ライフサイエンスコーパス: antigen specificity

1 beta epitope (in a prior nomenclature for e-antigen specificity).

2 rally unrelated hapten-BSA adducts confirmed antigen specificity.

3 ild-type IgG1 (IgG1/wt) or IgG2 of identical antigen specificity.

4 ditioned secondary recipients, demonstrating antigen specificity.

5 ved with IgG1/wt, IgG2, or IgG4 of identical antigen specificity.

6 fetal antigen, demonstrating their inherent antigen specificity.

7 for ERCC1-XPF were not rigorously tested for antigen specificity.

8 model antigens were preserved demonstrating antigen specificity.

9 tly regulated event and is governed by islet antigen specificity.

10 + regulatory T cells (T(reg)) independent of antigen specificity.

11 reased on memory CD8(+) T cells according to antigen specificity.

12 terminant of preferential infection based on antigen specificity.

13 tumor progression regardless of CD8(+) TILs' antigen specificity.

14 ls without impairing phenotype, function, or antigen specificity.

15 s and effector Th2 cells displaying the same antigen specificity.

16 beta chain libraries pre-enriched for target antigen specificity.

17 lation likely requires in vivo generation of antigen specificity.

18 previously derived from IAC, without losing antigen specificity.

19 munoglobulin (Ig) gene usage, clonality, and antigen specificity.

20 entify and isolate NK T cells based on their antigen specificity.

21 in, and entered the CNS independent of their antigen specificity.

22 x T cell populations that differ in size and antigen specificity.

23 he heavy and the light chains contributed to antigen specificity.

24 f B cells and for determining their eventual antigen specificity.

25 ss II molecules is as or more important than antigen specificity.

26 sely adjacent Treg cells regardless of their antigen specificity.

27 -specific antibodies is separable from their antigen specificity.

28 B cell helper quality differed depending on antigen specificity.

29 therapeutics for autoimmunity is the lack of antigen specificity.

30 therapeutic functions while still retaining antigen specificity.

31 nd beta-chains contribute to determining TCR antigen specificity.

32 the infused T-cell population had restricted antigen specificity.

33 at allows proliferative responses, enforcing antigen specificity.

34 aid in the design of antibodies with altered antigen specificity.

35 described, based on their TCR repertoire and antigen specificity.

36 n induce tumor-specific T cells with defined antigen specificity.

37 s to redirect T cell and natural killer cell antigen specificity.

38 n enormous array of receptors with different antigen specificities.

39 madelta T cells rather than constrains their antigen specificities.

40 ment has little role in generating different antigen specificities.

41 e an almost infinitely diverse repertoire of antigen specificities.

42 autoimmune hepatitis, and they have diverse antigen specificities.

43 (V(H)3-30), despite an apparent diversity of antigen specificities.

44 ssion, rapid effector responses and 'public' antigen specificities.

45 te repertoires with extensive collections of antigen specificities.

46 fection of CD4 T cells of different pathogen/antigen specificities.

47 fic TILs without previous knowledge of their antigen specificities.

48 on of DSA (including two new human leukocyte antigen specificities) 2 months after initial bortezomib

49 These cells showed antigen specificity against HIV proteins.

50 Antigen specificity also factored into TLR7-induced dise

51 These two subsets differ in their principal antigen specificities and in the T-cell receptor signal

52 Notably, the tumor-antigen specificities and TCR repertoires of the circula

53 unresolved, especially with regard to their antigen specificities and the cellular and molecular pat

54 The antigen specificity and affinity of both receptors is de

55 gic memory that has 2 basic characteristics, antigen specificity and an amplified response upon subse

56 two-step staining approach is used to detect antigen specificity and antibody expression: in order to

57 ion and purification, the Mbs retained their antigen specificity and bound primary CD8(+) T cells fro

58 combinant IgG-DAF chimeric proteins retained antigen specificity and bound to dansylated Chinese hams

59 acent CD1 residues in a manner that explains antigen specificity and CD1 restriction.

60 Importantly, however, the antigen specificity and cellular origin of maternal T(re

61 h2G7 retained identical antigen specificity and comparable affinity as m2G7.

62 ovel TCR transgenic mice with a defined self-antigen specificity and conventional mouse models, we de

63 vided insight into the mechanisms underlying antigen specificity and cross-reactivity.

