ライフサイエンスコーパス: antibiotics

1 wth phase-dependent persistence to quinolone antibiotics.

2 g obstacles in discovery and research of new antibiotics.

3 tive antiparasitic drug, without ineffective antibiotics.

4 ermeable to external insults, including many antibiotics.

5 vels were linked to therapeutic responses to antibiotics.

6 obtained, indicate a negligible presence of antibiotics.

7 road-spectrum antibiotics vs narrow-spectrum antibiotics.

8 s), 868 (35%) were prescribed broad-spectrum antibiotics.

9 helicidin and was significantly increased by antibiotics.

10 trations from being achieved for a number of antibiotics.

11 nts with a nonbacterial AURI were prescribed antibiotics.

12 agnosis, and 48 (92.3%) received unnecessary antibiotics.

13 common among patients with ASB treated with antibiotics.

14 likely to drive resistance than conventional antibiotics.

15 veral opiates, antidepressants, statins, and antibiotics.

16 a large number of inappropriately prescribed antibiotics.

17 nt than developed resistance to conventional antibiotics.

18 us, and Mycobacterium smegmatis to quinolone antibiotics.

19 ence of symptoms, 96% were erroneously given antibiotics.

20 producer strains resistant to multiple other antibiotics.

21 blood factor in the activity of sulfonamide antibiotics.

22 gative bacteria inherently resistant to many antibiotics.

23 the leprosy bacillus is sensitive to several antibiotics.

24 s, or even just their pregnant mothers, with antibiotics.

25 ate susceptibility or resistance to specific antibiotics.

26 the use of medications, with an emphasis on antibiotics.

27 f the isolates were resistant to one or more antibiotics.

28 ctions attributed to use of broader-spectrum antibiotics.

29 e to rifampin, isoniazid and fluoroquinolone antibiotics.

30 scape created by the widespread use of other antibiotics.

31 ravated by incorrect prescription and use of antibiotics.

32 treatment and following cure by 6 months of antibiotics.

33 rational engineering of nonribosomal peptide antibiotics.

34 evelopment and treatment with broad-spectrum antibiotics.

35 ation of bacterial susceptibility to certain antibiotics.

36 ne that confers intrinsic resistance to many antibiotics.

37 he rapid spread of resistance to last-resort antibiotics.

38 nhanced susceptiblity to cell wall targeting antibiotics.

39 oids for acute sore throat in the absence of antibiotics.

40 ultidisciplinary approach to optimise use of antibiotics.

41 duce the proportion of patients treated with antibiotics.

42 droponically with the same concentrations of antibiotics.

43 onisation are expensive and normally require antibiotics.

44 iotics and CDI in hospitalized adults taking antibiotics.

45 ecause it is resistant to some commonly used antibiotics.

46 availability of low-cost, essential generic antibiotics.

47 tibiotics, 72% of patients with ASB received antibiotics.

48 nced adjunctive activity in combination with antibiotics.

49 gh case fatality rate despite treatment with antibiotics.

50 al growth and resistance to cell wall-active antibiotics.

51 the emergence of resistance than traditional antibiotics.

52 arget for herbicides, antifungal agents, and antibiotics.

53 d 66% of children in this age group received antibiotics.

54 cantly contribute for bacteria resistance to antibiotics.

55 plays a key role in bacterial resistance to antibiotics.

56 and identification of potent new monobactam antibiotics.

57 oriety in an era of increasing resistance to antibiotics.

58 ng with the most frequently tested drugs, BL antibiotics.

59 evelopment of even more powerful and durable antibiotics.

60 ding further investigations and the need for antibiotics.

61 the development of resistance to one of the antibiotics.

62 Patient was started on IV fluids and antibiotics.

63 ases in regulating resistance to beta-lactam antibiotics.

64 natives to the resistance-prone conventional antibiotics.

