ライフサイエンスコーパス: antitumor effect

1 eficient mice, confirming a B-cell-dependent antitumor effect.

2 re cell transfer was required to mediate the antitumor effect.

3 on are potential mechanisms for the observed antitumor effect.

4 and CK2 inhibitor enhances 1,25D(3)-mediated antitumor effect.

5 secreted GM-CSF to have an immune-associated antitumor effect.

6 ctivation in established tumors has a potent antitumor effect.

7 ounding tumor tissue resulting in a vigorous antitumor effect.

8 o influence the suppressive tumor milieu and antitumor effect.

9 nanosheets, showing a promising and enhanced antitumor effect.

10 r phase of immune responses in enhancing the antitumor effect.

11 locked by IB-MECA without antagonizing their antitumor effect.

12 the concentrations of statins necessary for antitumor effect.

13 bility to contrast agents rather than a true antitumor effect.

14 F mutation rather than showing a synergistic antitumor effect.

15 f either compound alone lacked a discernible antitumor effect.

16 ligands are more permissive of mAb-mediated antitumor effect.

17 es and thereby produces a strong and durable antitumor effect.

18 t an immune mechanism mediating the observed antitumor effect.

19 ss broad-reaching effects in vivo, including antitumor effects.

20 unotherapy resulted in significantly greater antitumor effects.

21 /IL-24-driven autocrine loop, culminating in antitumor effects.

22 ibition of its enzymatic activity could have antitumor effects.

23 escuing p53 pathway deficiency and promoting antitumor effects.

24 vated CD8 T cells, resulting in the observed antitumor effects.

25 suppression of ERK signaling and significant antitumor effects.

26 ion of the other population and compensatory antitumor effects.

27 utralization of IL-23 causes IL-12-dependent antitumor effects.

28 gramming in pyruvate impaired glycolysis and antitumor effects.

29 SARI expression is necessary for mda-7/IL-24 antitumor effects.

30 s broad range of physiological functions and antitumor effects.

31 is necessary and sufficient for progesterone antitumor effects.

32 eased beta-carotene consumption is linked to antitumor effects.

33 h pathway cross-talk and display synergistic antitumor effects.

34 ion, which results in potent immune-mediated antitumor effects.

35 umors and may work with radiation to enhance antitumor effects.

36 immunotherapy still resulted in significant antitumor effects.

37 -2, can activate T and NK cells resulting in antitumor effects.

38 emotherapy and immunotherapy for synergistic antitumor effects.

39 OR inhibitors to show promising, yet modest, antitumor effects.

40 y abrogated particulate beta-glucan-mediated antitumor effects.

41 r-exposed host cells, resulting in sustained antitumor effects.

42 ntly been shown to lead to both protumor and antitumor effects.

43 ted every 2 mo patients experienced additive antitumor effects.

44 of SHH-subtype medulloblastoma exerts potent antitumor effects.

45 el, compound 3 had statistically significant antitumor effects.

46 BPTES nanoparticle monotherapy led to modest antitumor effects.

47 iple myeloma, which correlates with clinical antitumor effects.

48 PI3K inhibitors but does induce substantial antitumor effects.

49 sly unrecognized role of PLP binding in Pfn1 antitumor effects.

50 TLA-4 immune checkpoints leads to remarkable antitumor effects.

51 y or intraperitoneal) at levels that yielded antitumor effects.

52 hirsutinolide-mediated mechanisms to induce antitumor effects.

53 ified Bifidobacterium as associated with the antitumor effects.

54 The enhanced antitumor effect achieved by ex vivo depletion of CD25(+

55 ce also resulted in significantly diminished antitumor effects after immunotherapy.

56 alone, the combination exhibited a superior antitumor effect against trastuzumab-resistant tumor xen

57 s and inhibit colony formation with superior antitumor effects against aggressive and drug-resistant

58 coumarin (5, SS5020), has been reported with antitumor effects against chemically induced mammary tum

59 d T-replete CBT may provide superior Tc1-Th1 antitumor effects against high-risk hematologic malignan

60 ning a CD28 signaling domain mediated potent antitumor effects against primary AML and MM while spari

61 B13 exerted its anti-invasive and antitumor effects against prostate cancer cells, with mi

62 eptor consensus half-site was found to exert antitumor effects against prostate cancer xenografts.