64 MHC) tetramer staining to directly correlate antigen specificity and cytolytic ability on a single-ce

65 ts priming of naive CD8+ T cells that retain antigen specificity and cytotoxic function for more than

66 More surprisingly, immunocytokine antigen specificity and Fcgamma receptor interactions di

67 However, the antigen specificity and functional properties of these c

68 f human malignancies and, given their target antigen specificity and generally minimal toxicity, are

69 erein, we discuss different forms of NK cell antigen specificity and how these responses may be tuned

70 e restored by transfer of Ig irrespective of antigen specificity and isotype.

71 and characterization of B-CLL mAbs to study antigen specificity and of B-CLL DNA to investigate mole

72 Therapeutic activity required tumor antigen specificity and perforin expression by the adopt

73 HCV TCRs that differ in antigen specificity and polyfunctionality were examined.

74 ell clones expressing cloned TCRs with known antigen specificity and relative affinities.

75 ition of the signal on the array defined the antigen specificity and the antibody class was defined b

76 iew, the mechanism of action of Tregs, their antigen specificity and their frequency and function in

77 fficient to recruit CTLs regardless of their antigen specificity and to induce insulitis.

78 c anaphylaxis in vivo and to investigate the antigen specificity and underlying mechanisms of rapid d

79 However, antigen specificity and VLA-4 expression were required f

80 Expression of LIR-1 was dependent on CTL-antigen specificity and was associated with a differenti

81 Such auto- antigen specificity and/or cross-reactivity may dictate

82 CARs combine antigen-specificity and T cell activating properties in

83 between antibody features (IgG subclass and antigen specificity) and effector function activities (a

84 surface immunoglobulin (sIg), which provides antigen specificity, and a noncovalently associated sign

85 tility owing to their biocompatibility, high antigen specificity, and targeted immune stimulation.

86 populations, which have not taken account of antigen specificity, and understanding their properties

87 e diseases, self-reactive T cells with known antigen specificity appear to be particularly promising

88 Although the antigen specificities are presently unknown, similar cha

89 is system, clonal naive T cells with defined antigen specificity are generated by retrovirus-mediated

90 While their precise role and antigen specificity are unclear, T cell-derived cytokine

91 d version of E16 was generated that retained antigen specificity, avidity and neutralizing activity.

92 I binding, demonstrating the need for target antigen specificity both in vitro and in vivo.

93 NKT cells are of limited antigen specificity but possess the ability to be recrui

94 n does little to constrain gammadelta T cell antigen specificities, but instead determines their effe

95 lood-brain barrier (BBB) regardless of their antigen specificity, but studies have focused on CD4 T c

96 rs (3.9 +/- 1.3 %ID/g, P < 0.01), indicating antigen specificity by (89)Zr-alphaGPC3.

97 Fv and IgG mutant forms were then tested for antigen specificity by ELISA, for tissue specificity by

98 Redirecting T lymphocyte antigen specificity by gene transfer can provide large n

99 We assessed the antigen specificity, cytokine signature, and mechanisms

100 dicate that BCR signal strength, rather than antigen specificity, determines mature B cell fate.

101 crosomal type 1 (LKM-1) showing a remarkable antigen-specificity directed against cytochrome P4502D6.

102 infiltrate dynamics and the requirement for antigen specificity during progression of autoimmune dia

103 urprisingly, T cell populations differing in antigen specificity expand, contract, and enter the T ce

104 tailored generation of T cells of unlimited antigen specificity for improving the effectiveness of a

105 eering of novel T-cell receptors that impart antigen specificity for virally infected or malignant ce

106 very different clinical features relative to antigen specificity; for example, most patients with Weg

107 In contrast, T cells with other antigen specificities from these patients, or autoreacti

108 The recent work on the antigen specificity, generation and mode of action of T

109 and antibody expression: in order to detect antigen specificity, hybridoma cells are incubated with

110 onstraint of fitting a diverse repertoire of antigen specificities in a limited total population of l

111 cells (LT-HSCs) alters the representation of antigen specificities in the peripheral B-cell repertoir

112 The consistency of CD2, CD3, CD11a, and CD45 antigen specificities in thymoglobulin was determined us

113 t parasites and venoms and are the source of antigen specificity in allergic patients, yet the develo

114 coordination and the generation of a common antigen specificity in CBD.

