ライフサイエンスコーパス: antimicrobial

1 sceptible to other quaternary ammonium based antimicrobials.

2 s to play a significant role in tolerance to antimicrobials.

3 treatment strategies, with a focus on novel antimicrobials.

4 ting in high mortality and irrational use of antimicrobials.

5 Cationic steroid antimicrobial 13 (CSA13) shares cationic nature and anti

6 ining natural products, which exhibit potent antimicrobial activities against multidrug-resistant pat

7 were used as model pathogens to evaluate the antimicrobial activities of nisin and thymol formulation

8 and LCE3A in particular, have defensin-like antimicrobial activity against a variety of bacterial ta

9 With the aim of improving antimicrobial activity and hemolytic properties, we use

10 They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epi

11 ate preserved nisin structure as well as its antimicrobial activity during spray-drying.

12 on surfaces exhibit varying, albeit limited, antimicrobial activity in vitro.

13 The cabbage extracts exhibited antimicrobial activity mainly on the ninth day after the

14 gues with a more than 32-fold improvement in antimicrobial activity observed against multidrug-resist

15 Salmonella In conclusion, we define a novel antimicrobial activity of adenosine in the gastrointesti

16 A non-selective antimicrobial activity of all ITCs was revealed in the c

17 Thereafter, we assessed the antimicrobial activity of exposed airway samples using b

18 Our results show that the antimicrobial activity of larval food was significantly

19 In addition, antimicrobial activity of the conjugate was determined a

20 of this electrolyte has on the stability and antimicrobial activity of these nanoparticles.

21 mulsion (particle size 10.1nm) showed better antimicrobial activity than emulsions at the same concen

22 helicidin family, demonstrating an increased antimicrobial activity toward a broad range of bacteria,

23 ouse, pig, and dog cathelicidins, which lack antimicrobial activity under cell culture conditions, on

24 trated that the embedded surface has a broad antimicrobial activity under white light and that the su

25 This antimicrobial activity was independent of IL-26, because

26 Antimicrobial activity was significant, especially again

27 In addition to their antimicrobial activity, immunoregulatory functions have

28 small quantities and shown to have promising antimicrobial activity, the structure of the conformatio

29 l of these peptides displayed broad-spectrum antimicrobial activity, validating our LSTM-based peptid

30 oiety was important for both biochemical and antimicrobial activity.

31 d negatively charged bacteria to exert their antimicrobial activity.

32 c and retained potent P. aeruginosa-specific antimicrobial activity.

33 ng membrane disruptive capability and potent antimicrobial activity.

34 thelial cells influence the efficacy of most antimicrobials against P. aeruginosa biofilm formation,

35 r 5-aminolevulinic acid, which is used as an antimicrobial agent in photodynamic therapy, potentiates

36 it a remarkably efficient optically mediated antimicrobial agent.

37 nion to generate hypochlorous acid, a potent antimicrobial agent.

38 e was the most frequently prescribed (24.6%) antimicrobial agent.

39 ntified reuterin to be the precursor-induced antimicrobial agent.

40 cin disaccharide to provide even more potent antimicrobial agents [VRE minimum inhibitory concentrati

41 noparticles to carry and selectively release antimicrobial agents after attachment or within oral bio

42 s, micro-organisms to identify fungitoxic or antimicrobial agents for controlling serious plant patho

43 apid selection and distribution of effective antimicrobial agents for treatment and postexposure prop

44 aluated the benefits of local application of antimicrobial agents into ERC contrast media in preventi

45 ignificance of S. lugdunensis isolation, the antimicrobial agents prescribed, if any, and the clinica

46 pecies: sanitation, nutrition, vaccines, and antimicrobial agents.

47 a concomitant increase in the need for novel antimicrobial agents.

48 gdunensis are susceptible to narrow-spectrum antimicrobial agents.

49 peptide (193-209) exhibits immunomodulatory, antimicrobial and antihypertensive activity.

50 ere evaluated for their preliminary in vitro antimicrobial and antioxidant activities.

