ライフサイエンスコーパス: antiepileptic drug

1 site for levetiracetam, a second generation antiepileptic drug.

2 improved with age for infants exposed to any antiepileptic drug.

3 g lacosamide ((R)-1), a low-molecular-weight antiepileptic drug.

4 ed with introduction of a previously untried antiepileptic drug.

5 Randomization was stratified by antiepileptic drug.

6 d in people with epilepsy taking concomitant antiepileptic drugs.

7 tic effects that alter the concentrations of antiepileptic drugs.

8 of exploration for the development of novel antiepileptic drugs.

9 ce by reducing target-site concentrations of antiepileptic drugs.

10 ve been associated with a worse tolerance of antiepileptic drugs.

11 ssociated with the mode of action of several antiepileptic drugs.

12 rebral lateralisation induced by exposure to antiepileptic drugs.

13 vasopressors, and treatment with third-line antiepileptic drugs.

14 g NMDA receptors being potential targets for antiepileptic drugs.

15 e manic symptoms were more likely to receive antiepileptic drugs.

16 eficits, we treated hAPP mice with different antiepileptic drugs.

17 s differ from those targeted by conventional antiepileptic drugs.

18 res than those who had been exposed to other antiepileptic drugs.

19 gnitive difficulties associated with certain antiepileptic drugs.

20 f regulatory randomized controlled trials of antiepileptic drugs.

21 B2 may lead to development of first-in-class antiepileptic drugs.

22 o not achieve adequate seizure control using antiepileptic drugs.

23 eutic effectiveness of these potentially new antiepileptic drugs.

24 eizures have adverse effects, independent of antiepileptic drugs.

25 2 weeks, depending on use of enzyme-inducing antiepileptic drugs.

26 ate the effects of epilepsy from the role of antiepileptic drugs.

27 channels may be attractive targets for novel antiepileptic drugs.

28 ome of childhood) are insensitive to classic antiepileptic drugs.

29 ifferentiated from common adverse effects of antiepileptic drugs.

30 lso make it a very useful model in screening antiepileptic drugs.

31 ies following comparative studies with older antiepileptic drugs.

32 bid cognitive deficits or adverse effects of antiepileptic drugs.

33 es may ultimately serve as targets for novel antiepileptic drugs.

34 along with potency greater than that of the antiepileptic drugs.

35 hanism of action distinct from that of other antiepileptic drugs.

36 ntrolled despite the availability of over 20 antiepileptic drugs.

37 relation to seizure burden and control with antiepileptic drugs.

38 uctive outcomes, with or without exposure to antiepileptic drugs.

39 patients (62%) were in remission, 5 without antiepileptic drugs.

40 and is blocked by prior ingestion of typical antiepileptic drugs.

41 many local anesthetics, antiarrhythmics, and antiepileptic drugs.

42 eizure per month and failure of at least two antiepileptic drugs.

43 I 1.00, 1.02) as did those who had used more antiepileptic drugs (1.05; 95% CI 1.01 to 1.09).

44 Despite the availability of numerous antiepileptic drugs, 20-30% of epileptic patients are ph

45 ilepticus etiologies included subtherapeutic antiepileptic drugs (43%), alcohol or other nonantiepile

46 5%, p < .001), and treatment with third-line antiepileptic drugs (51% vs. 17%, p < .001).

47 Despite the success of several new antiepileptic drugs, about one third of patients with ep

48 Conventional antiepileptic drugs act by blocking sodium channels or e

49 pective, longitudinal observational study of antiepileptic drug adherence in a consecutive cohort of

50 , the current study is the first to describe antiepileptic drug (AED) combination therapy patterns ac

51 Antiepileptic drug (AED) exposure during pregnancy incre

52 xposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perin

53 rn exists that breastfeeding during maternal antiepileptic drug (AED) therapy may be harmful.

