ライフサイエンスコーパス: antiapoptotic

1 in isolated rat islets and investigated its antiapoptotic action against exogenous cytokines interle

2 and, PDGF may exert vascular stabilizing and antiapoptotic actions through endothelial-pericyte and e

3 rier stabilization and anti-inflammatory and antiapoptotic actions; and (3) a regenerative on the bas

4 P in such a way that cellular IAP levels and antiapoptotic activities are maintained.

5 nd it was recently suggested that AAT exerts antiapoptotic activities, we aimed to explore whether ad

6 wth and MET dependency via proliferative and antiapoptotic activities.

7 ous to cFLIPs, with NF-kappaB-activating and antiapoptotic activities.

8 ssential for PEDF-mediated cell survival and antiapoptotic activities.

9 mulating hormone, with anti-inflammatory and antiapoptotic activities; alkaline phosphatase, which de

10 Here we report that ATR has an antiapoptotic activity at mitochondria in response to UV

11 This antiapoptotic activity in E. faecalis-infected cells was

12 he F1L N-terminal region does not impede F1L antiapoptotic activity in the context of a viral infecti

13 Thus, the antiapoptotic activity of AnkG is controlled by p32-medi

14 ot only a mechanistic basis for the enhanced antiapoptotic activity of phosphorylated Bcl-2, but also

15 We report that endogenous MCL-1's antiapoptotic activity promotes survival during BCR-ABL

16 cellular pathogen Coxiella burnetii displays antiapoptotic activity which depends on a functional typ

17 ins their unusual stability and their potent antiapoptotic activity.

18 his relationship, due to insulin's mitogenic/antiapoptotic activity.

19 ephosphorylation of Bcl-2 and inhibiting its antiapoptotic activity.

20 ective phosphorylation at ser70 enhances its antiapoptotic activity.

21 lated by growth factor signals that manifest antiapoptotic activity.

22 These results define a novel function of the antiapoptotic, adenoviral E1B 19K protein that may limit

23 Our results define a new function of the antiapoptotic, adenoviral protein E1B 19K, which we have

24 sor gene in ALCL models, likely acting as an antiapoptotic agent.

25 at extend to nonerythroid tissues, including antiapoptotic and anti-inflammatory effects.

26 More importantly, the antiapoptotic and antiautophagic functions of vBcl-2 wer

27 cation but showed little or no effect on the antiapoptotic and antiautophagic functions of vBcl-2.

28 eplication is genetically separated from its antiapoptotic and antiautophagic functions, suggesting t

29 Furthermore, the Nrf2 protein levels and antiapoptotic and antioxidant enzyme levels are higher i

30 we found that this pathway is important for antiapoptotic and cell proliferation signaling.

31 wth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic mechanisms via VE

32 The LPA2 GPCR mediates antiapoptotic and mucosal barrier-protective effects in

33 phorylation of CREB, increased expression of antiapoptotic and neurotrophic molecules and reduced apo

34 leading to cancer involve the activation of antiapoptotic and proliferation programs, as well as eva

35 ve capacity, acquiring angiogenic, invasive, antiapoptotic and survival properties, becoming free fro

36 ation, NO production, and anti-inflammatory, antiapoptotic, and antioxidant effects.

37 Erythropoietin exerts anti-inflammatory, antiapoptotic, and cytoprotective effects in addition to

38 ribute to pathogenesis via proproliferative, antiapoptotic, and proangiogenic activities.

39 C)-induced cytoprotective effects, including antiapoptotic, anti-inflammatory, and barrier stabilizat

40 myeloid cell leukemia 1 (Mcl1) but not other antiapoptotic B cell leukemia/lymphoma 2 (Bcl2) family m

41 ree major classes of antiapoptotic proteins: antiapoptotic B cell lymphoma 2 (BCL-2) proteins, inhibi

42 Although lowering the levels of the antiapoptotic B-cell lymphoma (BCL)2 family proteins, BA

43 Antiapoptotic B-cell lymphoma 2 (Bcl-2) family members s

44 COPD AMs had elevated levels of Mcl-1, an antiapoptotic B-cell lymphoma 2 family member, with sele

45 hat chemical and genetic loss-of-function of antiapoptotic Bcl-2 and Bcl-x(L) significantly augments

46 umbers of apoptotic cells but high levels of antiapoptotic Bcl-2 expression, some dividing cells, and

47 can even promote Treg expansion by enhancing antiapoptotic Bcl-2 expression.