51 Type I interferons (IFN-I) are critical in antimicrobial and antitumor defense.

52 y of the polyphenols and on the antioxidant, antimicrobial and antitumoral activities of the yerba ma

53 l activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in

54 GA by itself is a mild antimicrobial and has a pro-oxidant ability.

55 benefits but also unintended consequences of antimicrobial and infection prevention strategies aimed

56 mainly of monoterpenes, including the potent antimicrobial and insecticidal monoterpene 3-carene.

57 ntireflection, enhanced color, adhesion, and antimicrobial and specific cell-attachment properties.

58 composition might influence the response to antimicrobial and steroid therapies and the risk of lung

59 For widespread clinical use of the new antimicrobial and therapeutic materials, whether they wo

60 ere is an urgent need for discovery of novel antimicrobials and carbohydrate-based anti-adhesive stra

61 To promote the appropriate use of antimicrobials and combat antimicrobial resistance, the

62 f biotechnologically relevant compounds with antimicrobial, anti-cancer and other activities.

63 ential to lessen the public health burden of antimicrobial-associated diseases.

64 provide an efficacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to Staphylococcus aure

65 rationalize eventual, different nutritional, antimicrobial, cell stimulative and antigenic properties

66 The efficacy of antimicrobial central venous catheters (CVCs) remains qu

67 have shown that certain materials possessing antimicrobial characteristics may reduce the severity of

68 Triclosan (TCS), an antimicrobial chemical with potential endocrine-disrupti

69 Human exposure to parabens and other antimicrobial chemicals is continual and pervasive.

70 or Yersinia pseudotuberculosis resistance to antimicrobial chemokines and survival during mouse infec

71 om across England by the British Society for Antimicrobial Chemotherapy and from the Cambridge Univer

72 usion method according to British Society of Antimicrobial Chemotherapy guidelines.

73 fective chemical synthesis method to produce antimicrobial cocktails, which was based on the heat con

74 n upon exposure to three clinically relevant antimicrobials (colistin, imipenem or ciprofloxacin) by

75 despite the widespread use of small-molecule antimicrobial combination therapy.

76 y to have an important secondary function in antimicrobial competition and niche protection.

77 reased as the incorporation of the AgBr/NPVP antimicrobial composite increased.

78 teria convert glycerol to the broad-spectrum antimicrobial compound reuterin.

79 ere shown to represent a potential source of antimicrobial compounds for food and health benefits.

80 chemical defence systems comprised of potent antimicrobial compounds released by prospective hosts in

81 in PS and MDBP may serve as antioxidants and antimicrobial compounds.

82 Phe-Pro beta-turn of the cyclic beta-hairpin antimicrobial decapeptide tyrocidine A, (Tyrc A) was sub

83 ce of skin microbiota in the biofilm form to antimicrobial decontamination, and there are no quantita

84 ing lectin involved in immune regulation and antimicrobial defense, is a target for these proteases a

85 heir cytolytic activity that is important in antimicrobial defense, MAIT cells have immune-modulatory

86 g with secretion and compromising intestinal antimicrobial defense.

87 ith exhaustion and failure to participate in antimicrobial defense.

88 IS treatment alters innate antimicrobial defenses and disrupts the gut microbiota,

89 terventions, infection control policies, and antimicrobial development.

90 e-S cluster synthesis is a viable target for antimicrobial development.

91 Despite progress in antimicrobial drug development, a critical need persists

92 or further exploration of novel analogues in antimicrobial drug development.

93 cure-alls for the past 80 years, increasing antimicrobial drug resistance requires a major and rapid

94 When resistance to anticancer or antimicrobial drugs evolves in a patient, highly effecti

95 Although conventional antimicrobial drugs have been viewed as miraculous cure-

96 tion can slow the evolution of resistance to antimicrobial drugs, even when resistant pathogens are p

97 ophages, and can be exploited to develop new antimicrobial drugs.

98 inum, gold and palladium showed the greatest antimicrobial efficacy in zone of inhibition (ZoI) assay

99 though not statistically significant) to all antimicrobials except nitrofurantoin (NIT) were higher i

100 e carcasses, which they shave and smear with antimicrobial exudates.

