ライフサイエンスコーパス: antisense DNA

1 eased mRNA production by the presence of the antisense DNA.

2 m)Tc-antisense DNA with increasing dosage of antisense DNA.

3 oplasm in cells incubated with 99mTc-labeled antisense DNA.

4 lementary DNA elongation in cells exposed to antisense DNA, acting therefore as an intracellular PCR

5 As reported earlier, an antisense DNA against the mdr1 mRNA coding for P-glycopr

6 , inhibition of polysialic acid synthesis by antisense DNA approach induced differentiation in both h

7 cumulations, our results may be explained if antisense DNAs are targeting mdr1 mRNAs produced at high

8 thesis, a novel approach using 99mTc-labeled antisense DNA as a probe of total mRNA from cells previo

9 regulating transcription in cells exposed to antisense DNA as no increase in mRNA levels was detected

10 One of the problems that hamper the use of antisense DNAs as effective drugs is the non-specific bi

11 omponents: (1) inhibition of pRNA by a short antisense DNA (asDNA) that can bind to the 3' end of the

12 s direct evidence for targeting neuroglia by antisense DNA-based SPION-gfap that enables in vivo MRI

13 riphosphate into RNA in cells exposed to the antisense DNA but not to the control DNA and, second, an

14 rget mRNA expression in cells exposed to the antisense DNA but not to the control DNA.

15 t preexposure of cells to targeted complexed antisense DNA can substantially block viral gene express

16 or its depletion by small interfering RNA or antisense DNA caused marked and sustained regression of

17 ctive in this study was to determine whether antisense DNA could be targeted to hepatocytes to preven

18 nd release Mipomersen, a clinically approved antisense DNA drug, in response to pH change.

19 e size, but not the relative position, of an antisense DNA fragment is important in mediating the ant

20 , 78 growth-retarded transformants harboring antisense DNA fragments were also identified.

21 The conjugation of fluorescently-labeled antisense DNA hairpin oligonucleotides to the surface of

22 nd the development of a second generation of antisense DNAs have occurred largely within the antisens

23 se DNA, an increased accumulation of (99m)Tc-antisense DNA in another RI alpha-positive tumor cell li

24 for the observed migration of 99mTc-labeled antisense DNA into the nucleus.

25 erived HT1080 cells were transfected with an antisense DNA ligase III expression vector and clones wi

26 cts prepared from human cells overexpressing antisense DNA ligase III mRNA possessed substantially le

27 Novel demethylating agents such as antisense DNA methyl transferase and small interference

28 ever, the observed specific accumulations of antisense DNAs of about 10(6) per cell over 10 h could n

29 treatment with dehydroepiandrosterone or the antisense DNA oligomer of G6PD mRNA resulted in the inhi

30 n (125)I was located close to the end of the antisense DNA oligonucleotide, we observed breaks in RNA

31 hibitor, 5-aza-2-deoxy-cytidine, and 2 DNMT1 antisense DNA oligonucleotides inhibits the phosphorylat

32 Defining antisense DNAs on the basis of their effects on global g

33 RNA hairpin could be mimicked by pairing of antisense DNA or RNA oligonucleotides to the nascent tra

34 ss of endoglin expression mediated by either antisense DNA or siRNA results in a direct perturbation

35 pected cellular accumulations of about 10(5) antisense DNAs per cell over 24 h suggest stabilization

36 hybridized to a digoxigenin-labeled telomere antisense DNA probe.

37 By Southern blot hybridization of specific antisense DNA probes to segments of genomic DNA that enc

38 PC12/Tat cells, as the inhibition of Id1 by antisense DNA restored the serum-dependent growth of PC1

39 The solution structure of an antisense DNA.RNA hybrid duplex, d(CGCGTT-MMI-TTGCGC).r(

40 Sixty-two nucleotides of an ftsZ(Bbu) antisense DNA sequence under the control of a tetracycli

41 A method of phosphorothioate antisense DNA sequencing analysis using UV detection cou

42 The deoxyriboses in the antisense DNA strand exhibit a mixed behavior with almos

43 antibodies to a peptide translated from the antisense DNA strand of PR-3 (complementary PR-3, cPR-3)

44 ctly (p <0.0001) detect the origin (sense vs antisense DNA strands) of DNA methylation at splice site

45 The progress of antisense DNA therapy demands development of reliable an

46 Antisense DNA to a 24-base sequence identified as being

47 om cells previously saturated with unlabeled antisense DNA was used to estimate the transcription rat

48 The question considered here is whether antisense DNAs will also be important to future nuclear

49 Therefore, the expectation is that antisense DNAs will be important to future chemotherapy.

50 e increased cellular accumulation of (99m)Tc-antisense DNA with increasing dosage of antisense DNA.