ライフサイエンスコーパス: antiparasitic

1 These high antiparasitic activities encourage us to propose these c

2 l profile and antioxidant, antimicrobial and antiparasitic activities of the hydroalcoholic extract o

3 nt of biological probes and drugs with novel antiparasitic activities.

4 C50 of 2.2 muM, against TbFolD and displayed antiparasitic activity against T. brucei (IC50 49 muM).

5 arasite egress and invasion and shows strong antiparasitic activity against T. gondii The same compou

6 ive antitoxin immunity, suggesting that both antiparasitic activity and antidiarrheal activity can be

7 Apicidin's antiparasitic activity appears to be due to low nanomola

8 against human cells while retaining a potent antiparasitic activity both in vitro and in vivo and cle

9 Expression of molecules with antiparasitic activity by genetically transformed symbio

10 We assessed antiparasitic activity by testing for the presence of T.

11 um complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesized, cis,fac-[R

12 A subset of inhibitors also displayed potent antiparasitic activity in a Toxoplasma gondii model.

13 acemic version of 15a, also displayed superb antiparasitic activity in a Toxoplasma gondii strain tha

14 It has stronger antiparasitic activity in cellular experiments, cures th

15 We report the preparation and antiparasitic activity in vitro and in vivo of a series

16 This compound showed antiparasitic activity in vitro with an EC50 of 2 nM and

17 xcellent ligand efficiency (LE), and display antiparasitic activity in vitro.

18 ion of iron by desferrioxamine abrogates the antiparasitic activity of artemisinins and corresponding

19 gs demonstrate for the first time the direct antiparasitic activity of CCL20 against an enteric proto

20 e of the human parasite Brugia malayi to the antiparasitic activity of cyclosporin A (CsA) may arise

21 al parasites has not been described, and the antiparasitic activity of NO produced by B. bovis-stimul

22 sible for the highly potent trypanocidal and antiparasitic activity of the monoenone curcuminoids.

23 y reported a prodrug approach to improve the antiparasitic activity of this inhibitor by converting t

24 r shortly after immunization, the protective antiparasitic activity of this T cell response also is l

25 phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causat

26 ion of their mechanism of action or superior antiparasitic activity relative to analogs with the orig

27 oxolanes would exhibit Fe(II) reactivity and antiparasitic activity similar to that achieved with can

28 e CD8(+) T cells are not capable of exerting antiparasitic activity unless previously primed by paras

29 idone derivatives were synthesized and their antiparasitic activity was evaluated.

30 ors were also evaluated and found to possess antiparasitic activity, suggesting that HDA is an attrac

31 Biological and biophysical data show that antiparasitic activity, toxicity, and DNA binding of thi

32 matodes and in insects to be a target of the antiparasitic agent avermectin.

33 atal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

34 the unexpected synergistic combination of an antiparasitic agent, pentamidine, and a phenothiazine an

35 ulated by ivermectin (IVM), a broad-spectrum antiparasitic agent.

36 n antioxidant, and/or benzonidazole (BZ), an antiparasitic agent.

37 s, suggesting their further investigation as antiparasitic agents against T. b. rhodesiense.

38 d for development of potent, mechanism-based antiparasitic agents against these diseases.

39 To further investigate their utility as antiparasitic agents, we compare the cellular effects of

40 In search of antiparasitic agents, we here identify arylmethylamino s

41 importance of plant essential oils as novel antiparasitic agents.

42 tractive target for the development of novel antiparasitic agents.

43 ssible antiviral, anticancer, antifungal and antiparasitic agents.

44 n issues that challenge their development as antiparasitic agents.

45 e these compounds as promising candidates as antiparasitic agents.

46 rypanosoma brucei FolD (TbFolD) as potential antiparasitic agents.

47 antiviral, 105 anti-HIV, 959 antifungal, 80 antiparasitic and 185 anticancer peptides.

48 Almost two-thirds of patients had an antiparasitic and 27% had an antibiotic during the study

49 1 gene, whose complement C3-like product has antiparasitic and antibacterial activity.

50 When Giardia-specific tests and antiparasitic and antibiotic prescriptions were examined

51 to the N1 aromatic ring generally decreases antiparasitic and antimitotic potency, but placement of

52 orters have been implicated in the uptake of antiparasitic and experimental drugs in these and other

53 s, of use in bone resorption therapy, and as antiparasitic and immunotherapeutic agents.

54 Inclusion of antiparasitics and other beneficial interventions in HIV

55 The antiparasitic, antibiotic and antibiotic-modifying activ

56 antitumor, anti-inflammatory, antimicrobial, antiparasitic, antimutagenic, chemopreventive and chemot

57 ficant antibacterial, antifungal, antiviral, antiparasitic, antitumour, anti-inflammatory, antioxidan

58 apeutically diverse compound which possesses antiparasitic, antiviral and antibacterial properties.

