ライフサイエンスコーパス: anti-sense

1 f 'UCU', or not reported at all, such as the anti-sense 5' -3' motif 'ACGA'.

2 either under reported in literature, such as anti-sense 5' -3' motif 'UCU', or not reported at all, s

3 B4 cells caused no observed phenotype due to anti-sense activities.

4 diversity, which included a higher ratio of anti-sense and inter-genic transcripts, reflecting a per

5 pared with wild type at day 21 after sowing, anti-sense and overexpressing lines showed, on average,

6 ranscriptase-polymerase chain reaction using anti-sense and sense primers designed from Exons 2 and 3

7 etermined using (51)Cr release in hsp25 cDNA anti-sense and sense-transfected cells expressing minima

8 ilarly, ROS production increased markedly in anti-sense and untransformed, but not overexpressor, roo

9 l sequences in the host genome gives rise to anti-sense, anti-viral piRNAs.

10 importance of these observations, sense and anti-sense (AS) ANX II RNA-expressing clones of intestin

11 We show here that it is the anti-sense (AS) strand of these genes that is transcribe

12 ty of miRNA precursors, especially at the 5'-anti-sense (AS) terminal base pair.

13 Pre-treatment of RTLGA with anti-sense but not missense p21(waf1/cip1) oligonucleoti

14 Anti-sense but not sense oligonucleotides to the human N

15 hsp72 anti-sense (C2/AS) and vector-only transfected C2 (C2/CE

16 MtDNA-depleted cells stably expressing anti-sense cathepsin L RNA, TGFbeta1 RNA, or treated wit

17 reatment with an adenoviral vector harboring anti-sense caveolin-1 specifically potentiates transform

18 Transgenic Arabidopsis plants expressing an anti-sense cDNA encoding a type III peroxidase, French b

19 roteinase in cutaneous epidermal cells using anti-sense cDNA expression in human keratinocytes.

20 In situ hybridization with anti-sense cDNA probes was used to test for expression o

21 ered or slightly decreased, respectively, in anti-sense cDNA-infected cells compared with control cel

22 Likewise, the Brn-3b anti-sense cell lines showed reduced cellular growth and

23 Transfection of cells with sense or anti-sense CK2 constructs modulates c-myc protein levels

24 ines were studied in an organ culture model, anti-sense clones were highly invasive compared with vec

25 keratinocytes were transfected with sense or anti-sense constructs of the EP(2) receptor.

26 Sense and anti-sense constructs were identified and transfected, a

27 ch had been transfected with Brn-3b sense or anti-sense constructs.

28 In this study, in situ hybridization with anti-sense cRNA riboprobe was used to show expression of

29 t of hepatocytes with group II PLA2-specific anti-sense DNA oligonucleotides: 1) abolished accumulati

30 ed CpGs was concordant between the sense and anti-sense DNA strand, suggesting that it is a stable ep

31 that YUSAC-2 cells transfected with survivin anti-sense expressed less endogenous survivin and exhibi

32 rofiling and RT-PCR analysis showed that the anti-sense (FBP1) transgenic plants had reduced levels o

33 at an apparent slow rate with the sense and anti-sense forks moving at 0.32 and 0.23 kb/min.

34 Interestingly, for some miRNAs sense and anti-sense hairpins score highly and mature miRNAs from

35 y stable transfection of PC3M-LN4 cells with anti-sense HAS2 or HAS3 expression constructs diminishes

36 Stable hsp anti-sense IEC-18 cell clones were obtained by electropo

37 itative analysis of melanin in the sense and anti-sense infectant cells demonstrated an increase and

38 erexpressing cells but slightly decreased in anti-sense infectant cells.

39 cts were only identified from the sense- and anti-sense-infected clones, not from the parental cells

40 induced mouse ESC differentiation, and their anti-sense inhibitors substantially reversed spontaneous

41 important for transcription termination and anti-sense initiation.

42 actions returned to control levels 12 h post anti-sense injection.

43 lity, we transfected MDA-231BO cells with an anti-sense IRS-2 construct.