54 between children who become seizure-free on antiepileptic drug (AED) treatment and those children wi

55 mine whether surgery soon after failure of 2 antiepileptic drug (AED) trials is superior to continued

56 To investigate antiepileptic drug (AED)-related weight changes in patie

57 Antiepileptic drugs (AEDs) are commonly prescribed for e

58 Antiepileptic drugs (AEDs) are commonly prescribed for n

59 30% of epilepsy patients receiving antiepileptic drugs (AEDs) are not fully controlled by t

60 Antiepileptic drugs (AEDs) are relatively cheap but high

61 Antiepileptic drugs (AEDs) are the only neurotherapeutic

62 Currently available antiepileptic drugs (AEDs) fail to control seizures in 3

63 New antiepileptic drugs (AEDs) have been a major change in t

64 Antiepileptic drugs (AEDs) have cognitive side effects t

65 xcitability and controlling its degree using antiepileptic drugs (AEDs) is of prime importance for cl

66 Antiepileptic drugs (AEDs) remain the primary treatment.

67 es join the chemical fragments of well-known antiepileptic drugs (AEDs) such as ethosuximide, levetir

68 operties of the widely used older generation antiepileptic drugs (AEDs) suggest that they might be re

69 alpha-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs) that exhibit pronounced antic

70 To evaluate the effects of epilepsy and antiepileptic drugs (AEDs) used during pregnancy on feta

71 Antiepileptic drugs (AEDs) were generally ineffective an

72 perspectives for the design and discovery of antiepileptic drugs (AEDs) with fewer side effects by fo

73 atients with Alzheimer's disease with select antiepileptic drugs (AEDs), in low doses, is usually wel

74 REVIEW: Despite the availability of many new antiepileptic drugs (AEDs), only around 50% of people wi

75 idal thoughts and behavior related to use of antiepileptic drugs (AEDs).

76 e simultaneous detection and quantitation of antiepileptic drugs (AEDs).

77 tly suffering with epilepsy are resistant to antiepileptic drugs (AEDs).

78 ed sensitivity or availability of targets to antiepileptic drugs (AEDs; i.e., carbamazepine and pheny

79 ants, drugs used in addictive disorders, and antiepileptic drugs) after prison release.

80 hat captured the spectrum of nonadherence to antiepileptic drugs among children with newly diagnosed

81 bsequently assigned immediate treatment with antiepileptic drugs and 721 were assigned deferred treat

82 regarding critical drug interactions between antiepileptic drugs and antiretrovirals, but are also pr

83 ldren of women with epilepsy who did not use antiepileptic drugs and children of fathers with epileps

84 particularly with respect to the activity of antiepileptic drugs and compounds representing novel mec

85 yndromes, show specific responses to certain antiepileptic drugs and differentiate between responder

86 ing further advantage of 'simple' organisms, antiepileptic drugs and genetic modifiers of seizure act

87 that there may be drug interactions between antiepileptic drugs and hormonal therapies, which can pr

88 ted with incident epilepsy in the absence of antiepileptic drugs and in the absence of diagnosed psyc

89 s) with epilepsy who were taking concomitant antiepileptic drugs and not currently receiving lamotrig

90 ies compared with those exposed to the other antiepileptic drugs and on non-verbal and executive func

91 P3A4-dependent 1,25(OH)(2)D(3) metabolism by antiepileptic drugs and other PXR ligands may diminish i

92 disrupted by long-term therapy with certain antiepileptic drugs and the antimicrobial agent rifampin

93 reports of significant interactions between antiepileptic drugs and the efficacy of human growth hor

94 eral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to thes

95 nomics of drug response (pharmacogenomics of antiepileptic drugs) and genomics of drug resistance.

96 erization of drugs that modulate SV2A (e.g., antiepileptic drugs) and potentially could be a biomarke

97 ificant association of epilepsy, exposure to antiepileptic drugs, and adverse outcomes exists in preg

98 week), had failed to respond to at least two antiepileptic drugs, and had not been treated previously

99 Patients were treated with sedation, antiepileptic drugs, and immunotherapy.

100 The newer antiepileptic drugs appear to be safe, as no carcinogeni

101 Some new antiepileptic drugs are modifications of those already a

102 Older antiepileptic drugs are often prescribed at seizure pres

103 itive effects of fetal exposure of humans to antiepileptic drugs are uncertain.

