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1 fficacy of MEDI-573, an IGF-1/2-neutralizing antibody.
2 orrelation with the anti-carp PAV monoclonal antibody.
3 s FcgammaRs compared with the wild-type IgG1 antibody.
4 hed in mice administered with an anti-CXCL10 antibody.
5 the structure of the Fab fragment of such an antibody.
6 with in vivo administration of an anti-Ly6G antibody.
7 antibody, and anti-Ro/SS-A and anti-La/SS-B antibodies.
8 in viral diversity generated more efficient antibodies.
9 cts abrogated by neutralizing anti-IFN-gamma antibodies.
10 eatment with one or a cocktail of monoclonal antibodies.
11 mechanisms of virus infection inhibition by antibodies.
12 biotherapies such as vaccines and monoclonal antibodies.
13 designed to date have failed to elicit such antibodies.
14 oadly neutralizing, but not nonneutralizing, antibodies.
15 helping B cells to produce neutralizing IgG antibodies.
16 nificantly and increased protective specific antibodies.
17 n is also the primary target of neutralizing antibodies.
18 he in vivo protective activity of anti-HIV-1 antibodies.
19 Tspan5 has been limited by the lack of good antibodies.
20 d, limiting access to aggregation-modulating antibodies.
21 aces of HIV-1 particles are targeted by host antibodies.
22 ir strong cross-reactivity with anti-EMC-RBD antibodies.
23 ance, leading to the formation of inhibitory antibodies.
24 llular space to the potential of therapeutic antibodies.
25 other hand, the persistence of IgE blocking antibody 1 year after discontinuation might be an early
26 41 SOSIP Env trimers in complex with CD4 and antibody 17b, or with antibody b12, at resolutions of 3.
27 pathological pathway, we conjugated SOD with antibodies (Ab/SOD, size 10nm) to plasmalemmal vesicle-
28 n of viral variants that escape cellular and antibody (Ab)-mediated immune pressure, yet possess cont
29 us (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogene
35 rs old, serum concentrations of PFASs and of antibodies against diphtheria and tetanus were measured
36 -linked immunosorbent assays with monoclonal antibodies against PfLDH or PfIDEh showed detection limi
38 hepatocytes were isolated using a monoclonal antibody against a hepatic surface protein, leucine amin
39 of nerve fibers that reacted with a labeled antibody against calcitonin gene-related peptide (CGRP),
40 ous study suggested that the 18B7 monoclonal antibody against glucuronoxylomannan (GXM), the major co
43 say (ELISA) for PEG by tethering an anti-PEG antibody (AGP3) via tethers with different dimensions on
44 f influenza virus infections have shown that antibodies alone are sufficient to provide broad protect
45 fied by immunohistochemistry using the CM2B4 antibody alone, represent a more aggressive subtype that
46 40E8 and p396) and C-terminal half (4E4) tau antibodies also reduced tau uptake despite removing less
47 ation titers against 16 broadly neutralizing antibodies and 30 sera from chronic clade C infections.
49 /or therapeutic vaccines to boost functional antibodies and assist in eliminating the latent reservoi
50 luorescence staining with anti-alpha-tubulin antibodies and cell cycle analysis indicated that tubuli
51 ion secreted and membrane-bound single-chain antibodies and identify antibodies that can replace eith
53 al influenza viruses influenced HAI-specific antibodies and protective efficacy using a broadly prote
55 Binding of specific monoclonal anti-DARC antibodies and recombinant DBP to CD71(high)/RNA(high) r
56 F) conformation is a target for neutralizing antibodies and therefore an attractive antigen candidate
58 articles heavily decorated with anti-ERalpha antibody and horseradish peroxidase (MP-Ab-HRP) were use
60 flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in incre
61 ls is of critical importance but mast cells, antibodies, and basophils have few or no nonredundant ro
62 s have been associated with T cell-dependent antibodies, and their importance in both humans and mous
63 rs including renal disease, antiphospholipid antibody, and anti-Ro/SS-A and anti-La/SS-B antibodies.