48 haracterized in vitro sensitivity to the pan-antiapoptotic BCL-2 family inhibitor obatoclax mesylate

49 Bcl-xL, an antiapoptotic Bcl-2 family member, undergoes conformatio

50 These results demonstrate that the antiapoptotic Bcl-2 family members do not directly inhib

51 o directly test the impact of the endogenous antiapoptotic Bcl-2 family members on autophagy in the a

52 Unlike other antiapoptotic Bcl-2 family members, Mcl-1 also mediates

53 n tumor cell growth as well as expression of antiapoptotic BCL-2 family members.

54 Cs (cDCs) and their dependence on individual antiapoptotic BCL-2 family members.

55 Several reports suggested that the antiapoptotic Bcl-2 family protein Bcl2a1/Bfl-1/A1 plays

56 tial resistance mediated by induction of the antiapoptotic Bcl-2 family proteins Bcl-xL and Bfl-1.

57 Accordingly, BCL2 mutations can affect antiapoptotic Bcl-2 function, are associated with increa

58 merization, and permeabilization by pro- and antiapoptotic Bcl-2 members at the single-vesicle level.

59 im or, to a lesser extent, overexpression of antiapoptotic Bcl-2 or Mcl-1, significantly accelerated

60 tor signaling leads to overexpression of the antiapoptotic BCL-2 protein and is implicated in the pat

61 Accordingly, strategies to antagonize the antiapoptotic Bcl-2 proteins have largely focused on the

62 The prosurvival function of the antiapoptotic Bcl-2 proteins is manifested by capturing

63 between the transmembrane domains of Bax and antiapoptotic Bcl-2 proteins represent a previously unap

64 Overexpression of antiapoptotic Bcl-2 proteins such as Bcl-2, Bcl-xL, and

65 establish latency by modulating or mimicking antiapoptotic Bcl-2 proteins to promote survival of carr

66 lecule BH3 mimetic, inhibits the function of antiapoptotic Bcl-2 proteins.

67 unresponsive to antagonistic effects of the antiapoptotic BCL-2 proteins.

68 here that Emicro-directed expression of the antiapoptotic Bcl-B protein in mice drives an MM phenoty

69 rotein PUMA induces significant unfolding of antiapoptotic Bcl-xL at the interface, which in turn dis

70 In contrast, antiapoptotic Bcl-xL induces transient permeability alte

71 Furthermore, JUNB and BCL2L1 (which encodes antiapoptotic BCL-xL) mRNA levels were markedly reduced

72 y microenvironmental signals that upregulate antiapoptotic Bcl-xl, Mcl-1, and A1, which can be counte

73 and functionality of the complex represents antiapoptotic Bcl-XL.Bax complexes in the MOM.

74 ucible antioxidant (NQO1, NQO2, HO-1, GCLC), antiapoptotic (Bcl-2), metabolic (G6PD, TKT, PPARgamma),

75 ormal and malignant lymphocytes, whereas the antiapoptotic BCL2 confers resistance.

76 Expression of the antiapoptotic BCL2 protein or inactivation of the p53 pr

77 expression signature, hairy morphology, and antiapoptotic behavior.

78 T cells express higher transcript levels of antiapoptotic but lower levels of proapoptotic factors,

79 ome mutant Bcl-2 proteins exhibited enhanced antiapoptotic capacity in vitro.

80 d Noxa, and did not explain the differential antiapoptotic capacity of the Bcl-2 proteins.

81 nd can trigger important proinflammatory and antiapoptotic changes in latently infected cells.

82 plasmacytomas highlight the significance of antiapoptotic changes in multiple myeloma, which include

83 PR, resulting in increased production of the antiapoptotic chaperone BiP/GRP78, preparing cancer cell

84 -cell production of various inflammatory and antiapoptotic cytokines.