59 Doramectin is a commercial antiparasitic avermectin analog produced by fermenting a

60 Here, we show that these antiparasitic cardenolides can also impose significant c

61 zoan parasites are resistant to conventional antiparasitic chemotherapies and the currently available

62 ways provide numerous successful targets for antiparasitic chemotherapy, but the human pathogen Crypt

63 has been advanced as a potential target for antiparasitic chemotherapy.

64 aptopurine and allopurinol, and a target for antiparasitic chemotherapy.

65 mmunosuppressive, antiviral, anticancer, and antiparasitic chemotherapy.

66 The antiparasitic clioquinol (CQ) represents a class of nove

67 using natural variation in concentrations of antiparasitic compounds among plants.

68 Overall, our results suggest that the use of antiparasitic compounds carries substantial costs, which

69 lved medication behaviours, whereby they use antiparasitic compounds from their environment to protec

70 study, we explore the costs of the usage of antiparasitic compounds in monarch butterflies (Danaus p

71 ure-centric approach to support discovery of antiparasitic compounds promises much.

72 represent targets of the avermectin class of antiparasitic compounds, have recently been cloned from

73 ibutes to strategies for the design of novel antiparasitic compounds.

74 al model for rapid, inexpensive screening of antiparasitic compounds.

75 he parasite population through the intake of antiparasitic compounds.

76 Mass antiparasitic drug administration programs and other con

77 loroquine, tetracycline and a broad spectrum antiparasitic drug atovaquone.

78 itrichomonas foetus is a rational target for antiparasitic drug design because it is the primary enzy

79 ine proteases are exciting novel targets for antiparasitic drug design.

80 n Toxoplasma gondii is a rational target for antiparasitic drug design.

81 fication and validation of novel targets for antiparasitic drug discovery in veterinary medicine.

82 ng highlights exciting new opportunities for antiparasitic drug discovery resulting from major advanc

83 The approach is especially applicable to antiparasitic drug discovery where the phylogenetic dist

84 ioselective approach to the synthesis of the antiparasitic drug fluralaner (Bravecto, presently sold

85 ubunits confers high-level resistance to the antiparasitic drug ivermectin.

86 ction for T. gondii mutants resistant to the antiparasitic drug monensin, we have isolated a strain t

87 eukaryotes, is a potential antimicrobial and antiparasitic drug target.

88 tion of its biosynthesis may provide a novel antiparasitic drug target.

89 Atovaquone is an antiparasitic drug that selectively inhibits electron tr

90 Albendazole is a new, broad-spectrum antiparasitic drug, which was approved recently by the F

91 followed by or concurrent with an effective antiparasitic drug, without ineffective antibiotics.

92 At least 564 women received antiparasitic drugs according to a standard protocol.

93 nt study demonstrated that combining these 2 antiparasitic drugs improves antiparasitic efficacy.

94 Some HIV and antiparasitic drugs might induce diabetes, whereas helmi

95 In 21 studies, efficacy of treatment with antiparasitic drugs ranged from 0 to 100% (35.7% of 269

96 bally, this is pushing discovery research of antiparasitic drugs toward new agents endowed with new m

97 ents should be treated with corticosteroids, antiparasitic drugs, and shunting if hydrocephalus is pr

98 gram aimed at discovering novel DNA-targeted antiparasitic drugs, the phenylfuran-benzimidazole unfus

99 cult to implement, lagging behind the use of antiparasitic drugs, vaccine development and transmissio

100 is an overall unmet and urgent need for new antiparasitic drugs.

101 e therefore emerged as promising targets for antiparasitic drugs.

102 eases and the potential of vinyl sulfones as antiparasitic drugs.

103 facilitate the eventual design of selective antiparasitic drugs.

104 ent opportunity for directed design of novel antiparasitic drugs.

105 sistant crops, as well as new antibiotic and antiparasitic drugs.

106 patients are treated with prednisone and/or antiparasitic drugs.

107 have not demonstrated a clinical benefit for antiparasitic drugs.

108 the prospects for using enzyme inhibitors as antiparasitic drugs.

109 able Giardia-specific diagnostic testing and antiparasitic drugs.

110 e used for the development of more effective antiparasitic drugs.

111 Human DHFR was found to fully negate the antiparasitic effect of WR99210, thus demonstrating that

112 In search of additional antiparasitic effector genes, we have generated transgen

113 (IFN)-gamma-producing T cells, which induce antiparasitic effector mechanisms in infected cells, as

114 h a fundamental role in the amplification of antiparasitic effector mechanisms, provide a useful way

115 it its activity in vitro, and produce strong antiparasitic effects in the cultured TC cells.

