ライフサイエンスコーパス: antibiotic

1 e of the gonococcus to a clinically relevant antibiotic.

2 acquired 7 minutes after introduction of the antibiotic.

3 of action of rifaximin, a minimally absorbed antibiotic.

4 the emergence of resistance than traditional antibiotics.

5 arget for herbicides, antifungal agents, and antibiotics.

6 d 66% of children in this age group received antibiotics.

7 cantly contribute for bacteria resistance to antibiotics.

8 plays a key role in bacterial resistance to antibiotics.

9 and identification of potent new monobactam antibiotics.

10 oriety in an era of increasing resistance to antibiotics.

11 ng with the most frequently tested drugs, BL antibiotics.

12 evelopment of even more powerful and durable antibiotics.

13 ding further investigations and the need for antibiotics.

14 the development of resistance to one of the antibiotics.

15 Patient was started on IV fluids and antibiotics.

16 ases in regulating resistance to beta-lactam antibiotics.

17 natives to the resistance-prone conventional antibiotics.

18 wth phase-dependent persistence to quinolone antibiotics.

19 g obstacles in discovery and research of new antibiotics.

20 tive antiparasitic drug, without ineffective antibiotics.

21 ermeable to external insults, including many antibiotics.

22 vels were linked to therapeutic responses to antibiotics.

23 nts with a nonbacterial AURI were prescribed antibiotics.

24 a large number of inappropriately prescribed antibiotics.

25 producer strains resistant to multiple other antibiotics.

26 the leprosy bacillus is sensitive to several antibiotics.

27 e to rifampin, isoniazid and fluoroquinolone antibiotics.

28 nhanced susceptiblity to cell wall targeting antibiotics.

29 ecause it is resistant to some commonly used antibiotics.

30 ere able to provide diagnostic challenges to antibiotics [40/44 (91%]) and local anaesthetics [41/44

31 Twenty-two antibiotics (81 formulations and strengths) were analyze

32 is structure is associated with an increased antibiotic activity against bacterial strains possessing

33 substituents appropriate for enhancement of antibiotic activity.

34 hospital, and emergency department delays in antibiotic administration and in-hospital mortality amon

35 condary outcomes included blood culture use, antibiotic administration between 24 and 72 hours, clini

36 The primary outcome was antibiotic administration in the first 24 hours.

37 lative risk = 1.22 [1.09-1.36]; p = 0.0006), antibiotic administration within 6 hours (relative risk

38 Impairment of host colonization using antibiotics also caused hyperactivity in conventionally

39 ased the use of penicillin and cephalosporin antibiotics among inpatients reporting penicillin allerg

40 oups received a course of empirical systemic antibiotics (amoxicillin and clavulanic acid, 375 mg, to

41 o compare potential suspicion criteria using antibiotic and culture order combinations in terms of pa

42 mouse model using clarithromycin as a model antibiotic and Helicobacter pylori infection as a model

43 se of sporicidal cleaning methods, enhancing antibiotic and possibly proton pump inhibitor stewardshi

44 of AMF exposure, and combination studies of antibiotics and AMF demonstrate a 5-log increase in the

45 which protects bacteria from aminoglycoside antibiotics and contributes to biofilm architecture thro

46 ference of selenoprotein biosynthesis by the antibiotics and elucidate potential side effects.

47 is the target for some of our most powerful antibiotics and has thus been the subject of intense res

48 n 2001), attention would turn to the role of antibiotics and the intestinal microflora in the rising

49 wing concern regarding the widespread use of antibiotics and their presence in the aqueous environmen

50 examined the times to the administration of antibiotics and to the completion of an initial bolus of

51 ly recognition, culture-specific intravenous antibiotics and urgent surgical treatment combined with

52 bacterial resistance to existing classes of antibiotics and with the emergence of vancomycin-resista

53 in and napyradiomycin class of meroterpenoid antibiotics, and we demonstrate that the alpha-hydroxyke

54 We are warned of an impending 'antibiotic apocalypse', where mankind faces its biggest

55 ntibiotic courses pre- and post-AAT-AMS, and antibiotic appropriateness (using standard definitions).