85 The antiapoptotic effect of AAC-11 may be clinically relevan

86 T phosphorylation and a 20% reduction in the antiapoptotic effect of exogenous MIF.

87 ion of SGK activity completely abrogates the antiapoptotic effect of GM-CSF.

88 f MCL1, which proved to be essential for the antiapoptotic effect of IFNgamma in an IM-treated CML li

89 onstrated that in an IM-treated CML line the antiapoptotic effect of IFNgamma was independent of BCL6

90 The antiapoptotic effect of MIF was absent in Cxcr7(-/-) mur

91 inhibition of p65 DNA binding abolished the antiapoptotic effect of ouabain in Stx2-exposed tubular

92 The antiapoptotic effect of rhIL-7 was associated with incre

93 tory diseases and autoimmunity including its antiapoptotic effect on epithelial cells.

94 viability and proliferation and revealed an antiapoptotic effect on insulinoma cells.

95 P-1 signaling ameliorates CP-induced AKI via antiapoptotic effects and that this gut-kidney axis coul

96 Endothelial antiapoptotic effects of HDL(Healthy) were observed afte

97 hannels and adhesion molecules or antagonize antiapoptotic effects on B-cell lymphoma 2 family member

98 MitoNEET-challenged alpha-cells exert potent antiapoptotic effects on beta-cells and prevent cellular

99 thy)) has been proposed to exert endothelial antiapoptotic effects that may represent an important an

100 potent anti-inflammatory, antinecrotic, and antiapoptotic effects that protect against ischemic AKI.

101 istic studies indicated that CTSH exerts its antiapoptotic effects through decreased JNK and p38 sign

102 tions, tapentadol elicited proneurogenic and antiapoptotic effects via activation of beta2 and alpha2

103 ree iron, which exerts anti-inflammatory and antiapoptotic effects.

104 ly nuclear and nuclear IRS1 is known to have antiapoptotic effects.

105 is factor (TNF)-alpha, the proangiogenic and antiapoptotic enzyme cyclooxygenase-2, the IL-8 receptor

106 c pressure overload, but it affected neither antiapoptotic ERK1/2 signaling nor overall physiological

107 and Bcl-XL that support NF-kappaB-dependent antiapoptotic events.

108 mily of proteins, and vaccinia virus harbors antiapoptotic F1L that potently inhibits the mitochondri

109 resulted in the increased expression of the antiapoptotic factor Bcl-2 and decreased expression of t

110 ctivated nuclear factor-kappaB to upregulate antiapoptotic factor Bcl-2 and induced etoposide resista

111 oliferation concomitant to downregulation of antiapoptotic factor expression such as Bcl2.

112 interaction between the NF-kappaB-regulated antiapoptotic factor GADD45beta and the JNK kinase MKK7

113 STAT3 is considered as a critical antiapoptotic factor in various malignancies.

114 that P38 activation led to a decrease in the antiapoptotic factor MCL1, which is often upregulated in

115 tumor-initiating population and serves as an antiapoptotic factor, facilitating anchorage independenc

116 The long variant (Mcl-1L) acts as an antiapoptotic factor, whereas the short isoform (Mcl-1S)

117 ease significant levels of proangiogenic and antiapoptotic factors in the ischemic microenvironment.

118 induced the expression of Bcl-2 and Bcl-xL, antiapoptotic factors that negatively regulate autophagy

119 optosis and consist of both proapoptotic and antiapoptotic factors.

120 in bioenergetic efficiency and stably uphold antiapoptotic features is unknown.

121 Data suggest that CRM1 exerts an antiapoptotic function and is highly prognostic in AML.

122 eport that D-cyclins perform a rate-limiting antiapoptotic function in vivo.

123 redox regulatory mechanisms that control the antiapoptotic function of Bcl-2.

124 Surprisingly, we found that the antiapoptotic function of D-cyclins also operates in qui

125 l and appears to be crucial in mediating the antiapoptotic function of Lyn in this disease.

126 eperfusion (IR) damage, local enhancement of antiapoptotic function, and downregulation of innate Tol

127 ormational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival mo

128 The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising an

129 , Op-IAP3 stabilizes SfIAP and preserves its antiapoptotic function.

