ライフサイエンスコーパス: antiepileptic

1 =6) to various drugs (mainly antibiotics and antiepileptics).

2 ptic transmission, and their antagonists are antiepileptic.

3 restraints, and exposure to vasopressors and antiepileptics.

4 evaluate the potential of MAGL inhibitors as antiepileptics.

5 There is insufficient evidence for other antiepileptics.

6 000 subjects with different illnesses) of 11 antiepileptics.

7 promising candidates for development as new antiepileptics.

8 ugs, selective calcium channel blockers, and antiepileptics.

9 embrane oxygenation, convulsions, and use of antiepileptics.

10 neficial in certain cases; for instance, the antiepileptic action of a high fat and low carbohydrate

11 To test whether NPY and galanin have antiepileptic actions in human epileptic tissue as well,

12 emizole binds to serotonin receptors and its antiepileptic activity can be mimicked by drugs acting o

13 ABHD6 blockade retained its antiepileptic activity over chronic dosing and was not a

14 f the neuronal cultures, suggesting possible antiepileptic activity.

15 th greater efficacy than currently available antiepileptics (AEDs).

16 (SAR) for the N-benzyl group in the clinical antiepileptic agent (R)-lacosamide [(R)-N-benzyl 2-aceta

17 h is responsible for clearing the endogenous antiepileptic agent adenosine (Ado) from the extracellul

18 s, alpha-adrenergic agents, and possibly the antiepileptic agent carbamazepine.

19 the activities observed for the traditional antiepileptic agents phenytoin, phenobarbital, and valpr

20 a small number of "high-risk" drugs such as antiepileptic agents, sulfonamides, and antiretroviral d

21 ntidepressants, atypical antipsychotics, and antiepileptic agents.

22 otrigine, or valproate) or not exposed to an antiepileptic, an antidepressant, or lithium during 30 y

23 The antiepileptic and antiallodynic drug gabapentin (GBP) bi

24 y prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed signifi

25 blocking cerebellar AMPA receptors would be antiepileptic and devoid of motor impairment.

26 these channels have been identified as novel antiepileptics and analgesics.

27 Moreover, antiepileptics and calcium channel blockers may provide

28 justment of antibiotics, immunosuppressives, antiepileptics, and other drugs, but its use for traditi

29 nhibition will be enhanced by neurosteroids, antiepileptics, and sedative/hypnotic drugs.

30 ics, beta blockers, anesthetics, analgesics, antiepileptics, antidepressants, and others), 10 metabol

31 f other diuretics, aspirin, antidepressants, antiepileptics, antihypertensives, or central nervous sy

32 study examines the hypothesis that the three antiepileptics approved for bipolar disorder (carbamazep

33 mpts or suicides was not associated with the antiepileptics approved for bipolar disorder.

34 vals were classified as either exposed to an antiepileptic (carbamazepine, lamotrigine, or valproate)

35 , the current study is the first to describe antiepileptic drug (AED) combination therapy patterns ac

36 Antiepileptic drug (AED) exposure during pregnancy incre

37 xposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perin

38 rn exists that breastfeeding during maternal antiepileptic drug (AED) therapy may be harmful.

39 mine whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued

40 To investigate antiepileptic drug (AED)-related weight changes in patie

41 We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial tha

42 usual concomitant medications, including an antiepileptic drug (phenytoin or carbamazepine), dexamet

43 its application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described.

44 uire concurrent treatment with more than one antiepileptic drug (rational polytherapy), but there is

45 pective, longitudinal observational study of antiepileptic drug adherence in a consecutive cohort of

46 The antiepileptic drug carbamazepine (CBZ) is one of the mos

47 In contrast, the antiepileptic drug carbamazepine was found to inhibit vo

48 Treatment options included antiepileptic drug changes, epilepsy surgery, and pacema

49 However, at this point, antiepileptic drug choice in patients with epilepsy rema

50 to compare the efficacy and side effects of antiepileptic drug combinations in animals.

51 Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase

52 Clinical trials as part of antiepileptic drug development are increasingly expensiv

53 psy and undertook subgroup analysis based on antiepileptic drug exposure in women with epilepsy.

