ライフサイエンスコーパス: anticancer activity

1 ng in different biological responses such as anticancer activity.

2 erebral ischemia, as a potentiator of statin anticancer activity.

3 reparing stable nanoformulations with potent anticancer activity.

4 erocyclic base phenanthridine, has promising anticancer activity.

5 m is an aryl sulfonamide drug with selective anticancer activity.

6 HuR inhibition has profound anticancer activity.

7 erpene constituents and has some interesting anticancer activity.

8 itro antiplasmodial activity as well as good anticancer activity.

9 stereochemistry is a significant factor for anticancer activity.

10 nd co-inhibition of mTOR and DNA-PK enhances anticancer activity.

11 to potent complexes with novel mechanisms of anticancer activity.

12 (6) were synthesized and evaluated for their anticancer activity.

13 adverse effects while preserving substantial anticancer activity.

14 uptake, and cellular retention for sustained anticancer activity.

15 ponent of saffron spice, is known to have an anticancer activity.

16 in animals and plants, is well known for its anticancer activity.

17 of natural products known to display potent anticancer activity.

18 ssant and more recently was shown to possess anticancer activity.

19 ivities as a measurement for their potential anticancer activity.

20 a small molecule with strong antibiotic and anticancer activity.

21 terospermum lanceolatum and is known to have anticancer activity.

22 lar disrupting agent with potent preclinical anticancer activity.

23 gain deeper insights into the basis for its anticancer activity.

24 und 18 was orally bioavailable and possessed anticancer activity.

25 pounds should be further evaluated for novel anticancer activity.

26 lkaloids that display both antibacterial and anticancer activity.

27 ric oxide (NO) prodrug JS-K is shown to have anticancer activity.

28 crucial for potent proteasome inhibition and anticancer activity.

29 developed as an iron chelator with selective anticancer activity.

30 ported that modified forms of pectin possess anticancer activity.

31 developed from curcumin and exhibited potent anticancer activity.

32 el small molecule antagonists with potential anticancer activity.

33 previously showed potent, selective in vitro anticancer activity.

34 prepared and evaluated for hypoxia-selective anticancer activity.

35 0) to screen >100,000 chemical compounds for anticancer activity.

36 roducts have been prepared and evaluated for anticancer activity.

37 r derivatives have been shown to have potent anticancer activity.

38 ters have been synthesized and evaluated for anticancer activity.

39 logue (19-nor-1,25(OH)2D2; paricalcitol) had anticancer activity.

40 of the roles of the L periphery in affecting anticancer activity.

41 linkage to the first sugar to exhibit better anticancer activity.

42 frequently prescribed for schizophrenia with anticancer activity.

43 synthesized compounds have shown a very high anticancer activity.

44 cluding compounds with significantly greater anticancer activity.

45 tant class of nucleosides with antiviral and anticancer activity.

46 on the SAR of compound 2e may result in good anticancer activity.

47 onist showing promising in vitro and in vivo anticancer activity.

48 photodynamic agents, leading to significant anticancer activity.

49 ing the hydrolysis to PTX and increasing the anticancer activity.

50 under NIR irradiation, resulting in enhanced anticancer activity.

51 intracellular distribution, and potentiated anticancer activity.

52 91, lambdamax up to 750 nm) and photodynamic anticancer activity.

53 cer-bearing host of immune cells with direct anticancer activity.

54 that the 1H-imidazole is essential for high anticancer activity.

55 e dithiopyrrolone derivatives display potent anticancer activities.

56 same seeds, has been shown to have potential anticancer activities.

57 Vitamin D may have anticancer activities.

58 ic effects of curcumin are important for its anticancer activities.

59 emonstrating promising anti-inflammatory and anticancer activities.

60 NF-kappaB inhibitors, and to evaluate their anticancer activities.

61 nd find it to exhibit potent, broad-spectrum anticancer activities.

62 may be the plausible mechanisms behind their anticancer activities.

63 fibrate, a lipid-lowering drug with multiple anticancer activities.