63 n of the purified EPHA7(TR) protein produces antitumor effects against xenografted human lymphomas.

64 ressing antitumor cytokines induces a potent antitumor effect and antitumor immunity by ameliorating

65 On their own, HDPDL1 exhibited no antitumor effect and CAd-VECPDL1 alone reduced tumors on

66 point inhibitor alpha-PD-1 provides the best antitumor effect and longest overall survival, and may b

67 The secondary endpoints were antitumor effect and safety (UMIN000009446).

68 The secondary endpoints were antitumor effect and safety (UMIN000009446).

69 l studies, pomalidomide mediated both direct antitumor effects and immune activation by binding cereb

70 iety of subcutaneous tumors mediated limited antitumor effects and induced significant cachexia and l

71 IFNgamma exhibits potent antitumor effects and plays important roles in the innat

72 rovide new understanding of CpG ODN-mediated antitumor effects and support for the development of TLR

73 posed antitumor mechanisms, in vivo reported antitumor effects, and possible mechanisms that may expl

74 aspase-3 signaling underlies OSU-2S-mediated antitumor effects, and that differences in the antitumor

75 hough SPIR is an aldosterone antagonist, its antitumor effects are independent of the mineralocortico

76 euroendocrine tumors; however, data on their antitumor effects are limited.

77 studies; however, the mechanisms behind its antitumor effects are not completely understood.

78 However, the mechanisms underlying TIMP-2 antitumor effects are not fully characterized.

79 ion of SPIO-DOX and IRE demonstrate enhanced antitumor effect as compared with individual treatments

80 ibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block rep

81 3K inhibitor plus ADI-PEG20 yielded additive antitumor effects as compared with either agent alone.

82 o reduced glucose uptake and correlated with antitumor effects as measured by micro-computed tomograp

83 Antitumor effects, as assessed by tumor growth delay wer

84 pathway with an agent known to induce potent antitumor effects but now also appears to potently suppr

85 ed neuropathic pain without interfering with antitumor effects, but also reversed it once established

86 upported by the fact that compound 10 exerts antitumor effect by inducing cell apoptosis through acti

87 rated that CB T cells mediated this enhanced antitumor effect by rapid infiltration of the tumor with

88 of STAT5CA-transduced TCs produced superior antitumor effects compared with nontransduced TCs.

89 and prevented metastatic disease in vivo The antitumor effect correlates with the fact that pioglitaz

90 Furthermore, antitumor effects could be recapitulated by engineering

91 Surprisingly, CTL tumor recognition and antitumor effects decreased in the presence of interfero

92 antimetastatic activity but lost its direct antitumor effects due to kinome reprogramming, which res

93 p53 interaction has been shown to produce an antitumor effect, especially in MDM2 amplified tumors.

94 It also resulted in long-term antitumor effects, even against tumors in which viral re

95 nges in tumor lesions and the improvement of antitumor effects from HBS-Fc-lv immunization were depen

96 Given that antitumor effects have correlated with increased host im

97 lines and primary specimens and had a robust antitumor effect in a disseminated MM mouse model.

98 immunodeficient mice and induced a superior antitumor effect in intrafemural multiple myeloma-bearin

99 together, Stattic inhibit Stat3 and display antitumor effect in NPC, and enhanced chemosensitivity a

100 However, rapamycin did not induce antitumor effect in the majority of tumors with activate

101 ll immune response with improved therapeutic antitumor effect in tumor-bearing mice.

102 nvolvement of additional mechanisms in their antitumor effect in vivo.

103 high-dose interleukin-2 (HDIL-2) has durable antitumor effects in 5% to 10% of patients with melanoma

104 This compound demonstrates robust antitumor effects in a Karpas-422 xenograft model when d

105 city (GI50 0.55 +/- 0.04 microM) and in vivo antitumor effects in a MIA PaCa-2 xenograft mouse model.

106 amatically potentiated the drugs' individual antitumor effects in a mouse model of breast cancer.

107 We found that STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-

108 receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers.

109 bilizing effects, and T-epoxide demonstrated antitumor effects in a xenograft model of breast cancer.