65 xysilane coated magnetite nanoparticles with antibody (antiHER2/APTMS-Fe3O4), as a platform bioconjug
68 nst malaria and further shows IgG3 and GLURP antibodies are key in the OP mechanism, thus giving furt
69 rved already at 1 month of age, when the IgA antibodies are predominantly maternally derived in breas
70 Within this framework, protoxin-neutralizing antibodies are the key effector molecules while a shift
72 sence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (A
73 n complex with CD4 and antibody 17b, or with antibody b12, at resolutions of 3.7 A and 3.6 A, respect
76 icant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodim
77 c disease had increased titers of cow's milk antibodies before the appearance of anti-TG2A or celiac
80 e charge-transfer resistance decreased after antibody binding, because there was an additional amount
81 erplay between the carbohydrate receptor and antibody binding, we conducted hemagglutination inhibiti
83 -time-PCR analysis followed by inhibitor and antibody-blocking assays revealed that the arthropod HSP
87 correlation with the anti-cod PAV polyclonal antibody, but no correlation with the anti-carp PAV mono
94 on extensive structural analyses of antigen-antibody complexes.Single-particle electron cryomicrosco
96 eceived >/=1 prior therapy with an anti-CD20 antibody-containing regimen were treated with 560 mg ibr
98 METHODS AND We combined a model of specific antibody deficiency, B cell-specific CD79a-Cre x XBP1 (X
99 ese studies support DNA-delivered monoclonal antibodies delivery as a potential strategy to augment t
101 bs, readily induced by vaccines, can trigger antibody-dependent cellular effector functions, through
105 most of the broadly prevalent, neutralizing antibodies did not bind, conferred a selective advantage
107 estigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the inter
109 nfectious pathogens.DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vi
110 pyrrolobenzodiazepine (PBD)-based anti-CD19 antibody drug conjugate (ADC) being investigated for tre
111 and unusual story of GO, which was the first antibody-drug conjugate approved for human use by the FD
112 Vadastuximab talirine (SGN-CD33A, 33A) is an antibody-drug conjugate consisting of pyrrolobenzodiazep
113 Current strategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or ine
117 bodies at transplant, de novo donor-specific antibodies (DSA), antibody-mediated rejection (AMR), acu
118 We hypothesized that de novo donor-specific antibody (DSA) causes complement-dependent endothelial c
119 Here, we characterize how an anti-idiotypic antibody (E1) binds antibody HM14c10, which potently neu
120 crystal structures of Pfs25 in complex with antibodies elicited by immunization via Pfs25 virus-like
121 ty-matured human NANP-reactive memory B cell antibodies elicited by natural Pf exposure that potently
122 se variants were not efficiently detected by antibodies elicited by the wild-type HA from viruses sel
124 cles that are functionalized with anti MC-LR antibody Fab' fragments for the selective capture of MC-
126 combined with immunodetection with specific antibodies for gliadins, gamma-gliadins, LMW subunits an
128 the pharmacokinetics of the Alexa750-labeled antibody formats showed shorter blood half-times and hig
129 -diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity
130 todomain of Lassa GP bound to a neutralizing antibody from a human survivor at 3.2-angstrom resolutio
131 have the likely evolutionary precursors, the antibody gene deaminase AID and the RNA/DNA editing enzy
132 ses aberrant insertions by releasing cleaved antibody gene fragments that subsequently reintegrate in
133 Passive immunization using Abeta-specific antibodies has been demonstrated to reduce amyloid depos
135 asion assays, binding-inhibitory activity of antibodies has been reported to be associated with prote
138 rstanding the developmental pathway of these antibodies has provided insights into their precursors,
142 ional monoclonal antibodies, many bispecific antibodies have issues regarding production, stability,
143 reen, isolate, and characterize HIV-specific antibodies have led to the identification of a new gener
144 ze how an anti-idiotypic antibody (E1) binds antibody HM14c10, which potently neutralizes DENV seroty
145 ard broader practical delivery of monoclonal antibody immunotherapeutics for additional infectious pa
147 nosensor, capable of identifying circulating antibodies in real time, can also be applied in the diag
148 8-2014 on the kinetics of maternal pertussis antibodies in unvaccinated women and their infants (grou
151 pported the production of virus-neutralizing antibodies independently of the classical MHC haplotype.