64 atural products with potent insecticidal and anticancer activities.

65 de A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell

66 d structurally related compounds showed weak anticancer activities against HeLa and U-937 cells.

67 These new HDACi possess anticancer activities against various cancer cell lines

68 Compound 19 has significant in vivo anticancer activity against a human breast cancer xenogr

69 elective flavonoid with significant in vitro anticancer activity against a multidrug resistant (MDR)

70 utaminase activity of L-ASP is necessary for anticancer activity against ASNS-positive cell types but

71 clinical trials, SAHA has shown significant anticancer activity against both hematologic and solid t

72 HA is in clinical trials and has significant anticancer activity against both hematologic and solid t

73 monstrated low in vivo toxicity but profound anticancer activity against both the L1210 leukemia and

74 cell panel and exerted selective synergistic anticancer activity against ErbB2-overexpressing breast

75 ned, synthesized, and evaluated for in vitro anticancer activity against four human tumor cell lines.

76 Entire compounds were evaluated for their anticancer activity against HeLa (cervical cancer), MCF-

77 Vorinostat has demonstrated significant anticancer activity against hematologic and solid tumors

78 In several clinical trials Triapine showed anticancer activity against hematological diseases, howe

79 several of the compounds revealed promising anticancer activity against MCF-7 cells.

80 its parent drug, P-SMART showed significant anticancer activity against melanoma cells in cytotoxici

81 These compounds have shown remarkable anticancer activity against multiple human cancer cell l

82 tor that binds the inactive hTS and exhibits anticancer activity against ovarian cancer cells.

83 ring of this natural product is critical for anticancer activity against PC3 cells.

84 12u demonstrates potent anticancer activity against primary chronic lymphocytic

85 me intermediates were evaluated for in vitro anticancer activity against several human tumor cell lin

86 In addition, PTX-S-S-VE had greater anticancer activity against the KB-3-1 cell line tumor x

87 nd Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line

88 Anticancer activity against various malignancies was typ

89 gate in vitro the health-promoting benefits (anticancer activity, alpha-amylase and alpha-glucosidase

90 0 exhibited antibacterial, antimalarial, and anticancer activity, although they are less bioactive th

91 Specifically, their combined anticancer activities and selective visual signal respon

92 compounds 2d-f, and 2h exhibited encouraging anticancer activity and also selectivity towards particu

93 novel microtubule inhibitors have promising anticancer activity and can be potentially used to overc

94 ndings on the association between elesclomol anticancer activity and cellular metabolic state.

95 ets and correlated them to that required for anticancer activity and determined that Des1 inhibition

96 These results suggest that l-ase anticancer activity and glutamine uptake inhibition are

97 ted receptor gamma (PPARgamma) agonists have anticancer activity and influence cell differentiation.

98 ion with redox modulators can potentiate the anticancer activity and maximize the selectivity of orga

99 ated a series of boronic chalcones for their anticancer activity and mechanisms of action.

100 s, with the three most important areas being anticancer activity and selective cytotoxicity, anti-Alz

101 CRGs have an essential role in drug-mediated anticancer activity and that anticancer agents can be id

102 daunorubicin play a significant role in its anticancer activity and topo II inhibition.

103 g these peptides, LTX-315 displayed superior anticancer activity and was selected as a lead candidate

104 derstanding of molecular mechanisms of HDACi anticancer activity, and a preclinical and clinical upda

105 alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological prof

106 tive compound, isofuranodiene, known for its anticancer activity, and of its Cope rearrangement produ

107 The library was screened for their anticancer activity, and several cytotoxic lead compound

108 analyzed for sensitivity patterns, synergy, anticancer activity, and were validated in low-throughpu

109 Once inside the cell, its anticancer activity appears mediated primarily through t

110 ave been proposed, but the mechanisms of its anticancer activities are not clearly understood.

111 he type of cancer and cells where they exert anticancer activity, are described and summarized in tab

112 therapeutic agents, while maintaining potent anticancer activity, are of particular interest.