110 ce in vitro and was associated with enhanced antitumor effects in an in vivo xenograft model.

111 and (2) to determine if immunization induced antitumor effects in an orthotopic rat model of intrahep

112 ultiple TLR agonists have been shown to have antitumor effects in animal models.

113 ur in vitro results suggest that MLN9708 has antitumor effects in breast cancer and can sensitize bre

114 s, which contrast strongly with the powerful antitumor effects in conventional mouse models.

115 from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin in myeloi

116 IRB) cells, which displayed superior in vivo antitumor effects in mice.

117 acokinetic properties along with significant antitumor effects in multiple human cancer xenograft mod

118 ated T cells showed enhanced persistence and antitumor effects in murine T cell receptor and chimeric

119 ated for their tumor-targeting potential and antitumor effects in nude mice with tumors that were sen

120 ring a preclinical rationale to evaluate its antitumor effects in other cancers.

121 LX4032-resistant tumors and displayed potent antitumor effects in ovarian and prostate cancers.

122 Targeting CD73 results in favorable antitumor effects in pre-clinical models and combined tr

123 e examined the generation of immune-mediated antitumor effects in response to treatment by bortezomib

124 CRCs and whether its inhibition might elicit antitumor effects in the presence of APC mutations.

125 or programmed death receptor-1 (PD-1) showed antitumor effects in treatment-naive tumors in orthotopi

126 anscription also correlates with significant antitumor effects in vitro and in vivo, including the re

127 ibitors with HDAC inhibitors had synergistic antitumor effects in vitro.

128 Importantly, IL-36gamma exerted profound antitumor effects in vivo and transformed the tumor micr

129 astoma: PlGF/Nrp1 blockade results in direct antitumor effects in vivo, resulting in medulloblastoma

130 a potent induction of apoptosis in vitro and antitumor effects in vivo.

131 enoviruses coding for CD40L mediate multiple antitumor effects including oncolysis, apoptosis, induct

132 OM-trastuzumab (DAR 4) showed dose-dependent antitumor effects, including complete tumor eradications

133 ckdown of CXCR7 in CaP cells caused multiple antitumor effects, including decreased cell proliferatio

134 ant NKT cells (iNKTs), RLI did not induce an antitumor effect, indicating a critical role for recipie

135 duced cytotoxicity in MM cell lines, and its antitumor effect is associated with suppression of the A

136 s provide new insights into endostatin whose antitumor effect is not limited to inhibiting angiogenes

137 be used to augment the donor T-cell-mediated antitumor effect is the infusion of allogeneic donor-der

138 D8 and CD4 T cells and generated Ag-specific antitumor effect, it simultaneously increased the absolu

139 etastases can occasionally elicit a systemic antitumor effect, known as the abscopal effect, but hist

140 thaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels that are

141 COSL pathway might play a causal role in the antitumor effects mediated by anti-CTLA-4, we conducted

142 o the immune cell subset responsible for the antitumor effects observed.

143 The antitumor effect of 15-PGDH is mediated through its enzy

144 On the basis of our finding that the antitumor effect of 5-{4-[(1-methylcyclohexyl)methoxy]be

145 We examined the antitumor effect of adenoviral-mediated gene transfer of

146 ver, the molecular mechanisms underlying the antitumor effect of ailanthone on HCC have not been exam

147 cells partially but significantly eliminates antitumor effect of anti-CD137 antibody.

148 Although the antitumor effect of anti-CD40/CpG did not require T cell

149 The SFK inhibitor dasatinib enhanced the antitumor effect of BKM120 and fulvestrant against estro

150 n or TNFalpha neutralization can restore the antitumor effect of BRAF inhibition in mice receiving Cp

151 T cell-dependent manner and that the optimal antitumor effect of CD73 blockade requires inhibiting bo

152 STING-deficiency dramatically reduced the antitumor effect of cGAMP.

153 ockout mice, lumican significantly increased antitumor effect of chemotherapy.

154 ctivated type II NKT cells contribute to the antitumor effect of CpG in the B16 melanoma model.

155 beta-arrestin responses did not dictate the antitumor effect of CXCL12.

