ライフサイエンスコーパス: antioxidant response element

1 ygenase 1, markers for the activation of the antioxidant response element.

2 ss stimulated HO-1 promoter activity via the antioxidant response element.

3 e redox-sensitive metal response element and antioxidant response element.

4 of Nrf2 and the binding of Nrf2 to the HO-1 antioxidant response element.

5 g phase II drug-metabolizing enzymes via the antioxidant response element.

6 ctive oxygen species (ROS) via a presumptive antioxidant response element.

7 enzymes via a electrophilic response element/antioxidant response element.

8 he composite major late transcription factor/antioxidant response element.

9 assays demonstrated binding of Nrf2 to Bcl-2 antioxidant response element.

10 of a vast number of genes by binding to the antioxidant response element.

11 pathways influencing genes controlled by the antioxidant response element.

12 ulated through cis-acting sequences known as antioxidant response elements.

13 ressing a luciferase reporter gene driven by antioxidant response elements.

14 with emphasis on Nrf2-mediated activation of antioxidant response elements.

15 nuclear proteins to activating protein-1 and antioxidant response elements.

16 irected mutagenesis assays demonstrated that antioxidant response element 1 is activated upon infecti

17 ted by NFE2-related factor 2 (Nrf2)-mediated antioxidant response element activation.

18 2, a transcription factor known to bind the antioxidant response element and activate antioxidant de

19 sic-region leucine zipper protein(s), to the antioxidant response element and consequently in gene tr

20 cated into the nucleus where it binds to the antioxidant response element and coordinately activates

21 rf2 in the nucleus of a cell upregulates the antioxidant response element and induces the expression

22 Nrf2 binds to the antioxidant response element and regulates expression an

23 T cells, as evidenced by Nrf2 binding to the antioxidant response element and the subsequent upregula

24 Cys506 impede binding of Nrf2 to endogenous antioxidant response element and to coactivator cAMP res

25 Analyses of antioxidant response elements and carbohydrate response

26 transcriptional regulator BACH1 binds HMOX1 antioxidant response elements and represses transcriptio

27 ion of phase II enzymes through induction of antioxidant response elements and support the approach o

28 The antioxidant response elements are regulatory sequences f

29 on of Txnip by high glucose by binding to an antioxidant response element (ARE) (-1286 to -1276) of t

30 ent to elicit the pharmaceutically important antioxidant response element (ARE) activation, and the r

31 riptional up-regulation of both subunits are antioxidant response element (ARE) and activator protein

32 lated factor 2 (Nrf2), where it binds to the antioxidant response element (ARE) and induces up-regula

33 The antioxidant response element (ARE) and Nrf2 are known to

34 Antioxidant response element (ARE) and nuclear transcrip

35 The antioxidant response element (ARE) and transcription fac

36 Transcriptional regulation of the antioxidant response element (ARE) by Nrf2 is important

37 are induced occurs through activation of the antioxidant response element (ARE) by the oxidative-stre

38 factor NRF2, which in turn binds cis-acting antioxidant response element (ARE) enhancers and induces

39 say revealed that NRF2 directly binds to one antioxidant response element (ARE) found in the -230-bp

40 s is mediated, at least in part, through the antioxidant response element (ARE) found in the regulato

41 ranscription factor Nrf2, which binds to the antioxidant response element (ARE) found in the upstream

42 Amongst these were a group of antioxidant response element (ARE) genes encoding phase

43 ear factor E2-related factor 2 (Nrf2) to the antioxidant response element (ARE) in neural cells resul

44 gets because of their role in regulating the antioxidant response element (ARE) in response to oxidat

45 ctrophilic stress, Nrf1 is displaced from an antioxidant response element (ARE) in the gene promoter

46 cription factor that binds and activates the antioxidant response element (ARE) in the promoters of m

47 gulates cytoprotective genes that contain an antioxidant response element (ARE) in their promoters.

48 The antioxidant response element (ARE) is a cis-acting regul

49 The antioxidant response element (ARE) is known to regulate

50 putative USF binding site which overlaps an antioxidant response element (ARE) located at -101 bp re

51 2 in the cytosol prevents Nrf2 activation of antioxidant response element (ARE) mediated gene express

52 The antioxidant response element (ARE) mediates the transcri

53 r levels and binding activity of MafG to the antioxidant response element (ARE) of GCLC but lower Nrf

54 ine zipper transcription factor Nrf2 and the antioxidant response element (ARE) of Nqo1.