104 We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial tha

105 e seizure-free and had started withdrawal of antiepileptic drugs; articles also had to contain inform

106 Are antiepileptic drugs associated with reduced pain intensi

107 Fetal exposure of animals to antiepileptic drugs at doses lower than those required t

108 Nineteen patients (45.2%) had withdrawn from antiepileptic drugs at least once; 12 of those (63.2%) h

109 n issued a warning regarding suicidality and antiepileptic drugs based on meta-analyses of 199 random

110 epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in

111 ore antiepileptic drug withdrawal, number of antiepileptic drugs before withdrawal, female sex, famil

112 do not show a good response to conventional antiepileptic drugs, but respond to immunotherapies.

113 Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal

114 es of epilepsy and the metabolic activity of antiepileptic drugs can adversely affect hypothalamic an

115 Epilepsy and antiepileptic drugs can alter sex hormone levels to prom

116 lation of brain excitability using available antiepileptic drugs can have serious side effects, espec

117 a mechanism by which early life exposure to antiepileptic drugs can impact cognitive and behavioral

118 substantial evidence indicates that several antiepileptic drugs can increase thyroid hormone metabol

119 t, the availability of more than 20 approved antiepileptic drugs can reduce the incentive to enrol in

120 The antiepileptic drug carbamazepine (CBZ) is one of the mos

121 In contrast, the antiepileptic drug carbamazepine was found to inhibit vo

122 Treatment options included antiepileptic drug changes, epilepsy surgery, and pacema

123 However, at this point, antiepileptic drug choice in patients with epilepsy rema

124 inical history, seizure types and frequency, antiepileptic drugs, cognitive, social and functional ou

125 to compare the efficacy and side effects of antiepileptic drug combinations in animals.

126 Use of multiple antiepileptic drugs compared with the reference group wa

127 Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase

128 Clinical trials as part of antiepileptic drug development are increasingly expensiv

129 er adjustment for maternal IQ, maternal age, antiepileptic-drug dose, gestational age at birth, and m

130 provide the first evidence that exposure to antiepileptic drugs during a sensitive postnatal period

131 Clinical Question: Is maternal use of antiepileptic drugs during pregnancy associated with maj

132 Exposure to antiepileptic drugs during pregnancy is associated with

133 trials of topical agents (e.g., capsaicin), antiepileptic drugs (e.g., gabapentin), injection of oth

134 twice a day for patients on enzyme-inducing antiepileptic drugs (EIAEDs) and 400 mg once a day for t

135 iconvulsant: Patients taking enzyme-inducing antiepileptic drugs (EIAEDs) received 340 mg/m2, and pat

136 s not currently treated with enzyme-inducing antiepileptic drugs (EIAEDs) with 100 mg/d of erlotinib

137 receiving and not receiving enzyme-inducing antiepileptic drugs (EIAEDs).

138 seizures despite treatment with at least two antiepileptic drugs, eight patients who had been seizure

139 The Equivalence among Generic Antiepileptic Drugs (EQUIGEN) chronic-dose study was a r

140 iconvulsants are of considerable interest as antiepileptic drugs, especially because of their potenti

141 d on cost, against the routine use of modern antiepileptic drugs, except when older drugs have failed

142 psy and undertook subgroup analysis based on antiepileptic drug exposure in women with epilepsy.

143 Since foetal antiepileptic drug exposure is associated with lower ver

144 , we examined dose-related effects of foetal antiepileptic drug exposure on verbal and non-verbal cog

145 At 36 months, prenatal antiepileptic drug exposure was associated with adverse

146 The association of epilepsy and antiepileptic drug exposure with pregnancy outcomes need

147 Sodium valproate has been a first-line antiepileptic drug for 40 years.

148 eight patients who had been seizure-free on antiepileptic drugs for at least a year after 3 or more

149 Two patients who had received multiple antiepileptic drugs for several years presented with a b

150 fficacy of epilepsy surgery and use of newer antiepileptic drugs for the treatment of intractable epi

151 The Equivalence Among Antiepileptic Drug Generic and Brand Products in People

152 Although the number of available antiepileptic drugs has increased substantially during t

153 The introduction of 10 new antiepileptic drugs has provided greater choice for pati

154 study conducted in the UK (Standard and New Antiepileptic Drugs) has confirmed what most practising

155 Antiepileptic drugs have been implicated in causing psyc

156 Ten antiepileptic drugs have been licensed since 1990.

157 ular drugs, painkillers, contrast media, and antiepileptic drugs have been recorded well above thresh

158 Several antiepileptic drugs have multiple or uncertain mechanism

159 tenuate mutant seizure activity; seven other antiepileptic drugs have no effect.