54 Since foetal antiepileptic drug exposure is associated with lower ver

55 , we examined dose-related effects of foetal antiepileptic drug exposure on verbal and non-verbal cog

56 At 36 months, prenatal antiepileptic drug exposure was associated with adverse

57 The association of epilepsy and antiepileptic drug exposure with pregnancy outcomes need

58 The Equivalence Among Antiepileptic Drug Generic and Brand Products in People

59 ponse to the addition of a previously unused antiepileptic drug in a cohort of 155 people with refrac

60 The antiepileptic drug levetiracetam (LEV) is a potential tr

61 50, and 150 mug/kg) or preblocking with the antiepileptic drug levetiracetam at 10 and 30 mg/kg.

62 urthermore, the addition of the SV2A-binding antiepileptic drug levetiracetam to the medium inhibited

63 ncluding an expedient total synthesis of the antiepileptic drug levetiracetam.

64 However, neither such methods nor antiepileptic drug mechanisms of action have yet proven

65 we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigi

66 The onset and evolution of antiepileptic drug nonadherence in children with newly d

67 Lamotrigine was selected as the antiepileptic drug of interest because of its wide use,

68 was applied to the "green" synthesis of the antiepileptic drug Phenytoin, with no use of any harmful

69 born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2

70 Phenytoin was the most common antiepileptic drug prescribed de novo (61%).

71 hat they are important currently unexploited antiepileptic drug targets.

72 rovide an example of cross-over pharmacology antiepileptic drug testing.

73 Levetiracetam (LEV) is a prominent antiepileptic drug that binds to neuronal synaptic vesic

74 AZA is an antiepileptic drug that has been shown to inhibit AQP4 e

75 Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability

76 Third-line antiepileptic drug therapies with sedating or anesthetic

77 l seizures who do not respond to appropriate antiepileptic drug therapy consisting of 2 or more medic

78 Antiepileptic drug therapy, though beneficial for restra

79 precipitating cause; determine the need for antiepileptic drug therapy; and recognize nonconvulsive

80 rom immediate remission after taking a first antiepileptic drug to frequent unremitting seizures with

81 CSD was also decreased by the antiepileptic drug topiramate, but not by carbamazepine.

82 re the absence of a control group continuing antiepileptic drug treatment and a consistent definition

83 to treatment failure were treatment history (antiepileptic drug treatment prior to randomisation), EE

84 ergency that is typically terminated through antiepileptic drug treatment, leads to hippocampus dysfu

85 to breastfeed their children irrespective of antiepileptic drug treatment.

86 in children exposed, in utero, to different antiepileptic drug treatments.

87 of improvement is similar to that of recent antiepileptic drug trials in drug resistant epilepsy (DR

88 linear regression adjusted for maternal IQ, antiepileptic drug type, standardised dose, gestational

89 herapy were not different from those without antiepileptic drug use at both time points (PFS: HR, 0.9

90 combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy

91 definite cause of pancreatitis is due to the antiepileptic drug valproic acid (VPA).

92 1.35), treatment history (taking a non-SANAD antiepileptic drug vs treatment naive, 0.64, 0.52-0.78),

93 Carbamazepine (CBZ) is an antiepileptic drug which is persistent in wastewater tre

94 VPA is a commonly prescribed antiepileptic drug with known teratogenic effects.

95 With increasing age and treatment duration, antiepileptic drug withdrawal may be justified.

96 fore remission, seizure-free interval before antiepileptic drug withdrawal, age at onset of epilepsy,

97 fore remission, seizure-free interval before antiepileptic drug withdrawal, number of antiepileptic d

98 The antiepileptic drug, levetiracetam, blocked Kv4.2 depleti

99 that exposing mouse brain capillaries to the antiepileptic drug, valproic acid (VPA; 5 muM), signific

100 Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large exte

101 site for levetiracetam, a second generation antiepileptic drug.

102 improved with age for infants exposed to any antiepileptic drug.

103 g lacosamide ((R)-1), a low-molecular-weight antiepileptic drug.

