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1 ine or systemic 2-deoxy-d-glucose (a glucose antimetabolite).
2 ly described cellular efflux system for this antimetabolite.
3 as comparable to that observed with specific antimetabolites.
4 il in high-risk patients, despite the use of antimetabolites.
5 oach and are being investigated as potential antimetabolites.
6 the mechanistic classes except one class of antimetabolites.
7 nct from those of calcineurin antagonists or antimetabolites.
8 fety profile compared to trabeculectomy with antimetabolites.
9 for modulating activity of chemotherapeutic antimetabolites.
10 orticosteroids, cyclosporine, and the purine antimetabolites.
11 ding of TS degradation and its regulation by antimetabolites.
12 d pantothenate analogs are growth-inhibiting antimetabolites.
14 The present studies demonstrate that the antimetabolite 1-beta-D-arabinofuranosylcytosine (ara-C)
16 tion and death were decreased by the glucose antimetabolite 2-deoxyglucose and increased by high bloo
17 se deprivation or treatment with the glucose antimetabolite 2-deoxyglucose caused nontransformed cell
18 naffected by food deprivation or MA, and the antimetabolite 2-DG has no impact on GAL in any area.
20 C), which is phosphorylated to the activated antimetabolite, 2'3'-dideoxycytidine triphosphate by cyt
22 nd the loss of functional p53 signaling, the antimetabolite 5-fluorouracil (5-FU) failed to induce ar
24 s strikingly resistant to the effects of the antimetabolite 5-fluorouracil (5-FU), the mainstay of ad
26 HMG-CoA reductase inhibitor lovastatin, the antimetabolite 5-fluorouracil, and the cyclic nucleotide
27 racerebroventricular infusion of the glucose antimetabolite 5-thioglucose selectively promoted respon
28 use of antiscarring agents, particularly the antimetabolites 5-fluorouracil and mitomycin C, have rev
31 whether inhibition of Chk1 could potentiate antimetabolites, a mainstay of cancer therapy, which con
32 ermine more precisely the processes by which antimetabolites act as radiation sensitizers and to defi
34 d for at least 1 year with infliximab and an antimetabolite agent experienced a relapse within 1 year
39 east 1 year with scheduled infliximab and an antimetabolite and had been in corticosteroid-free remis
47 atients on combined maintenance therapy with antimetabolites and identified factors associated with r
49 lt and is restricted to structurally similar antimetabolites and semi-synthetic analogues of their co
51 cted drug), 5-fluorouracil and methotrexate (antimetabolites), and vinblastine (a microtubule inhibit
52 en combined with Thymoglobulin induction, an antimetabolite, and corticosteroids, TAC and CsA are com
53 received Thymoglobulin, corticosteroids, an antimetabolite, and cyclosporine monitored by C2 (n=50)
54 me, Ca(2+)-independence, resistance to an AA antimetabolite, and induction by another unsaturated fat
57 h antibody induction, calcineurin inhibitor, antimetabolite, and RDP versus historical controls treat
59 cell killing using halogenated pyrimidines, antimetabolites, and other DNA-damaging agents or sensit
60 eated with DNA-damaging agents or nucleotide antimetabolites, and p53-deficient fibroblasts and Mdm2/
61 agents: including DNA cross-linking agents, antimetabolites, and topoisomerase I and II inhibitors.