160 Some newer antiepileptic drugs have novel mechanisms of action, inc

161 0.2 mg/kg), and only two did not need rescue antiepileptic drugs (ie, met rescue criteria; one on 0.0

162 Seizures may persist despite antiepileptic drugs if the precipitating cause is untrea

163 g because: (i) there may be some response to antiepileptic drugs; (ii) in infants with multisystem pa

164 ponse to the addition of a previously unused antiepileptic drug in a cohort of 155 people with refrac

165 lsive epilepsy without detectable amounts of antiepileptic drugs in blood.

166 Although the effects of antiepileptic drugs in central hypothyroidism have not y

167 Mucocutaneous discoloration induced by antiepileptic drugs in general and ezogabine in particul

168 of more than 80% without the need for rescue antiepileptic drugs in more than 50% of infants.

169 The aim is to review rational polytherapy of antiepileptic drugs in terms of conventional and novel m

170 nitive and behavioural impact of exposure to antiepileptic drugs in utero.

171 e age of 6 years after exposure to different antiepileptic drugs in utero.

172 Other antiepileptic drugs increase sex hormone-binding globuli

173 Each new antiepileptic drug is well tolerated and demonstrates st

174 Switching between generic antiepileptic drugs is a highly debated issue that affec

175 The use and selection of antiepileptic drugs is often further complicated by the

176 t occurs after long-term treatment with some antiepileptic drugs is thought to be mediated by increas

177 proate, as compared with other commonly used antiepileptic drugs, is associated with an increased ris

178 The antiepileptic drug levetiracetam (LEV) is a potential tr

179 50, and 150 mug/kg) or preblocking with the antiepileptic drug levetiracetam at 10 and 30 mg/kg.

180 urthermore, the addition of the SV2A-binding antiepileptic drug levetiracetam to the medium inhibited

181 ncluding an expedient total synthesis of the antiepileptic drug levetiracetam.

182 The antiepileptic drug, levetiracetam, blocked Kv4.2 depleti

183 indicate that the effectiveness of VPA as an antiepileptic drug may be partially explained by the HDA

184 Antiepileptic drugs may also cause EDS or influence slee

185 Treatment of epilepsy and selection of antiepileptic drugs may be important to reproductive hea

186 erological response to immunotherapies, when antiepileptic drugs may be ineffective.

187 Various antiepileptic drugs may differ in this regard.

188 other antiepileptic drugs suggest that these antiepileptic drugs may have long-term effects.

189 suggest conventional sodium channel blocking antiepileptic drugs may worsen the disease, we predicted

190 However, neither such methods nor antiepileptic drug mechanisms of action have yet proven

191 pilepsy who became seizure-free while taking antiepileptic drugs might consider discontinuing their m

192 uicide and whether psychiatric disorders and antiepileptic drugs modify the risk of attempted suicide

193 we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigi

194 premenopausal women with epilepsy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine

195 At age 6 months, infants of mothers using antiepileptic drugs (n = 223) had a higher risk of impai

196 The onset and evolution of antiepileptic drug nonadherence in children with newly d

197 icus episodes were treatment with third-line antiepileptic drugs (odds ratio, 12.08; 95% confidence i

198 Lamotrigine was selected as the antiepileptic drug of interest because of its wide use,

199 We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up

200 fects of traditional and recently introduced antiepileptic drugs on excitatory and inhibitory brain m

201 ailable for the effects of second-generation antiepileptic drugs on hypopituitarism treatment.

