anti-apoptotic MCL-1.

167 The canonical anti-apoptotic mechanism involves entrapment of activate

168 The dual anti-apoptotic mechanism of pUL37 x 1 may be considered

169 LI1 cells, indicating that GLI1 may activate anti-apoptotic mechanisms(s) independently of Bcl2.

170 ation, and stimulated phosphorylation of the anti-apoptotic mediator Akt but not ERK MAPK.

171 Changes in the equilibrium of pro- and anti-apoptotic members of the B-cell lymphoma-2 (Bcl-2)

172 Pro- and anti-apoptotic members of this family keep each other in

173 1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal stress protein, migrates to th

174 n part through maintaining expression of the anti-apoptotic molecule A1, and provide new insight into

175 d metabolism, expresses increased amounts of anti-apoptotic molecules and subsequently displays enhan

176 epinephrine as well as the levels of several anti-apoptotic molecules are elevated in tumours from mi

177 cells treatment repressed the expression of anti-apoptotic molecules Bcl-2, Bcl-xL and survivin, cou

178 nction of immune costimulatory receptors and anti-apoptotic molecules by RT-PCR, Western blot analysi

179 lls (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs t

180 appaB-dependent induction of pro-survival or anti-apoptotic molecules is a well-known late checkpoint

181 lpha-cleavage, has been shown to produce the anti-apoptotic N1 and the scrapie-resistant C1 peptide f

182 otein as a critical regulator of E6-mediated anti-apoptotic network in HPV18-infected cervical adenoc

183 einase-2 (TIMP2), and phosphor-activation of anti-apoptotic p70s6 kinase, Akt and Erk (immunoblot).

184 bined targeting of HER2 and the BCL-XL/BCL-2 anti-apoptotic pathway may increase responses to anti-HE

185 Here, we focus on the BCL2 anti-apoptotic pathway.

186 7p21.1 AHR, the dioxin receptor involved in anti-apoptotic pathways and melanoma progression; and 9q

187 Analysis of the pro- and anti-apoptotic pathways indicated no significant changes

188 for the concept that targeting metabolic and anti-apoptotic pathways may be an effective therapeutic

189 The suppression of these two anti-apoptotic pathways silences the typical routes by w

190 further supporting its role in conferring an anti apoptotic phenotype.

191 SUM149) derived from SUM149 with an enhanced anti-apoptotic phenotype was resistant to FOXP3-specific

192 t to healthy PASMCs, a pro-proliferative and anti-apoptotic phenotype, sustained in time by the activ

193 xhibit a "cancer-like" pro-proliferative and anti-apoptotic phenotype.

194 croRNA-21 as a STAT3 target gene with strong anti-apoptotic potential, suggesting that noncoding RNAs

195 of tumorigenesis, and inducing expression of anti-apoptotic, pro-oncogenic, and angiogenic factors du

196 ed mDCs from primary human-monocytes display anti-apoptotic profile, exhibited by elevated phosphoryl

197 the importance of endocytic recycling in the anti-apoptotic properties of FPR2/ALX and identifies the

198 feration, viability under hypoxic condition, anti-apoptotic properties, resistance to anti-cancer dru

199 uced colitis model via anti-inflammatory and anti-apoptotic properties.

200 e cells to bind in niches where they acquire anti-apoptotic properties.

201 matory, pro-tumorigenic, pro-angiogenic, and anti-apoptotic properties.

202 ed by blocking TLR2 signaling indicating its anti-apoptotic property.

203 Caspase 3 levels with a parallel decrease in anti-apoptotic protein B-cell leukemia/lymphoma 2 levels

204 mplex in the mitochondria phosphorylates the anti-apoptotic protein B-cell lymphoma extra-large (Bcl-

205 Taken together, this study identifies the anti-apoptotic protein BAG-1 as a suppressor of the inhi

206 We have recently shown that the anti-apoptotic protein BAG-1, highly expressed in pre-ma

207 neonatal platelets had higher levels of the anti-apoptotic protein Bcl-2 and were more resistant to

208 ng approach to reengineer the multi-specific anti-apoptotic protein Bcl-x(L) to remove its interactio

209 h IL-6 cytokines increases expression of the anti-apoptotic protein Bcl-xL and induces activation of

210 ) signaling pathways and increased levels of anti-apoptotic protein Bcl-xL and Mcl-1, which are downs

211 Furthermore that the anti-apoptotic protein Bcl-xL is regulated by CLPTM1L in

212 e) polymerase activation, down-regulation of anti-apoptotic protein Bcl-XL, an arrest of the cell cyc

213 Levels of the anti-apoptotic protein Bcl-xL, beta-catenin, connective

214 ription factor MYC and its downstream target anti-apoptotic protein BCL-XL.