156 Accordingly, a significantly decreased antitumor effect of dFdC was observed in mice bearing M.

157 In vitro studies investigated the antitumor effect of ErPC3 in 9L rat gliosarcoma cells.

158 Our findings demonstrate a potent antitumor effect of ErPC3 in vitro, in vivo, and ex vivo

159 f anti-CD40/CpG did not require T cells, the antitumor effect of IC/anti-CTLA-4 was dependent on T ce

160 ade of IL-10, but not TGF-beta, enhanced the antitumor effect of imiquimod by significantly prolongin

161 The antitumor effect of imiquimod is multifactorial, althoug

162 e we show that cGAS is indispensable for the antitumor effect of immune checkpoint blockade in mice.

163 The antitumor effect of lymphodepletion/anti-PD-L1 therapy w

164 Similar antitumor effect of N6L has been observed in a highly an

165 for abrogating resistance and maximizing the antitumor effect of NK314.

166 This significantly enhanced antitumor effect of oAd/DCN/LRP-PEG-NT was mediated by a

167 We hypothesized that the potent antitumor effect of ONC201/TIC10 in colorectal cancer in

168 s likelihood, NK cell depletion impaired the antitumor effect of paclitaxel plus F8-IL2.

169 and that this activation is critical for the antitumor effect of PG545.

170 ge, this is the first study that reveals the antitumor effect of PI-103 in intracranial gliomas.

171 tion of IFN-beta and, more surprisingly, the antitumor effect of RT is abolished in type I IFN nonres

172 lls along with CD4 T cells further maximized antitumor effect of T cells in 2 different murine tumor

173 Most importantly, it could potentiate the antitumor effect of the anticancer drug paclitaxel.

174 The antitumor effect of the aptamer was nearly twofold stron

175 T cells, NK cells, macrophages) bases of the antitumor effect of the BMDCs from any protumorigenic ef

176 enesis, and was associated with an increased antitumor effect of the chemotherapy.

177 based combination strategies to maximize the antitumor effect of the compound.

178 pletion of CD4(+) cells did not abrogate the antitumor effect of the vaccine, nor did it inhibit the

179 put to PI3K/Akt are required for the optimal antitumor effect of therapeutic inhibitors of the HER2 o

180 CD4(+) T cells were essential to the optimal antitumor effect of this combination treatment in an IFN

181 cation of CD4 T cells significantly enhanced antitumor effect of unmodified CD8 T cells.

182 One implication of these results is that the antitumor effects of A(2A)R blockade that can be mediate

183 Similarly, inhibition of IL6R enhanced the antitumor effects of aflibercept in DU145 prostate tumor

184 1 (IRS-1), and IRS-1 knockdown enhances the antitumor effects of ALK inhibitors.

185 f the FAP(+) stromal cell also uncovered the antitumor effects of alpha-CTLA-4 and alpha-PD-L1, indic

186 ion on bone marrow cells is required for the antitumor effects of AMO.

187 bitor pictilisib (GDC-0941) can increase the antitumor effects of anastrozole in primary breast cance

188 NPP4B downregulation, thereby mitigating the antitumor effects of androgen ablation.

189 activating and inhibitory FcgammaRs for the antitumor effects of antibodies targeting the TNFR gluco

190 f tumor-associated inflammation in which the antitumor effects of antigen-specific CTLs are eradicate

191 colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type neoplas

192 To confirm specificity, we show that the antitumor effects of AT are blocked by cotreatment with

193 cer and provide a mechanism for the proposed antitumor effects of beta-carotene.

194 d EBV reactivation, and in the inhibition of antitumor effects of BMP signaling in normal and virus-i

195 The antitumor effects of bortezomib-induced tumor cell immun

196 immunologic mechanisms subtending the potent antitumor effects of bromodomain blockers.

197 thasone (Dex) has been shown to increase the antitumor effects of calcitriol in squamous cell carcino

198 human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vita

199 ults provide biological explanations for the antitumor effects of CD19 CARs and for the observations

200 In addition, the antitumor effects of CD47 blockade required expression o

201 Here, we report the cellular and antitumor effects of CFI-402257, a potent (Mps1 Ki = 0.0

202 The antitumor effects of chemotherapies can in part be due t

203 We examined the antitumor effects of combined inhibition of these pathwa

204 Antitumor effects of combined treatment related to the k

205 RAF) signaling pathways, we investigated the antitumor effects of combining phenformin with a BRAF in

206 al one molecular mechanism through which the antitumor effects of conventional cancer chemotherapy an

207 We find that the antitumor effects of CTLA-4 blockade depend on distinct

208 stimulator (ICOS) as a crucial player in the antitumor effects of CTLA-4 blockade.