65 ere able to provide diagnostic challenges to antibiotics [40/44 (91%]) and local anaesthetics [41/44

66 phylaxis included the following: NMBA (35%), antibiotics (46%), chlorhexidine (8%), patent blue dye (

67 luding patients with non-UTI indications for antibiotics, 72% of patients with ASB received antibioti

68 Twenty-two antibiotics (81 formulations and strengths) were analyze

69 drugs can lead to timely availability of new antibiotics, accelerated by existing safety profiles.

70 ed with oral antibiotics, use of intravenous antibiotics after discharge in children with complicated

71 phage-therapy (phage) alone or combined with antibiotics against experimental endocarditis (EE) due t

72 Impairment of host colonization using antibiotics also caused hyperactivity in conventionally

73 Bactericidal antibiotics alter microbial metabolism as part of their

74 ased the use of penicillin and cephalosporin antibiotics among inpatients reporting penicillin allerg

75 oups received a course of empirical systemic antibiotics (amoxicillin and clavulanic acid, 375 mg, to

76 nt is consistent with the ancient origins of antibiotics and a variety of studies support a long natu

77 nges in the environment, such as exposure to antibiotics and also to trigger production of virulence

78 of AMF exposure, and combination studies of antibiotics and AMF demonstrate a 5-log increase in the

79 which protects bacteria from aminoglycoside antibiotics and contributes to biofilm architecture thro

80 prevent inappropriate and untargeted use of antibiotics and control the antibiotic resistance crisis

81 phylaxis also minimized the use of treatment antibiotics and drastically reduced C. difficile infecti

82 ference of selenoprotein biosynthesis by the antibiotics and elucidate potential side effects.

83 lly and mechanistically unrelated classes of antibiotics and enhance survival following heat shock an

84 onjunctivitis fill prescriptions for topical antibiotics and factors associated with antibiotic presc

85 is the target for some of our most powerful antibiotics and has thus been the subject of intense res

86 orts to investigate the relationship between antibiotics and human weight gain.

87 Exposure to antibiotics and hypoxic environment resulted in higher o

88 ctamases (BLs) able to hydrolyze beta-lactam antibiotics and more importantly the last resort carbape

89 of synbiotics may help to reduce the use of antibiotics and multidrug resistance.

90 After adjustment for preadmission antibiotics and NAI treatment propensity, preadmission N

91 inhibited bacterial growth compared to free antibiotics and non-responsive nanogel counterparts.

92 prescription of oral rehydration solutions, antibiotics and other medications as well as education p

93 t is the target for our most frequently used antibiotics and provides important small molecules that

94 These manifestations were prevented by antibiotics and reversed by low-FODMAP (LFM) diet.

95 nipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner.

96 n 2001), attention would turn to the role of antibiotics and the intestinal microflora in the rising

97 wing concern regarding the widespread use of antibiotics and their presence in the aqueous environmen

98 examined the times to the administration of antibiotics and to the completion of an initial bolus of

99 ly recognition, culture-specific intravenous antibiotics and urgent surgical treatment combined with

100 ng CaSO4 beads that contained fluorescein or antibiotics and were pre-coated with human blood or syno

101 bacterial resistance to existing classes of antibiotics and with the emergence of vancomycin-resista

102 rious environmental factors, including diet, antibiotics, and early-life microbial exposures.

103 iagnostic tests, reducing unnecessary use of antibiotics, and leading to a reduction in hospital leng

104 kup including blood cultures, broad-spectrum antibiotics, and mechanical ventilatory support.

105 in and napyradiomycin class of meroterpenoid antibiotics, and we demonstrate that the alpha-hydroxyke

106 At a time when antibiotics are becoming less effective, no vaccines to

107 Most antibiotics are derived from secondary metabolites produ

108 ide and gonococcal strains resistant to many antibiotics are emerging.

