ライフサイエンスコーパス: antimicrobials

1 repurpose old drugs for new applications (as antimicrobials).

2 imicrobials) and susceptibility data (5 of 7 antimicrobials).

3 I pathway should aid in the discovery of new antimicrobials.

4 plexes, mucus production, and mucosa-derived antimicrobials.

5 sceptible to other quaternary ammonium based antimicrobials.

6 ere, we describe the importance of effective antimicrobials.

7 rocessing strains and aid in identifying new antimicrobials.

8 some features that could be targeted for new antimicrobials.

9 gents in the presence of clinically relevant antimicrobials.

10 hibitors of HpalphaCA that may lead to novel antimicrobials.

11 ure sustained, worldwide access to effective antimicrobials.

12 LTx despite prophylaxis with broad-spectrum antimicrobials.

13 bacteremia typically receive long courses of antimicrobials.

14 the baseline sample and were also exposed to antimicrobials.

15 iofilm-resident bacteria resist immunity and antimicrobials.

16 s to play a significant role in tolerance to antimicrobials.

17 r alone or associated with local or systemic antimicrobials.

18 lent target for the development of selective antimicrobials.

19 rapeutic target for the development of novel antimicrobials.

20 omes, and an increased level of tolerance to antimicrobials.

21 ce is an alternative approach to develop new antimicrobials.

22 increase access to appropriately prescribed antimicrobials.

23 d isolates were resistant to all tested oral antimicrobials.

24 treatment strategies, with a focus on novel antimicrobials.

25 tionic peptide to produce membrane-targeting antimicrobials.

26 nical usefulness of the beta-lactam class of antimicrobials.

27 sure to sub-lethal concentrations of natural antimicrobials.

28 ions (cIAIs) supports the development of new antimicrobials.

29 atalytic center are attractive leads for new antimicrobials.

30 re, it acts synergistically with traditional antimicrobials.

31 S could be new targets for the design of new antimicrobials.

32 ance against most of the currently available antimicrobials.

33 ng about more rapid regulatory review of new antimicrobials.

34 nd TCR coreceptors, and they may function as antimicrobials.

35 ll, has prompted research into radically new antimicrobials.

36 tion is more severe in patients treated with antimicrobials.

37 nt of contaminants and use of broad-spectrum antimicrobials.

38 due to its resistance to most currently used antimicrobials.

39 n alternative strategy for discovering novel antimicrobials.

40 e and pterin sites of a bNOS and function as antimicrobials.

41 es, where there are often limited choices of antimicrobials.

42 efforts by directing providers to preferred antimicrobials.

43 pulations to tolerate high concentrations of antimicrobials.

44 e on how RND pumps assemble to fight diverse antimicrobials.

45 ation are needed to guide discontinuation of antimicrobials.

46 istently high appropriate use for all target antimicrobials.

47 tment of neutrophils, were decreased by both antimicrobials.

48 ata revealed susceptibility to commonly used antimicrobials.

49 simple concept for rapid development of new antimicrobials.

50 atients receiving 1 or more of 13 identified antimicrobials.

51 ons as frequent resources for learning about antimicrobials.

52 drugs that restore the efficacy of existing antimicrobials.

53 livery, bio-imaging, tissue engineering, and antimicrobials.

54 in vitro characterization of sensitivity to antimicrobials.

55 T-160 (n = 106) were susceptible to all four antimicrobials.

56 cteriocins, a diverse group of proteinaceous antimicrobials.

57 fforts to develop kinase inhibitors as novel antimicrobials.

58 ting in high mortality and irrational use of antimicrobials.

59 ent failure rates in comparison to all other antimicrobials.

60 bacteria under therapeutic concentrations of antimicrobials.

61 in standard culture, and when treated with 2 antimicrobials.

62 ould facilitate the design of new, effective antimicrobials.

63 membrane-selective and sequence-independent antimicrobials.

64 ainst the known side-effect profile of these antimicrobials.

65 anoparticles (Ag NPs) have long been used as antimicrobials.

66 should include prophylactic and pre-emptive antimicrobials.