152 otent, highly selective humanized monoclonal antibody inhibitor of MMP9, has shown promise in treatin
153 vo DSA emergence, whereas the persistence of antibodies is predicted by DSA strength and specificity.
158 F59/SF-2 rgp120 vaccine had higher-magnitude antibody levels than adults (gp120 median FIs of 15,509
159 red between the cohorts, and that changes in antibody levels to Apical Membrane Antigen 1 suggested a
161 day 4 post-challenge, we measured increased antibody levels, ASCs and HAI titers with reduced viral
162 marked reduction in TFH cell numbers and IgE antibody levels, but type 2 cytokine responses and eosin
163 ically the research related to intracellular antibodies, link this to the TRIM21 effector mechanism,
165 Competitive binding of the human monoclonal antibody (mAb) LE2E9 revealed overlapping epitopes with
168 of antiviral therapies, including monoclonal antibodies (mAbs), have naturally relied extensively on
170 at NP contain elevated levels of B cells and antibodies, making NP an ideal system for studying B cel
171 ential to outperform conventional monoclonal antibodies, many bispecific antibodies have issues regar
174 versing immune exhaustion with an anti-PD-L1 antibody may improve human immunodeficiency virus type 1
175 fter lung transplantation is associated with antibody mediated rejection, acute cellular rejection, a
177 renal allograft injury in a model of severe antibody-mediated damage in highly sensitized recipients
181 K) cells localize in the microcirculation in antibody-mediated rejection (AMR) and have been postulat
183 nt, de novo donor-specific antibodies (DSA), antibody-mediated rejection (AMR), acute cellular reject
184 antidonor antibodies results in accelerated antibody-mediated rejection (AMR), complement activation
186 eloped high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral
187 an help improve blood safety by reducing the antibody negative window period in blood donors in resou
188 fraction of virus particles are resistant to antibody neutralization despite high antibody concentrat
191 therapy to a similar degree as PD-1 blocking antibodies, offering a next-generation approach in the d
193 suggest that clinicians should consider IgM antibody or polymerase chain reaction testing for Zika v
195 glec-8 in combination with integrin blocking antibodies, pharmacologic inhibitors, phosphoproteomics,
199 on between GDF15 and GFRAL with a monoclonal antibody prevented the metabolic effects of GDF15 in rat
201 acquisition of adaptive immune responses and antibody production in response to foreign antigens.
204 died from anoxia, more likely to be HCV and antibody reacting to hepatitis B core antigen+, and less
209 d airways, early induction of virus specific antibodies, reduced levels of pro-inflammatory cytokines
210 an overview of ongoing research on mAbs and antibody-related theranostics in preclinical and clinica
211 incompatible renal transplant performed with antibody removal and conventional immunosuppression cont
212 dies have demonstrated that broadly reactive antibodies require Fc-Fc gamma receptor interactions for
214 safe and effective and induces an increased antibody response compared with standard influenza vacci
216 rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon c
217 ve of not significantly boosting the mucosal antibody response, it augmented the frequency of IFN-gam
220 uced H3-specific hemagglutination inhibition antibody responses, and consequently might affect vaccin
221 d CCL28 induces significantly higher mucosal antibody responses, involved in providing long-term cros
223 on into sensitized recipients with antidonor antibodies results in accelerated antibody-mediated reje
225 equencing experiments using an anti-O-GlcNAc antibody revealed significant chromatin enrichment of O-
226 Antibody production and the frequency of antibody-secreting cells were significantly elevated in
228 ed as a self-limiting infection and anti-HEV antibodies seem to protect against reinfection, its path
230 imaging using a phospho-specific p-T153/Y155 antibody showed that phosphorylated TDP-43 was specifica
231 therapy to a similar degree as PD-1-blocking antibodies.Significance: These findings show how GSK-3 i
