ライフサイエンスコーパス: antiangiogenic effect

1 saccharide-neutralizing protein, also has an antiangiogenic effect.

2 ance MHC class I presentation and exhibit an antiangiogenic effect.

3 mpair periodontal tissue repair, despite its antiangiogenic effect.

4 doses of type I IFNs occurs through a direct antiangiogenic effect.

5 horioallantoic membrane assay, suggesting an antiangiogenic effect.

6 VEGF-A signaling, whereas IFNgamma shows an antiangiogenic effect.

7 The Y2R antagonist also exerted an antiangiogenic effect.

8 ivity in vivo, presumably as a result of its antiangiogenic effect.

9 tion of specific antimitotic and nonspecific antiangiogenic effects.

10 ombospondin-1, reinforcing its antitumor and antiangiogenic effects.

11 proteolytic fragments of these hormones have antiangiogenic effects.

12 clinical trials partly based on their potent antiangiogenic effects.

13 ults indicate a role for CD8+ T cells in the antiangiogenic effects.

14 nhances Th1-type T-cell responses and exerts antiangiogenic effects.

15 is and present a molecular mechanism for its antiangiogenic effects.

16 ceeded concentrations necessary for in vitro antiangiogenic effects.

17 h and metastasis by both direct and indirect antiangiogenic effects.

18 ty of indications have been shown to exhibit antiangiogenic effects.

19 ma agent that has both antiproliferative and antiangiogenic effects.

20 ctivated endothelial cells leading to potent antiangiogenic effects.

21 well tolerated in children, with evidence of antiangiogenic effect and potential clinical benefit in

22 growth factor receptor-beta (PDGFR-beta) for antiangiogenic effects and also inhibit human thymidylat

23 IFN-gamma and the Fas/FasL pathway in early antiangiogenic effects and in antitumor responses sugges

24 letely defined but are postulated to involve antiangiogenic effects and induction of apoptosis.

25 synthase on the cell surface may mediate its antiangiogenic effects and the down-regulation of endoth

26 ith this, alpha1(IV)NC1 elicited significant antiangiogenic effects and tumor growth inhibition in vi

27 than antigen-specific tumor immunity (e.g., antiangiogenic effects) and that use of human IL-12 shou

28 autophagy, an antitumor immune response, an antiangiogenic effect, and a significant "bystander" ant

29 imizing efficacy of chemotherapeutic agents, antiangiogenic effects, and altering antitumor immunity.

30 Antiangiogenic effects at high concentrations were assoc

31 effects were most probably mediated via its antiangiogenic effects because TSP-1 did not affect the

32 a dominant-negative sKDR results in a strong antiangiogenic effect both on directly targeted cells an

33 ea catechins, possesses immunomodulatory and antiangiogenic effects, both of which contribute to its

34 enoside from ginseng root extract, possesses antiangiogenic effects, but its role on ocular cells has

35 in tumor cell lines, has been shown to have antiangiogenic effects, but the molecular mechanism of t

36 We found that P14ARF mediates antiangiogenic effects by upregulating expression of tis

37 teady-state MRI is highly sensitive to early antiangiogenic effects caused by small molecule drugs.

38 s benefit appears largely due to an enhanced antiangiogenic effect: Combination therapy reduced both

39 ivo angiogenesis assay further confirmed the antiangiogenic effect generated by CRT/E7 and CRT.

40 Local inhibition of CXCR4 is required for an antiangiogenic effect in CNV lesions.

41 ort the hypothesis that TNF-alpha exerts its antiangiogenic effect in part by modulating the VEGF-spe

42 tumor vascular density, suggesting a potent antiangiogenic effect in the brain.

43 Neither angiostatin nor MAb3D5AB1 showed an antiangiogenic effect in the corneal neovascularization

44 In vivo, ferritin opposed HKa's antiangiogenic effects in a human prostate cancer xenogr

45 Q8 elicits antiangiogenic effects in a VEGF-independent in vitro mo

46 that miR-146a is a critical mediator of the antiangiogenic effects in endothelial cells.

47 oxides 17,18-EEQ-EA and 19,20-EDP-EA exerted antiangiogenic effects in human microvascular endothelia

48 n surface localization and modulation of its antiangiogenic effects in the eye and bone.

49 This suggests that local CsA has negligible antiangiogenic effects in the human cornea, at least in

50 receptor kinase inhibitor SU5416, increased antiangiogenic effects in vitro and in a zebrafish angio

51 We found that ANGPTL7 itself has strong antiangiogenic effects in vitro.

52 th inhibition, inhibition of metastasis, and antiangiogenic effects in vivo.

53 Within a certain window of antiangiogenic effects, interstitial convection within t

54 However, how IL-12 exerts its antiangiogenic effect is largely unknown.

55 f thalidomide, an immunomodulatory drug with antiangiogenic effects, is limited by its toxicity.

56 mycin in vivo, and provide evidence that its antiangiogenic effects may represent a downstream conseq

57 uggest that multikinase inhibitors may exert antiangiogenic effects not only by direct effects on end

58 of VEGF by bevacizumab explain the additive antiangiogenic effects observed in combination with Q8.

59 which may be an additional mechanism for the antiangiogenic effect of 2ME(2).

