ライフサイエンスコーパス: antiporter

1 lains previously controversial data for this antiporter.

2 ticulum (ER) membrane and acts as an ATP/ADP antiporter.

3 encodes a putative mitochondrial Ca(2+)/H(+) antiporter.

4 luded by lack of substrates, is a Na(+)/H(+) antiporter.

5 ys an important role in pH regulation of the antiporter.

6 ct, suggesting no role for a nitrate/nitrite antiporter.

7 mechanism of action and pH regulation of an antiporter.

8 toichiometry of this well-studied Cl(-)/H(+) antiporter.

9 anscription of the functional subunit of the antiporter.

10 n symporter while NarK2 is a nitrate/nitrite antiporter.

11 strate that Letm1 is a mitochondrial Ca2+/H+ antiporter.

12 L-ornithine, which inhibit the E. coli AdiC antiporter.

13 the well-characterized electrogenic E. coli antiporter.

14 11, a key component of the cystine/glutamate antiporter.

15 is shared by Cl(-) channels and 2Cl(-):1H(+) antiporters.

16 activity of endosomal sodium/proton NHX-type antiporters.

17 Cl(-) ion channels and others are Cl(-)/H(+) antiporters.

18 homeostasis in all cells requires Na(+)/H(+) antiporters.

19 o subunits from the Mrp family of Na(+)/H(+) antiporters.

20 porter-like glutamate, and yet are F(-)/H(+) antiporters.

21 rs: H(+)-gated Cl(-) channels and Cl(-)/H(+) antiporters.

22 uence similarity to multi-subunit Na(+)/H(+) antiporters.

23 side the cell, i.e. monovalent cation/proton antiporters.

24 ere recently shown to function as Cl(-)/H(+) antiporters.

25 be a paradigm for organophosphate:phosphate antiporters.

26 anistic principles that characterize all MFS antiporters.

27 port significant antiport by any of the test antiporters.

28 ial for electrogenic transport in Na(+)/H(+) antiporters.

29 nto the transport mechanism of sodium/proton antiporters.

30 erial transport systems of the cation/proton antiporter-2 (CPA2) family led to suggestions that this

31 tion mutants in members of the cation/proton antiporters-2 antiporter superfamily KEA1, KEA2, and KEA

32 SLC9A3 encodes Na(+)/H(+) antiporter 3 (NHE3), which is the major intestinal brush

33 rs and their homologues in the cation/proton antiporter 3 family of the Membrane Transporter Database

34 w, higher abundance of renal sodium-hydrogen antiporter 3, and lower lithium clearance than WT mice.

35 Monovalent cation proton antiporter-3 (Mrp) family antiporters are widely distrib

36 ter families, the NhaC and the cation/proton antiporter-3 antiporter families.

37 genes activated by AphB encode a Na(+)/H(+) antiporter, a carbonic anhydrase, a member of the ClC fa

38 comprised of a central RND proton-substrate antiporter, a membrane fusion protein, and an outer memb

39 ism of the homotrimeric RND-type proton/drug antiporter AcrB, the active component of the major efflu

40 tudy demonstrates that one of the Na(+)/H(+) antiporters acting at the tonoplast of E. californica ce

41 glutamate released by the cystine/glutamate antiporter activated extrasynaptic, but not synaptic, NM

42 We further demonstrate that blocking antiporter activity interferes with DC differentiation f

43 The antiporter activity is abolished upon reactivation by th

44 Asc-1 antiporter activity is enhanced by D-isoleucine (D-Ile),

45 ifferentiation from monocyte precursors, but antiporter activity is not required for LPS-induced phen

46 tive force across the membranes that powered antiporter activity upon subsequent addition of Na(+).

47 Antiporter activity was 5-fold greater in acetate-grown

48 Na(+)/H(+) antiporter activity was demonstrated by a fluorescence-b

49 In Escherichia coli, the l-arginine/agmatine antiporter AdiC facilitates the export of agmatine in ex

50 The antiporter AdiC is the master orchestrator of the argini

51 ificity of the wild-type l-arginine/agmatine antiporter AdiC.