116 e that we previously found to produce potent antiparasitic effects in Trypanosomatidae.

117 ase of T. spiralis infection and to test the antiparasitic effects of such antibodies.

118 mbining these 2 antiparasitic drugs improves antiparasitic efficacy.

119 s beyond IgE-mediated allergic responses and antiparasitic functions.

120 ma9Vdelta2 T cells that in turn exert remote antiparasitic functions.

121 generate transgenic mosquitoes that express antiparasitic genes in their midgut epithelium, thus ren

122 To determine what topological changes antiparasitic heterocyclic dications can have on kinetop

123 host-nematode interactions and uncover host antiparasitic immune reactions.

124 IgE antibodies mediate antiparasitic immune responses and the inflammatory reac

125 IgE antibodies are key mediators of antiparasitic immune responses, but their potential for

126 red for the establishment and maintenance of antiparasitic immunity in the liver, as well as for immu

127 eloping theme in field studies investigating antiparasitic immunity is the emergence, establishment,

128 s, including MHC expression, senescence, and antiparasitic immunity, and shifted the transcriptional

129 sphorylation constitutes a viable target for antiparasitic intervention.

130 e future approaches to expand the horizon of antiparasitic interventions.

131 Surprisingly, the antiparasitic nucleosides AraT, AraC, and IDC are not su

132 ), and with previous antibiotic (P = .02) or antiparasitic(P = .04) use.

133 Flowers that produce antiparasitic phytochemicals, including thymol, could po

134 tory effects on T. cruzi CYP51 activity, and antiparasitic potencies of a new set of beta-phenyl imid

135 ouping 404 non-cytotoxic compounds with high antiparasitic potency, drug-likeness, structural diversi

136 dult sequences most frequently began with an antiparasitic prescription.

137 set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), w

138 y new chemotypes that could deliver the same antiparasitic profile.

139 Given its potent antiparasitic properties and its ease of synthesis, comp

140 iproliferative, antivascular, antiviral, and antiparasitic properties have attracted the attention of

141 Heterocyclic diamidines are compounds with antiparasitic properties that target the minor groove of

142 compounds with optimized pharmacological and antiparasitic properties.

143 essential immune effector molecule mediating antiparasitic resistance.

144 in controlling infection intensity-dependent antiparasitic responses.

145 low toxicity in fibroblasts in vitro, while antiparasitic results against Trypnosoma cruzi, Leishman

146 provide insights for the development of new antiparasitic strategies.

147 feasibility of targeting host proteins as an antiparasitic strategy, mammalian PKC inhibitors demonst

148 ) stores by the enhancer may be an effective antiparasitic strategy.

149 his study provides the first insight on this antiparasitic target enzyme essential for survival of th

150 diverse parasitic nematodes, suggesting the antiparasitic target potential of SBT-1.

151 smodium and is not found in humans, it is an antiparasitic target.

152 hosphate dehydrogenase as the most selective antiparasitic targets.

153 r structural and functional studies of novel antiparasitic targets.

154 ns, they are now emerging as novel potential antiparasitic targets.

155 with more effective, affordable, and benign antiparasitic therapeutics.

156 enetic processes will aid the development of antiparasitic therapeutics.

157 used as alternatives or adjuncts to current antiparasitic therapies.

158 therapy, there is no consistently effective antiparasitic therapy for cryptosporidiosis in AIDS.

159 With appropriate use of antiparasitic therapy, the visual prognosis for patients

160 rt and is, therefore, a potential target for antiparasitic therapy.

161 t for these drugs and a potential target for antiparasitic therapy.

162 All of them completed antiparasitic treatment and underwent follow-up brain MR

163 The efficacy of current antiparasitic treatment for cerebral Taenia solium cysti

164 These findings suggest that, in CCPs, antiparasitic treatment improved the quality of Ag-speci

165 Antiparasitic treatment is controversial as to its indic

166 nt study was to analyze the early effects of antiparasitic treatment on CD8(+) T cells from CCPs with

167 es, including all the villages in which mass antiparasitic treatment plus vaccination was implemented

168 ly to have ocular involvement (P = .043) and antiparasitic treatment was associated with less ocular

169 cal markers to evaluate the effectiveness of antiparasitic treatment, and little is known about the e

170 that involved screening of humans and pigs, antiparasitic treatment, prevention education, and pig r

171 Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neu

172 omarkers for monitoring the effectiveness of antiparasitic treatment.

173 differentiation in the context of protective antiparasitic type 2 immunity.

174 gh potency of piritrexim (PTX) with the high antiparasitic vs mammalian selectivity of trimethoprim (

175 TMFS method to discover that mebendazole, an antiparasitic with recently discovered and unexpected an