115 A characterization of the antigen specificity in DO11.10 TCR transgenic mice demon

116 these cells lack polyreactivity yet manifest antigen specificity in the context of lipids, shaping MP

117 gether, our data highlight the importance of antigen specificity in the functional dynamics of the T-

118 -related TCR, and therefore sharing the same antigen specificity, invariably shared the same NKG2A co

119 As antigen specificity is a hallmark of an adaptive immune

120 Antigen specificity is critical in immune response and r

121 It is currently thought that islet antigen specificity is not a requirement for islet entry

122 logous peripheral CD8(+) T lymphocytes whose antigen specificity is redirected by transduction with l

123 munity, Lennon et al. demonstrate that islet-antigen specificity is required for accumulation in the

124 The match of T-cell effector function with antigen specificity is thus determined by the type of ba

125 Antigen-specificity is a hallmark of adaptive T cell-med

126 inflammatory property of IgG, independent of antigen specificity, is described.

127 y-purified antibodies were also examined for antigen specificity, isotype, and crossreactivity.

128 ation and cytokine production independent of antigen specificity, its therapeutic effect is abrogated

129 However, the degree of antigen specificity mediated by alloreactive T cells, an

130 the post-translational acquisition of novel antigen specificities might play an important role in th

131 ale proteome array to systematically profile antigen specificities of antibody responses to C. tracho

132 This review focuses on antigen specificities of autoantibodies in lupus anticoa

133 the CDR3 regions were found to determine the antigen specificities of T10- and T22-reactive gammadelt

134 roteome and used them to determine the major antigen specificities of the human humoral immune respon

135 activity and potentially harmful unpredicted antigen specificities of the resultant TCRs.

136 ic response after adoptive transfer, but the antigen specificities of the T cells transferred have no

137 cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes

138 Bispecific antibodies (bsAbs) combine the antigen specificities of two distinct Abs and demonstrat

139 In summary, we have combined the antigen specificities of two highly efficacious anti-H5N

140 We investigated the antigen specificity of a human gammadelta-TCR previously

141 We also found that the antigen specificity of a single T-cell clone can be dege

142 ation is needed to identify the mechanism of antigen specificity of adverse reactions to foods in FPI

143 To help understand the frequency and antigen specificity of AMAs in an asymptomatic populatio

144 cells), these entities combine the exquisite antigen specificity of antibodies with the polyfunctiona

145 We examined the timing and HIV-1 antigen specificity of antiviral CD8(+) T cells during A

146 polyclonal and virus-specific processes, the antigen specificity of B cells in lymphoid tissues of mo

147 emic associated with the origin, target, and antigen specificity of both endogenous and induced regul

148 These results indicate antigen specificity of both immune induction and the rec

149 ase inhibitor (SLPI), and to investigate the antigen specificity of both NE and PR3 ANCA in patients

150 However, very little is known about the antigen specificity of CD4(+) Treg cells.

151 The antigen specificity of CD8(+) T cells infiltrating islet

152 olipin binding, raising the possibility that antigen specificity of certain antibodies may exclusivel

153 The TCR diversity and antigen specificity of CMV-specific T cells remained rem

154 ted that costimulatory molecule B7 modulates antigen specificity of CTLs, and provides a missing link

155 regulatory T cells alone can account for the antigen specificity of dominant transplantation toleranc

156 The antigen specificity of each construct was for the hapten

157 esults challenge current paradigms about the antigen specificity of GvHD effector mechanisms and conf

158 ime (MST), and alloimmune responses, and the antigen specificity of induced tolerance were studied.

159 Furthermore, these studies revealed that the antigen specificity of influenza virus-reactive CD4 and

160 ant role for negative selection in mediating antigen specificity of mature T cells and a molecular me

161 To investigate the antigen specificity of regulatory T cells capable of pre

162 Antigen specificity of RTL raises the question as to whe

163 However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are sc

164 y complex is the key interaction involved in antigen specificity of T cells.

165 ity complex (MHC) multimers which mirror the antigen specificity of T-cell receptor recognition.

166 cient killing of bacteria, regardless of the antigen specificity of the antibody.