56 Membrane-active antibiotics are potential alternatives to the resistance

57 Whereas many antibiotics are prescribed appropriately to treat infect

58 c treatment regimens, which hyper-emphasizes antibiotics as if they were the sole mechanism responsib

59 tively discriminates against the beta-lactam antibiotics as potential inhibitors, and in favor of the

60 ting this problem is the overprescription of antibiotics as well as a lack of development of new anti

61 ood contaminants and supplements, drugs, and antibiotics as well as their biotransformation products,

62 Our series represents a severe form of antibiotic-associated colitis in critically ill patients

63 enterotoxin (CPE) causes food poisoning and antibiotic-associated diarrhea.

64 infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (proca

65 atory tract infection and prescribed an oral antibiotic between January 2015 and April 2016 in a netw

66 mal RNA decoding site, fluorescently reports antibiotic binding and provides diffraction information

67 BC bottles containing antibiotic binding resins may not sufficiently inactivat

68 By adding antibodies to antibiotic (ceftriaxone)-treated mice, we further reduce

69 Parental reports of the most common antibiotics (cephalosporins, penicillins, and macrolides

70 rally occurring bacterial populations facing antibiotic challenge.

71 advantages and disadvantages of alternative antibiotic choices, and suggest areas for future researc

72 Differences by antibiotic class should be further explored, as this kno

73 at switching between certain combinations of antibiotics completely suppresses the development of res

74 Three animals were rescued with antibiotics (convalescent animals).

75 ticular, suggest that a previously abandoned antibiotic could be used again to treat a minority of go

76 nation of bacterial sensitivity to different antibiotics could have clinical and research application

77 were "de-labeled" of their AAL, spectrum of antibiotic courses pre- and post-AAT-AMS, and antibiotic

78 healthy controls were transplanted into the antibiotic depletion mice model.

79 Exposure to systemic antibiotics destabilized the wound microbiota, rather th

80 ettings may be suitable candidates for early antibiotic discontinuation.

81 hospital-acquired infections and limited new antibiotic discovery are jeopardizing human health at gl

82 PRF may have more of an impact on decreasing antibiotic DOTs compared with PPA.

83 AST methods are based on bacterial growth in antibiotic doubling dilution series, which means that an

84 In this study, the efficacy of antibiotics (doxycycline, oxacillin and rifampicin) in p

85 thogens, which has led to renewed efforts in antibiotic drug discovery.

86 al threat as the clinically available potent antibiotic drugs are becoming exceedingly scarce.

87 ells, a prerequisite for using them as novel antibiotic drugs.

88 ein P (SELENOP) is particularly sensitive to antibiotics due to its ten in frame UGA codons.

89 als with psychological distress and users of antibiotics during the enteritis.

90 ntified the relationship between exposure to antibiotics during the first 2 years of life and the ris

91 importance of validating in vitro studies of antibiotic effects with in vivo models.

92 d slow diffusion out of cells act to prolong antibiotic effects, thereby allowing for less frequent d

93 nduced during treatment, such as AMP, reduce antibiotic efficacy and enhance phagocytic killing.

94 Biofilm antibiotic efficacy studies should be assessed using var

95 activation, antibiotic target alteration and antibiotic efflux were the dominant resistance mechanism

96 ry Enterococcus Faecalis UC-100 substituting antibiotics enhanced growth and health of weaned pigs.

97 esults suggest that dysbiosis resulting from antibiotic exposure affects bee health, in part due to i

98 Antibiotic exposure can alter the gut microbiome.

99 ificant additive interaction between CMA and antibiotic exposure in the later development of JIA.