104 ed with introduction of a previously untried antiepileptic drug.

105 Randomization was stratified by antiepileptic drug.

106 I 1.00, 1.02) as did those who had used more antiepileptic drugs (1.05; 95% CI 1.01 to 1.09).

107 ilepticus etiologies included subtherapeutic antiepileptic drugs (43%), alcohol or other nonantiepile

108 5%, p < .001), and treatment with third-line antiepileptic drugs (51% vs. 17%, p < .001).

109 Antiepileptic drugs (AEDs) are commonly prescribed for e

110 30% of epilepsy patients receiving antiepileptic drugs (AEDs) are not fully controlled by t

111 Antiepileptic drugs (AEDs) are the only neurotherapeutic

112 Currently available antiepileptic drugs (AEDs) fail to control seizures in 3

113 New antiepileptic drugs (AEDs) have been a major change in t

114 Antiepileptic drugs (AEDs) have cognitive side effects t

115 xcitability and controlling its degree using antiepileptic drugs (AEDs) is of prime importance for cl

116 Antiepileptic drugs (AEDs) remain the primary treatment.

117 es join the chemical fragments of well-known antiepileptic drugs (AEDs) such as ethosuximide, levetir

118 operties of the widely used older generation antiepileptic drugs (AEDs) suggest that they might be re

119 alpha-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs) that exhibit pronounced antic

120 To evaluate the effects of epilepsy and antiepileptic drugs (AEDs) used during pregnancy on feta

121 Antiepileptic drugs (AEDs) were generally ineffective an

122 perspectives for the design and discovery of antiepileptic drugs (AEDs) with fewer side effects by fo

123 atients with Alzheimer's disease with select antiepileptic drugs (AEDs), in low doses, is usually wel

124 REVIEW: Despite the availability of many new antiepileptic drugs (AEDs), only around 50% of people wi

125 tly suffering with epilepsy are resistant to antiepileptic drugs (AEDs).

126 trials of topical agents (e.g., capsaicin), antiepileptic drugs (e.g., gabapentin), injection of oth

127 The Equivalence among Generic Antiepileptic Drugs (EQUIGEN) chronic-dose study was a r

128 0.2 mg/kg), and only two did not need rescue antiepileptic drugs (ie, met rescue criteria; one on 0.0

129 At age 6 months, infants of mothers using antiepileptic drugs (n = 223) had a higher risk of impai

130 icus episodes were treatment with third-line antiepileptic drugs (odds ratio, 12.08; 95% confidence i

131 (p=0.052) and a lower number of concomitant antiepileptic drugs (p=0.03).

132 We tested whether two commonly prescribed antiepileptic drugs (phenytoin, lamotrigine), as well as

133 ional anaesthetics (isoflurane, desflurane), antiepileptic drugs (topiramate, lacosamide, pregabalin,

134 5-0.99), treatment history (taking non-SANAD antiepileptic drugs [other than those listed above] vs t

135 Conventional antiepileptic drugs act by blocking sodium channels or e

136 hat captured the spectrum of nonadherence to antiepileptic drugs among children with newly diagnosed

137 regarding critical drug interactions between antiepileptic drugs and antiretrovirals, but are also pr

138 ldren of women with epilepsy who did not use antiepileptic drugs and children of fathers with epileps

139 yndromes, show specific responses to certain antiepileptic drugs and differentiate between responder

140 that there may be drug interactions between antiepileptic drugs and hormonal therapies, which can pr

141 ted with incident epilepsy in the absence of antiepileptic drugs and in the absence of diagnosed psyc

142 s) with epilepsy who were taking concomitant antiepileptic drugs and not currently receiving lamotrig

143 ies compared with those exposed to the other antiepileptic drugs and on non-verbal and executive func

144 disrupted by long-term therapy with certain antiepileptic drugs and the antimicrobial agent rifampin

145 reports of significant interactions between antiepileptic drugs and the efficacy of human growth hor

146 eral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to thes

147 Older antiepileptic drugs are often prescribed at seizure pres

148 Are antiepileptic drugs associated with reduced pain intensi

149 Nineteen patients (45.2%) had withdrawn from antiepileptic drugs at least once; 12 of those (63.2%) h

150 n issued a warning regarding suicidality and antiepileptic drugs based on meta-analyses of 199 random