232 ast, there has been less systematic study of antibody specificities that must rely mainly or exclusiv
234 terminal (Tau13) and middomain (6C5 and HT7) antibodies successfully prevented uptake of tau species,
236 benzodiazepine dimers linked to a monoclonal antibody targeting CD33, which is expressed in the major
238 ad significantly more anti-basement membrane antibodies than sera from patients with CRSwNP and contr
239 e structurally investigated two neutralizing antibodies that bind the attachment protein sigma1 of re
241 e-bound single-chain antibodies and identify antibodies that can replace either Sox2 and Myc (c-Myc)
242 cent mouse lung fibroblasts and screened for antibodies that recognized senescence-associated cell-su
243 vaccination also induced serum-neutralizing antibodies that targeted similar epitope domains at the
244 We treated our patient with ustekinumab, an antibody that binds the p40 subunit of interleukin-23 an
245 programmed death-ligand 1 (PD-L1) monoclonal antibody that inhibits PD-L1 and programmed death-1 (PD-
246 mab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results
247 r detection of Mycobacterium leprae-specific antibodies: the visual immunogold OnSite Leprosy Ab Rapi
248 luble ligands have commonly been targeted by antibody therapeutics for cancers and other diseases.
249 phenformin enhances the effect of anti-PD-1 antibody therapy on inhibiting tumor growth in the BRAF
250 ease category, previous exposure to anti-GD2 antibody therapy, and tumour MYCN amplification status.
253 rates and lower hemagglutination-inhibition antibody titer geometric mean fold increase against infl
254 iruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replicati
255 To mitigate the decline in measles virus antibody titers in IVIGs and to ensure consistent produc
256 directly compared and determine the minimal antibody titers required to halt transmission in differe
259 ysium using an immunofluorescence assay, and antibodies to a deamidated gliadine peptide using an imm
260 ted the capacity of anti-receptor monoclonal antibodies to deliver vaccine components to skin DC subs
263 ore, this study investigated how preexisting antibodies to historical influenza viruses influenced HA
266 antibodies to merozoites did not decline and antibodies to IE surface antigens expressing virulent ph
269 ian time period of 10 years and analyzed for antibodies to tissue transglutaminase (anti-TG2A) using
270 chain reaction (PCR)- and the prevalence of antibodies to two P. falciparum antigens (MSP-1, AMA-1).
271 ple sclerosis (MS), we administered blocking antibody to CLEC12A that significantly ameliorated disea
272 protection and the failure of a neutralizing antibody to correlate with protection against dengue vir
274 n the spinal cord using a saporin-conjugated antibody to Mac1, we demonstrate a causal role for micro
275 te the utility of employing an anti-idiotype antibody to monitor a patient's specific immune response
276 he FOURIER trial of evolocumab, a monoclonal antibody to proprotein convertase subtilisin-kexin type
277 d that administration of cis P-tau targeting antibody to rodents reduces or delays pathological featu
282 ed to assess the persistence of bactericidal antibodies up to 4 years after a three-dose schedule of
284 mbinant variable domains of heavy-chain-only antibodies (VHHs) are becoming a salient option as immun
285 also generated prolonged virus-neutralizing antibodies (VNAs), resulting in better protection agains
287 The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constan
288 , intra-mPFC infusion of a BDNF-neutralizing antibody was performed to test the necessity of BDNF rel
293 nal HNPs conjugated with anti-MG1 monoclonal antibodies were synthesized, and the coupling efficiency
294 rface-functionalized with polyclonal anti-M1 antibodies, which then serve to identify the universal b
297 We thus developed novel glycylation-specific antibodies with which we detected glycylation in many pr
298 Less (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability t
299 re of the epitope recognized by a monoclonal antibody with opsonophagocytic activity and representati
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