215 des with respect to their affinities for the anti-apoptotic protein Bcl-xL.

216 spase 9 and PARP, with the downregulation of anti-apoptotic protein Bcl2 in HepG2 cells.

217 In circumstances where expression of the anti-apoptotic protein BCL2 is high, Casp8p41 instead bi

218 Overexpression of the anti-apoptotic protein Bcl2, but not the oncoprotein Myc

219 the systemic delivery of siRNA that targets anti-apoptotic protein Bcl2.

220 ciated with an increase in expression of the anti-apoptotic protein Bfl-1 and a decrease in expressio

221 suppressor TP53; mutated genes encoding the anti-apoptotic protein BIRC3 and Toll-like receptor 2 (T

222 cumulating pro-apoptotic signal arising from anti-apoptotic protein degradation, generation of a swit

223 and increases the ratio of the apoptotic to anti-apoptotic protein expression.

224 A2 overexpression degraded the mitochondrial anti-apoptotic protein HAX-1, an effect attenuated by Uc

225 a yeast two-hybrid screen, we identified the anti-apoptotic protein HAX1 to interact with RNF217.

226 Survivin, an overexpressed anti-apoptotic protein in cancer, represents a pharmacol

227 ecific actin-binding protein functions as an anti-apoptotic protein in the gastrointestinal epitheliu

228 (hVDAC-2) functions primarily as the crucial anti-apoptotic protein in the outer mitochondrial membra

229 The target gene was survivin, an anti-apoptotic protein induced by chemotherapy and assoc

230 er with computational modeling and selective anti-apoptotic protein inhibitors, uncovers new mechanis

231 ed that L. donovani exploited the macrophage anti-apoptotic protein MCL-1 to prevent BAK-mediated mit

232 pproaches, we documented that the macrophage anti-apoptotic protein myeloid cell leukemia 1 (MCL-1) i

233 t PPAN is a novel interaction partner of the anti-apoptotic protein nucleophosmin (NPM).

234 udies in vitro and in vivo, we show that the anti-apoptotic protein poly(ADP-ribose) polymerase (PARP

235 ficant increase in mRNA levels for the known anti-apoptotic protein serum and glucocorticoid-regulate

236 The anti-apoptotic protein survivin (Sur) plays an important

237 d to screen 157 compounds in 6 h against the anti-apoptotic protein target Bcl-x(L).

238 cytoplasmic C terminus of Kv3.3 to Hax-1, an anti-apoptotic protein that regulates actin nucleation t

239 er the levels of pro-apoptotic protein, Bax, anti-apoptotic protein, Bcl-2, caspase-3 and cytochrome

240 we examined the critical role of Bcl-xL, an anti-apoptotic protein, during brain development.

241 from apoptosis, suggesting that GIMAP6 is an anti-apoptotic protein.

242 (P < 0.05) increased expression of p-Akt and anti-apoptotic proteins (Bcl-2 and Bcl-xL), while reduce

243 Golgi anti-apoptotic proteins (GAAPs) are hydrophobic proteins

244 Golgi anti-apoptotic proteins (GAAPs) are multitransmembrane p

245 Extracts decreased expression of anti-apoptotic proteins (survivin, cIAP-2, XIAP), induce

246 cs detects production of only a few critical anti-apoptotic proteins against a background of general

247 the protein levels of survivin, a member of anti-apoptotic proteins and a known mediator of melanoma

248 erm sites of hnRNPA1 promotes translation of anti-apoptotic proteins and is indispensable for the pro

249 or of apoptosis (PUMA) counters Bcl-2 family anti-apoptotic proteins and promotes apoptosis.

250 ABT-737 inhibits the anti-apoptotic proteins B-cell lymphoma 2 (BCL-2) and BC

251 entified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent se

252 s of potent small-molecule inhibitors of the anti-apoptotic proteins Bcl-2 and Bcl-xL.

253 rimarily from differential expression of the anti-apoptotic proteins Bcl-xL and Mcl-1 relative to Bak

254 pathways or of altered expression of pro- or anti-apoptotic proteins can thus be compared.