151 epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in

152 ore antiepileptic drug withdrawal, number of antiepileptic drugs before withdrawal, female sex, famil

153 es of epilepsy and the metabolic activity of antiepileptic drugs can adversely affect hypothalamic an

154 a mechanism by which early life exposure to antiepileptic drugs can impact cognitive and behavioral

155 substantial evidence indicates that several antiepileptic drugs can increase thyroid hormone metabol

156 t, the availability of more than 20 approved antiepileptic drugs can reduce the incentive to enrol in

157 Use of multiple antiepileptic drugs compared with the reference group wa

158 provide the first evidence that exposure to antiepileptic drugs during a sensitive postnatal period

159 Clinical Question: Is maternal use of antiepileptic drugs during pregnancy associated with maj

160 Exposure to antiepileptic drugs during pregnancy is associated with

161 eight patients who had been seizure-free on antiepileptic drugs for at least a year after 3 or more

162 Two patients who had received multiple antiepileptic drugs for several years presented with a b

163 fficacy of epilepsy surgery and use of newer antiepileptic drugs for the treatment of intractable epi

164 Although the number of available antiepileptic drugs has increased substantially during t

165 ular drugs, painkillers, contrast media, and antiepileptic drugs have been recorded well above thresh

166 Several antiepileptic drugs have multiple or uncertain mechanism

167 tenuate mutant seizure activity; seven other antiepileptic drugs have no effect.

168 Some newer antiepileptic drugs have novel mechanisms of action, inc

169 Although the effects of antiepileptic drugs in central hypothyroidism have not y

170 Mucocutaneous discoloration induced by antiepileptic drugs in general and ezogabine in particul

171 of more than 80% without the need for rescue antiepileptic drugs in more than 50% of infants.

172 The aim is to review rational polytherapy of antiepileptic drugs in terms of conventional and novel m

173 Other antiepileptic drugs increase sex hormone-binding globuli

174 Switching between generic antiepileptic drugs is a highly debated issue that affec

175 Antiepileptic drugs may also cause EDS or influence slee

176 erological response to immunotherapies, when antiepileptic drugs may be ineffective.

177 suggest conventional sodium channel blocking antiepileptic drugs may worsen the disease, we predicted

178 pilepsy who became seizure-free while taking antiepileptic drugs might consider discontinuing their m

179 uicide and whether psychiatric disorders and antiepileptic drugs modify the risk of attempted suicide

180 We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up

181 fects of traditional and recently introduced antiepileptic drugs on excitatory and inhibitory brain m

182 ailable for the effects of second-generation antiepileptic drugs on hypopituitarism treatment.

183 Exclusion of antiepileptic drugs prescribed before the index date did

184 caffold the chemical fragments of well-known antiepileptic drugs such as ethosuximide, levetiracetam,

185 report (p=0.03), a lower number of previous antiepileptic drugs taken (p=0.052) and a lower number o

186 Most antiepileptic drugs target neuronal mechanisms.

187 Although many clinically-approved antiepileptic drugs target voltage-gated persistent sodi

188 nces between splice variants are occluded by antiepileptic drugs that bind to and stabilize inactivat

189 defined as failure of adequate trials of two antiepileptic drugs to achieve sustained seizure freedom

190 The effects of the antiepileptic drugs used in the MESS study are greater f

191 Prenatal exposure to antiepileptic drugs was associated with impaired fine mo

192 ous breastfeeding in children of women using antiepileptic drugs was associated with less impaired de

193 Third-line antiepileptic drugs were administered in 47 cases (33%).

194 Bottom Line: Certain antiepileptic drugs were associated with increased rates

195 Antiepileptic drugs were categorized by MOA: sodium chan

196 andomised controlled trial in which standard antiepileptic drugs were compared with new treatments.

197 Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as

198 antile epilepsies (<3 months), whereas other antiepileptic drugs were less effective.

199 tive function (r=-0.42, p=0.0004), but other antiepileptic drugs were not.