101 ch Neisseria gonorrhoeae evades host-derived antimicrobial factors and to identify protective and imm

102 d lead discovery with efforts to develop new antimicrobials for mycobacterial infections.

103 We demonstrate a substantial loss of antimicrobial function when the peptide was exposed to l

104 robial 13 (CSA13) shares cationic nature and antimicrobial function with antimicrobial peptide cathel

105 ned augmentation of phagocyte metabolism and antimicrobial function.

106 hich respond to both cytokines to upregulate antimicrobial functions but exhibit pro-inflammatory act

107 was augmented, suggesting that their innate antimicrobial functions were preserved.

108 ctor cells that die quickly after performing antimicrobial functions.

109 prime microbial pattern-induced secretion of antimicrobial furanocoumarins (phytoalexins) in cultured

110 2) production, enterocyte proliferation, and antimicrobial gene expression in a microbiota-dependent

111 epithelial cell (EC) scanning, expression of antimicrobial genes, and glycolysis.

112 fluid (ALF), which contains homeostatic and antimicrobial hydrolytic activities, termed hydrolases.

113 ion plays an important role in antitumor and antimicrobial immune responses.

114 ount example of a chronic infection in which antimicrobial immunity is protective in the vast majorit

115 ngly, functional details of gammadeltaT cell antimicrobial immunity to infection remain largely unexp

116 local tissue injury and augmenting systemic antimicrobial immunity.

117 The use of antimicrobials in contrast media was associated with a s

118 In India, the use of antimicrobials in food animal production is unregulated.

119 pathway is a potential target for evaluating antimicrobials in gram-positive bacteria.

120 Agricultural use of antimicrobials in subtherapeutic concentrations is incre

121 capacitive sensor corresponded well with the antimicrobial information in the literature and to the m

122 ects, quantitation of penicillin G, a common antimicrobial, is possible in plasma and in urine, with

123 Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during bacterial

124 oding of peptide sequences into differential antimicrobial mechanisms is reported.

125 Neutrophils possess multiple antimicrobial mechanisms that are critical for protectio

126 Antimicrobial N-substituted glycine (peptoid) oligomers

127 Svetamycin G, the most potent antimicrobial of this suite of compounds, inhibited the

128 The antimicrobial peptide (AMP) RNase 7 is constitutively ex

129 human granulysin, is a cationic amphiphilic antimicrobial peptide (AMP) that is produced by cytotoxi

130 Colistin is a cationic antimicrobial peptide (CAMP) antibiotic that permeabiliz

131 We propose a topological model for linear antimicrobial peptide activity based on the increase in

132 -positive burn patients with altered urinary antimicrobial peptide activity developed either an E. fa

133 )-OH (3-4 d), the preparation of the labeled antimicrobial peptide BODIPY-cPAF26 by solid-phase synth

134 ionic nature and antimicrobial function with antimicrobial peptide cathelicidin.

135 We observed a shift in antimicrobial peptide hydrophobicity and activity betwee

136 wth of S. praecaptivus in the presence of an antimicrobial peptide in vitro, inactivation of both pho

137 early source of innate IL-17, which promotes antimicrobial peptide production, whereas pathogen-speci

138 the concept that early assessment of urinary antimicrobial peptide responses and the bacterial microb

139 Ubiquicidin is an antimicrobial peptide with great potential for nuclear i

140 ies revealed that dynorphin(1-13) induces an antimicrobial peptide-like response in Pseudomonas, with

141 Here, we demonstrate that antimicrobial peptides (AMPs) are an effective antibiofi

142 Many organisms rely on antimicrobial peptides (AMPs) as a first line of defense

143 The application of antimicrobial peptides (AMPs) is largely hindered by the

144 Antimicrobial peptides (AMPs) represent a promising ther

145 r resistance to membrane disrupting cationic antimicrobial peptides (CAMPs), such as polymyxins.