130 the mitochondrial outer membrane and exerted antiapoptotic function.

131 cholesterol efflux and anti-inflammatory and antiapoptotic functions seemed to be more severely suppr

132 tance to apoptosis by directly targeting the antiapoptotic gene BCL2 Finally, mir-200 was able to ant

133 e a chromosomal translocation that links the antiapoptotic gene BCL2 to the regulatory elements of im

134 eurotrophins coordinate transcription of the antiapoptotic gene bclw with transport of bclw mRNA to t

135 se 7 and de-repressing the expression of the antiapoptotic gene cFlar.

136 hift in the balance between proapoptotic and antiapoptotic gene expression programs.

137 oncomitant upregulation of NF-kappaB-induced antiapoptotic gene expression, thereby suppressing IFN-g

138 eopolyhedrovirus (AcMNPV) mutant lacking the antiapoptotic gene p35 (vAc(P35)) and a cosmid represent

139 cells by selectively enhancing mRNA decay of antiapoptotic gene transcripts, including Bcl2L1, Bcl2A1

140 Antiapoptotic gene transfer is a potentially powerful to

141 Ki67, minichromosome maintenance genes 2-5, antiapoptotic gene X-linked inhibitor of apoptosis, and

142 We detected upregulation of antiapoptotic genes (e.g., XIAP and GADD45B) and downreg

143 t expression of several growth promoting and antiapoptotic genes as well as for cell-cycle progressio

144 families then targeted and downregulated the antiapoptotic genes Bcl-2 and Bcl-xL, respectively, to i

145 associated with the marked expression of the antiapoptotic genes BIRC5 and IFI6 When the expression o

146 AA-induced apoptosis and down-regulation of antiapoptotic genes can be inhibited by overexpressing G

147 Tuberculosis cases had reduced levels of antiapoptotic genes compared to HHCs with a significant

148 e 21, leading to the sustained expression of antiapoptotic genes, including IGF1, B cell CLL/lymphoma

149 , partially inhibiting expression of several antiapoptotic genes.

150 defective expression of NF-kappaB-dependent antiapoptotic genes.

151 (P-STAT3) that activates expression of many antiapoptotic genes.

152 gly reduces the expression of the inducible, antiapoptotic HSP70 family members HSPA1L and HSPA2, the

153 decreased expression of transcripts encoding antiapoptotic HuR target RNAs.

154 Antiapoptotic IGF-II decreases apoptosis in vitro and si

155 effector-memory differentiation, and reduced antiapoptotic IL7Ralpha (CD127) expression on antigen-ex

156 nd BAX were expressed more highly than their antiapoptotic inhibitors.

157 oxide, suggesting that MrBI-1 contributes to antiapoptotic-like cell death via the endoplasmic reticu

158 splicing variant (MCL1-S) and diminishes the antiapoptotic, long variant (MCL1-L).

159 poptotic programmed cell death protein 5 and antiapoptotic macrophage migration inhibitory factor acc

160 Similarly, pro- and antiapoptotic mammalian regulatory elements are absent i

161 44 knockout animals revealed lower levels of antiapoptotic MCL1, a higher propensity to apoptosis, an

162 ations revealed that NF-kappaB mediated this antiapoptotic mechanism by upregulating expression of UA

163 Here, we describe a novel antiapoptotic mechanism in vascular SMCs that involves i

164 However, the antiapoptotic mechanism of viral IAPs in host insects ha

165 y affected by O-GlcNAcylation as a potential antiapoptotic mechanism.

166 ell proliferation and survival, however, its antiapoptotic mechanisms are not fully understood.

167 YAP as a key regulator of proliferation and antiapoptotic mechanisms in CC and provide first evidenc

168 l blood malignant cell samples suggested the antiapoptotic mediator B-cell lymphoma 2 (BCL2) as a pot

169 lation of STAT5 and Akt and transcription of antiapoptotic mediator bcl-xL Several small-molecule inh

170 ctor (HGF), is known to function as a potent antiapoptotic mediator in normal and neoplastic cells.