209 ally deficient mice were used to dissect the antitumor effects of developmentally different NK cell s

210 -associated dendritic cells (DCs) attenuates antitumor effects of DNA vaccines.

211 mycin inhibitor BEZ235 (BEZ) potentiates the antitumor effects of doxorubicin (DOX) against pancreati

212 r heterogeneity, in order to interrogate the antitumor effects of EGFR-targeted drugs in mCRC (n = 40

213 Notably, DCA potentiated the antitumor effects of elesclomol, a pro-oxidative drug cu

214 The mechanism of action (MOA) underlying the antitumor effects of FL118 remains to be fully elucidate

215 a potential involvement of this gene in the antitumor effects of IFNalpha.

216 ed induction of MCP-1, implicating it in the antitumor effects of IgE.

217 Overall, our findings clearly indicate that antitumor effects of IH may be mediated through modulati

218 stemness properties drastically improved the antitumor effects of IL1beta-cultured Th17 cells.

219 Thus, T cells are crucial to the antitumor effects of imatinib in GIST, and concomitant i

220 mune system contributes substantially to the antitumor effects of imatinib.

221 ced DCs in mouse tumors enhanced the in vivo antitumor effects of immunostimulatory CpG DNA; however,

222 In the present study, we investigated the antitumor effects of inhibiting mTORC2 plus HSP90 in mou

223 double-strand breaks (DSB) may determine the antitumor effects of ionizing radiation (IR) by inducing

224 dronate before radiotherapy can increase the antitumor effects of ionizing radiation (IR), either as

225 -gamma plays a pivotal role in mediating the antitumor effects of IR therapy.

226 The local and systemic antitumor effects of IT-IC were inhibited by depletion o

227 on of tumor stroma, we evaluated the in vivo antitumor effects of MEDI-575 in tumor-bearing severe co

228 Its overexpression can overcome the antitumor effects of miR-1 and promote androgen-independ

229 was attenuated, exhibited resistance to the antitumor effects of nab-paclitaxel therapy.

230 We report the antitumor effects of nitric oxide (NO) releasing derivat

231 Here, we evaluated the antitumor effects of NK cell-based immunotherapy by seri

232 The antitumor effects of NT-7-16 were evaluated in an MDA-MB

233 ophils have an important role to play in the antitumor effects of oncolytic MV.

234 ylation in uterine epithelial cells, and the antitumor effects of P4 are mediated by the endometrial

235 The antitumor effects of paclitaxel are generally attributed

236 s, and, notably, does not interfere with the antitumor effects of paclitaxel.

237 e or antibiotic-treated mice ameliorated the antitumor effects of PD-1 blockade, whereas FMT from non

238 e models of lymphoma, we determined that the antitumor effects of PG545 are critically dependent on N

239 ced immune activation and cereblon/ikaros in antitumor effects of pomalidomide in vivo is unknown.

240 The potent antitumor effects of PPD/polyIC should spur its developm

241 MyD88, is required for type I IFN-dependent antitumor effects of radiation.

242 However, studies comparing the therapeutic antitumor effects of radiolabeled SSTR agonists versus a

243 latory molecules CD137 and CD40 enhanced the antitumor effects of radiotherapy and promoted the rejec

244 In this study, we examined whether the antitumor effects of radiotherapy, in established triple

245 xenograft studies, and greatly augments the antitumor effects of standard chemotherapy.

246 osphorylation of certain RTKs, restoring the antitumor effects of sunitinib in models of acquired or

247 T-oligo can form a G-quadruplex and that the antitumor effects of T-oligo may be mediated through POT

248 The antitumor effects of targeting Dll4 were augmented signi

249 ion, and p300 inhibition similarly augmented antitumor effects of the adoptively transferred T cells.