44 n 12 cDNA, and in situ hybridization with an anti-sense keratin 12 riboprobe.

45 Further, a microarray study using an anti-sense line showed AOX influences outside mitochondr

46 wed no increase in oxidative damage, whereas anti-sense lines had levels of damage greater than those

47 This study uncovers an anti-sense lncRNA (APOA4-AS), which is co-expressed with

48 function and gain-of-function studies, using anti-sense locked-nucleic acids (LNAs) and synthetic RNA

49 Inhibition of MAPK activation by anti-sense MEK expression in MDA-MB-468 cells significan

50 erved 48-72 h after transduction with 1.4 kb anti-sense membrane type 1 matrix metalloproteinase cons

51 ved via retroviral expression of a 5' 1.4 kb anti-sense membrane type 1 matrix metalloproteinase cons

52 apoptotic nuclear fragmentation after 1.4 kb anti-sense membrane type 1 matrix metalloproteinase cons

53 Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence inflammatio

54 ation to growth control in experiments using anti-sense molecules or dominant negative STAT protein e

55 Using a dominant negative construct or anti-sense morpholino oligos (MOs) to disrupt meis3 func

56 Anti-sense morpholinos against lmx1b.1 and lmx1b.2 resul

57 Xtgfbi knockdown by anti-sense morpholinos causes defective organizer induct

58 vided in experiments that showed that cIAP-2 anti-sense morpholinos permit LIGHT to induce apoptosis

59 Trans-perturbations with anti-sense morpholinos reveal a co-dependency between si

60 lial development, we utilized site-directed, anti-sense morpholinos to inhibit scl mRNA.

61 As) ('CUTs'), along with ~642 predicted long anti-sense ncRNAs (asRNAs), ~178 intergenic ncRNAs and,

62 also seems to be regulated by a cis-acting, anti-sense non-protein-coding transcript.

63 A knock down agents, HBV release inhibitors, anti-sense nucleosides, exogenous interferon stimulation

64 orothioate intercellular adhesion molecule-1 anti-sense oligodeoxynucleotide in a cream formulation.

65 cr protein by incubating cells with a 3' BCR anti-sense oligodeoxynucleotide increased the growth rat

66 Using a specific anti-sense oligodeoxynucleotide to CTGF the procontracti

67 Anti-sense oligodeoxynucleotides were used to determine

68 Gelsolin anti-sense oligonucleotide (20 microM) treatment of NR6

69 n, Pkd2WS25/- mice were treated with an mTOR anti-sense oligonucleotide (ASO) that blocks mTOR expres

70 ents with CD and then incubated with a Smad7 anti-sense oligonucleotide (knock down).

71 ction of zebrafish embryos with a morpholino anti-sense oligonucleotide corresponding to the ortholog

72 model enzyme to test nuclease sensitivity of anti-sense oligonucleotide drugs.

73 An anti-sense oligonucleotide to feline SP (SP-asODN) was i

74 llagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, a

75 We further show that a miR-27a anti-sense oligonucleotide, by opposing the effects of m

76 ession, as well as by transfection of a FLIP anti-sense oligonucleotide.

77 use PCT and NIH3T3 fibroblast lines by using anti-sense oligonucleotides against PTEN.

78 Treatment with pharmacologic grade DNMT1 anti-sense oligonucleotides and STAT3 small-interfering

79 ults strongly suggest that topically applied anti-sense oligonucleotides can be delivered to target s

80 rvations suggest that cholesterol-conjugated anti-sense oligonucleotides may offer a novel approach t

81 Preincubation of CF-T43 cells with CFTR anti-sense oligonucleotides prevented an increase in 36C

82 transfected or microinjected with surviving anti-sense oligonucleotides produce significantly more p

83 Anti-sense oligonucleotides to the cloned sequence drama

84 eLa cells, whereas down-regulation of ALY by anti-sense oligonucleotides virtually eliminates TCR alp

85 P-expressing cells or cells treated with PS1 anti-sense oligonucleotides were less capable of taking

86 Pre-clinical data from knockouts, anti-sense oligonucleotides, and siRNA for Nav1.3, 1.7,

87 fere with EphA4 levels in feather buds using anti-sense oligonucleotides, demonstrating a severe effe

88 een fluorescence protein-conjugated survivin anti-sense or green fluorescence protein-conjugated surv

89 ipocalin 2 (mouse 24p3) expression by either anti-sense or siRNA approaches strongly reduces the over

90 ith sense cDNA, not from cells infected with anti-sense or vector-alone, or from the uninfected-paren

91 fragment of the 1392 bp su cDNA in sense and anti-sense orientation, and a 403 bp 3' fragment.