55 igrate to the nucleus where it activates the antioxidant response element (ARE) of phase 2 genes and

56 In addition, BTG2 is detectable at the antioxidant response element (ARE) of several NFE2L2-res

57 These genes contain an antioxidant response element (ARE) or ARE-like transcrip

58 egulated by a cis-acting element, called the antioxidant response element (ARE) or electrophile-respo

59 usions, and increased expression of the NRF2-antioxidant response element (ARE) pathway.

60 or nuclear factor E2-related factor 2 (Nrf2)-antioxidant response element (ARE) regulates intracellul

61 Antioxidant response element (ARE) regulates the inducti

62 in Keap1 is required for termination of Nrf2-antioxidant response element (ARE) signaling by escortin

63 hich the Nrf2 transcription factor-dependent antioxidant response element (ARE) signaling is activate

64 The antioxidant response element (ARE) signaling pathway pla

65 nalysis of the human Trx1 gene identified an antioxidant response element (ARE) that is required for

66 Mutation of an antioxidant response element (ARE) that maps at -84/-76

67 factor NF-E2-related factor (Nrf2) binds to antioxidant response element (ARE) to induce antioxidant

68 tor NF-E2-related factor (Nrf2) binds to the antioxidant response element (ARE) to induce antioxidant

69 ated antioxidant response as measured by the antioxidant response element (ARE) using a luciferase re

70 kinase (HSV-TK/GCV) under the regulation of antioxidant response element (ARE), a cis-acting enhance

71 to identify functional polymorphisms in the antioxidant response element (ARE), a cis-acting enhance

72 -1 promoter by the triterpenoids requires an antioxidant response element (ARE), a cyclic AMP respons

73 anslocates into the nucleus and binds to the antioxidant response element (ARE), activating defensive

74 duction of these enzymes is regulated by the antioxidant response element (ARE), as demonstrated in r

75 everal important cis-elements, including the antioxidant response element (ARE), the xenobiotic respo

76 ble GCLC and GCLM expression by means of the antioxidant response element (ARE), we hypothesized that

77 rans-activates gene expression by way of the antioxidant response element (ARE), which controls the e

78 otein from HepG2 cells (YABP) that binds the antioxidant response element (ARE), which is required fo

79 s regulated by NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE), which play an import

80 enetic response pathway linked to PAH is the antioxidant response element (ARE), which regulates expr

81 nuclear translocation and activation of the antioxidant response element (ARE), which regulates phas

82 ement revealed that it contained a consensus antioxidant response element (ARE), which was confirmed

83 Both IAB and tBHQ induced antioxidant response element (ARE)-directed green fluore

84 Using two well-characterized antioxidant response element (ARE)-driven gene promoters

85 2, modulates the transcriptional activity of antioxidant response element (ARE)-driven genes.

86 eductase, a phase II detoxifying enzyme, and antioxidant response element (ARE)-linked reporter gene

87 Antioxidant response element (ARE)-mediated expression a

88 (Nrf2) is a CNC/b-zip protein that regulates antioxidant response element (ARE)-mediated expression,

89 f Nrf2, a transcription factor essential for antioxidant response element (ARE)-mediated gene express

90 Nrf2 activates antioxidant response element (ARE)-mediated gene express

91 or) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity

92 CA activated the DNA-binding of NRF2 and the antioxidant response element (ARE)-mediated transcriptio

93 scription of p66Shc is activated through the antioxidant response element (ARE)-nuclear factor erythr

94 o malonate and 3NP and demonstrate increased antioxidant response element (ARE)-regulated transcripti

95 These compounds induce the expression of the antioxidant response element (ARE)-related genes and cau

96 sfection of reporter plasmids containing the antioxidant response element (ARE).

97 oxidative stress response genes through the antioxidant response element (ARE).

98 and antioxidant proteins via its binding to antioxidant response element (ARE).

99 AD(P)H: quinone oxidoreductase 1 (NQO1) gene antioxidant response element (ARE).

100 transcriptionally activate genes through the antioxidant response element (ARE).

101 zymes through the regulatory sequence termed antioxidant response element (ARE).

102 700 and -683; this 20-bp region contains the antioxidant response element (ARE).