146 Bacteria exploit an arsenal of antimicrobial peptides and proteins to compete with each

147 Antimicrobial peptides are components of the innate immu

148 Defensins are cysteine-rich cationic antimicrobial peptides contributing to the innate immuni

149 gamma interferon (IFN-gamma) as well as the antimicrobial peptides CRAMP and mbetaD-3.

150 act infection, suggesting a role for urinary antimicrobial peptides in susceptibility to select uropa

151 lausibly be modified to produce a panoply of antimicrobial peptides now known.

152 our results revealed that the expression of antimicrobial peptides that play a vital role in insect

153 Increased IL-1beta boosts local antimicrobial peptides to facilitate microbiota remodell

154 a mutant S. aureus that is more sensitive to antimicrobial peptides was killed more efficiently by IF

155 significantly enhanced and the induction of antimicrobial peptides was reduced in the absence of ear

156 ading pathogens via reactive oxygen species, antimicrobial peptides, and neutrophil serine proteases

157 amphipathic, both classic characteristics of antimicrobial peptides, and we observed that IFN-beta ca

158 ich refer to a series of small, proline-rich antimicrobial peptides, are predominantly active against

159 In contrast to most antimicrobial peptides, cWFW neither permeabilizes the m

160 ut microbiota and on the expression of ileal antimicrobial peptides.

161 with enhanced expression of IL-22-inducible antimicrobial peptides.

162 e increased bacterial load and expression of antimicrobial peptides.

163 gh alterations in the urinary microbiome and antimicrobial peptides.

164 tation, low pH, and the presence of cationic antimicrobial peptides.

165 de destruxin A by increasing the activity of antimicrobial peptides.

166 findings challenge the preconceptions about 'antimicrobial' peptides, supporting the notion that thei

167 mpared to CMS, it showed a similar or better antimicrobial performance against two MDR isolates of Ps

168 o-called homochiral sequences, assemble into antimicrobial pores and form contiguous helices that are

169 6 released by Th17 clones and rhIL-26 lacked antimicrobial potency against P. acnes.

170 ctural changes have been explored to improve antimicrobial potency and provide additional synergistic

171 the incidence of C difficile infections and antimicrobial prescribing data (1998-2014) were combined

172 e the physiological impact of lysogeny under antimicrobial pressure.

173 Patients who were transferred, received antimicrobials prior to emergency department arrival, or

174 The antimicrobial properties of SAMN@TA were tested on Liste

175 that, in addition to their well-established antimicrobial properties, neutrophils can contribute to

176 hness, lower hydrophobicity, and significant antimicrobial properties.

177 can inhibit microorganisms, because of their antimicrobial properties.

178 ) contains bioactives having antioxidant and antimicrobial properties.

179 ts with advanced immunosuppression, enhanced antimicrobial prophylaxis combined with ART resulted in

180 eived planned manual review of perioperative antimicrobial prophylaxis regimen and manual review for

181 Here, we report on the effects of enhanced antimicrobial prophylaxis, which consisted of continuous

182 pha-dependent release of the IL-22 inducible antimicrobial protein calprotectin without modulating IL

183 The combination of antimicrobial, protein-repellent, and calcium phosphate

184 ohibited in Brazil and other countries, this antimicrobial reached fish.

185 It is unknown if antimicrobial regimens possessing in vitro MRSA activity

186 The ever-growing threat of antimicrobial resistance (AMR) demands immediate counter

187 ales, although how hospitals themselves fuel antimicrobial resistance (AMR) in the wider environment

188 hospitals (TCHs) are thought to have higher antimicrobial resistance (AMR) rates when compared to sm

189 ity reference data on the molecular basis of antimicrobial resistance (AMR), with an emphasis on the

190 The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficia

191 allenges, from its own funding shortfalls to antimicrobial resistance and immense health inequities.

192 ontribute to uptake of genes associated with antimicrobial resistance and pathogenicity.

193 phenomenon mirrors the worldwide increase in antimicrobial resistance and the emergence of other MDR

194 trategy in efforts to address the escalating antimicrobial resistance crisis.