67 ng it a promising target for next-generation antimicrobials.

68 i (VRE), necessitates the development of new antimicrobials.

69 residues arising from production inputs (75 antimicrobials, 10 coccidiostats and 121 pesticides) hav

70 The World Health Organization ranking of antimicrobials according to their relative importance in

71 In patients who received appropriate antimicrobials after onset of hypotension, source of inf

72 delay in the adoption of new breakpoints for antimicrobials against emerging pathogens when containme

73 provide a foundation for platforms to launch antimicrobials against gastrointestinal tract pathogens,

74 thelial cells influence the efficacy of most antimicrobials against P. aeruginosa biofilm formation,

75 to restore the activity of clinically useful antimicrobials against these organisms and, potentially,

76 cteria RNA polymerase (RNAP) is a target for antimicrobials against tuberculosis, motivating structur

77 ced by plants; mycotoxins produced by fungi; antimicrobials and acaricides that are introduced by bee

78 ADE) is a strategy to reduce the spectrum of antimicrobials and aims to prevent the emergence of bact

79 ere is an urgent need for discovery of novel antimicrobials and carbohydrate-based anti-adhesive stra

80 To promote the appropriate use of antimicrobials and combat antimicrobial resistance, the

81 te crop and livestock breeding, engineer new antimicrobials and control disease-carrying insects with

82 ss to clean water, access to assured quality antimicrobials and diagnostics, travel, and migration.

83 Petrolatum robustly modulates antimicrobials and epidermal differentiation barrier mea

84 a potentially new therapeutic approach with antimicrobials and fibrinolytic drugs, particularly duri

85 pment pipeline (including new and repurposed antimicrobials and host-directed drugs) as they are appl

86 ibosylated derivatives were both more potent antimicrobials and more selective to inhibition of proka

87 Novel antimicrobials and new approaches to developing them are

88 for resistance to eleven clinically relevant antimicrobials and phenotypic occurrence of ESBLs as mod

89 To promote the judicious use of antimicrobials and preserve their usefulness in the sett

90 n cells has been implicated in resistance to antimicrobials and recurrent infections.

91 eveal the extent of ARGs without exposure to antimicrobials and the ecologic changes created in the o

92 rform at-will broth microdilution testing of antimicrobials and to address a critical testing gap.

93 on of tolerance to otherwise lethal doses of antimicrobials and to other antimicrobial activities.

94 potential as a target for the design of new antimicrobials and vaccine formulations against Streptoc

95 ical Pharmacology/Micromedex support (6 of 7 antimicrobials) and susceptibility data (5 of 7 antimicr

96 e, 22-80 months), 8 have ceased prophylactic antimicrobials, and 5 have ceased immunoglobulin replace

97 ntimicrobials, attributable to resistance to antimicrobials, and the potential effect of vaccines in

98 Early diagnosis, selection of appropriate antimicrobials, and timely surgical intervention are key

99 s intrinsically resistant to a wide range of antimicrobials, and treatment with ineffective antimicro

100 ndent of age, sex, diabetes, indications for antimicrobials, and underlying ophthalmic conditions.

101 follow-up; 2) SRP, in combination with local antimicrobials; and 3) patients with periodontitis and D

102 enge after drug-induced liver injury (DILI): antimicrobials; and central nervous system, cardiovascul

103 Aquaculture uses hundreds of tonnes of antimicrobials annually to prevent and treat bacterial i

104 tic uses of polymeric drugs as sequestrants, antimicrobials, antivirals, and anticancer and anti-infl

105 Both antimicrobials appeared to be effective on reducing prob

106 to make the correct diagnosis and prescribe antimicrobials appropriately, in addition to weak health

107 Antimicrobials are a class of drugs of particular concer

108 interactions via aqueous diffusion, volatile antimicrobials are able to act at a distance and diffuse

109 Although water-soluble antimicrobials are limited to proximal interactions via

110 ficult due to antibiotic resistance, and new antimicrobials are needed to treat infections.

111 arch suggests that many clinically important antimicrobials are used indiscriminately.