171 Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic member of the Bcl-2 family of proteins tha

172 Mcl-1, an antiapoptotic member of the Bcl-2 family of proteins, is

173 MCL-1 is an antiapoptotic member of the BCL-2 protein family, whose

174 t promote plasma cell survival by regulating antiapoptotic members of the Bcl-2 family including Mcl-

175 ften associated with the upregulation of the antiapoptotic members of the Bcl-2 family of proteins.

176 BH3-only proteins inhibit antiapoptotic members of the Bcl-2 family.

177 found that IFNgamma also upregulated several antiapoptotic members of the BCL2 and BIRC gene families

178 Here we report that alphaB-crystallin, an antiapoptotic molecular chaperone implicated in the path

179 l number was marked by low expression of the antiapoptotic molecule B cell lymphoma 2 (Bcl2) and incr

180 te the expression of the gene coding for the antiapoptotic molecule Bcl-2, the proapoptotic molecule

181 et, interferon gamma, interleukin 2, and the antiapoptotic molecule Bcl-2, whereas it dampened the di

182 ted the expression of the cytoprotective and antiapoptotic molecule heme oxygenase-1 (HO-1) at the tr

183 -pathway reaction, has been identified as an antiapoptotic molecule in mammals.

184 APK pathway, with the latter also supporting antiapoptotic molecule liberation.

185 und that GLI1 binds to the promoter of these antiapoptotic molecules and regulates their expression a

186 Bax, and Fas in CD28(null) T cells, whereas antiapoptotic molecules Bcl-2 and Bcl-xL were similar in

187 nregulation and an inverted ratio of pro- to antiapoptotic molecules, both of which were reversed by

188 ling cascade that results in upregulation of antiapoptotic molecules, cytokine secretion, and enhance

189 1 can be overcome by overexpression of other antiapoptotic molecules.

190 medium supplemented with growth factors and antiapoptotic molecules.

191 or growth, cell viability, and expression of antiapoptotic molecules.

192 sis activation include the regulation of pro/antiapoptotic mRNAs through their 3'-untranslated region

193 ockdown decreased cellular protein levels of antiapoptotic myeloid cell leukemia 1 (Mcl-1), an effect

194 lines has concomitant high expression of the antiapoptotic myeloid cell leukemia 1 (MCL-1).

195 Here, antiapoptotic myeloid cell leukemia 1 (MCL1) was found t

196 consistently blocked TRAIL induction of the antiapoptotic NF-kappaB target genes A1/Bfl-1 and/or Mcl

197 nhibiting tissue damage, through probably an antiapoptotic pathway.

198 ly promotes the understanding of the role of antiapoptotic pathways in bacterial infection, but has a

199 The cytokine induces proliferative and antiapoptotic pathways in epithelial cells allowing enha

200 eceptor) genes involved in proliferation and antiapoptotic pathways in mouse B cells.

201 Antiapoptotic pathways of the host cell play integral ro

202 MV-dependent shift from Mcl-1 as the primary antiapoptotic player to the related protein, Bcl-2, late

203 d IAPs explains their relative stability and antiapoptotic potency.

204 is proactive effect through activation of an antiapoptotic program in cardiomyocytes.

205 iPSC-EVs enhanced angiogenic, migratory, and antiapoptotic properties of murine cardiac endothelial c

206 oepoxy derivative of DHEA, was shown to have antiapoptotic properties via mechanisms involving the ne

207 focused on variant (v) 1, demonstrating its antiapoptotic properties.

208 e pituitary, in nonpituitary cells GH exerts antiapoptotic properties.

209 tion and noticeable in vitro antioxidant and antiapoptotic properties.

210 eraction module, and that can prevent AAC-11 antiapoptotic properties.

211 e treatment of multiple sclerosis and exerts antiapoptotic properties.

212 s protection was mediated by upregulation of antiapoptotic protein (c-IAP-2) through calmodulin-depen

213 which results in constitutive activation of antiapoptotic protein B cell lymphoma 2 (BCL2) in a subs

214 Pim kinases control the translation of antiapoptotic protein Bcl-2 at an internal ribosome entr

215 Overexpression of the antiapoptotic protein Bcl-2 is observed in the majority

216 senger RNA and protein concentrations of the antiapoptotic protein Bcl-2 were increased after Ucp2 kn

217 41 also binds with nanomolar affinity to the antiapoptotic protein Bcl-2, which sequesters Casp8p41 a

218 nts), and the concomitant down-regulation of antiapoptotic protein Bcl-2.