113 -targeting capability and exerted measurable anticancer activities as confirmed with percent tumor ne

114 nes and 1,4-heterocyclic quinones with known anticancer activity as potent and selective splicing inh

115 min, which has previously been shown to have anticancer activity, as an inhibitor of MDM2 expression.

116 Importantly, Cmpd-43 exerted potent anticancer activity both in vitro and in vivo in a murin

117 ontradictory impact on drug accumulation and anticancer activity both in vitro and in vivo.

118 po2L/TRAIL) has shown remarkable preclinical anticancer activity but lacked broad efficacy in patient

119 enoic acid (DHA; n-3, 22:6) is known to have anticancer activity, but its mechanisms of action remain

120 Paclitaxel has powerful anticancer activity, but some tumors are inherently resi

121 tification of small molecules with promising anticancer activity, but the difficulty in characterizin

122 PI3K) signaling pathway have shown promising anticancer activity, but their efficacy in the brain tum

123 In summary, GE exerts anticancer activities by inducing apoptosis and suppress

124 eveloping therapeutic drugs that exert their anticancer activities by producing massive chromosome an

125 whether AhR plays a role in 17-AAG-mediated anticancer activity by functioning as a downstream targe

126 induce up to 70% AKT degradation and enhance anticancer activity by more than 25-fold compared to the

127 op1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1-DNA clea

128 leic acid (DNA) bis-intercalator with potent anticancer activity, can bind the estrogen response elem

129 The improved anticancer activity compared with i.v. Taxotere, observe

130 rocess and so with their neuroprotective and anticancer activity; cooking of dark beans improves thei

131 udies for discovering natural compounds with anticancer activities, coupled with clinical evaluation

132 This paper examines two biological models of anticancer activity, cytotoxicity and hollow fiber (HF)

133 Preliminary anticancer activity demonstrated clinical benefit for th

134 ts on DNA having a structure and spectrum of anticancer activity distinct from those of the parent dr

135 rlier studies demonstrated that DFO exhibits anticancer activity due to its ability to deplete cancer

136 mulation as the q-NTD conjugate but superior anticancer activity due to its more effective release of

137 our most potent compounds showed substantial anticancer activity (EC50 37-150 nM) vs MCT1-expressing

138 ,5,4'-truhydroxystilbene) possesses a strong anticancer activity exhibited as the induction of apopto

139 platform through the identification of novel anticancer activities for cycloviolacins by their cytoto

140 g combinations of approved drugs with potent anticancer activity for further mechanistic study and tr

141 Its potential anticancer activity has been validated in preclinical in

142 rstanding of the mechanisms underlying their anticancer activity has remained elusive.

143 ysates or peptides with immunomodulatory and anticancer activities have been reported from a variety

144 tioxidant compounds that display significant anticancer activity have been described.

145 splastic syndrome, but the mechanisms of its anticancer activity have remained unclear.

146 nd previously identified to have significant anticancer activity in a mouse tumor model.

147 these materials were screened for potential anticancer activity in a range of human cancer cell line

148 abilizes cyclin D1, resulting in significant anticancer activity in a subset of KRAS mutant tumors in

149 tors of histone deacetylases (HDACi) exhibit anticancer activity in a variety of tumor cell models an

150 ibits an antiangiogenesis effect and a broad anticancer activity in a variety of tumor xenografts inc

151 acetate (designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia (AML)

152 FR) tyrosine kinase have demonstrated modest anticancer activity in advanced bronchioloalveolar carci

153 is an experimental clinical drug with broad anticancer activity in animal models, owing to its abili

154 beit with undefined mechanisms, and exhibits anticancer activity in animal models.

155 ADNR exhibited potent anticancer activity in both drug-sensitive (K562) and dr

156 b, a cyclooxygenase-2 (COX-2) inhibitor with anticancer activity in both preclinical studies and clin

157 tion of AZD6244 with PLX4720 had synergistic anticancer activity in BRAF-mutant cells but not in Galp

158 entially superior candidates with comparable anticancer activity in cell culture, enhanced metabolic

159 bitor, is currently under evaluation for its anticancer activity in clinical trials.