112 Local antimicrobials as an adjunct to scaling and root planing

113 In patients with DM and CP, use of local antimicrobials as an adjunct to SRP may result in additi

114 review aims to evaluate the effects of local antimicrobials as an adjunct to SRP, compared with SRP a

115 ications for the rational design of targeted antimicrobials as well as microbiome-based diagnostics a

116 were used to survey volunteers about use of antimicrobials as well as other potential risk factors.

117 presence of bioactive compounds, volatiles, antimicrobials, as well as on the toxicological effects

118 S-OPAT program could administer their own IV antimicrobials at home with outcomes as good as, or bett

119 patients to complete extended courses of IV antimicrobials at home.

120 ncluded well-controlled patients and applied antimicrobials at the deepest sites or sites with baseli

121 MS was used to visualize the distribution of antimicrobials at the inhibition zone between bacteria a

122 e disease burden caused by limited access to antimicrobials, attributable to resistance to antimicrob

123 ercentage of each physician's patients whose antimicrobials began within 3 hours of emergency departm

124 has the potential not only for the design of antimicrobials but also for the selective discrimination

125 ScPMA1 do not confer resistance to unrelated antimicrobials, but do confer cross sensitivity to the a

126 led that adjunctive use of local delivery of antimicrobials, but not systemic antibiotic usage, with

127 is clearly a need for the development of new antimicrobials--but more importantly, there is the need

128 ltilingual instruction to self-administer IV antimicrobials by gravity, tested for competency before

129 Among topical antimicrobials, cadexomer iodine may be associated with

130 Bacterial cell wall degrading enzyme antimicrobials can be engineered to enhance their value

131 Because antimicrobials can have unintended adverse health and en

132 rly diagnosis and treatment with appropriate antimicrobials can improve survival rates.

133 ith which patients were started on empirical antimicrobials, characteristics of the empirical regimen

134 dapt and develop resistance to virtually all antimicrobials clinically available.

135 n upon exposure to three clinically relevant antimicrobials (colistin, imipenem or ciprofloxacin) by

136 s necessary to improve access to life-saving antimicrobials, conserving them, and ensuring continued

137 Antimicrobials considered the highest priority among the

138 the impact of ventilator-associated event on antimicrobials consumption and mechanical ventilation du

139 ates the ability to be combined with topical antimicrobials currently used to treat MRSA skin infecti

140 clinically available cell membrane-targeting antimicrobials (daptomycin and telavancin), but also res

141 Ketolides are promising new antimicrobials effective against a broad range of Gram-p

142 digestive inhibition, pathogen enhancement, antimicrobials, endocrine disruption, and primer pheromo

143 mprovements in life expectancy and access to antimicrobials, especially in low-income and lower-middl

144 their active profile as radical scavengers, antimicrobials, estrogen-like activators and acetylcholi

145 though not statistically significant) to all antimicrobials except nitrofurantoin (NIT) were higher i

146 Importantly, resistance to all the tested antimicrobials, except carbapenems and amikacin, was obs

147 by combining antivirulence and conventional antimicrobials, extending the lifespan of these drugs.

148 ction (CDI), and the resistance of spores to antimicrobials facilitates the relapse of infection.

149 Conversely, meta-analysis on systemic use of antimicrobials failed to detect significant differences

150 cing antimicrobial resistance and preserving antimicrobials for future generations.

151 regarding the toxicity of the most effective antimicrobials for Gram-negative pathogens.

152 well as for optimizing formulations of such antimicrobials for medical applications or crop protecti

153 s suggest that improved targeting of empiric antimicrobials for multidrug-resistant bacteria, Candida

154 d lead discovery with efforts to develop new antimicrobials for mycobacterial infections.

155 nt step for preserving the benefits of these antimicrobials for people.

156 lant-derived organic essential oils (EOs) as antimicrobials for post-harvest produce operations are l

157 ker, clinicians may consider more aggressive antimicrobials for rapid bacterial load reduction in hig

158 TD and antimicrobials for TD proved to be independent risk fact

159 2 combinations of existing noncephalosporin antimicrobials for treatment of patients with urogenital

160 stems, where subinhibitory concentrations of antimicrobials frequently occur.