219 The role of the antiapoptotic protein Bcl-xL in regulating mitochondrial

220 damage, and rupture by sequestration of the antiapoptotic protein Bcl-xL.

221 and identified 1 of the substrates to be the antiapoptotic protein Bcl-xL.

222 g p73 allele, exhibit elevated levels of the antiapoptotic protein Bcl2 and thus dampen apoptosis.

223 t to apoptosis, exhibited high levels of the antiapoptotic protein BCL2, and remained refractory to r

224 partially restored by overexpression of the antiapoptotic protein BCL2, whereas heterozygous deficie

225 results with venetoclax, an inhibitor of the antiapoptotic protein BCL2.

226 tion that FLT3 TKI treatment upregulates the antiapoptotic protein Bcl6, limiting the drug's apoptoti

227 gulation of FasL and to the induction of the antiapoptotic protein cFLIP.

228 The antiapoptotic protein HAX-1 (HS-associated protein X-1)

229 Bcl-XL is a major antiapoptotic protein in the Bcl-2 family whose overexpr

230 thesis of myeloid cell leukemia 1 (MCL1), an antiapoptotic protein known to play a role in cancer cel

231 gainst the protein interaction site of human antiapoptotic protein Mcl-1 and found that four of the t

232 sunitinib by enhancing the stability of the antiapoptotic protein MCL-1 and inducing mTORC1 signalin

233 ance, which correlates with induction of the antiapoptotic protein Mcl-1 and less consistently with d

234 ot very effective against melanoma, with the antiapoptotic protein MCL-1 as the main contributor to r

235 USP9x protects the antiapoptotic protein Mcl-1 from degradation, and cells

236 biquitination and enhancing stability of the antiapoptotic protein MCL1; therefore, IRAK inhibition r

237 Helicobacter pylori induces the antiapoptotic protein myeloid cell leukemia 1 (Mcl1) in

238 Although the antiapoptotic protein on which a cell depends is typical

239 finities of an atropisomeric mixture against antiapoptotic protein targets Bcl-2 and Bcl-xL.

240 AAC-11 is an antiapoptotic protein that is upregulated in most cancer

241 hat inhibits the production of clusterin, an antiapoptotic protein that is upregulated in response to

242 Human Bax inhibitor-1 (hBI-1) is an antiapoptotic protein that mediates a calcium leak and i

243 In this study, we identified the antiapoptotic protein YAP, a core component of the Hippo

244 An antiapoptotic protein, AfBIR1, opposes this process by i

245 ess by stabilizing the mRNA for Bcl-x(L), an antiapoptotic protein.

246 As in conventional chondrosarcoma, antiapoptotic proteins (Bcl-2, and/or Bcl-xl) were highl

247 idant enzymes (catalase, SOD1, and SOD2) and antiapoptotic proteins (Bcl-2/Bcl-xL).

248 Golgi antiapoptotic proteins (GAAPs) are highly conserved Golg

249 rocess stimulates the upregulation of select antiapoptotic proteins allowing for the differentiation

250 e to cadmium in the BEAS-2B cells as well as antiapoptotic proteins and antioxidant enzymes.

251 through NF-kappaB-dependent upregulation of antiapoptotic proteins and NF-kappaB-independent inactiv

252 through CXCR3-B decreased the levels of the antiapoptotic proteins Bcl-2 and Bcl-xL and increased th

253 lase and superoxide dismutase as well as the antiapoptotic proteins Bcl-2 and Bcl-xL.

254 ntioxidant proteins catalase and SOD and the antiapoptotic proteins Bcl-2 and Bcl-xL.

255 apoptotic pathway and enhances expression of antiapoptotic proteins Bcl-2 and Bcl-XL.

256 The antiapoptotic proteins BCL-2 and myeloid cell leukemia s

257 ing along with JAK-dependent upregulation of antiapoptotic proteins Bcl2 and BclXL.