100 e performed experiments to determine whether antibiotic exposure increases susceptibility to infectio

101 Antibiotic exposure ranged by specimen type from 43.5% t

102 Despite antibiotic exposure, 15 of the 39 patients (approximatel

103 However, no association was found for antibiotics exposure early in life and objective atopy m

104 and exacerbation, yet with the exception of antibiotics, few treatments are available that specifica

105 ly by S. aureus and treated with appropriate antibiotic for at least 2 days still progressed to VAP.

106 after the index date, therapy with an active antibiotic for at least 2 days when blood cultures were

107 or high-value care on the appropriate use of antibiotics for acute respiratory tract infections.

108 egivers substantially reduced prescribing of antibiotics for childhood upper respiratory tract infect

109 hese data support the use of narrow-spectrum antibiotics for most children with acute respiratory tra

110 oup provides recommendations for appropriate antibiotics for the treatment of sepsis.

111 ls to define novel ways of using an existing antibiotic, fosfomycin, to treat ESBL-producing Enteroba

112 Assay was validated by spiking OTC to antibiotic free milk samples and results could be accomp

113 Release of antibiotic from PCL-PVP dosage forms was shown over 5 da

114 multidrug resistance by transporting diverse antibiotics from the cell.

115 rates target directed genome mining methods, antibiotic gene cluster predictions and 'essential gene

116 Children treated with guideline-adherent antibiotics had lower 30-day ACS-related (odds ratio [OR

117 The effectiveness of antibiotics has been widely compromised by the evolution

118 Antibiotics have revolutionised medicine in many aspects

119 was to examine the degradation of veterinary antibiotics in milk during boiling.

120 factors and conferring resistance to various antibiotics in pathogenic microbes.

121 ies were excluded if they were not RCTs, the antibiotics in the two arms were not the same, neither m

122 ient mice, with no additional suppression by antibiotics in these mice.

123 in II, an alanine-containing streptogramin A antibiotic, in the context of a functional 70S ribosome

124 Antibiotic inactivation, antibiotic target alteration an

125 gens are intrinsically resistant to multiple antibiotics, including beta-lactams, aminoglycosides, fl

126 Antibiotics inhibited the clinical benefit of ICIs in pa

127 t Gram-negative bacteria within two hours of antibiotic introduction rather than 8-24 h.

128 ant, and development of clinically effective antibiotics is lagging.

129 Antibiotic management was most significantly correlated

130 ng and translocation suggests that miscoding antibiotics may impact protein synthesis by impairing th

131 Resistance to beta-lactam antibiotics mediated by metallo-beta-lactamases (MBLs) i

132 against many orally acquired pathogens, and antibiotic-mediated depletion of the microbiota reduces

133 Antibiotic-mediated microbiota destruction and the conse

134 In the absence of antibiotic-mediated selection, sensitive bacteria are ex

135 drug-target complex dissociates rapidly, the antibiotic must be kept constantly at a concentration th

136 sity of the gut microbiome of children in an antibiotic-naive community.

137 nsible for the biosynthesis of the polyether antibiotics nanchangmycin (1) and salinomycin (4) harbor

138 roduction and observed a shift away from the antibiotic napyradiomycin towards 8-amino-flaviolin, an

139 placebo-controlled, and two (10%) evaluated antibiotics no longer recommended for acute infectious d

140 s was a longer time to the administration of antibiotics (odds ratio, 1.04 per hour; 95% CI, 1.03 to

141 pathogenic bacteria since the golden age of antibiotics of the mid-20th century.

142 The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption o

143 Children with three or more antibiotic orders had a greater odds of milk allergy (Od

144 7; 2.72-3.46) compared with children with no antibiotic orders.

145 Bacteriuria contributes to antibiotic overuse through treatment of asymptomatic bac

146 ter disinfection with 1.25% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsu

147 lops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their ch

148 vs 58%; P < .001) and more likely to have an antibiotic prescription (28% vs 25%; P = .04).

149 iently fast diagnostic test to guide correct antibiotic prescription at the point of care.

150 Antibiotic prescription fills did not differ for persons

151 5% confidence intervals (CIs) for filling an antibiotic prescription for acute conjunctivitis.