202 5-0.99), treatment history (taking non-SANAD antiepileptic drugs [other than those listed above] vs t

203 (p=0.052) and a lower number of concomitant antiepileptic drugs (p=0.03).

204 Antiepileptic drugs, particularly cytochrome P450 enzyme

205 e effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in prev

206 was applied to the "green" synthesis of the antiepileptic drug Phenytoin, with no use of any harmful

207 usual concomitant medications, including an antiepileptic drug (phenytoin or carbamazepine), dexamet

208 We tested whether two commonly prescribed antiepileptic drugs (phenytoin, lamotrigine), as well as

209 g patients discharged with a prescription of antiepileptic drugs, phenytoin and levetiracetam were pr

210 s epilepticus episodes treated by third-line antiepileptic drugs, predictors of poor outcome were old

211 born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2

212 Phenytoin was the most common antiepileptic drug prescribed de novo (61%).

213 Exclusion of antiepileptic drugs prescribed before the index date did

214 re, age, known diagnosis of epilepsy, use of antiepileptic drugs, prior treatment, and length of seiz

215 its application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described.

216 uire concurrent treatment with more than one antiepileptic drug (rational polytherapy), but there is

217 y 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need.

218 r approach in evaluating young patients with antiepileptic drug-resistant seizures.

219 caffold the chemical fragments of well-known antiepileptic drugs such as ethosuximide, levetiracetam,

220 e and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin

221 ary axis have shown that chronic use of many antiepileptic drugs, such as carbamazepine, oxcarbazepin

222 r valproate compared with those taking other antiepileptic drugs suggest that these antiepileptic dru

223 Current antiepileptic drugs suppress seizures without influencin

224 Phenytoin, one of the most widely used antiepileptic drugs, suppresses the abnormal brain activ

225 report (p=0.03), a lower number of previous antiepileptic drugs taken (p=0.052) and a lower number o

226 e has been pursued as an antinociceptive and antiepileptic drug target.

227 ood in detail, despite the fact that several antiepileptic drugs target GABA(A) receptors.

228 Most antiepileptic drugs target neuronal mechanisms.

229 Although many clinically-approved antiepileptic drugs target voltage-gated persistent sodi

230 hat they are important currently unexploited antiepileptic drug targets.

231 Of the four antiepileptic drugs tested in this model, only phenytoin

232 rovide an example of cross-over pharmacology antiepileptic drug testing.

233 Levetiracetam (LEV) is a prominent antiepileptic drug that binds to neuronal synaptic vesic

234 a lipophilic molecule used as a sedative and antiepileptic drug that elicits a multitude of effects i

235 AZA is an antiepileptic drug that has been shown to inhibit AQP4 e

236 daily injections of phenytoin (40 mg/kg), an antiepileptic drug that prevents CA3 dendritic retractio

237 Retigabine (RTG) is a first-in-class antiepileptic drug that suppresses neuronal excitability

238 nces between splice variants are occluded by antiepileptic drugs that bind to and stabilize inactivat

239 ts with nonepileptic seizures are prescribed antiepileptic drugs that do not treat nonepileptic seizu

240 ociated with the dosing of two commonly used antiepileptic drugs that elicit their pharmacologic acti

241 need for a thyroxine dose increase with some antiepileptic drugs, the effect of excessive thyroxine i

242 n part be attributed to the use of GABAergic antiepileptic drugs, the stability in glutamine across p

243 Our results signify that no matter how many antiepileptic drug therapies have failed, there is alway

244 Third-line antiepileptic drug therapies with sedating or anesthetic

245 l seizures who do not respond to appropriate antiepileptic drug therapy consisting of 2 or more medic

246 cted in women with epilepsy who discontinued antiepileptic drug therapy during pubertal maturation.

247 VNS is as effective as antiepileptic drug therapy, and serious complications ar

248 re predicting seizure outcome after starting antiepileptic drug therapy, measured by both time to fir

249 Antiepileptic drug therapy, though beneficial for restra

250 or selective alpha(2A)AR agonists as a novel antiepileptic drug therapy.

251 drug withdrawal outcomes after initiation of antiepileptic drug therapy.