195 Detection of antimicrobial resistance currently relies on a conventio

196 itations, we present MEGARes, a hand-curated antimicrobial resistance database and annotation structu

197 ndardization of nomenclature associated with antimicrobial resistance determinants through an interna

198 MinION allowed successful identification of antimicrobial resistance genes in the draft assembly cor

199 show any correlation between the presence of antimicrobial resistance genes in the gut microbiota and

200 e that temperate phages do not need to carry antimicrobial resistance genes to play a significant rol

201 The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae is glo

202 Antimicrobial resistance in pathogenic gram-negative bac

203 iosis, outbreaks, and clinically significant antimicrobial resistance increased.

204 Antimicrobial resistance is an important threat to inter

205 Slowing the evolution of antimicrobial resistance is essential if we are to conti

206 An intriguing opportunity to address antimicrobial resistance is represented by the inhibitio

207 National Outbreak Reporting System, National Antimicrobial Resistance Monitoring System, and Foodborn

208 vasive pneumococci, and invasive pneumococci antimicrobial resistance patterns, in India.

209 Antimicrobial resistance poses a growing threat to publi

210 Saharan Africa lacks diagnostic capacity and antimicrobial resistance surveillance.

211 nucleic acid amplification testing including antimicrobial resistance testing in men with symptoms of

212 and interfere with cell envelope integrity, antimicrobial resistance, and GIT colonization.

213 test for trend to examine trends in rates of antimicrobial resistance, and negative binomial regressi

214 This is in part a result of antimicrobial resistance, highlighting the need to uncov

215 infections has resulted in the emergence of antimicrobial resistance, necessitating alternative trea

216 ing threats-risks to global health security, antimicrobial resistance, non-communicable diseases, and

217 in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative

218 appropriate use of antimicrobials and combat antimicrobial resistance, the workgroup provides recomme

219 tics are urgently needed to address emerging antimicrobial resistance.

220 e data are essential to reduce the burden of antimicrobial resistance.

221 hey could potentially serve as reservoirs of antimicrobial resistance.

222 ffect on enterococcal envelope integrity and antimicrobial resistance.

223 for improved and accurate identification of antimicrobial resistance.

224 The development of antimicrobial-resistant (AMR) bacteria poses a serious w

225 comial pneumonia is commonly associated with antimicrobial-resistant Gram-negative pathogens.

226 We found a high burden of community-onset antimicrobial-resistant infection among patients with ac

227 fy independent predictors of community-onset antimicrobial-resistant infections.

228 he monitoring of the global dissemination of antimicrobial-resistant N. gonorrhoeae strains.

229 sed to demonstrate nosocomial acquisition of antimicrobial-resistant sequence type 156 (ST156) seroty

230 -22, a cytokine critical for stimulating the antimicrobial response.

231 tients with ALF and might be used to restore antimicrobial responses to patients.

232 the collapse of lipid metabolism in favor of antimicrobial responses.

233 ing this pipeline, we have widened the known antimicrobial spectrum for V. odorata cyclotides, includ

234 ion of antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) is no

235 Improved outcomes in men with NGU and better antimicrobial stewardship are likely to arise from the i

236 As antimicrobial stewardship becomes a mandatory aspect of

237 Infectious diseases (ID) consultation and antimicrobial stewardship intervention have been shown t

238 Antimicrobial stewardship is needed to ensure prompt app

239 lergy skin testing (BLAST) is recommended by antimicrobial stewardship program (ASP) guidelines, yet

240 This study demonstrates that antimicrobial stewardship programs support, and do not c

241 TJC antimicrobial stewardship standards demonstrate actions

242 ary care setting, pragmatic interventions on antimicrobial stewardship targeting providers and caregi

243 infectious agents improve patient outcomes, antimicrobial stewardship, and length of hospital stay.

244 d of these pathogens and an integral part of antimicrobial stewardship.

245 lly due to infection prevention measures and antimicrobial stewardship.

246 ultures has improved clinical management and antimicrobial stewardship.

247 e dietary modification overwhelms vital host antimicrobial strategies, leading to fatal staphylococca

248 -destruction of infected cells is a powerful antimicrobial strategy in metazoans.