160 pophilic derivative of DIM, has demonstrated anticancer activity in different types of cancers.

161 bitor cytochalasin B, and by comparing their anticancer activity in DU145 cells and a GLUT1 knockdown

162 ity in endocrine-resistance models and shown anticancer activity in early-phase mBC clinical trials.

163 ease inhibitors (PI) have been shown to have anticancer activity in non-HIV-associated human cancer c

164 a safe therapy with encouraging and durable anticancer activity in patients with R/R NHL.

165 t the cell membrane has been associated with anticancer activity in preclinical and early clinical st

166 ine kinase inhibitor, demonstrated increased anticancer activity in preclinical and early clinical st

167 factor receptor (PDGFR), with broad-spectrum anticancer activity in preclinical and early-phase trial

168 drug GDC-0941, which exhibits excellent oral anticancer activity in preclinical models and is now und

169 a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbo

170 Preliminary evidence of anticancer activity in sarcoma was demonstrated.

171 ed PK11007, to be mild thiol alkylators with anticancer activity in several cell lines, especially th

172 Most compounds have anticancer activity in several solid tumor cell lines an

173 G-quadruplex binders and have examined their anticancer activity in T24 bladder cancer cells bearing

174 bitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.

175 inhibitor, called SP141, which exerts potent anticancer activity in various breast cancer models.

176 Therefore, our studies illustrate the anticancer activity in vitro and in vivo of mushroom ext

177 olecules have emerged that exhibit promising anticancer activity in vitro and in vivo, as single agen

178 one-based iron chelators that exhibit marked anticancer activity in vitro and in vivo.

179 2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo.

180 /IL-24 (mda-7/IL-24) displays broad-spectrum anticancer activity in vitro, in vivo in preclinical ani

181 In addition, some NSAIDs show anticancer activity in vitro.

182 cells while sparing normal cells and exhibit anticancer activity in vivo with improved therapeutic ra

183 mitochondrial targeting of Met enhances its anticancer activities, including aggressive cancers like

184 ure and has derivatives possessing important anticancer activity, including the recently Food and Dru

185 an ongoing evaluation of Top1 inhibition and anticancer activity, indenoisoquinolines were linked via

186 The anticancer activity is associated with reduced mitochond

187 ajor target in the cell, responsible for the anticancer activity, is nuclear DNA, which is packaged i

188 ver, although AG490 routinely shows in vitro anticancer activity, it has not consistently demonstrate

189 n product 3,3'-diindolylmethane (DIM) showed anticancer activity mediated by its pleiotropic effects

190 ed several analogues with increased in vitro anticancer activity, most notably D-threoside 60 (NSC 74

191 ty, stability, and proteasome-inhibitory and anticancer activities of (-)-EGCG in human breast cancer

192 study provides mechanistic insights into the anticancer activities of 1,25(OH)2D3 in human breast can

193 Evaluation of the in vitro and in vivo anticancer activities of 3 SMART compounds, SMART-H (H),

194 rambucil, herein we report the synthesis and anticancer activities of a 63-member library of chloramb

195 The immunomodulatory and anticancer activities of food derived protein hydrolysat

196 fine and characterize the antiangiogenic and anticancer activities of itraconazole in relevant precli

197 his study, antioxidant, antiinflammatory and anticancer activities of leave extracts and its isolates

198 al constituents that are responsible for the anticancer activities of propolis were analyzed.

199 id within the RasGAP317-326 sequence for the anticancer activities of TAT-RasGAP317-326.

200 For example, the anticancer activities of tazarotene, adapalene, acitreti

201 mistry of their tetrapeptidic backbones, the anticancer activities of these precursors largely match

202 h is regulated by AhR, was shown to increase anticancer activity of 17-AAG in cells.

203 wnstream target of 17-AAG, but also enhances anticancer activity of 17-AAG in lung AD cells.