109 Aminoglycoside antibiotics are known toxins to cochlear hair cells, cau

110 g of antibiotics has proven challenging-some antibiotics are most effective when they are administere

111 Antibiotics are often employed after discharge to preven

112 Membrane-active antibiotics are potential alternatives to the resistance

113 Whereas many antibiotics are prescribed appropriately to treat infect

114 Many antibiotics are prescribed inappropriately in pediatric

115 Streptogramin antibiotics are used clinically to treat multidrug-resis

116 is, likely to be phenotypically resistant to antibiotics, are present in large numbers in tissue.

117 rugs, we propose that the development of new antibiotics around proven natural scaffolds is the best

118 c treatment regimens, which hyper-emphasizes antibiotics as if they were the sole mechanism responsib

119 ivestock, investigators explored the role of antibiotics as magic bullets for human malnutrition.

120 tively discriminates against the beta-lactam antibiotics as potential inhibitors, and in favor of the

121 ting this problem is the overprescription of antibiotics as well as a lack of development of new anti

122 ood contaminants and supplements, drugs, and antibiotics as well as their biotransformation products,

123 infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (proca

124 tion of bacterial susceptibility to specific antibiotics based on the IR spectra of the bacteria.

125 ls is a novel strategy of peptide-nucleotide antibiotics biosynthesis that may help control productio

126 e of sepsis care and rapid administration of antibiotics, but not rapid completion of an initial bolu

127 Treatment is by antibiotics, but such therapy is linked to antibiotic re

128 Chronic periodontitis is controlled without antibiotics by scaling and root planing (SRP) to remove

129 genic bacterium Pseudomonas aeruginosa PA14, antibiotics called phenazines act as oxidants to balance

130 ld be similarly effective, (ii) low doses of antibiotics can be as effective as high doses, and (iii)

131 Parental reports of the most common antibiotics (cephalosporins, penicillins, and macrolides

132 member of a subfamily of enediyne antitumour antibiotics characterized by a 10-membered carbocycle fu

133 , to allow conservative and effective use of antibiotics clinical settings require better diagnostic

134 r population developed resistance to several antibiotics coinciding with periods of antibiotic therap

135 ) of 360 patients in the POCT group received antibiotics compared with 294 (83%) of 354 controls (dif

136 at switching between certain combinations of antibiotics completely suppresses the development of res

137 Three animals were rescued with antibiotics (convalescent animals).

138 Development of resistance-resistant antibiotics could be achieved via the coordinated networ

139 nation of bacterial sensitivity to different antibiotics could have clinical and research application

140 Exposure to systemic antibiotics destabilized the wound microbiota, rather th

141 tempered by controlled studies showing that antibiotics did not serve as useful, nonspecific growth

142 ause of their unusually robust resistance to antibiotics, disinfectants, and desiccation.

143 with comparable affinities, the bactericidal antibiotics dissociate from the ribosome with significan

144 In this study, the efficacy of antibiotics (doxycycline, oxacillin and rifampicin) in p

145 ein P (SELENOP) is particularly sensitive to antibiotics due to its ten in frame UGA codons.

146 cteriaceae are resistant to most beta-lactam antibiotics due to the production of the Klebsiella pneu

147 als with psychological distress and users of antibiotics during the enteritis.

148 ntified the relationship between exposure to antibiotics during the first 2 years of life and the ris

149 The use of the most prescribed antibiotics during the first 4 years of life, regardless

150 Female sex and receipt of antibiotics during the hospital admission consistently p

151 ry Enterococcus Faecalis UC-100 substituting antibiotics enhanced growth and health of weaned pigs.

152 have become one of effective alternatives to antibiotics enhancing animal health and performance thro

153 cluding protection from chemicals (including antibiotics), entrapment of useful extracellular enzymes

154 A subset of antibiotics exhibited substantial price increases, and m

155 However, no association was found for antibiotics exposure early in life and objective atopy m

156 and exacerbation, yet with the exception of antibiotics, few treatments are available that specifica

157 or high-value care on the appropriate use of antibiotics for acute respiratory tract infections.

