ライフサイエンスコーパス: antigen-binding site

1 ns that are involved in the formation of the antigen binding site.

2 tions located on surface loops distal to the antigen binding site.

3 within the VH CDR3 loop at the center of the antigen binding site.

4 did not affect the kinetic properties of the antigen binding site.

5 y repertoire is focused at the centre of the antigen binding site.

6 thymine bases in hydrophobic pockets on the antigen binding site.

7 might affect the structural integrity of the antigen binding site.

8 e Ig molecule at a location distant from the antigen binding site.

9 ain variable fragments with mutations in the antigen-binding site.

10 vy chain (CDR-H3), the center of the classic antigen-binding site.

11 the Ig variable-region genes that encode the antigen-binding site.

12 edominated, especially at amino acids in the antigen-binding site.

13 h the CDR loops disposed to form part of the antigen-binding site.

14 mains on Herceptin (HER), which included the antigen binding sites.

15 l-encoded regions were generally proximal to antigen binding sites.

16 against gp120 are tyrosine sulfated at their antigen binding sites.

17 that the nucleophiles are located within the antigen binding sites.

18 cules with variability on one or both of the antigen binding sites.

19 xplains the high abundance of Tyr in natural antigen-binding sites.

20 ion of a dimeric Mr 50,000 molecule with two antigen-binding sites.

21 n for amino acid replacement at the putative antigen-binding sites.

22 ch have an RGD-related RYD sequence in their antigen-binding sites.

23 er function, the origin of replication and T antigen binding site 1.

24 ied specific positions that clustered in the antigen binding site (28, 30-33, 35 in V(H) and 24, 49-5

25 More than half of the putative antigen-binding sites (ABS) of class II were under posit

26 ves is approximately 1.8 times the number of antigen-binding sites accessible for targeting by radiol

27 lementarity-determining region) loops at the antigen binding site adopt nearly identical conformation

28 d the electrostatic surface potential of the antigen binding site, allowing for an increase in positi

29 lectrostatic complementarity between the mAb antigen binding site and the p40 D1 domain epitope appea

30 nzyl-DTPA and its complexes bind both to the antigen binding site and to multiple charged sites on th

31 did not participate in the formation of the antigen binding site and were not at the interface of th

32 lance of reciprocal binding events among the antigen binding sites and distant points on the constant

33 his model, may also propagate beyond the TCR antigen-binding site and directly affect self-associatio

34 eletions are clustered at "hot-spots" in the antigen-binding site and frequently result in the creati

35 ontribute generally to the affinity of naive antigen-binding sites and is detrimental to specificity.

36 ng and the content of Tyr, Ser or Gly in the antigen-binding site, and in fact, the most specific ant

37 mous variation, concentrated in the putative antigen-binding sites, and little synonymous variation.

38 l heterogeneity and slow dynamics at protein antigen binding sites appears to be a conserved feature

39 ino terminus of e23(V H), possibly where the antigen binding sites are located.

40 Natural antigen-binding sites are enriched for tyrosine and seri

41 antibodies from all strains, the distinctive antigen-binding sites associated with VHQ52 differ subst

42 rst step, the overall positive charge of the antigen binding site attracts the negatively charged DNA

43 ps and, also, nonconventional libraries with antigen-binding sites built from CDR3 and the former lig

44 to support both conventional libraries with antigen-binding sites built from the three CDR loops and

45 regions have been pursued to design a second antigen-binding site (chi-site) in a chimeric single-cha

46 tep involved generation of a library of m836 antigen binding sites combined with diverse human germli

47 Thus, tailoring of the antigen-binding site combined with glycan modulation and

48 and bacteria may share structurally similar antigen-binding site configurations.

49 contributed predominantly to stabilizing the antigen-binding site conformation.

50 The chCD1-2 antigen-binding site consists of a compact, narrow, cent

51 eral, mutation of amino acid residues at the antigen binding site disrupts LPA binding.