167 o, but the extent of this activation and the antigen specificity of the CD8(+) T cells remain uncerta

168 a, implying a common mechanism, the issue of antigen specificity of the cells involved has not yet be

169 enzymes may enable pathogens to subvert the antigen specificity of the humoral immune response to fa

170 for extracellular bacteria, we assessed the antigen specificity of the induction and recall of this

171 Because of the antigen specificity of the inhibition, these results col

172 s more compelling if concordance between the antigen specificity of the leukocyte antibodies in the d

173 which does not depend upon knowledge of the antigen specificity of the original T cell clone trigger

174 Antigen specificity of the suppressive nanovesicles was

175 However, the antigen specificity of the T-cell response to C. neoform

176 udy, we used two approaches to determine the antigen specificity of the T-cell response to C. neoform

177 lls but not resting T cells, irrespective of antigen specificity of the target T cells.

178 antibody types (4.6-6.0), demonstrating the antigen specificity of the tumor targeting.

179 lesions (CIMDL), but the pathogenic role and antigen specificity of these antibodies are unknown.

180 sitive target cells further demonstrated the antigen specificity of these CTLs.

181 rotection following CNS injury; however, the antigen specificity of these T cells and how they mediat

182 Here we examined the antigen specificity of tissue-infiltrating CD4(+) T cell

183 at virtually every CDR can contribute to the antigen-specificity of a T cell.

184 e unresolved issue of antigen-dependency and antigen-specificity of autoimmune disease suppression by

185 Here, to identify the origin and antigen-specificity of intestinal Treg cells, we perform

186 We characterized the antigen-specificity of L363 toward several different gly

187 regulation which is thought to maintain the antigen-specificity of T cell apoptosis.

188 We investigated the antigen-specificity of T cells isolated from patients wi

189 the isotype and IgG subclasses, but not the antigen specificity, of the local antibody response.

190 Helper T cells confer antigen specificity on eosinophil cytotoxicity, but not

191 drug without measurable impairment of their antigen specificity or cytotoxic activity.

192 and warn that care must be taken when using antigen-specificity or surface IgG as an indicator of B

193 Despite their antigen specificity, pea-T10 cells of patients with PA w

194 ave a large antibody repertoire with diverse antigen specificities, poised to react to invading patho

195 Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessi

196 responses of CTL populations that differ in antigen specificity range in magnitude from large, domin

197 let membrane preparations, others have known antigen specificities, reacting with defined islet cell

198 How this diversity captures antigen specificity remains incompletely understood.

199 However, CARs have a fixed antigen specificity such that only one tumor-associated

200 mber injection of antigen, as shown by their antigen specificity, surface expression of CD8, and capa

201 ces of adaptive immunity, which is built for antigen specificity, tend to produce organ-specific auto

202 ur data indicated that despite their similar antigen specificity, the functional NKT cell subsets wer

203 , and despite the lack of information on TCR antigen specificity, the sharing of top abundant clones

204 diversity of immune functions by coupling of antigen specificity through the Fab domain to signal tra

205 e we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequence

206 formation is currently available about their antigen specificity, tissue distribution, and biological

207 sary for the induction of ACAID and conveyed antigen specificity to the suppressor T cells.

208 y their functional heterogeneity, breadth in antigen specificity, transient appearance in circulation

209 suspected CJD group were further studied for antigen specificity using cell-based assays.

210 Their antigen specificity was assessed by cytofluorimetry usin

211 Their antigen specificity was assessed by cytofluorimetry usin

212 Antigen specificity was confirmed in lines from six diab

213 rent regions of the TCR play in affinity and antigen specificity, we have studied the TCR from T cell

214 r bulk CXCR5(+) CD4(+) T cells nor other HIV antigen specificities were associated with gp120-specifi

215 tibodies, 20-1 and NZA6, with very different antigen specificities were found to be highly homologous

216 Antigen specificities were very similar, with a slightly

217 reg and their immunosuppressive function and antigen specificity were assessed using flow cytometry,

218 O1, O4, A2B5, and HNK-1), each with distinct antigen specificities, were evaluated and found to promo

219 cells from CHB patients, regardless of their antigen specificity, were impaired in their ability to p

220 contain antibodies with numerous and diverse antigen specificities, whereas sera from conidium-expose

221 press either VLRAs or VLRCs of yet undefined antigen specificity, whereas the VLRB antibodies secrete

222 CD8(+) T regs display antigen-specificity, which is most exquisitely manifeste

223 ional plasticity enabling the integration of antigen specificity with environmentally responsive immu

224 s, including surface markers, cytokines, and antigen specificity with modified peptide-MHC tetramers.

225 Memory T cells exhibit tremendous antigen specificity within the immune system and accumul