158 egivers substantially reduced prescribing of antibiotics for childhood upper respiratory tract infect

159 CT)-based algorithms to decrease duration of antibiotics for critically ill patients with sepsis.

160 hese data support the use of narrow-spectrum antibiotics for most children with acute respiratory tra

161 Many patients started on antibiotics for possible ventilator-associated pneumonia

162 Early initiation of effective antibiotics for septic patients is essential for patient

163 oup provides recommendations for appropriate antibiotics for the treatment of sepsis.

164 sting studies comparing intravenous and oral antibiotics for this purpose are limited.

165 applications without resorting to the use of antibiotics, for which bacteria are developing a resista

166 multidrug resistance by transporting diverse antibiotics from the cell.

167 eptibility within a few minutes to different antibiotics, gentamicin, ceftazidime, nitrofurantoin, na

168 Here we report that oral antibiotics given during active disease removed harmful

169 The primary exposure was antibiotics given within 6 hours of emergency department

170 Children treated with guideline-adherent antibiotics had lower 30-day ACS-related (odds ratio [OR

171 acteria to a broad spectrum of commonly used antibiotics has become a global health-care problem.

172 The effectiveness of antibiotics has been widely compromised by the evolution

173 Identifying optimal dosing of antibiotics has proven challenging-some antibiotics are

174 ste, especially waste containing therapeutic antibiotics, has a significant impact on microbial popul

175 Historically, antibiotics have been highly effective against most bact

176 Antibiotics have revolutionised medicine in many aspects

177 thway and is a target for the development of antibiotics, herbicides, and antimalarial drugs.

178 synergistically and detoxify aminoglycoside antibiotics highly efficiently.

179 y when reared on artificial diets containing antibiotics, hormones, or a mixture of contaminants.

180 nderscore the developmental caveats of using antibiotics in adipogenic studies.

181 roxarsone (ROX), and sulfamethoxazole (SMX) antibiotics in agriculturally relevant matrices.

182 With recent FDA rules for phasing-out antibiotics in animal production, pressure is mounting t

183 VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the

184 Bacterial resistance to most antibiotics in clinical use has reached alarming proport

185 s and the decline in number of potential new antibiotics in development there is a fervent need to re

186 est that treatment of common infections with antibiotics in infancy is unlikely to be a main contribu

187 e manifestation of resistance to beta-lactam antibiotics in many Enterobacteriaceae and Pseudomonas a

188 was to examine the degradation of veterinary antibiotics in milk during boiling.

189 factors and conferring resistance to various antibiotics in pathogenic microbes.

190 The observed photodegradation kinetics for antibiotics in solutions containing dissolved organic ma

191 ies were excluded if they were not RCTs, the antibiotics in the two arms were not the same, neither m

192 ient mice, with no additional suppression by antibiotics in these mice.

193 ence the recommendations for clinical use of antibiotics in young children at risk for T1D or CD.

194 in were equally highly resistant to multiple antibiotics including methicillin and had identical geno

195 gens are intrinsically resistant to multiple antibiotics, including beta-lactams, aminoglycosides, fl

196 Whereas many antibiotics increase risk of Clostridium difficile infec

197 pared to ST131, ST73 was susceptible to most antibiotics, indicating that multidrug resistance was no

198 Frontline antibiotics inhibit mycomembrane biosynthesis, leading t

199 Antibiotics inhibited the clinical benefit of ICIs in pa

200 Aminoglycoside antibiotics interfere with ribosomal function and may ca

201 Innovative approaches to the use of existing antibiotics is an important strategy in efforts to addre

202 ant, and development of clinically effective antibiotics is lagging.