249 uture harm from triclosan, triclocarban, and antimicrobial substances with similar properties and eff

250 m formation at the site of infection reduces antimicrobial susceptibility and can lead to chronic inf

251 er a new technology to more rapidly evaluate antimicrobial susceptibility and to simultaneously asses

252 Comparatively few in vitro data on antimicrobial susceptibility are available due to the sc

253 To illustrate the concept of rapid digital antimicrobial susceptibility assessment, we employ the d

254 dropFAST, for bacterial growth detection and antimicrobial susceptibility assessment.

255 and could be used for rapid determination of antimicrobial susceptibility in a wider range of Gram ne

256 is study was to determine the prevalence and antimicrobial susceptibility pattern of external ocular

257 us vancomycin by effectively designing their antimicrobial susceptibility reports to convey this mess

258 Antimicrobial susceptibility results from broth microdil

259 Antimicrobial susceptibility testing (AST) is a fundamen

260 rovide rapid species identification (ID) and antimicrobial susceptibility testing (AST) results for t

261 Antimicrobial susceptibility testing of 66 isolates reve

262 Antimicrobial susceptibility testing of isolates from 47

263 ified selection for changes in motility, and antimicrobial susceptibility testing suggested that the

264 ovides an effective quantitative measure for antimicrobial susceptibility testing, and determination

265 for broad-based bacterial identification or antimicrobial susceptibility testing.

266 sm identification and automated-system-based antimicrobial susceptibility testing.

267 Antimicrobial susceptibility tests were done by the disc

268 Antimicrobial susceptibility to natural products could a

269 typed pneumococcal isolates, and established antimicrobial susceptibility using standard study protoc

270 nformation regarding microbial aetiology and antimicrobial susceptibility, but sub-Saharan Africa lac

271 information including bacterial identity and antimicrobial susceptibility, but they often require sev

272 ic tools that provide rapid determination of antimicrobial susceptibility.

273 quantitative PCR or digital PCR to determine antimicrobial susceptibility.

274 tribute to dynamic population shifts between antimicrobial susceptible and resistant Salmonella.

275 tested the feasibility of a system based on antimicrobial synbodies.

276 cteria and the potential of these systems as antimicrobial targets.

277 ed by the slow turnovers of the conventional antimicrobial testing techniques, which require days of

278 rtunity to create programmable gene-specific antimicrobials that are far less likely to drive resista

279 latory complexities of bacterial response to antimicrobials that involve multiple riboregulators.

280 gs lay the foundation for the development of antimicrobials that target this novel, essential pathway

281 rational design and could lead to potential antimicrobial therapeutic targets.

282 stance have led to increasing demand for new antimicrobial therapies.

283 strategy for the development of light-based antimicrobial therapies.

284 versus 10.31 days; P = 0.002) and length of antimicrobial therapy 24.30 versus 18.97 days; P = 0.018

285 Despite recent advances in antimicrobial therapy, pneumococcal meningitis remains a

286 including all patients receiving appropriate antimicrobial therapy, with no false-negative cases.

287 hospitalization and initiation of empirical antimicrobial therapy.

288 y can provide health benefits and as natural antimicrobials they offer preservation of foods.

289 Appropriate antimicrobial treatment and prevention, including effect

290 Results also indicated that the enhanced antimicrobial treatment reduced weight loss and pitting

291 This approach can help to track antimicrobial use and resistance.

292 e use of sepsis prediction scores, judicious antimicrobial use, and the development of preventive mea

293 ass method for the HPLC-MS/MS analysis of 29 antimicrobials, validated according to the Commission De

294 ative outcomes following administration of 2 antimicrobials versus a single agent for the prevention

295 The median time to antimicrobial was 3.77 hours (interquartile range = 1.96

296 Time to initial antimicrobial was also associated with in-hospital morta

297 thogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of cir

298 Antimicrobials were extracted with trichloroacetic acid

299 ts profiting most obviously from intraductal antimicrobials were those with secondary sclerosing chol

300 patients who initiated CAS, the most common antimicrobials were trimethoprim-sulfamethoxazole, penic