92 carrying a 623 bp portion of luc in sense or anti-sense orientation.

93 e generated: AtAOX1a overexpressors, AtAOX1a anti-sense plants, and overexpressors of a mutated, cons

94 We used anti-sense pp32 and RNAi transfection to study the effec

95 ce to DOX, we inhibited PR3 expression by an anti-sense PR3 oligodeoxynucleotide and showed that inhi

96 RT-PCR analysis with exon 9 anti-sense primer generated 2 major amplicons with the u

97 is known about the regulation or function of anti-sense promoters and the non-coding RNAs they genera

98 We propose that anti-sense promoters serve as platforms for TF binding a

99 strated by showing that transfection with an anti-sense RAR beta construct blocked atRA-induced STAT1

100 e genome, and disclosing a potential natural anti-sense regulation for gene expressions.

101 e maternal DNA methyltransferase (xDnmt1) by anti sense RNA during cleavage stages is associated with

102 onvergent promoters, we find no evidence for anti-sense RNA control.

103 ed by RNAse protection assays using a 710 bp anti-sense RNA probe that spanned the alternatively spli

104 trkB and p75 mRNA using digoxigenin-labeled anti-sense RNA probes.

105 ed to be mediated by the generation of short anti-sense RNA species expressed with low abundance.

106 Together, we have identified new sense and anti-sense RNA transcripts, novel mRNAs and mi/siRNA-siz

107 t RNA II could regulate RNA I function as an anti-sense RNA.

108 as measured by quantitative real-time PCR of anti-sense RNA.

109 ents the formation of polycistronic RNAs and anti-sense RNAs, which are generally detrimental to the

110 ssociated with the location of the sense and anti-sense segments in the genome.

111 roliferation, while depletion of SOCS1 by an anti-sense SOCS1 cDNA construct enhances cell proliferat

112 xpression and activity) by transfection with anti-sense Src expression vectors increases susceptibili

113 an enzymatic ligation reaction (leaving the anti-sense strand dissociable).

114 NA duplex internal stability and siRNA sense/anti-sense strand secondary structure.

115 oded reverse transcriptase which cleaves the anti-sense strand.

116 ed in intestinal epithelia stably expressing anti-sense to hsp25.

117 useful near promoters where sufficient sense/anti-sense transcript mapping information is lacking.

118 ntains a promoter for a paternally expressed anti-sense transcript, Kcnq1ot1, and we define the exten

119 Anti-sense transcription originating upstream of mammali

120 suggesting that some of them might regulate anti-sense transcription.

121 ncRNAs comprise microRNAs, anti-sense transcripts and other Transcriptional Units c

122 and tick-specific operons and paralogs, and anti-sense transcripts that suggest novel expression reg

123 , including trans-acting non-coding RNAs and anti-sense transcripts.

124 As, 5' untranslated regulatory elements, and anti-sense transcripts.

125 We further discover a group of anti-sense TSSs in macrophages with an enhancer-like chr

126 Notably, as the distance between sense and anti-sense TSSs increases, so does the size of the NDR,

127 We find that coupled sense and anti-sense TSSs precisely define the boundaries of a nuc

128 otein levels by stable transformation of the anti-sense VDR in MCF-7 reduced the sensitivity of MCF-7

129 Introduction of anti-sense wt-p53 into wt-p53 cells abrogated the 2-MeOE

130 In situ hybridization with anti-sense zGCAP4, zGCAP5 and zGCAP7 RNA showed exclusiv