203 The efficacy of beta-lactam antibiotics is threatened by the emergence and global sp

204 ng and translocation suggests that miscoding antibiotics may impact protein synthesis by impairing th

205 Resistance to beta-lactam antibiotics mediated by metallo-beta-lactamases (MBLs) i

206 Antibiotics methymycin (MTM) and pikromycin (PKM), co-pr

207 nsible for the biosynthesis of the polyether antibiotics nanchangmycin (1) and salinomycin (4) harbor

208 programs that emphasize the judicious use of antibiotics need to continue to be a focus of public hea

209 ries of four analogues of the aminoglycoside antibiotics neomycin and paromomycin is described in whi

210 to topical treatment with povidone-iodine or antibiotics (neomycin-polymyxin B-gramicidin in the Phil

211 placebo-controlled, and two (10%) evaluated antibiotics no longer recommended for acute infectious d

212 s was a longer time to the administration of antibiotics (odds ratio, 1.04 per hour; 95% CI, 1.03 to

213 Carbapenems are widely regarded as the antibiotics of choice for the treatment of ESBL-producin

214 e rise of "superbugs," bacteria resistant to antibiotics of last resort.

215 pathogenic bacteria since the golden age of antibiotics of the mid-20th century.

216 The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption o

217 imited data are available on the efficacy of antibiotics on bacterial airway colonization and/or prev

218 5/544); 94.9% (516/544) of patients received antibiotics on day 0, and 1.1% (6/544) experienced sever

219 esults do not rule out a potential effect of antibiotics on microbiome composition and the use of ant

220 for applying thermal stimulation to release antibiotics on-demand.

221 for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant

222 acute respiratory symptoms requiring either antibiotics or systemic steroids, and severe events by t

223 d from CCM formation, and a single course of antibiotics permanently alters CCM susceptibility in mic

224 We extracted oral antibiotics recommended for common outpatient conditions

225 Here, we review how antibiotics reduce colonization resistance against Enter

226 NTERPRETATION: Limiting population use of 4C antibiotics reduced selective pressures favouring multid

227 Direct exposure to antibiotics remains the primary risk factor for CDI but

228 In addition, antibiotics removed Lachnospiraceae and increased the re

229 d the data about the influence of cooking on antibiotics residues in eggs are limited.

230 eveloped to screen the oxytetracycline (OTC) antibiotics residues in milk samples.

231 used to identify the creep towards complete antibiotics resistance in bacteria using genome sequenci

232 ups, with 29% and 27% of patients prescribed antibiotics, respectively.

233 trum antibiotics vs 91.5 for narrow-spectrum antibiotics; score difference for full matched analysis,

234 ation of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state.

235 50s, amid initial findings that low doses of antibiotics served as growth promoters in animal livesto

236 ics on microbiome composition and the use of antibiotics should always be judicious, they suggest tha

237 Our data indicate that beta-lactam antibiotics should be included in the treatment regimen

238 we demonstrated that systemic application of antibiotics significantly improved the alveolar bone and

239 ons, our competition experiments showed that antibiotics significantly increased the advantage of non

240 great value in tailoring dosing regimens of antibiotics so as to maximize the duration of their usef

241 f calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clinically appro

242 ccus, P. aeruginosa and Salmonella typhi) to antibiotics such as ampicillin and kanamycin.

243 city of magnetite to bind not only quinolone antibiotics such as nalidixic acid (NA) and flumequine (

244 rved when cells were directly incubated with antibiotics, suggesting that these effects are indirect.

245 None of the participants received any antibiotics (systemic or topical therapy) within 1 month

246 Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microb

247 res was associated with higher resistance to antibiotics than in either monoculture.

248 ilms were significantly more tolerant to the antibiotics than those grown in MWP without the continuo

249 ted that weight may be adversely affected by antibiotics that destroy existing microbiomes and replac

250 l lead to the discovery of new streptogramin antibiotics that overcome previous limitations of the cl

251 scalable synthesis of group A streptogramin antibiotics that proceeds in 6-8 linear steps from simpl

252 ycins are a relatively understudied group of antibiotics that target the essential process of transla

253 provide an effective platform to develop new antibiotics that target this fundamental cellular proces

254 using it, their resistance against classical antibiotics, the formation of a biofilm and the difficul

255 re driven by reductions in use of particular antibiotics, then incidence of C difficile infections ca

256 Despite prompt treatment with appropriate antibiotics, there were variable visual outcomes.

257 he rapid emergence of resistance to approved antibiotics, this group is being reconsidered.