204 Anticancer activity of 17-AAG was determined by measurin

205 n in lung AD cells, AhR expression increased anticancer activity of 17-AAG.

206 These results agree with the in vivo anticancer activity of 2-methoxyestradiol 3-phosphate in

207 Chirality influenced the anticancer activity of 3 and 4 in human prostate cancer

208 of endoplasmic reticulum (ER) stress in the anticancer activity of 3-AP and the derivative N(4),N(4)

209 ay, use of reduction, to improve the in vivo anticancer activity of a prodrug for nanocarrier deliver

210 The direct comparison of the anticancer activity of all naturally occurring (-)-agela

211 t decade, many studies have demonstrated the anticancer activity of alpha-tocopherol, the main and mo

212 pirin ratios in serum, it is likely that the anticancer activity of aspirin is also due to the salicy

213 Therefore, CGC-11093 enhances the anticancer activity of bortezomib by augmenting JNK-medi

214 ercoils and because it is the target for the anticancer activity of camptothecins, we assessed TOP1 t

215 Thus, the anticancer activity of CDDO-Me is due, in part, to activ

216 The anticancer activity of cGMP signaling in animal studies

217 , CH1iB, reactivates p53 and potentiates the anticancer activity of cis-platinum in HPV-positive HNSC

218 Furthermore, the anticancer activity of compounds correlated with their a

219 The anticancer activity of cytarabine (AraC) and gemcitabine

220 ling ability of small molecules controls the anticancer activity of EISA.

221 hway and HSPB1 phosphorylation increases the anticancer activity of erastin in human xenograft mouse

222 et ligands, which may be used to enhance the anticancer activity of existing PDK1 inhibitors.

223 The phenomenon is reminiscent of the anticancer activity of gamma-tocopherol, which reduces N

224 The anticancer activity of histone deacetylase inhibitors (H

225 ation, and vascular damage contribute to the anticancer activity of Ing3A in vivo.

226 CsA also impaired the anticancer activity of Ing3A, whereas the anti-inflammat

227 ron, thus laying the basis for the promising anticancer activity of iron chelators.

228 mechanism underpinning the well-established anticancer activity of isothiocyanate.

229 ivity is a promising strategy to enhance the anticancer activity of lexatumumab.

230 nce cancer-selective expression and targeted anticancer activity of mda-7/IL-24, we created a tropism

231 These data demonstrated clearly that the anticancer activity of NH125 was more correlated with in

232 This may contribute to the potent anticancer activity of paclitaxel and provide a novel ba

233 The anticancer activity of papaya pectin is dependent on the

234 ighting a novel mechanism accounting for the anticancer activity of perifosine and a potential strate

235 Nuclear DNA is the target responsible for anticancer activity of platinum anticancer drugs.

236 that disrupting autophagy would augment the anticancer activity of SAHA.

237 Finally, we show the anticancer activity of SC66 by using a soft agar assay a

238 izotinib and GSK1363089 greatly enhanced the anticancer activity of SM-164 in all resistant cell deri

239 The anticancer activity of some of the obtained compounds ag

240 e has been growing interest in the potential anticancer activity of statins based on preclinical evid

241 ynergize with statins to further enhance the anticancer activity of statins in vivo.

242 Apoptosis was the mechanism involved in the anticancer activity of such compounds.

243 are incompletely effective and decrease the anticancer activity of the allogeneic graft.

244 In addition, lucanthone enhanced the anticancer activity of the histone deacetylase inhibitor

245 The anticancer activity of the reengineered agent, called WB

246 In vitro anticancer activity of the synthesized compounds was tes

247 te that the GHRH agonists can potentiate the anticancer activity of the traditional chemotherapeutic

248 The anticancer activity of these complexes was further inves

249 The anticancer activity of these heavier tetraponerines agai

250 observations provide an explanation for the anticancer activity of this class of compounds, which ha

251 re, blockage of NF-kappaB should improve the anticancer activity of TNF.