161 validated an HPLC-MS/MS method to detect 29 antimicrobials from eight classes and applied it to 43 a

162 We also show that CRISPR-Cas9 antimicrobials function in vivo to kill S. aureus in a m

163 Strategic use of antimicrobials further reinforces this intricate intersp

164 external root surface, and local delivery of antimicrobials has been suggested to be a complementary

165 Fortunately, securing access to effective antimicrobials has finally gained a place on the global

166 al resistance of iNTS against most available antimicrobials has steadily increased, with a predominan

167 industrial efforts to find and develop novel antimicrobials have been severely reduced during the pas

168 PSD) as a suitable target for development of antimicrobials; however no inhibitors of this class of e

169 medical science has been the development of antimicrobials; however, a consequence of their widespre

170 gher induction of TH17-related cytokines and antimicrobials (IL-17A, IL-19, CCL20, LL37, and peptidas

171 ic pH reduces the activity of individual ASL antimicrobials, impairs synergism between them, and thus

172 Producing antimicrobials imposes a fitness cost on burying beetles

173 In smokers with CP, adjunctive use of local antimicrobials improved efficacy of non-surgical periodo

174 tary/herbal supplements in 6 events (18.8%), antimicrobials in 2 events (6.3%), and miscellaneous med

175 genetic variants underlying resistance to 17 antimicrobials in 3,144 isolates from four taxonomically

176 e de-escalation in number and/or spectrum of antimicrobials in 77% of patients.

177 organisms were sensitive to the administered antimicrobials in 93%.

178 h others about the global responsible use of antimicrobials in a world of escalating antimicrobial re

179 The determination of antimicrobials in aquaculture fish is important to ensur

180 anoparticles (AgNP) are increasingly used as antimicrobials in consumer products.

181 The use of antimicrobials in contrast media was associated with a s

182 al. (2016) show that even therapeutic use of antimicrobials in dairy calves has an appreciable enviro

183 In India, the use of antimicrobials in food animal production is unregulated.

184 he nontherapeutic use of medically important antimicrobials in food animal production.

185 as been published about algae ingredients as antimicrobials in food.

186 pathway is a potential target for evaluating antimicrobials in gram-positive bacteria.

187 leads to widespread use of non-prescription antimicrobials in household products such as Triclocarba

188 that unregulated use of clinically relevant antimicrobials in Indian broiler and layer farms may con

189 ut limited potential therapeutic efficacy as antimicrobials in nasal applications, as concentrations

190 longitudinal resistance patterns for topical antimicrobials in New Zealand.

191 on and CAL gain associated with use of local antimicrobials in patients with type 1 and type 2 DM.

192 impact for human health of veterinary use of antimicrobials in prophylaxis, metaphylaxis and growth p

193 ination as a marker for resistance to common antimicrobials in returning travelers, where severe dise

194 At one go, lipophilic antimicrobials in Salvia miltiorrhiza root samples were

195 ew of adult inpatients receiving one or more antimicrobials in six US hospitals on 4 days during 2009

196 within the corneal tissue and the effect of antimicrobials in storage media.

197 Agricultural use of antimicrobials in subtherapeutic concentrations is incre

198 ensive farming operations that routinely use antimicrobials in subtherapeutic doses.

199 Most (85%) patients had received antimicrobials in the 72 hours before admission.

200 Adult patients treated with antimicrobials in the emergency department between 2009

201 with severe sepsis or septic shock receiving antimicrobials in the emergency department, door-to-anti

202 Our data suggest cost-sharing of antimicrobials in the public sector might drive demand t

203 judicious and sustainable uses of synthetic antimicrobials, including the design of greener and safe

204 ot persist after conventional treatment with antimicrobials, indicating that ongoing symptoms in pati

205 tive mechanism to deliver microparticles and antimicrobials inside S. mutans biofilms.

206 ity water microsprays to enhance delivery of antimicrobials into 3-d-old S. mutans biofilms.

