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1 hereas others (raloxifene and GW7604) remain antiestrogenic.
2 :ER complex from estrogen-like to completely antiestrogenic.
3 that Pak1 overexpression interfered with the antiestrogenic action of tamoxifen upon the ER transacti
5 eceptor (ER), all of these compounds exhibit antiestrogenic action when the side chain length is n >
8 posed that tissue-specific estrogenic and/or antiestrogenic actions of certain xenoestrogens may be a
9 apies to exert tissue-specific estrogenic or antiestrogenic activities, this knowledge will be crucia
10 activity in addition to its well-documented antiestrogenic activity and raises the possibility that
12 addition, CPC showed concentration-dependent antiestrogenic activity half maximal effective concentra
14 have investigated at the molecular level the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-
16 ential AhR-ER cross-talk is evidenced by the antiestrogenic activity of MCDF and the degradative effe
17 brief, the characterization of structure and antiestrogenic activity of MTA1s peptide highlight its t
19 ancer is limited by the mixed estrogenic and antiestrogenic activity of selective estrogen receptor m
21 In all three cases, there was overlap of the antiestrogenic activity with the mitochondrial inhibitor
28 de and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro
29 investigate the activities of estrogenic and antiestrogenic compounds in yeast Saccharomyces cerevisi
30 macological behaviour of many estrogenic and antiestrogenic compounds, including the naturally occurr
34 to understand the mechanisms underlying the antiestrogenic effect of this prototype SERM, we perform
38 This finding suggests that TCDD may have antiestrogenic effects in the uterine myometrium, in con
40 ty rates in Asian countries and the putative antiestrogenic effects of isoflavones have fueled specul
41 research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK.
42 However, tumors that are refractory to the antiestrogenic effects of selective ER modulators often
44 esults provide a molecular mechanism for the antiestrogenic effects of TCDD and demonstrate the prese
46 In mechanistic studies, we found that the antiestrogenic effects of the MTA1s peptide were due to
48 lective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue
49 n experiments conducted with Ishikawa cells, antiestrogenic effects were confirmed by dose-dependent
51 ed thus far in fish have known estrogenic or antiestrogenic effects, and as such cause the inappropri
52 Proposed mechanisms include estrogenic and antiestrogenic effects, induction of cancer cell differe
57 -analogues of estradiol have tissue specific antiestrogenic/estrogenic actions, characteristics of se
58 to genistein treatments, suggesting that the antiestrogenic function of genistein is unrelated to the
60 uired for this activity as TCDD is no longer antiestrogenic in a mutant cell line that is deficient i
62 aken together, these results suggest a novel antiestrogenic mechanism for specific polyamine analogue
63 droxy-N-desmethyltamoxifen), the most potent antiestrogenic metabolite, are reduced in women whose CY
65 s (PCBs) have been shown to have estrogenic, antiestrogenic, or antiandrogenic properties; as a resul
67 rast, a mutation at AA 400 does not, and the antiestrogenic properties of raloxifene are retained.
68 -Tetrachlorodibenzo-p-dioxin (TCDD) exhibits antiestrogenic properties, including the inhibition of e
69 as been reported to have weak estrogenic and antiestrogenic properties, to be an antioxidant, to inhi
70 tably expressing either SULT1A1*1 or *2, the antiestrogenic response to OHT was found to be allele-sp
71 nsiveness to estradiol (E2) and also retains antiestrogenic responsiveness to both raloxifene and ICI
72 l AI/SERM, while in breast cancer tissue the antiestrogenic SERM activity of a dual AI/SERM could act
77 nsteroidal anti-inflammatory) and tamoxifen (antiestrogenic widely used in breast cancer therapy and
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