52 a membrane, orthologs of the Cl(-)/HCO(-)(3) antiporters ae1 and pendrin, and two isoforms of carboni

53 Nigericin, a K(+)/H(+) antiporter, also increases NADPH oxidase activity, leadi

54 TGD1, -2, or -3 included a potassium efflux antiporter and a TIM17/22/23 family protein, but these w

55 vage generated a hyperfunctional form of the antiporter and increased NCX currents (I(NCX)) in the re

56 at prestin can act as a weak Cl(-)/HCO(3)(-) antiporter and it is proposed that, in addition to parti

57 s expression system, it acts as a nucleotide antiporter and prefers various (deoxy-) purine nucleotid

58 the defining characteristics of a CLC Cl-/H+ antiporter and show that this transporter is the predomi

59 channel' family consists of both Cl(-)/H(+) antiporters and Cl(-) channels.

60 t implications for the biology of Cl(-)/H(+) antiporters and perhaps for pH regulation in highly acid

61 cerevisiae lacking endogenous cation/proton antiporters and pumps, HsNHA2 can confer tolerance to Li

62 channel proteins, as well as sodium/hydrogen antiporters and sodium/calcium exchangers.

63 unique family of Golgi-localized Ca(2+)/H(+) antiporters and that modification of the Golgi Ca(2+) an

64 Mrp antiporters and their homologues in the cation/proton an

65 r mechanistic understanding of these unusual antiporters and to rigorously demonstrate that they func

66 ational dynamics of a mammalian H(+)-coupled antiporter, and also identify key aspects of the mode of

67 ne ClbM is characterized as a cation-coupled antiporter, and residues important to the cation-binding

68 the Na(+)/Ca(2+) (NCX) and Ca(2+)/H(+) (CAX) antiporters, and in mammals the NCX and related proteins

69 more than half of the ClC family members are antiporters, and not channels, as was previously thought

70 Recent work shows that MFS antiporters, and perhaps all members of the MFS, share t

71 like in Saccharomyces cerevisiae, Na(+)/H(+) antiporter appeared to have an important role in this pr

72 imental data on the kinetics of Na(+)-Ca(2+) antiporter are available, the structure and composition

73 els Aqy1 and hAQP1, and the CLC-ec1 chloride antiporter are presented in which the active site geomet

74 Na+/H+ antiporters are central to cellular salt and pH homeosta

75 Sodium/proton antiporters are essential for sodium and pH homeostasis

76 Na(+)/H(+) antiporters are found in all kingdoms of life and exhibi

77 Na(+)/H(+) antiporters are located in the cytoplasmic and intracell

78 ty, but we lack explanations for why so many antiporters are needed and for the value added by specif

79 Na(+)/H(+) antiporters are ubiquitous membrane proteins that play a

80 lent cation proton antiporter-3 (Mrp) family antiporters are widely distributed and physiologically i

81 ss of function of the two envelope K(+)/H(+) antiporters AtKEA1 and AtKEA2 was shown previously to ha

82 nitrate/proton symporters or nitrate/nitrite antiporters based on sequence homology, these transporte

83 independent, l-carnitine/gamma-butyrobetaine antiporter belonging to the betaine/carnitine/choline tr

84 e transporter, typically an ATPase or proton antiporter, binds and translocates export or efflux subs

85 Ca(2+) efflux by Ca(2+) cation antiporter (CaCA) proteins is important for maintenance

86 ow activity of secondary, DeltaPsi-consuming antiporters can elicit increased capacity for DeltaPsi g

87 g, a gene encoding a calcium(2+)/hydrogen(+) antiporter, cation/hydrogen(+) exchanger1 (CAX1), was id

88 (EIPA), a specific inhibitor for Na(+)/H(+) antiporters, caused a 38 +/- 5% decrease in the initial

89 because of mutations of the chloride/proton antiporter, chloride channel-5 (CLC-5), resulting in low

90 iana) genome contains numerous cation:proton antiporters (CHX), which may mediate K+ transport; howev

91 t the intracellular surface of the bacterial antiporter CLC-ec1 are examined here as possible pathway

92 he crystal structure of the Escherichia coli antiporter ClC-ec1 provides an invaluable molecular fram

93 ng ion channels, whereas others act as Cl-/H+antiporters (ClC-4 and ClC-5).