207 developments suggest that local delivery of antimicrobials into periodontal pockets improve periodon

208 The passage of these antimicrobials into the aquatic environment selects for

209 ve neutrophil recruitment and the release of antimicrobials into the tears and protected the eye from

210 The discovery and development of new antimicrobials is critically important, especially as mu

211 to hypothesize that resistance to intestinal antimicrobials is essential for long-term GIT colonizati

212 Delayed initiation of appropriate antimicrobials is linked to higher sepsis mortality.

213 Securing access to effective antimicrobials is one of the greatest challenges today.

214 Access to quality-assured antimicrobials is regarded as part of the human right to

215 om resolution; however, the role of previous antimicrobials is unclear.

216 particularly to expensive, newer generation antimicrobials, is unique in global health and requires

217 Some but not all physicians started antimicrobials later for patients who were normotensive

218 aecalis tolerates high concentrations of GIT antimicrobials, like cholate and lysozyme, leading us to

219 A) associated with resistance to beta-lactam antimicrobials, macrolides, or fluoroquinolones.

220 to the inflamed intestinal mucosa, and host antimicrobials may play a critical role in mediating Sod

221 timicrobials, and treatment with ineffective antimicrobials may result in case fatality rates (CFRs)

222 st the development of oligonucleotides-based antimicrobials of superior efficacy.

223 lized colistin as adjunctive therapy to i.v. antimicrobials or as monotherapy in the treatment of ven

224 h usual care (dressings and bandages without antimicrobials) or an alternative topical or systemic an

225 cant for age, sex, diabetes, indications for antimicrobials, or underlying ophthalmic conditions.

226 ricidal agent (P = .005) and use of multiple antimicrobials (P = .01).

227 Reducing use of antimicrobials-particularly those deemed to be criticall

228 eristics of patients at the time of starting antimicrobials, patterns of changes to empirical therapy

229 hat the global average annual consumption of antimicrobials per kilogram of animal produced was 45 mg

230 practices are associated with regular use of antimicrobials, potentially increasing selection pressur

231 Patients who were transferred, received antimicrobials prior to emergency department arrival, or

232 lar nutrients and the bacterial secretion of antimicrobials provide a direct means of competition bet

233 d and validated for the quantification of 14 antimicrobials (quinolones and tetracyclines) in fish.

234 e need for the development of new classes of antimicrobials, rather than drugs based upon analogues o

235 Both antimicrobials reduced overall prevalence of Salmonella;

236 -hour delay to initial and first appropriate antimicrobials, respectively.

237 academic hospitals are more likely to delay antimicrobials should be further explored in future tria

238 his, the administration and exposure of such antimicrobials should be restricted until required in or

239 Since antimicrobials, specifically fluoroquinolones, are one o

240 imitations of current Gram-negative-targeted antimicrobials such as polymyxin B.

241 Limited data for new investigational antimicrobials such as the ketolide solithromycin sugges

242 seful in the study of other broadly reactive antimicrobials, such as hydrogen peroxide (H2O2).

243 provides a new avenue for the development of antimicrobials targeting spirochaetes.

244 an clinical isolates were susceptible to the antimicrobials tested based on CLSI guidelines for Strep

245 Among the commonly prescribed antimicrobials tested for susceptibility pattern; amoxic

246 midis significantly more so than traditional antimicrobials tested.

247 United States were more susceptible to these antimicrobials than were isolates from other countries.

248 Curing infections increasingly requires antimicrobials that are broader spectrum, more toxic, an

249 rtunity to create programmable gene-specific antimicrobials that are far less likely to drive resista

250 anner reminiscent of plasmid-derived peptide antimicrobials that commonly mediate antagonism among cl

251 of secondary metabolites, many of which are antimicrobials that impact on polymicrobial community co

252 latory complexities of bacterial response to antimicrobials that involve multiple riboregulators.