255 e p23 to Hsp90 and induced overexpression of anti-apoptotic proteins Hsp70 and Hsp27 are thought to c

256 The increased cap-independent translation of anti-apoptotic proteins is involved in the development o

257 se-12 were dramatically decreased, while the anti-apoptotic proteins of Bcl-2 and NF-kappaB were sign

258 oresistant cells that express high levels of anti-apoptotic proteins such as BCL-XL is thought to res

259 Infected AmEpCs up-regulated anti-apoptotic proteins survivin and Bcl-xL by mechanism

260 ies, which become dependent on expression of anti-apoptotic proteins to counter expression of pro-apo

261 to BH3 mimetics reflects the identity of the anti-apoptotic proteins to which BAK is constitutively b

262 d CD4(+) T cells facilitated the transfer of anti-apoptotic proteins via nanotubes, resulting in incr

263 d PLGA-NP were internalized in HCC cells and anti-apoptotic proteins were down regulated with apoptos

264 Notably, the same anti-apoptotic proteins were previously found to reduce

265 able to maintain the cellular homeostasis of anti-apoptotic proteins, Abcd1-deletion in B12 oligodend

266 aperones, the protein degradation machinery, anti-apoptotic proteins, and transcription factors.

267 aster regulator of numerous antioxidants and anti-apoptotic proteins, including HO-1, also accumulate

268 pounds show selectivity for Mcl-1 over other anti-apoptotic proteins, possess cytotoxicity to cancer

269 to the up-regulation of NF-kappaB-dependent anti-apoptotic proteins, such as BCL2, c-FLIPS, XIAP, an

270 l differentiation protein (Mcl-1), two major anti-apoptotic proteins, were present within the nanotub

271 rgins were characterized by pro-survival and anti-apoptotic proteins, whereas perinecrotic regions we

272 teins impact the expression of oncogenes and anti-apoptotic proteins.

273 ly in cancer cells by downregulating several anti-apoptotic proteins.

274 ics to derepress proapoptotic molecules from anti-apoptotic proteins.

275 iR-34a directly inhibits Bcl2 and XIAP, both anti-apoptotic proteins.

276 inducing apoptosis by reducing the levels of anti-apoptotic proteins.

277 and alphaB-crystallin act as chaperones and anti-apoptotic proteins.

278 ing, but also primes cells for inhibitors of anti-apoptotic proteins.

279 ncoding protein chaperones (e.g. iHsp70) and anti-apoptotic proteins.

280 e subverted by pathogens through use of host anti-apoptotic proteins.

281 ems-level data also support co-targeting the anti-apoptotic regulator HSF1 to promote cell death by b

282 nd BBC3, and with decreased abundance of the anti-apoptotic regulator Mcl1.

283 ombined inhibition of Bid and Bax elicits an anti-apoptotic response that is effective over a range o

284 ow these factors exert pro-proliferative and anti-apoptotic responses in PAH remains unclear.

285 tochondrial autophagy, further supporting an anti-apoptotic role for Bnip3-induced mitophagy.

286 tumor target in IBC cells however increased anti-apoptotic signaling can lead to immune evasion.

287 M*-mediated effects on pro-proliferative and anti-apoptotic signaling cascades and protein and DNA sy

288 hose ligation triggers pro-proliferative and anti-apoptotic signaling cascades.

289 et of rapamycin (mTOR), proinflammatory, and anti-apoptotic signaling pathways, as well as downregula

290 ading to the activation of proliferative and anti-apoptotic signaling pathways.

291 ed xenografts induces both pro-apoptotic and anti-apoptotic signaling responses that limit cell killi

292 on of rtPA while reducing ROS and activating anti-apoptotic signaling.

293 for SrcFKs in multiple pro-proliferative and anti-apoptotic signalling pathways relating to oxidative

294 n of homologous recombination DNA repair and anti-apoptotic signals in this population.

295 Anti-apoptotic survivin, along with other inhibitor of a

296 eins, Mcl-1(S) (pro-apoptotic) and Mcl-l(L) (anti-apoptotic); the latter isoform is predominant in di

297 evated PAR production and NF-kappaB-mediated anti-apoptotic transcription in human and mouse colon ca

298 can compete with canonical MOMP to act as an anti-apoptotic tuning mechanism, reducing the mitochondr

299 2 that positively regulate growth, and V1 is anti-apoptotic when overexpressed.

300 ction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expressio