200 ne phase) receiving one to three concomitant antiepileptic drugs were recruited from 99 centres acros

201 ften fatal syndrome, initially responsive to antiepileptic drugs which over time becomes refractory a

202 spiny neurons from neonatal rats exposed to antiepileptic drugs with proapoptotic action (phenobarbi

203 tients; however, data for the interaction of antiepileptic drugs with the pituitary axis have shown t

204 ants, drugs used in addictive disorders, and antiepileptic drugs) after prison release.

205 erization of drugs that modulate SV2A (e.g., antiepileptic drugs) and potentially could be a biomarke

206 Despite the availability of numerous antiepileptic drugs, 20-30% of epileptic patients are ph

207 ificant association of epilepsy, exposure to antiepileptic drugs, and adverse outcomes exists in preg

208 do not show a good response to conventional antiepileptic drugs, but respond to immunotherapies.

209 Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal

210 inical history, seizure types and frequency, antiepileptic drugs, cognitive, social and functional ou

211 seizures despite treatment with at least two antiepileptic drugs, eight patients who had been seizure

212 iconvulsants are of considerable interest as antiepileptic drugs, especially because of their potenti

213 g patients discharged with a prescription of antiepileptic drugs, phenytoin and levetiracetam were pr

214 s epilepticus episodes treated by third-line antiepileptic drugs, predictors of poor outcome were old

215 y 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need.

216 e and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin

217 ary axis have shown that chronic use of many antiepileptic drugs, such as carbamazepine, oxcarbazepin

218 Phenytoin, one of the most widely used antiepileptic drugs, suppresses the abnormal brain activ

219 need for a thyroxine dose increase with some antiepileptic drugs, the effect of excessive thyroxine i

220 n part be attributed to the use of GABAergic antiepileptic drugs, the stability in glutamine across p

221 patients (62%) were in remission, 5 without antiepileptic drugs.

222 and is blocked by prior ingestion of typical antiepileptic drugs.

223 many local anesthetics, antiarrhythmics, and antiepileptic drugs.

224 eizure per month and failure of at least two antiepileptic drugs.

225 tic effects that alter the concentrations of antiepileptic drugs.

226 of exploration for the development of novel antiepileptic drugs.

227 ce by reducing target-site concentrations of antiepileptic drugs.

228 ve been associated with a worse tolerance of antiepileptic drugs.

229 ssociated with the mode of action of several antiepileptic drugs.

230 rebral lateralisation induced by exposure to antiepileptic drugs.

231 vasopressors, and treatment with third-line antiepileptic drugs.

232 g NMDA receptors being potential targets for antiepileptic drugs.

233 e manic symptoms were more likely to receive antiepileptic drugs.

234 eficits, we treated hAPP mice with different antiepileptic drugs.

235 s differ from those targeted by conventional antiepileptic drugs.

236 o not achieve adequate seizure control using antiepileptic drugs.

237 ntrolled despite the availability of over 20 antiepileptic drugs.

238 d in people with epilepsy taking concomitant antiepileptic drugs.

239 relation to seizure burden and control with antiepileptic drugs.

240 uctive outcomes, with or without exposure to antiepileptic drugs.

241 g because: (i) there may be some response to antiepileptic drugs; (ii) in infants with multisystem pa

242 e seizure-free and had started withdrawal of antiepileptic drugs; articles also had to contain inform

243 in GABAergic networks and that the observed antiepileptic effects of carbenoxolone are likely to be

244 elucidated the mechanism responsible for the antiepileptic effects of the ketogenic diet in mice.