103 ation via a cis-acting sequence known as the antioxidant response element (ARE).

104 -lactamase reporter under the control of the antioxidant response element (ARE).

105 fection of a reporter plasmid containing the antioxidant response element (ARE).

106 gulates gene expression through the promoter antioxidant response element (ARE).

107 sfection of reporter plasmids containing the antioxidant response element (ARE).

108 l 3-kinase (PI3-K) activity, which represses antioxidant response element (ARE)/NF-E2 related factor

109 NRF2 binds to antioxidant response elements (ARE) and up-regulates pro

110 phase II detoxifying enzymes are induced via antioxidant response elements (ARE) in their promoters o

111 -responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promo

112 Many phase 2 genes are regulated by upstream antioxidant response elements (ARE) that are targets of

113 n part through cis-active sequences known as antioxidant response elements (ARE).

114 Antioxidant-response element (ARE) and nuclear factor Nr

115 ession of key protective enzymes through the antioxidant-response element (ARE).

116 ents in this region, including two potential antioxidant response elements (ARE3 and ARE4), separated

117 using a luciferase reporter regulated by the antioxidant response element ARE4.

118 pounds are attributed to their activation of antioxidant response elements (AREs) by reacting with th

119 expression of NDP52, which we show has three antioxidant response elements (AREs) in its promoter reg

120 rf2 nuclear translocation and occupancy of 4 antioxidant response elements (AREs) in the NRF-1 promot

121 lular proteins by recognizing and binding to antioxidant response elements (AREs) in their gene promo

122 he nucleus, and increased binding of Nrf2 to antioxidant response elements (AREs) or electrophile res

123 t defenses by activating gene expression via antioxidant response elements (AREs), but their roles in

124 ay leading to the induction of genes through antioxidant response elements (AREs).

125 ers for both GCLC and GCLM contain consensus antioxidant response elements (AREs).

126 often involves protein binding to cis-acting antioxidant response elements (AREs).

127 tional activating pathway involving Nrf2 and antioxidant-response elements (AREs), the mechanism of p

128 hat regulate the expression of genes bearing antioxidant-response elements (AREs).

129 eriments demonstrated that p65Nrf1 binds the antioxidant response element as a heterodimer with small

130 ys used to screen potential toxicants is the antioxidant response element beta lactamase reporter gen

131 enesis and transfection assays identified an antioxidant response element between nucleotides -3148 a

132 a gene that also contains a maf recognition/antioxidant response element but is less studied, respon

133 activity in cells transfected with the GSTA2 antioxidant response element-chloramphenicol acetyl tran

134 xposure increased Nrf2 binding to a putative antioxidant response element consensus sequence in the s

135 ctor critical for the expression of multiple antioxidant response element-dependent genes, plays an i

136 The ability of BRCA1 to stimulate antioxidant response element-dependent transcription and

137 1 (Kelch-like ECH-associated protein 1)/ARE (antioxidant response element)-driven target gene system

138 In this study, we observed a decrease in the antioxidant response element-driven antioxidants in FECD

139 pression of Fbw7 leads to down-regulation of antioxidant response element-driven gene activation, whe

140 d destabilization of Nrf1 leads to increased antioxidant response element-driven gene expression.

141 means of selective induction of one or more antioxidant response element-driven genes.

142 ro-15d-PGJ2 abolishes the inducibility in an antioxidant response element-driven luciferase assay.

143 lso impaired Nrf2-induced transactivation of antioxidant response element-driven reporter gene expres

144 Finally, BRCA1 stimulated antioxidant response element-driven transcriptional acti

145 human QR gene promoter with its electrophile/antioxidant response element (EpRE/ARE) or deleted or mu

146 , is known to be mediated by an electrophile/antioxidant response element (EpRE/ARE), we examined the

147 n is known to be mediated by an electrophile/antioxidant response element (EpRE/ARE).

148 Twenty-four base pairs of the human antioxidant response element (hARE) are required for hig

149 Mediated via the electrophile or human antioxidant response element (hARE), induction of the ex

150 Ethanol-induced HO-1 transcription involved antioxidant response elements, hypoxia-response elements

151 arity between the NF-E2/AP-1 element and the antioxidant response element identified in a number of p

152 nd 4, but no xenobiotic response elements or antioxidant response elements, implicated in the regulat

153 anscription factor NFE2L2 (NRF2) through the antioxidant response element in a BRCA1-dependent manner

154 t OA-NO2 increased the binding of Nrf2 to an antioxidant response element in the enhancer region of t

155 s and transfection experiments identified an antioxidant response element in the forward and reverse

156 Jun proteins bound to the antioxidant response element in the HS-2 region in vitro

157 ated factor 2 (NRF2) by direct binding to an antioxidant response element in the p62 promoter.