152 Using e-POCT, the most common indication for antibiotic prescription was severe disease (57%, 103/182

153 advantages in terms of clinical outcome and antibiotic prescription.

154 and accounts for approximately 20% of adult antibiotic prescriptions in the United States.

155 ondary outcomes were reconsultation, further antibiotic prescriptions, symptom duration, and symptom

156 95% CI, 0.81-0.86) had lower odds of filling antibiotic prescriptions.

157 Intrapartum antibiotic prophylaxis is the current mainstay of preven

158 benefit for eyes complicated by PCR, and IC antibiotic prophylaxis should be strongly considered for

159 chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by em

160 basic, Food and Drug Administration-approved antibiotic recommended by the World Health Organization

161 NTERPRETATION: Limiting population use of 4C antibiotics reduced selective pressures favouring multid

162 ting to autoimmune responses associated with antibiotic-refractory LA.

163 007 [1.002-1.013]; p = 0.006), time-to-first antibiotic (relative risk = 1.22 [1.09-1.36]; p = 0.0006

164 e, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets.

165 development of biosensors for the control of antibiotic residues in food are highlighted.

166 d the data about the influence of cooking on antibiotics residues in eggs are limited.

167 transfer is an important means of spreading antibiotic resistance .

168 e of processes, including membrane assembly, antibiotic resistance and metabolic coordination.

169 r their contribution to the dissemination of antibiotic resistance and the emergence of multiresistan

170 The Comprehensive Antibiotic Resistance Database is a manually curated res

171 ted improvements in pathogen identification, antibiotic resistance detection, and outbreak investigat

172 New hypervirulent strains and acquisition of antibiotic resistance exacerbates pathogenesis; however,

173 r rapid diagnostic methods that can evaluate antibiotic resistance for pathogenic bacteria in order t

174 ewater solids are a significant reservoir of antibiotic resistance genes (ARGs).

175 , and identification of stress tolerance and antibiotic resistance genes in bacteria.

176 otations for carbohydrate-active enzymes and antibiotic resistance genes.

177 that failure of antibiotic treatment due to antibiotic resistance has little clinical impact in the

178 However, the direct impact of antibiotic resistance in the severity and outcomes of P.

179 The rise in antibiotic resistance is a major threat for human health

180 by whole-genome sequencing from the CDC-FDA Antibiotic Resistance Isolate Bank were evaluated, inclu

181 landscape and challenges in the treatment of antibiotic resistance mechanisms at both bacterial cell

182 test methods and other strategies to counter antibiotic resistance of C. difficile.

183 ance systems for the routine surveillance of antibiotic resistance that would be helpful for a better

184 ing the outcome of P. aeruginosa infections, antibiotic resistance, and particularly multidrug-resist

185 oliferation of cataclysmic predictions about antibiotic resistance, cases of which are estimated to a

186 Widespread antibiotic resistance, especially of Gram-negative bacte

187 clinical outcome and promotes the spread of antibiotic resistance.

188 y often lead to health concerns or potential antibiotic resistance.

189 to limit conjugation-assisted persistence of antibiotic resistance.

190 used to identify the creep towards complete antibiotics resistance in bacteria using genome sequenci

191 ones rapidly emerge mainly by acquisition of antibiotic-resistance genes from other S. aureus strains

192 such practices could help reduce the load of antibiotic-resistance genes in the environment.

193 h2-B1 serves as a therapeutically important "antibiotic-resistance-breaker," which enhances the bacte

194 Increasing antibiotic resistant hospital-acquired infections and li

195 Bacterial pathogens are increasingly antibiotic resistant, and development of clinically effe

196 for a better understanding of how to manage antibiotic-resistant bacteria in the future.

197 therapeutic alternative for the treatment of antibiotic-resistant bacterial infections.

198 Antibiotic-resistant clones rapidly emerge mainly by acq

199 on and intra-patient dissemination of highly antibiotic-resistant pathogens.