245 tified (>30%) have published evidence of the antiepileptic efficacy (for example, curcumin) or antiep

246 Muscimol has potent antiepileptic efficacy after transmeningeal administrati

247 , GBR successfully identifies compounds with antiepileptic efficacy in animal models and, hence, it i

248 ched with drugs having published evidence of antiepileptic efficacy in animal models than expected by

249 abase as either having published evidence of antiepileptic efficacy or lacking such evidence, we demo

250 be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects i

251 Other therapeutic classes, like antiepileptics, hypertensives, and gastric and ulcer dru

252 s been identified as the binding site of the antiepileptic levetiracetam (LEV), making it an interest

253 interpretation, treatment with the atypical antiepileptic levetiracetam at a low dose shown previous

254 By using a low dose of the antiepileptic levetiracetam hippocampal activation in aM

255 onsteroidal antiinflammatories, antiseptics, antiepileptics, lipid regulators, beta-blockers and horm

256 Additionally, antiepileptic maneuvers may act as immunomodulators and

257 Antiepileptics may significantly decrease opioid require

258 Of these, 17 (11.0%) remained on antiepileptic medication (AED).

259 has been used for many years in Europe, this antiepileptic medication was approved for use in the USA

260 the electrical detection of phenytoin as an antiepileptic medication with a narrow therapeutic dosag

261 diagnosis of epilepsy, a carefully selected antiepileptic medication with consideration of comorbidi

262 ow therapeutic range, and is a commonly used antiepileptic medication.

263 % receiving immunotherapy, and 58% receiving antiepileptic medication.

264 80; 95% CI, 1.73-8.33; P < .001), the use of antiepileptic medications (OR, 3.24; 95% CI, 1.31-8.00;

265 f treatment goals, use of corticosteroids or antiepileptic medications is helpful in symptomatic pati

266 s Treatment Trial), compare effectiveness of antiepileptic medications, and rigorous examination of e

267 the narrow therapeutic and safety margins of antiepileptic medications, and the recognized complicati

268 izures had proven refractory to conventional antiepileptic medications, the sensitivity of mutant NMD

269 For women of childbearing potential who use antiepileptic medications, these findings must be balanc

270 m (EEG) readings, and treatment responses to antiepileptic medications.

271 ed, requiring long-term immunotherapy and/or antiepileptic medications.

272 omised controlled trial in patients starting antiepileptic monotherapy.

273 eptor (AR) agonists display antiischemic and antiepileptic neuroprotective activity, but peripheral c

274 e presence of recent new drug treatment with antiepileptics or allopurinol, respectively.

275 Antiepileptics (OR = 1.20, p = 0.60) did not affect seiz

276 ptic activity levels through exposure to the antiepileptic phenytoin or the inhibitory transmitter GA

277 ts with long-duration epilepsy, and those on antiepileptic polytherapy.

278 The antiepileptic pregabalin (Lyrica) shows clinical promise

279 Here, we investigate the antiepileptic properties of ranolazine exhibited through

280 ing periods when participants were receiving antiepileptics relative to periods when they were not (h

281 idence of an opposing endogenous homeostatic antiepileptic response.

282 that ABHD6 inhibition may represent a novel antiepileptic strategy.

283 ostasis in pyramidal cells could be a viable antiepileptic strategy.

284 throughout the brain and represent promising antiepileptic targets.

285 g DS, and offer a platform for screening new antiepileptic therapies.

286 and may represent a potential new target for antiepileptic therapies.

287 itability and thus may be a target for novel antiepileptic therapies.

288 ted cognitive decline and might benefit from antiepileptic therapies.

289 3-1.09; p < .001), treatment with third-line antiepileptic therapy (odds ratio 5.64; 95% confidence i

290 dard of aggressive therapy with conventional antiepileptic therapy in favor of early limitation of ca

291 To assess the response to antiepileptic therapy, we retrospectively reviewed the t

292 th regard to timing, dosing, and sequence of antiepileptic therapy.

293 an increase in use (from 2-fold increase for antiepileptics to 13-fold for hypertensives).

294 N: The data show that the BBB is a target of antiepileptic treatment and, more specifically, provide

295 Antiepileptic treatment of brain tumor patients mainly d

296 out 60% of patients with epilepsy receive no antiepileptic treatment, largely for economic and social

297 per day or placebo, in addition to standard antiepileptic treatment.

298 Of the most commonly prescribed antiepileptics, treatment outcomes appeared to be better

299 In contrast, antidepressants and antiepileptics were not significantly associated with vi

300 od candidates for development as new, potent antiepileptics with a potential in benzodiazepine-resist