158 d xenobiotic transporters by binding the cis-antioxidant response element in the promoter regions of

159 T, is dependent on the activity of a genetic antioxidant response element in their promoters.

160 on with small-Maf protein and binding to the antioxidant response element in vivo.

161 es coordinately regulated by maf recognition/antioxidant response elements in iron/oxygen/antioxidant

162 r-reporter assays revealed the importance of antioxidant response elements in Nrf1-mediated upregulat

163 2 antibodies revealed the binding of Nrf2 to antioxidant response elements in the promoter regions of

164 Tandem antioxidant response elements in the proximal promoter o

165 tin immunoprecipitation assays identified an antioxidant-response element in the reverse strand of th

166 ression) of phase 2 genes by binding to the "antioxidant response element" in their promoters.

167 Transcriptional activation through the antioxidant response elements involves members of the CN

168 t transcriptional activation by means of the antioxidant response element is known to coordinate the

169 ccumulation and subsequent activation of the antioxidant response element is regulated by the proteas

170 DEPs induced activity of the antioxidant response element located in the NQO1 gene pr

171 nd binds to a cis-acting enhancer called the antioxidant response element located in the promoters of

172 se elements, major late transcription factor/antioxidant response element (MLTF/ARE), the STAT3 bindi

173 Because BACH1 is thought to interact with antioxidant response element motifs, we further examined

174 eporter cell lines driven by functional ROS (antioxidant response elements), NFkappaB, and mothers ag

175 ly activated TGFbeta1 signaling through ROS (antioxidant response elements), NFkappaB, and SMAD3 in b

176 cts of tumor suppressor P53, and inhibit the antioxidant response element Nrf-2, resulting in deplete

177 d phase 2 inducers, the TP analogues use the antioxidant response element-Nrf2-Keap1 signaling pathwa

178 ead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.

179 ve transcription factor Nrf2, which binds to antioxidant response elements of various promoters.

180 nzymes via an electrophilic response element/antioxidant response element PAH o-quinones represent a

181 xygen species generation, activates the Nrf2/antioxidant response element pathway, inducing reactive

182 scription factors that bind NF-kappaB and/or antioxidant response elements play an activating role in

183 nce in ferritin genes is the maf recognition/antioxidant response element present in several other ge

184 The binding activities of Nrf2 on the antioxidant response element promoter regions of p62/Bcl

185 ted diminished Nfe2l2 protein binding to the antioxidant response element promoter site proximal to t

186 ne of the genes expressed in response to the antioxidant response element promoter.

187 ional inducers is mediated indirectly via an antioxidant response element rather than a xenobiotic re

188 atotoxicity caused by oxidative stress using antioxidant response element reporter gene assay models

189 lination appear normal, when crossed with an antioxidant response element reporter line, the mutant m

190 lity that Nrf1 plays a role in mediating the antioxidant response element response.

191 r factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element signaling and decreased act

192 ectrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which co

193 f2 (nuclear factor E2-related factor 2)/ARE (antioxidant response element) signaling system.

194 S-transferase) functions via the stress- or antioxidant-response elements (StRE/ARE).

195 ref(2)P promoter also contains a functional antioxidant response element that is directly bound by t

196 The NF-E2 binding site is a subset of the antioxidant response elements that have the sequence GCN

197 The HO-1 promoter region contains antioxidant-response elements that can bind the transcri

198 whereas deacetylation disengages it from the antioxidant response element, thereby resulting in trans

199 d Nrf2, a transcription factor that binds to antioxidant response elements, thus activating them.

200 o lycopene, focusing on the induction of the antioxidant response element transcription system and th

201 (K-Loop) of mVP24 leading to upregulation of antioxidant response element transcription, which is dis

202 In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway in

203 lex distinct from AP-1, but specific for the antioxidant response element, were detected.

204 wn transcription factors albumin binds to an antioxidant response element, which controls the express