252 biting Tdp1 has the potential to enhance the anticancer activity of Top1 inhibitors and to act as ant

253 We investigated the anticancer activity of two novel, highly specific agonis

254 These findings suggest that the anticancer activity of VEGI arises from coupling the inh

255 The anticancer activity of WL-276 was manifested in its supp

256 Consistent with the potential anticancer activity of zoledronic acid, overall survival

257 of the heat-shock response and had no overt anticancer activity on its own, it dramatically impaired

258 Most of them displayed anticancer activity on leukemia, melanoma, lung, colon,

259 novel compounds having potentially promising anticancer activity, one of which induces cell death in

260 a distinct mechanism to selectively enhance anticancer activity over cardiotoxicity, the most signif

261 We propose that GA, as part of its anticancer activity, perturbs early/recycling endosome s

262 ibition of HDAC1 and 2 may be sufficient for anticancer activity, providing an experimental framework

263 he literature on the phenolic compounds with anticancer activity published between 2008 and 2012 is p

264 , has received considerable attention to its anticancer activity recently.

265 or varied biological applications, including anticancer activity, regulation of gene expression, and

266 Structure-anticancer activity relationship studies indicated the i

267 corresponding chemoselective linker upon the anticancer activity/selectivity of the drug chlorambucil

268 preferred compound, 14, with 10-fold greater anticancer activity than 1, was shown to release H2S in

269 gar units (compound 3) showed 35-fold higher anticancer activity than compounds with a beta-linkage (

270 Quinacrine, a drug with antimalarial and anticancer activities that inhibits NF-kappaB and activa

271 Curcumin activates diverse anticancer activities that lead to inhibition of cancer

272 ment of compounds 2 and 3 having appreciable anticancer activities that seem to be due to inhibition

273 re thiazole-containing natural products with anticancer activity that are biosynthesized by polyketid

274 is for a new class of compounds with in vivo anticancer activity that is mediated through the inhibit

275 Excitingly, lead Tam-HDACi conjugates show anticancer activity that is selectively more potent agai

276 developed at City of Hope Cancer Center, has anticancer activity that stems primarily from the inhibi

277 ic inhibitor of canonical Wnt signaling with anticancer activity that warrants further development fo

278 Compound 7f and 8 exhibited anticancer activity that was 300-fold and 1 x 10(6)-fold

279 palm and rice bran oil, has been linked with anticancer activities, the mechanism of this action is p

280 d enhances DNA repair as a mechanism for its anticancer activity, the nucleotide excision repair gene

281 Despite the promising anticancer activity, these molecules showed a poor aqueo

282 s indicated that these compounds exert their anticancer activity through inhibition of tubulin polyme

283 ess dose) was 1.89 and 1.92 fold superior in anticancer activity to Los respectively in A549 orthotop

284 sp. SF2575 and displays exceptionally potent anticancer activity toward a broad range of cancer cell

285 s (AMPs) have recently been shown to display anticancer activity via a mechanism that usually entails

286 chta indica), was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat sh

287 -AR silenced PC-3 cells confirmed that their anticancer activity was alpha(1d)-AR-dependent.

288 This synergistic improvement in the anticancer activity was apoptosis-dependent that was con

289 In particular, enhanced anticancer activity was demonstrated in acute myeloid le

290 When the first titanium complex with anticancer activity was identified in the 1970s, it was

291 Their anticancer activity was tested in a number of cancer cel

292 cturally unique 16-membered macrolide having anticancer activity, was synthesized according to a stra

293 Anticancer activities were evaluated on three different

294 Immune function, safety, and anticancer activity were monitored.

295 hibition of HO1 by MGd may contribute to its anticancer activity, whereas its in vitro inhibition of

296 human breast cancer cell line MCF7 in vitro anticancer activity, which defines the molecular level u

297 se so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five dif

298 IL-10 family cytokine, exhibits pleiotropic anticancer activities without adversely affecting normal

299 OdDHL has also demonstrated anticancer activity, yet its ability to enhance pathogen

300 been developed that have a broad spectrum of anticancer activity, yet virtually no side effects.