94 the dimer interface of a bacterial F(-)/H(+) antiporter, ClC(F)-eca.

95 ther candidate I(-) conduits: the Cl(-)/H(+) antiporter, CLC-5, the cystic fibrosis transmembrane con

96 Na(+)/H(+) antiporters comprise a family of membrane proteins evolu

97 The Escherichia coli NhaA antiporter couples the transport of H(+) and Na(+) (or L

98 ClC-ec1 from Escherichia coli is an antiporter, coupling the transport of Cl(-) and H(+) ion

99 S. aureus protein, a predicted cation/proton antiporter, CpaA, which as we show here also directly bi

100 an optimized assay protocol for vesicles of antiporter-deficient E. coli EP432 transformants produce

101 Characterization of these antiporters in antiporter-deficient Escherichia coli KNabc showed overl

102 ces cerevisiae) mutant that lacks Na+(K+)/H+ antiporters (Deltanhx1 Deltanha1 Deltakha1) and plasma m

103 Blocking antiporter-dependent cystine transport decreases intrace

104 ological inhibition of the cystine/glutamate antiporter dramatically attenuated ischemia-gated curren

105 The Escherichia coli Na(+)/H(+) antiporter (Ec-NhaA) is the best-characterized of all pH

106 d into a divalent cationic drug/>/= 2 proton-antiporter, either by random mutagenesis or by rational

107 Vnx1p, a novel vacuolar monovalent cation/H+ antiporter encoded by the open reading frame YNL321w fro

108 The monovalent cation/proton antiporters encoded by these diverse genes fall into at

109 Four antiporter-encoding genes were isolated and cloned from

110 se, glutathione synthetase, catalase, Na+/H+ antiporter, etc) not found in Dg1.

111 n more surprisingly, CLC-ck2 is a Cl(-)/H(+) antiporter, even though it contains an isoleucine at the

112 This suggests that the activation of these antiporters exerts a neuroprotective action against stro

113 mice lacking a functional cystine/glutamate antiporter exhibited reduced anoxic depolarization and n

114 In some breast cancer cells, xCT antiporter expression is upregulated through the antioxi

115 ctives on two large monovalent cation/proton antiporter families, the NhaC and the cation/proton anti

116 the NhaC and the cation/proton antiporter-3 antiporter families.

117 ters in the CPA1 branch of the cation proton antiporter family drive the electroneutral exchange of H

118 lc11a2 is a symporter, whereas Slc11a1 is an antiporter fluxing divalent cations against the proton g

119 at least eight electrogenic Na(+)(K(+))/H(+) antiporters for cytoplasm acidification.

120 onal reconstitution of the seven-subunit Mrp antiporter from alkaliphilic Bacillus pseudofirmus OF4.

121 YiiP is a dimeric Zn(2+)/H(+) antiporter from Escherichia coli belonging to the cation

122 Crystal structures of the arginine/agmatine antiporter from Escherichia coli, AdiC, have been recent

123 EmrE, a multidrug antiporter from Escherichia coli, has presented biochemi

124 physiological study of the PaNhaP Na(+)/H(+) antiporter from Pyrococcus abyssi reconstituted into lip

125 We propose that these movements convert the antiporter from the proton-bound, outward-open state to

126 E. coli inner membrane is a secondary active antiporter from the ubiquitous major facilitator superfa

127 in proteinaceous channels, transporters, and antiporters from all kingdoms of life, these findings ha

128 We conclude that aberrant antiporter function disrupts glutathione homeostasis in

129 tivating effect of membrane potential on the antiporter function for a 3Na(+):1Ca(2+) electrogenic ex

130 n this paper, we present a detailed study of antiporter function in DCs and demonstrate a role for th

131 T imaging showed increased cystine/glutamate antiporter function in ischemic rats.

132 r, these data suggest that cystine/glutamate antiporter function is increased in ischemia, contributi

133 acyaB1 cells possessed defects in Na(+)/H(+) antiporter function.