62 lasses of drugs reviewed include alkylators, antimetabolites, anthracyclines, taxanes, camptothecins,
63 treated with low-dose glucocorticoids and an antimetabolite, anti-tumour necrosis factor (TNF) monocl
64 ic utility as a modulator of the activity of antimetabolite antitumor agents by virtue of its inhibit
65 surgery using an infusion, optimal method of antimetabolites application, new adjustable sutures, and
67 concern when powerful immune modulators and antimetabolites are used in combination, relatively few
68 n that combines a depleting antibody with an antimetabolite, avoiding calcineurin inhibitors and ster
69 reading, scavenging of nutrients, removal of antimetabolites, balancing of metabolite pools, and esta
70 ving lower-risk leukemia and received mainly antimetabolite-based continuation therapy; the 130 cases
71 responses to therapy, should be treated with antimetabolite-based therapy designed to maintain their
72 for acute myeloid leukemia with monosomy 7; antimetabolite-based therapy for acute lymphoblastic leu
73 xtend these results to patients treated with antimetabolite-based therapy, we performed Southern blot
77 een the substrate, allosteric regulator, and antimetabolite binding sites on pantothenate kinase and
78 ctural similarities to alkylating agents and antimetabolites, but which is non-cross-resistant with a
79 viously available immunosuppressives such as antimetabolites, calcineurin inhibitors, and alkylating
83 When challenged with both DNA damaging and antimetabolite chemotherapeutics, RB was required for pr
90 iazol-2-yl)-3,4-dihydroxybenzamide], a novel antimetabolite drug developed at City of Hope Cancer Cen
95 d the effects of 5-fluorouracil (5-FUra), an antimetabolite effective against colon tumors, on nitric
98 ential growth of Huh-7 cells, the effects of antimetabolites for several nucleoside biosynthesis path
102 phacoemulsification and trabeculectomy with antimetabolites have vastly improved the results of comb
104 pathways involved in radiosensitization with antimetabolites implicate base excision repair with the
105 -Fluorouracil (5-FU) is the most widely used antimetabolite in the treatment of colorectal, breast an
108 action with taxanes, anthracyclines and some antimetabolites in HER-2/neu-overexpressing breast cance
110 he major publications relating to the use of antimetabolites in ocular surface neoplasia and highligh
111 n encouraging experiences with high doses of antimetabolites in primary CNS lymphoma and with rituxim
112 they are also resistant to a number of other antimetabolites in the DNA synthesis pathway in a TNFalp
114 est and irregular cellular morphologies, the antimetabolite-induced arrest was highly reversible and
116 -fluorouracil), which acts at early steps of antimetabolite-induced stress by stimulating phosphoryla
117 tations that impart resistance to pyrimidine antimetabolite inhibitors also relieve CTP inhibition an
120 ione (DNP-SG) and leukotriene C4 (LTC4), the antimetabolite methotrexate, and the bile acid glycochol
123 of HBL100 cells treated with 5-fluorouracil (antimetabolite), methotrexate (antimetabolite), tamoxife
126 andard-dose cyclosporin or tacrolimus and an antimetabolite, mostly mycophenolate mofetil (91.7%).
127 tions of cyclosporine and those treated with antimetabolites (mycophenolate and azathioprine) have a
130 ction of p53 and associated G1 arrest by the antimetabolite, N-(phosphonoacetyl)-L-aspartate (PALA),
131 n Experiment 2, rats injected with the lipid antimetabolite Na-2-mercaptoacetate (MA) responded more
132 ho have failed or who are not candidates for antimetabolite or calcineurin inhibitor immunomodulation
134 inimum of 20 mg of prednisone, cyclosporine, antimetabolites, or any combination of these agents were
136 munosuppressive armamentarium, replacing the antimetabolite prodrug azathioprine, reports have associ
137 no acids have long been recognized for their antimetabolite properties and tendency to be uncovered t
142 ocedure, phacoemulsification-trabeculectomy, antimetabolites, results and complications, as well as c
143 Additionally, many surgeons are employing antimetabolites routinely in combined phacoemulsificatio
145 ould probably not be tested further, but its antimetabolite schedules and frequent drug administratio
146 results suggest that chlorambucil and/or an antimetabolite should be administered before cyclophosph
148 l pathways has allowed the emergence of new 'antimetabolite' strategies to increase the therapeutic e
149 ent approach, we identified a novel targeted antimetabolite strategy to exploit arginine deprivation
153 ence shows that second-line agents including antimetabolites, T-cell inhibitors and alkylating agents
154 Immunosuppressed patients were treated with antimetabolites, T-cell inhibitors, and/or alkylating ag
155 fluorouracil (antimetabolite), methotrexate (antimetabolite), tamoxifen (antiestrogen/antiproliferati
156 d trabeculectomy with releasable sutures and antimetabolites, techniques have improved considerably i
159 Nucleoside analogs are structurally similar antimetabolites that have a broad range of action and ar
161 study, we assessed the effects of an intense antimetabolite therapy alternating with APO on overall s
162 s with T-cell ALL treated with standard-dose antimetabolite therapy and implies that higher-dose meth
164 s protocols, in that more intensive systemic antimetabolite therapy was given before and during radio
165 tation in DHFS prevents the formation of the antimetabolite, thereby conferring resistance to PAS.
170 ts who underwent transplantation after 2000, antimetabolite use at 1 year was associated with improve
173 (DHFS) to generate a hydroxyl dihydrofolate antimetabolite, which in turn inhibits DHFR enzymatic ac
174 cause marked resistance to tetrahydrofolate antimetabolites, while still allowing cell survival.
175 ntensity than CAF and improved scheduling of antimetabolites with sequential methotrexate and 5-FU, a
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