200 The numbers of days on antibiotic(s) per patient were 1.73 in the cases and 2.1

201 ation of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state.

202 rimental and computational methods can guide antibiotic selection for TB.

203 we demonstrated that systemic application of antibiotics significantly improved the alveolar bone and

204 ons, our competition experiments showed that antibiotics significantly increased the advantage of non

205 Our findings have important implications for antibiotic stewardship and public health policies and, i

206 Our findings have important implications for antibiotic stewardship and should be considered as new p

207 A mixed persuasive-restrictive 4C antibiotic stewardship intervention was initiated in all

208 by promoting appropriate antibiotic use via antibiotic stewardship programs.

209 the PIP/TAZO shortage and the importance of antibiotic stewardship when mitigating drug shortages.

210 that have developed different approaches to antibiotic stewardship-the USA, South Africa, Colombia,

211 f calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clinically appro

212 inical features, visual acuity outcomes, and antibiotic susceptibility patterns.

213 Antibiotic susceptibility predictions were fully concord

214 crofluidic platform, we can correctly assign antibiotic susceptibility profiles of clinically relevan

215 The total time for antibiotic susceptibility testing, from loading of sampl

216 s of M. genitalium and assays to predict the antibiotic susceptibility to azithromycin.

217 Antibiotic susceptibility, biofilm formation, Staphyloco

218 e flow in the DFR significantly restored the antibiotic susceptibility.

219 capacity of each isolate to alter S. aureus antibiotic susceptibility.

220 Antibiotic inactivation, antibiotic target alteration and antibiotic efflux were

221 TB disease may reflect long-term effects of antibiotic TB treatment on the microbiome.

222 ilms were significantly more tolerant to the antibiotics than those grown in MWP without the continuo

223 chia coli populations producing colicins, an antibiotic that kills producer cells' close relatives.

224 ted that weight may be adversely affected by antibiotics that destroy existing microbiomes and replac

225 scalable synthesis of group A streptogramin antibiotics that proceeds in 6-8 linear steps from simpl

226 , the minimum inhibitory concentration of an antibiotic, the dosage at which bacterial growth is thwa

227 using it, their resistance against classical antibiotics, the formation of a biofilm and the difficul

228 Bacterial biofilms are recalcitrant to antibiotic therapy and a major cause of persistent and r

229 and MRI were sensitive to detect response to antibiotic therapy for pulmonary exacerbations.

230 ol this epidemic with screening programs and antibiotic therapy have failed.

231 d infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory in

232 Antibiotic therapy is a major risk factor for the develo

233 had more episodes of infection that required antibiotic therapy than the control group.

234 placement of the infected joint and weeks of antibiotic therapy, due to the formation of biofilm.

235 us identical placebo, together with standard antibiotic therapy.

236 icult to resolve without extended courses of antibiotic therapy.

237 tified as activated MSC co-administered with antibiotic therapy.

238 e a valid alternative to routine full-course antibiotic therapy.

239 Despite prompt treatment with appropriate antibiotics, there were variable visual outcomes.

240 n the biosynthesis of the potent thiopeptide antibiotic thiomuracin.

241 The first antibiotic to be widely used for leprosy treatment was d

242 hysicians to achieve fast adequate dosing of antibiotics to improve the outcome of patients with seps

243 o ensure early appropriate administration of antibiotics to save lives of patients, yet the present b

244 This high antibiotic tolerance is related to bacterial persisters,

245 shortage by shifting antibiotic usage toward antibiotics traditionally known to place patients at gre

246 ombining models of commensal colonization in antibiotic-treated and germ-free mice, using cultured co

247 idium orbiscindens, produced DAT and rescued antibiotic-treated influenza-infected mice.