134 s to propose an atomically detailed model of antiporter function.

135 sms of interactions that enable the specific antiporter functionality of AdiC.

136 We conclude that the EcNHX1 antiporter functions in the elicitor-initiated expressio

137 The bacterial antiporter GadC plays a central role in the glutamate (G

138 d the gene for glutamate-gamma-aminobutyrate antiporter (gadC) induced by the polyamine addition, but

139 te that over-expression of the sodium-proton antiporter gene nhaA confers the elevated AcR sodium ace

140 Similarly, the plasmid-borne antiporter gene, grmA, identified previously as being es

141 membranes from E. coli EP432 expressing Mrp antiporters generated higher DeltaPsi levels than contro

142 that Saccharomyces cerevisiae sodium-proton antiporter genes also contribute to sodium acetate, pota

143 cycle for the glycerol-3-phosphate:phosphate antiporter GlpT by using a novel approach in reconstruct

144 and identified the Glc-6-phosphate/phosphate antiporter GPT1 as the putative translocator of Glc-6-ph

145 The glucose-6-phosphate/phosphate antiporter GPT1 is a major route of entry of carbon into

146 Disruption of the xCT antiporter greatly improves cell viability after glucose

147 cherichia coli EmrE, a homodimeric multidrug antiporter, has been suggested to offer a convenient par

148 Intracellular Na(+)/H(+) (NHX) antiporters have important roles in cellular pH and Na(+

149 deletion of uhpT encoding hexose-6-phosphate antiporter in 4 of the E. coli inner colony mutants, whi

150 Sensitive 1 (SOS1), a plasma membrane Na+/H+ antiporter in Arabidopsis, is a salt tolerance determina

151 nction in DCs and demonstrate a role for the antiporter in DC differentiation and cross-presentation.

152 In a gene encoding a DHA1 antiporter in Pezizomycotina, we find a variety of predi

153 Characterization of these antiporters in antiporter-deficient Escherichia coli KNa

154 dues between NuoL/ND5 and MrpA of Na(+)/H(+) antiporters in the chromosomal nuoL gene.

155 Na(+)/H(+) antiporters in the CPA1 branch of the cation proton anti

156 ies of 12 predicted monovalent cation/proton antiporters in the genome of this thermophilic haloalkal

157 e decarboxylase) and CadB (lysine/cadaverine antiporter) in a lysine-rich environment.

158 ne, an FDA-approved inhibitor of cystine xCT antiporter, in culture and xenograft assays.

159 pport the involvement of ClC-7, a Cl(-)/H(+) antiporter, in this process, although many open question

160 esidues Glu(203) and Glu(148) in the ClC-ec1 antiporter, including the Grotthuss mechanism of proton

161 al dysfunction, the potential utility of xCT antiporter inhibition should be further tested.

162 tracellular NHX proteins are Na(+),K(+)/H(+) antiporters involved in K(+) homeostasis, endosomal pH r

163 structural model for the NhaA sodium-proton antiporter is constructed to provide mechanistic insight

164 ostasis, a biophysical model of Na(+)-Ca(2+) antiporter is introduced that is thermodynamically balan

165 We show that the antiporter is the major mechanism for transport of cysti

166 Sodium-calcium antiporter is the primary efflux pathway for Ca(2+) in r

167 derived mitochondrial DNA mutations, the xCT antiporter is upregulated and its inhibition improves mi

168 sults show that conformational change in CLC antiporters is not restricted to the Cl(-) permeation pa

169 ndamental question concerning the ClC Cl-/H+ antiporters is the nature of their proton transport (PT)

170 folates, and RFC, a folate/organic phosphate antiporter, is consistent with a classic exchange reacti

171 Human NHA2, a newly discovered cation proton antiporter, is implicated in essential hypertension by g

172 Ptch, a proton driven antiporter, is required for Smo inhibition via an unknow

173 y crystal structures of bacterial Cl(-)/H(+) antiporters, is apparently universal.