52 ate that at least three helically in-phase T-antigen binding sites exist in the GC box region located

53 dulated: antibody binding sites for antigen; antigen binding sites for antibody, and antibody Fc bind

54 d in most of the molecular features of their antigen-binding sites from antibodies that do not change

55 l antibodies were obtained from a library of antigen-binding sites generated by a binary code restric

56 We show that its antigen-binding site has adopted an architecture that po

57 letion analysis showed that only the large T-antigen binding site II (the core origin) was required b

58 ined through energy minimization, reveals an antigen binding site in the shape of a large canyon with

59 studies have revealed that the hearts of the antigen binding sites in both free anti-IL-1beta Fab and

60 triking similarities to the arrangement of T-antigen binding sites in the SV40 ori even though the re

61 Bispecific antibodies combine two different antigen-binding sites in a single molecule, enabling mor

62 16 amino acid positions that are part of the antigen binding site is 0.389 whereas that for the 67 am

63 odies are devoid of the light chain, and the antigen binding site is comprised exclusively of the var

64 d antigens suggest that the formation of the antigen-binding site is generally a destabilizing proces

65 As expected, sequence variability of the antigen-binding site is overall diminished compared to k

66 hat the overabundance of tyrosine in natural antigen-binding sites is a consequence of the side chain

67 ophilic residues such as Trp adjacent to the antigen binding site may explain difficulties in eliciti

68 pleen necrosis virus (SNV), that display the antigen binding site of an antibody on the viral surface

69 The antigen binding site of antibodies usually comprises ass

70 y-determining segments that form part of the antigen-binding site of a functional antibody.

71 ).We examined the effect of mutations in the antigen-binding site of a Kb-restricted TCR on T cell ac

72 CARs) on T cells is a means of combining the antigen-binding site of a monoclonal antibody with the a

73 study, extensive mutational analysis of the antigen-binding site of Fab b12 was carried out to inves

74 binatorial mutagenesis was used to study the antigen-binding site of Fab2C4, a humanized monoclonal a

75 Mutating the proliferating cell nuclear antigen-binding site of p21(Cip1) also prevents its IR-i

76 specific polymorphic amino acids lining the antigen-binding site of the DPbeta1*0201 allotypic prote

77 f a silanized glass capillary column and the antigen-binding sites of anti-Pac saturated with rhodami

78 The antigen-binding sites of antibodies (Abs) can express en

79 Interestingly, the antigen-binding sites of HCV1 and AP33 are completely di

80 able, drug-like compounds able to target the antigen-binding sites of most or all patients in a stere

81 es correlated with structural changes within antigen-binding sites of selecting M-CLL mAbs.

82 s and biophysical analyses revealed that two antigen-binding sites of these antibodies form a head-to

83 tion control for site-positioning paratopes (antigen binding site) of the antibody molecules.

84 urfaces displaying 35 times as many variable antigen-binding sites per square centimeter as surfaces

85 ain (VH-B1a) to support diversity within its antigen-binding site relative to the conventional antige

86 established modular architecture wherein the antigen-binding site residing in the antigen-binding fra

87 The amino acid sequence composition at the antigen binding site shows conservation within the light

88 Besides the canonical antigen binding site, so-called unconventional sites als

89 Here, we describe an antibody with an antigen binding site that binds two distinct proteins wi

90 b are similar in terms of the regions of the antigen-binding site that can tolerate diversity without

91 This unusual conformation creates an antigen-binding site that is significantly deeper than p

92 nd light-chain variable domains and form the antigen-binding site, the relative orientation of the he

93 egion affects the secondary structure of the antigen binding site, thus accounting for variations in

94 taining, IgG-like tetravalent BsAb, with two antigen-binding sites to each of its target antigens, by

95 y that contains an optimized RGD loop in its antigen binding site, was used as the model ligand.

96 igen-binding fragments (Fabs) with synthetic antigen-binding sites were isolated from phage-displayed

97 from cellular or serum proteins bound in the antigen-binding site, which copurify with the class II m

98 His L91 is now centered at the bottom of the antigen-binding site with the imidazole ring poised for

99 fragments (Fcabs) can be engineered to form antigen-binding sites with antibody properties.

100 ected for CDR2 mutations that blocked 72% of antigen-binding sites with N-linked glycan, decreased af

101 The antigen binding site within the Fab formed a distinct cr

102 on, the unusual level of conservation in key antigen binding sites within the V(H) region suggests th

103 markedly increases the density of available antigen-binding sites, yielding a system that is highly