252 precipitating cause; determine the need for antiepileptic drug therapy; and recognize nonconvulsive

253 rom immediate remission after taking a first antiepileptic drug to frequent unremitting seizures with

254 The choice of which antiepileptic drug to use may also be influenced by the

255 defined as failure of adequate trials of two antiepileptic drugs to achieve sustained seizure freedom

256 CSD was also decreased by the antiepileptic drug topiramate, but not by carbamazepine.

257 ional anaesthetics (isoflurane, desflurane), antiepileptic drugs (topiramate, lacosamide, pregabalin,

258 re the absence of a control group continuing antiepileptic drug treatment and a consistent definition

259 , randomised study of immediate and deferred antiepileptic drug treatment in 1847 patients with singl

260 isks and benefits of starting or withholding antiepileptic drug treatment in patients with few or inf

261 Antiepileptic drug treatment necessarily confounds analy

262 to treatment failure were treatment history (antiepileptic drug treatment prior to randomisation), EE

263 Immediate antiepileptic drug treatment reduces the occurrence of s

264 ergency that is typically terminated through antiepileptic drug treatment, leads to hippocampus dysfu

265 to breastfeed their children irrespective of antiepileptic drug treatment.

266 in children exposed, in utero, to different antiepileptic drug treatments.

267 of improvement is similar to that of recent antiepileptic drug trials in drug resistant epilepsy (DR

268 linear regression adjusted for maternal IQ, antiepileptic drug type, standardised dose, gestational

269 herapy were not different from those without antiepileptic drug use at both time points (PFS: HR, 0.9

270 combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy

271 The effects of the antiepileptic drugs used in the MESS study are greater f

272 We show here that the antiepileptic drug valproic acid (VPA) potently blocked

273 definite cause of pancreatitis is due to the antiepileptic drug valproic acid (VPA).

274 that exposing mouse brain capillaries to the antiepileptic drug, valproic acid (VPA; 5 muM), signific

275 1.35), treatment history (taking a non-SANAD antiepileptic drug vs treatment naive, 0.64, 0.52-0.78),

276 Prenatal exposure to antiepileptic drugs was associated with impaired fine mo

277 ous breastfeeding in children of women using antiepileptic drugs was associated with less impaired de

278 eizures in patients, for whom treatment with antiepileptic drugs was uncertain, who were randomly ass

279 Third-line antiepileptic drugs were administered in 47 cases (33%).

280 Bottom Line: Certain antiepileptic drugs were associated with increased rates

281 Antiepileptic drugs were categorized by MOA: sodium chan

282 andomised controlled trial in which standard antiepileptic drugs were compared with new treatments.

283 Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as

284 sy-proved low-grade glioma treated only with antiepileptic drugs were examined longitudinally with su

285 antile epilepsies (<3 months), whereas other antiepileptic drugs were less effective.

286 tive function (r=-0.42, p=0.0004), but other antiepileptic drugs were not.

287 ne phase) receiving one to three concomitant antiepileptic drugs were recruited from 99 centres acros

288 aving not responded positively to at least 2 antiepileptic drugs) were identified in 2000 and followe

289 Carbamazepine (CBZ) is an antiepileptic drug which is persistent in wastewater tre

290 ften fatal syndrome, initially responsive to antiepileptic drugs which over time becomes refractory a

291 Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large exte

292 In the future, this range of antiepileptic drugs will probably increase because of th

293 n binding site of levetiracetam (LEV), a new antiepileptic drug with a unique activity profile in ani

294 VPA is a commonly prescribed antiepileptic drug with known teratogenic effects.

295 Limited studies have compared the new antiepileptic drugs with more traditional medications an

296 spiny neurons from neonatal rats exposed to antiepileptic drugs with proapoptotic action (phenobarbi

297 tients; however, data for the interaction of antiepileptic drugs with the pituitary axis have shown t

298 With increasing age and treatment duration, antiepileptic drug withdrawal may be justified.

299 fore remission, seizure-free interval before antiepileptic drug withdrawal, age at onset of epilepsy,

300 fore remission, seizure-free interval before antiepileptic drug withdrawal, number of antiepileptic d