174 In electrogenic Na(+)/H(+) antiporters, it has been assumed that two ion-binding as

175 ouble mutations in the plastid K(+) exchange antiporter (KEA) transporters kea1kea2 and a single muta

176 e show that Arabidopsis thaliana K(+) efflux antiporter (KEA3) is critical for high photosynthetic ef

177 f plants have used a modified calcium/proton antiporter [known as short cation exchanger 1 (sCAX1)] t

178 Glutamate inhibits the xCT glutamate-cystine antiporter, leading to intracellular cysteine depletion.

179 The membrane arm contains four antiporter-like domains, energetically coupled to the qu

180 The membrane arm contains four antiporter-like domains, probably energetically coupled

181 ong-range conformational changes in the four antiporter-like domains, resulting in translocation of f

182 The membrane domain contains three antiporter-like subunits (NuoL, NuoM, and NuoN, Escheric

183 Three antiporter-like subunits in the membrane domain, NuoL, N

184 transmembrane helices, mostly contributed by antiporter-like subunits involved in proton translocatio

185 The fold of the homologous antiporter-like subunits L, M and N is novel, with two i

186 m in the three homologous and tightly packed antiporter-like subunits L, M, and N of the proton-trans

187 The antiporter-like subunits NuoL/M/N each contain 14 conser

188 osymmetric inverted-repeat structures of the antiporter-like subunits NuoL/M/N, we constructed a symm

189 present in addition to the channels in three antiporter-like subunits).

190 expectedly, similar to a half-channel of the antiporter-like subunits.

191 OsNHX1 is the most abundant K(+)-Na(+)/H(+) antiporter localized in the tonoplast and its gene expre

192 Sodium/proton (Na(+)/H(+)) antiporters, located at the plasma membrane in every cel

193 Sodium/proton antiporters maintain intracellular pH and sodium levels.

194 othesized that conformational changes in the antiporters may be limited to small movements localized

195 The multidrug/proton antiporter MdfA from Escherichia coli exchanges monovale

196 the structures of the archaeal sodium/proton antiporter MjNhaP1 in two complementary states.

197 operon with both hydrogenase and Na(+)/H(+) antiporter modules.

198 In these cells, the Na(+)/H(+) antiporter monensin did not affect the membrane potentia

199 The sodium/proton antiporter, monensin, which potentiates Na(+) pump funct

200 The role of the multisubunit sodium/proton antiporter (Mrp) of Methanosarcina acetivorans was inves

201 Like other CLC antiporters, mutation of the external glutamate gate (Gl

202 ntiport activity of the bacterial Na(+)/H(+) antiporter NapA from being electrogenic to electroneutra

203 e the active-state structure of a Na(+)/H(+) antiporter, NapA from Thermus thermophilus, at 3 A resol

204 hange in levels of the mitochondrial calcium antiporter NCLX.

205 the prokaryotic Na(+)/Ca(2+) exchanger (NCX) antiporter NCX_Mj protein from Methanococcus jannaschii

206 igin of the function of the bacterial Na+/H+ antiporter NhaA by evaluating the energetics of the Na+

207 ophilus and compare this to the prototypical antiporter NhaA from Escherichia coli and the human homo

208 as similar to that of the E. coli Na(+)/H(+) antiporter NhaA, and GerO, but not GerQ contained two ad

209 n is remarkably similar to the sodium/proton antiporter NhaA, despite having no detectable sequence h

210 pestis strains lacking the major Na(+)/H(+) antiporters, NhaA and NhaB, are completely attenuated in

211 protective involvement of the sodium/proton antiporter NhaC-2, tryptophanase A, and two putative reg

212 l Na(+)/H(+)-antiporter resembling the human antiporter NHE1, by electron crystallography of 2D cryst

213 tion, in turn, is linked to decreased Na+/H+ antiporter (NHE1) expression.