258 of pigs fed E. faecalis UC-100 substituting antibiotics, this study assessed fecal microbiota in pig

259 hysicians to achieve fast adequate dosing of antibiotics to improve the outcome of patients with seps

260 o ensure early appropriate administration of antibiotics to save lives of patients, yet the present b

261 bacteriovorus have been proposed as "living antibiotics" to combat antimicrobially-resistant pathoge

262 shortage by shifting antibiotic usage toward antibiotics traditionally known to place patients at gre

263 notype, transcription and function following antibiotics treatment in patients with tuberculous pleur

264 ous pleuritis and to monitor the response to antibiotics treatment.

265 Due to their resistance to antibiotics, treatment is often very challenging.

266 The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, ha

267 Compared with oral antibiotics, use of intravenous antibiotics after discha

268 alytical tool for ultrasensitive analysis of antibiotics used for empirical treatment of patients wit

269 maining 49 patients, 16 continued to receive antibiotics, usually for infections other than pneumonia

270 Efficacy of the antibiotics vancomycin (VAN) or tobramycin (TOB) alone a

271 ndicating that the photolytic fate of select antibiotics varies for agricultural and surface water ma

272 e biosynthesis using CRISPR interference and antibiotics, verifying our predictions that different ph

273 , M-4365, and rosamicin classes of macrolide antibiotics via late-stage diversification.

274 ely extrudes substrates, including macrolide antibiotics, virulence factors, peptides and cell envelo

275 ty of life (score of 90.2 for broad-spectrum antibiotics vs 91.5 for narrow-spectrum antibiotics; sco

276 Broad-spectrum antibiotics vs narrow-spectrum antibiotics.

277 ed a shift toward increased use of high-risk antibiotics was 1.30 (95% CI, 1.03-1.64; P < .05).

278 ermine whether receipt of guideline-adherent antibiotics was associated with lower readmission rates.

279 among those treated with povidone-iodine (vs antibiotics) was 1.46 in the Philippines (95% CI, 0.90-2

280 Antibiotics were associated with a 45% reduction in bloo

281 Broad-spectrum antibiotics were associated with a slightly worse child

282 kup was negative for all three patients, and antibiotics were discontinued after 2 days in the second

283 her than pneumonia; of the 33 patients whose antibiotics were discontinued, only two subsequently sho

284 The most prescribed antibiotics were fluoroquinolones (35%), followed by car

285 Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%

286 the number of manufacturers for common oral antibiotics were overall stable between 2013 and 2016, r

287 The effects of antibiotics were phenocopied in Stat1-deficient mice, wi

288 The released antibiotics were potent against tested bacterial strains

289 Guideline-adherent antibiotics were provided in 10654 of 14480 hospitalizat

290 as well as narrow-spectrum pathogen-specific antibiotics, which are of interest given new insights in

291 Diverse organisms secrete redox-active antibiotics, which can be used as extracellular electron

292 otic supplementation, e.g. after a course of antibiotics, which has the unwanted side effect of deple

293 on systemic administration of high doses of antibiotics, which result in side effects and drug resis

294 The quinolone class of antibiotics, which targets bacterial topoisomerases, fai

295 was the proportion of patients who received antibiotics while hospitalised (up to 30 days).

296 normally self-limiting infections, then (i) antibiotics with different pharmacodynamic properties wo

297 for specific and efficient genome mining for antibiotics with interesting and novel targets.

298 growth in the presence or absence of certain antibiotics with real-time quantitative PCR or digital P

299 rolides are among the most widely prescribed antibiotics worldwide.

300 CMA and JIA and to test whether exposure to antibiotics would be a covariate for this association.