258 NC201, but instead reduced expression of the antiapoptotic proteins FLIP, Mcl-1, Bcl-2, cIAP1, cIAP2,

259 Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cel

260 ed transcriptional regulation of short-lived antiapoptotic proteins is critical for the survival of t

261 Our data indicate that antiapoptotic proteins may play an important role in che

262 cytes by inducing the expression of cellular antiapoptotic proteins Mcl-1 and HSP27.

263 The antiapoptotic proteins of the BCL-2 family are key regul

264 ants of apoptosis, such as downregulation of antiapoptotic proteins revealed in gene expression array

265 domain that has the dual capacity to inhibit antiapoptotic proteins such as BCL-2 and MCL-1 and direc

266 ects of CDK4/6 inhibitors, the expression of antiapoptotic proteins that associate with response to C

267 n of human airway epithelial cells activates antiapoptotic proteins that suppress apoptosis and promo

268 d and tripled drugs, increased expression of antiapoptotic proteins was observed, requiring a fourth-

269 e mechanism of protection was related to the antiapoptotic proteins X-linked inhibitor of apoptosis (

270 lin-dependent kinase inhibitor p27(Kip1) and antiapoptotic proteins X-linked inhibitor of apoptosis a

271 nificantly reduced expression of a subset of antiapoptotic proteins, including BCL2, BFL1/A1, and 4-1

272 ally, HCMV upregulated two specific cellular antiapoptotic proteins, myeloid leukemia sequence 1 (Mcl

273 stress and quickly downregulates short-lived antiapoptotic proteins, XIAP and c-FLIPL by inhibiting g

274 expressions of both antioxidant enzymes and antiapoptotic proteins.

275 proteins up-regulate antioxidant enzymes and antiapoptotic proteins.

276 olomide has been related to the induction of antiapoptotic proteins.

277 receptors, and the Bax inhibitor 1 family of antiapoptotic proteins.

278 lations of AML tumor cells were enriched for antiapoptotic proteins.

279 inhibitors targeting three major classes of antiapoptotic proteins: antiapoptotic B cell lymphoma 2

280 Contrary to antiapoptotic rat and human v1, overexpression of rat v2

281 NAF-1 binds to both the pro- and antiapoptotic regions (BH3 and BH4) of Bcl-2, as demonst

282 Unlike BCL-2 and BCL-XL, the closest antiapoptotic relative BCL-W is required for spermatogen

283 ur systems biology approach has uncovered an antiapoptotic role for MRP8 in monocytes, which was corr

284 ATR may provide a mechanism for the observed antiapoptotic role of ATR in suppressing carcinogenesis

285 show that the activation of Syk provides an antiapoptotic signal, which is independent of Mcl-1, Bcl

286 rates 1 and 2 (IRS1/2) mediate mitogenic and antiapoptotic signaling from insulin-like growth factor

287 ively, our study identifies a HOIP-regulated antiapoptotic signaling pathway, and we envisage HOIP as

288 by activation of an adrenaline/ADRB2/PKA/BAD antiapoptotic signaling pathway.

289 and HSPA5/BIP expression, activated ERK and antiapoptotic signaling, and conferred relative resistan

290 nes, which are involved in cell survival and antiapoptotic signaling, in human breast cancer cells.

291 tor protein that regulates cell motility and antiapoptotic signaling.

292 Here we review host antiapoptotic signalling pathways manipulated by translo

293 poptosis, which tips the balance in favor of antiapoptotic signals and endows these cells with resist

294 Mechanistically, TLR9-mediated antiapoptotic signals in ZAP-70-positive CLL trigger sec

295 plicing targets, enhancing the production of antiapoptotic splicing isoforms and activating the mTOR

296 nction to increase the Bcl-2/Bax ratio to an antiapoptotic state and activate autophagy through induc

297 Ouabain activated the NF-kappaB antiapoptotic subunit p65, and the inhibition of p65 DNA

298 Accordingly, antiapoptotic T4SS effector proteins, like AnkG, have be

299 Consistent with these findings, Mcl-1, an antiapoptotic target of CREB-mediated transcription, was

300 to regulate the expression of the NF-kappaB antiapoptotic targets BCL2 and XIAP.