214 The small intestinal BB Na(+)/H(+) antiporter NHE3 accounts for the majority of intestinal

215 ndent inhibition of the isoform 3 Na(+)/H(+) antiporter (NHE3) to demonstrate a functional relevance

216 The NHX-type Na(+)/H(+) antiporters NHX5 and NHX6 localize to the Golgi, trans-G

217 Intracellular Na(+)/H(+) antiporters (NHXs) play important roles in cellular pH a

218 It functions as a Cl(-)/H(+) antiporter, not a Cl(-) channel; however, the molecular

219 The cystine transporter (system xC(-)) is an antiporter of cystine and glutamate.

220 The NhaA antiporter of Escherichia coli is the best studied membe

221 NhaA, the main antiporter of Escherichia coli, has homologues in all bi

222 OF4 and Bacillus subtilis and the homologous antiporter of Staphylococcus aureus (Mnh), all of which

223 Anion channels and antiporters of the ClC superfamily have been found to be

224 orters, including H(+) pumps and H(+):cation antiporters, often at residues that are well conserved a

225 s of up to 1,500 ions per second, Na(+)/H(+) antiporters operate by a two-domain rocking bundle model

226 rane where it was proposed to act as a K+/H+ antiporter or alternatively as a chaperone for selected

227 protein functions as a Cl- channel, a Cl-/H+ antiporter, or as something else entirely.

228 in the dimeric, electroneutral sodium/proton antiporter PaNhaP from Pyrococcus abyssi at 3.2 A, and h

229 demonstrate that they function as secondary antiporters, powered by an imposed proton motive force,

230 Therefore, although upregulation of the xCT antiporter promotes antioxidant defence, it antagonizes

231 ent the crystal structure of the Ca(2+)/H(+) antiporter protein YfkE from Bacillus subtilis at 3.1-A

232 The antiporters pump three charges per cycle across the memb

233 that couples H(+) and Cl(-) transport in the antiporters remains unknown.

234 , electroneutral and electrogenic Na(+)/H(+) antiporters, represent a carefully tuned self-regulatory

235 ic complexes, while most other cation/proton antiporters require only one membrane protein for their

236 These antiporters require six or seven hydrophobic proteins th

237 ClC-3 is a Cl(-)/H(+) antiporter required for cytokine-induced intraendosomal

238 NhaP1, an archaeal electroneutral Na(+)/H(+)-antiporter resembling the human antiporter NHE1, by elec

239 d expression of an Arabidopsis H(+)/Ca(2)(+) antiporter (sCAX1) in agricultural crops increases total

240 he advent of crystal structures of three MFS antiporters sheds light on their fundamental mechanism;

241 Na(+)/H(+) antiporters show a marked pH dependence, which is import

242 X-ray crystal structures of CLC antiporters show the Cl(-) ion pathway through these pro

243 fer from CusF directly to a site in the CusA antiporter, showing for the first time (to our knowledge

244 The glutamate/cystine antiporter solute carrier family 7 member 11 (SLC7A11, a

245 We hypothesize that a sodium-proton antiporter (SPAP) provided the first step towards modern

246 In NhaA, the Escherichia coli Na(+)/H(+) antiporter, specific single site mutations modulating th

247 We speculate that elevator-type antiporters such as NapA, and likely NHA2, use a subset

248 t chain of system xc-, the cystine/glutamate antiporter, suggests that PCP also regulates the activit

249 Phylogenetic analysis of the cation/proton antiporter superfamily has uncovered a previously unknow

250 n members of the cation/proton antiporters-2 antiporter superfamily KEA1, KEA2, and KEA3.

251 Members of the calcium/cation antiporter superfamily, including the cardiac sodium/cal

252 e light chain, xCT, of the cystine/glutamate antiporter system X(-)(c).

253 d, xCT, a component of the cystine/glutamate antiporter system x(c)(-), was significantly upregulated

254 r cystine for intracellular glutamate by the antiporter system xc (-) is implicated in numerous patho

255 functional subunit of the cystine/glutamate antiporter system xc(-), as a surface protein that is up

256 e synthesis and glutamate secretion by xc(-) antiporter system.