253 gs lay the foundation for the development of antimicrobials that target this novel, essential pathway

254 oeae has developed resistance to each of the antimicrobials that were previously recommended as first

255 For individual antimicrobials, the definitions with the highest rate of

256 Resistant to nearly all other antimicrobials, the infection was treated with amikacin

257 e carcass, perhaps through the production of antimicrobials themselves.

258 y can provide health benefits and as natural antimicrobials they offer preservation of foods.

259 tries, but increasing pathogen resistance to antimicrobials threatens to roll back this progress.

260 f infection; 2) surfaces that actively elute antimicrobials to avert bacterial adhesion and promote k

261 ood animal producers often employ the use of antimicrobials to improve the survival and growth of the

262 Antagonistic microorganisms produce antimicrobials to inhibit the growth of competitors.

263 This study demonstrates the use of targeted antimicrobials to modulate the microbiome structure allo

264 de-escalation from broad-spectrum empirical antimicrobials to pathogen-directed therapy.

265 rove antimicrobial stewardship by not giving antimicrobials to patients with negative UA results.

266 There is a need for new antimicrobials to replace over used conventional antibio

267 roved the efficacy and safety of CRISPR/Cas9 antimicrobials to therapeutic levels in both in vitro an

268 The polychlorinated aromatic antimicrobials triclosan and triclocarban are in widespr

269 ep SSIs were caused by bacteria resistant to antimicrobials used for prophylaxis, and 58% of patients

270 ated the reasons for the negative effects of antimicrobials used in food animals for human health.

271 has the potential to improve the efficacy of antimicrobials used to treat infections by Gram-positive

272 0 birds were tested for susceptibility to 11 antimicrobials using the disk diffusion method and valid

273 , we develop programmable, sequence-specific antimicrobials using the RNA-guided nuclease Cas9 (refs.

274 ass method for the HPLC-MS/MS analysis of 29 antimicrobials, validated according to the Commission De

275 cedure, the association between receipt of 2 antimicrobials (vancomycin plus a beta-lactam) versus ei

276 ative outcomes following administration of 2 antimicrobials versus a single agent for the prevention

277 Resistance to 14 of 19 tested antimicrobials was found to be significantly greater in

278 Slightly greater use of antimicrobials was observed among overweight (BMI 25-<30

279 reasing microbial resistance and limited new antimicrobials, we aimed to study the antimicrobial effe

280 thogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of cir

281 The most intense antimicrobials were characterized via HPTLC-high-resolut

282 y the 5th day of therapy, 12.5% of empirical antimicrobials were escalated, 21.5% were narrowed or di

283 In total, 15 antimicrobials were evaluated, with 11 for P. aeruginosa

284 Antimicrobials were extracted with trichloroacetic acid

285 mparisons showed that concentrations of both antimicrobials were higher on the experimental site in t

286 hest priority among the critically important antimicrobials were quinolones, third- and fourth-genera

287 ts profiting most obviously from intraductal antimicrobials were those with secondary sclerosing chol

288 patients who initiated CAS, the most common antimicrobials were trimethoprim-sulfamethoxazole, penic

289 therapy is lengthy and consists of multiple antimicrobials, which causes poor compliance and high tr

290 multaneously expanding appropriate access to antimicrobials, while restricting inappropriate access,

291 Here, we use CRISPR-Cas technology to create antimicrobials whose spectrum of activity is chosen by d

292 een 2010 and 2030, the global consumption of antimicrobials will increase by 67%, from 63,151 +/- 1,5

293 class of cationic, helical homo-polypeptide antimicrobials with a hydrophobic internal helical core

294 le that we will need approaches that combine antimicrobials with biofilm-disrupting agents and partne

295 present an untapped source of underexploited antimicrobials, with pleuromutilin-a diterpene produced

296 Among 421 eligible patients, 74% received antimicrobials within 3 hours of emergency department ar

297 Antimicrobials without an available reference standard w

298 to evaluate whether use of local or systemic antimicrobials would improve clinical results of non-sur

299 is one of the largest exposures of humans to antimicrobials, yet the effects of TB treatment on intes

300 consumes 11 tons/year of medically relevant antimicrobials, yet, this practice might not be critical