248 ents who responded to ICIs into germ-free or antibiotic-treated mice ameliorated the antitumor effect

249 icrobiota, we performed fecal transplants in antibiotic-treated mice and found that transplant of fec

250 The antibiotic-treated plants translocated ciprofloxacin thr

251 lth, but they also provide insights into how antibiotic treatment affects microbial communities and h

252 ratory tract symptom not requiring immediate antibiotic treatment and with no history of chronic pulm

253 The perception exists that failure of antibiotic treatment due to antibiotic resistance has li

254 r and expand access to lifesaving outpatient antibiotic treatment for infants with severe infection d

255 monitored the survivorship of bees following antibiotic treatment in order to determine if dysbiosis

256 Notably, intensive intravenous antibiotic treatment of patients with melioidosis result

257 Frequent antibiotic treatment of urinary tract infections has res

258 nses in the research for, and the design of, antibiotic treatment regimens, which hyper-emphasizes an

259 erefore without telescopic plugged catheter, antibiotic treatment was continued for 7 days.

260 Antibiotic treatment was started when prespecified diagn

261 When cultures were negative, the antibiotic treatment was stopped.

262 Antibiotic treatment with combinations of clindamycin an

263 erived metabolites affected by both diet and antibiotic treatment, which conformed to previously publ

264 f further follow-up or details regarding the antibiotic treatment.

265 ate intracellularly while protecting it from antibiotic treatment.

266 g bronchoscopy before starting probabilistic antibiotic treatment.

267 th severe infections and children in need of antibiotic treatment.

268 ogenic bacteria in order to deliver targeted antibiotic treatments.

269 Ten (50%) of 20 included antibiotic trials were among children with dysentery, no

270 solates was observed only in the presence of antibiotic trough concentrations.

271 e and responded to that shortage by shifting antibiotic usage toward antibiotics traditionally known

272 tions were associated with recent antecedent antibiotic use (adjusted odds ratio [aOR], 4.17; 95% con

273 llergies, but there have been few studies on antibiotic use and allergic disease.

274 ation off farm of ARGs under Finnish limited antibiotic use and suggest that such practices could hel

275 Antibiotic use in children or in their pregnant mother c

276 ave suggested a possible association between antibiotic use in infancy and risk of childhood obesity,

277 narrative literature review of evidence for antibiotic use in this setting that included recent clin

278 pressure for MDROs by promoting appropriate antibiotic use via antibiotic stewardship programs.

279 nd age, sex, history of breastfeeding, prior antibiotic use, adherence to study medication, or develo

280 on symptoms, duration of abnormal peak flow, antibiotic use, or nonserious adverse events.

281 mprove clinical care by reducing unnecessary antibiotic use, shortening length of hospital stay, impr

282 e, severe neutropenia, and prior beta-lactam antibiotic use.

283 livery, infant feeding, crowding, and recent antibiotic use.

284 tify factors associated with high outpatient antibiotic use.

285 such as dietary modifications and increased antibiotic use.

286 alytical tool for ultrasensitive analysis of antibiotics used for empirical treatment of patients wit

287 maining 49 patients, 16 continued to receive antibiotics, usually for infections other than pneumonia

288 d dimerization of the important glycopeptide antibiotic vancomycin in four different aqueous solvents

289 gs: the chemotherapeutic doxorubicin and the antibiotic vancomycin.

290 well as a boronic acid version of the iconic antibiotic vancomycin.

291 , M-4365, and rosamicin classes of macrolide antibiotics via late-stage diversification.

292 ed a shift toward increased use of high-risk antibiotics was 1.30 (95% CI, 1.03-1.64; P < .05).

293 Antibiotics were associated with a 45% reduction in bloo

294 kup was negative for all three patients, and antibiotics were discontinued after 2 days in the second

295 her than pneumonia; of the 33 patients whose antibiotics were discontinued, only two subsequently sho

296 The effects of antibiotics were phenocopied in Stat1-deficient mice, wi

297 Guideline-adherent antibiotics were provided in 10654 of 14480 hospitalizat

298 Diverse organisms secrete redox-active antibiotics, which can be used as extracellular electron

299 for specific and efficient genome mining for antibiotics with interesting and novel targets.

300 growth in the presence or absence of certain antibiotics with real-time quantitative PCR or digital P