60 The antiangiogenic effect of A fumigatus was completely abol

61 c-met signaling is a novel mechanism for the antiangiogenic effect of angiostatin.

62 several tumor cell lines, could inhibit the antiangiogenic effect of angiostatin.

63 se results provide a molecular basis for the antiangiogenic effect of anthracycline therapy and have

64 giogenesis during therapy, despite a greater antiangiogenic effect of bevacizumab, such that a revers

65 study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM

66 hile p56/Lck short hairpin RNA inhibited the antiangiogenic effect of HKa.

67 een lipid metabolism and angiogenesis and an antiangiogenic effect of HMG-CoA reductase inhibitors wi

68 The antiangiogenic effect of hyperoxia on retinal capillarie

69 essel formation in vivo, indicating that the antiangiogenic effect of IGFBP-3 is an IGF-independent p

70 is, and inhibition of GSK3beta abolished the antiangiogenic effect of PDGF-CC blockade.

71 ntly, GSK3beta activity was required for the antiangiogenic effect of PDGF-DD targeting.

72 The antiangiogenic effect of PRP was analysed by matrigel-ba

73 erved owing to the enhanced photothermal and antiangiogenic effect of RDLPNPs.

74 propose a novel molecular mechanism for the antiangiogenic effect of RGDfV.

75 F-1 alpha, and VEGF expression could lead to antiangiogenic effect of silibinin against CRC.

76 Antiangiogenic effect of silibinin was coupled with a st

77 eased angiogenesis in MM bone marrow and the antiangiogenic effect of Thal formed the empiric basis f

78 xperimental toxic neuropathy results from an antiangiogenic effect of these drugs, resulting in destr

79 Also evaluated was the antiangiogenic effect of this peptide in vivo using the

80 tro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo.

81 Consistent with the well-known antiangiogenic effect of TSP-1, the number of vasa vasor

82 y a potential mechanism of resistance to the antiangiogenic effect of TSP-1.

83 neal angiogenesis assays, HRGP inhibited the antiangiogenic effect of TSP-1.

84 ion in C57BL/6 mice was used to evaluate the antiangiogenic effects of 2-ME and other microtubule inh

85 Finally, the antitumor and antiangiogenic effects of AKB-6899 were abrogated when m

86 The antiangiogenic effects of angiostatin occur, in part, fr

87 , therefore, delineate the mechanisms of the antiangiogenic effects of bortezomib on multiple myeloma

88 acizumab or sunitinib treatment enhanced the antiangiogenic effects of both drugs.

89 o be used as an imaging biomarker to measure antiangiogenic effects of cancer treatments.

90 factor) could play a role in decreasing the antiangiogenic effects of docetaxel, whereas agents such

91 vations, bFGF, but not VEGF, neutralizes the antiangiogenic effects of doxorubicin in vivo.

92 e anti-breast tumor effects of G129R and the antiangiogenic effects of endostatin by creating a novel

93 ew recent studies on the antitumorigenic and antiangiogenic effects of exogenously administered 2-met

94 These studies demonstrate that the antiangiogenic effects of HKa depend on high-affinity bi

95 Further, ferritin antagonizes the antiangiogenic effects of HKa, enhancing the migration,

96 The antiangiogenic effects of IL-18 treatment appeared to be

97 ophagic survival response can potentiate the antiangiogenic effects of Kringle 5 in endothelial cells

98 an endothelial tube assay and attenuated the antiangiogenic effects of sFlt1.

99 Mechanistically, the antiangiogenic effects of sorafenib led to increased bon

100 The antiangiogenic effects of SU11248 were demonstrated usin

101 eated animals revealed antiproliferative and antiangiogenic effects of THC.

102 e- or ibuprofen-treated embryos reversed the antiangiogenic effects of the drugs.

103 totic, antiproliferative, antimigratory, and antiangiogenic effects of this commercial CRP preparatio

104 is and associated tumor growth, and that the antiangiogenic effects of TIMP-3 appear to be mediated t

105 epleting intracerebral copper, also exhibits antiangiogenic effects on brain tumor growth in mice.

106 also Necdin-mediated growth suppression and antiangiogenic effects on cancer cells.

107 h factor production from the tumor cells and antiangiogenic effects on endothelial cells.

108 The results showed that miR-499 had antiangiogenic effects on the HUVECs and suppressed the

109 anti-MM activity of PTK787, coupled with its antiangiogenic effects, provides the framework for clini

110 in tumor cells themselves could block these antiangiogenic effects, showing the complexity of the JA

111 fibrinogen polymer, sFBG, had antitumor and antiangiogenic effects similar to those of sFN.

112 t multiple myeloma (MM) because of its known antiangiogenic effects, the mechanism of its anti-MM act

113 nhibitor (FTI) exhibit antiproliferative and antiangiogenic effects through a mechanism that is poorl

114 This unorthodox antiangiogenic effect was mediated via VEGFR-1 activatio

115 This antiangiogenic effect was more pronounced in p53-null mi

116 To examine antiangiogenic effects, we studied the impact of ZD1839

117 ns of octreotide and NISAs are necessary for antiangiogenic effects, whereas nanomolar concentrations

118 ceptor pathways results in at least additive antiangiogenic effects, which may have implications for