257 bits cystine uptake by the cystine/glutamate antiporter (system x(c)(-)), creating a void in the anti

258 on and recovered the two subunits of the xCT antiporter (system xc(-)), which plays an antioxidant ro

259 Therefore, we propose that CgAcr3-1 is an antiporter that catalyzes arsenite-proton exchange with

260 CLC-ck2 is the first known antiporter that contains a nonpolar residue at this posi

261 id to product and CO2, and an inner membrane antiporter that exchanges external substrate for interna

262 CaiT is a homotrimeric antiporter that exchanges l-carnitine (CRN) with gamma-b

263 ate in the brain is released by xCT, a glial antiporter that exports glutamate and imports cystine.

264 ClC-5 is a Cl(-)/H(+) antiporter that functions in endosomes and is important

265 s a heteromeric amino acid cystine/glutamate antiporter that is constitutively expressed by cells of

266 LC7A11, a component of the cystine/glutamate antiporter that regulates reactive oxygen species (ROS)-

267 GlpT is an antiporter that transports G3P into the cell in exchange

268 of which (VI and VII) are absent from other antiporters that share the Ec-NhaA structural fold.

269 n vivo, demonstrating that ClC-7 is a Cl-/H+ antiporter, that it constitutes the major Cl- permeabili

270 g together with a putative arginine-agmatine antiporter, the CPn1032 homologs may have evolved conver

271 tion in frog oocytes that Slc11a1 acts as an antiporter, the most plausible interpretation of the dat

272 1p, the prevacuolar compartment-bound Na+/H+ antiporter, the vacuole-bound Vnx1p appears to play role

273 Like many Na(+)/H(+) antiporters, the activity of NhaA is regulated by pH, on

274 ese proteins are most likely nitrate/nitrite antiporters, they can also act in the net uptake of nitr

275 Unlike other antiporters, they require six or seven hydrophobic gene

276 working in tandem with an arginine-agmatine antiporter, this enzymatic cycle protects the organism b

277 ortant vacuolar ion transporters, Na(+)/H(+) antiporter (TNHXS1) and H(+)-pyrophosphatase (TVP1), wer

278 ribe the transformation of EmrE, a drug/H(+) antiporter to a polyamine importer by a single mutation.

279 eleased from the cell through the system Xc- antiporter to activate a metabotropic glutamate receptor

280 t to work in conjunction with an l-Asp/l-Ala antiporter to establish a proton gradient across the mem

281 We used monensin, a Na(+)/H(+) antiporter, to examine the role of the pump on the burst

282 verly Sensitive 1), encoding a sodium/proton antiporter, to plant salinity tolerance was analyzed in

283 e needed and for the value added by specific antiporter types in specific settings.

284 Finally, we show that inhibiting antiporter uptake of cystine interferes with presentatio

285 Overexpression of Ca2+ pump SERCA1, Ca2+/H+ antiporter Vcx1, or a Mn2+ transporting mutant of Vcx1 (

286 ession of system xc(-) cystine and glutamate antiporter via the JAK/STAT1 pathway.

287 light chain of X(c)(-), a glutamate/cystine antiporter, was analyzed by RT-PCR, immunoblotting, and

288 f the bacterial APC family arginine/agmatine antiporter, we introduced amino acid substitutions liabl

289 ichia coli NhaA is a prototype sodium-proton antiporter, which has been extensively characterized by

290 nvironmental cystine acquisition via the xCT antiporter, which is expressed on one-third of triple-ne

291 LT OVERLY SENSITIVE1 (SOS1), a sodium/proton antiporter, which represents an essential component of p

292 e synthesis depends on the cystine/glutamate antiporter, which transports the rate-limiting precursor

293 host cells usually possess zero to one such antiporter while other stress-exposed bacteria exhibit e

294 te transporter (DTDST) is a sulfate/chloride antiporter whose function is impaired in several human c

295 coded by the NCLX gene, and of a H(+)/Ca(2+) antiporter, whose identity is still debated.

296 nity for nitrate and NarK2 a nitrate/nitrite antiporter with lower affinity for nitrate.

297 NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria.

298 Detailed structures of antiporters with bound substrate ions are essential for

299 via phosphorylation of the cystine-glutamate antiporter xCT.

300 utamine dependence via the cystine/glutamate antiporter xCT/SLC7A11.