250 In this study, we report that the in vivo antitumor effects of the c-KIT inhibitor, dasatinib, on

251 dependent breast cancer, we investigated the antitumor effects of the dual IGF-1R/InsR tyrosine kinas

252 Mechanistic studies showed that the antitumor effects of the tyrosine isomers were mediated

253 The antitumor effects of therapeutic mAbs may depend on immu

254 this cytokine was necessary for the observed antitumor effects of therapy with IL-12 plus 4D5.

255 s on the molecular mechanisms underlying the antitumor effects of these drugs in CRC.

256 t not CD4(+) or CD8(+) T cells) mediated the antitumor effects of this treatment combination.

257 the contribution of these mechanisms to the antitumor effects of TIMP-2.

258 In this study, we investigated the antitumor effects of trastuzumab in combination with gly

259 ly, stable expression of CCL22 abrogated the antitumor effects of treatment with RLR or TLR ligands.

260 Additionally, CD4+ Th2 cells mediated the antitumor effects of TSLP, challenging the notion that T

261 nsplanted 4T1 tumors and had an even greater antitumor effect on lung metastases of the same mice, wh

262 ives (SOID-1 to SOID-12) and evaluated their antitumor effects on melanoma.

263 ruit neutrophils that could have protumor or antitumor effects on tumor development.

264 ccine, surprisingly, it mediated synergistic antitumor effects on tumor growth and metastasis in esta

265 As(2)O(3) exerted antitumor effects only in immunocompetent mice and enhan

266 but the mechanisms by which it generates its antitumor effects remain unknown.

267 However, how PG545 exerts its antitumor effect remains incompletely defined.

268 d immunomodulatory drugs (IMiDs) exert their antitumor effects remains unclear.

269 These antitumor effects require host's effector T cells but no

270 Surprisingly, this combinatorial antitumor effect required an intact T-cell immune system

271 ), an endogenous angiogenesis inhibitor with antitumor effects shown to increase endothelial NO produ

272 The antitumor effect stems from an induction of cell death i

273 of cGAMP and PD-L1 antibody exerted stronger antitumor effects than did either treatment alone.

274 pies would be synergistic, producing greater antitumor effects than the additive effects of each form

275 Therefore, simvastatin possesses antitumor effects that are dependent upon the apoptotic

276 For long-term antitumor effects, this therapy altered the metabolism o

277 Thus, Onconase likely exerts its antitumor effect through these miRNAs.

278 vity generated by the SMI MO-I-1100 leads to antitumor effects through inhibiting Notch signaling cas

279 other gene insertions that might enhance the antitumor effect, thus bringing the field closer to the

280 P-specific CD8 T cells, generating effective antitumor effect to prevent clinically relevant carcinog

281 ced promotion of apoptosis may contribute to antitumor effects to be gauged in future clinical invest

282 FN system were absolute requirements for the antitumor effects to occur.

283 The mechanism(s) for this antitumor effect was associated with reduced activation

284 Antitumor effect was expressed as the tumor growth ratio

285 eneic to the lymphoma demonstrated that this antitumor effect was mediated by alloreactive rather tha

286 Unexpectedly, an immune-independent antitumor effect was observed that depended on the ectop

287 The antitumor effect was transient in all tested groups.

288 tors of systemic immune responses, including antitumor effects, we hypothesized that components of th

289 The BA-mediated cellular Sp1 degradation and antitumor effect were also confirmed in a xenograft mous

290 These antitumor effects were accompanied by decreased cellular

291 These antitumor effects were reversed upon reconstitution with

292 These antitumor effects were significantly enhanced upon addit

293 small numbers of CTLs could mediate a potent antitumor effect when combined with chemotherapy.

294 ntrast, the same antiplatelet regimen had no antitumor effect when HCC was induced nonimmunologically

295 findings show that type I IFNs have a strong antitumor effect, which is at least in part explained by

296 n (HCT) technology: balancing the beneficial antitumor effect with the harmful anti-host effect.

297 microenvironment, and demonstrated improved antitumor effects with a CAR T cell-intrinsic PD-1 block

298 Preclinical studies have suggested enhanced antitumor effects with combined mTOR and VEGF pathway-ta

299 can be significantly increased, we observed antitumor effects with follow-up imaging, and single pat

300 in tumor antigen-specific T cells to enhance antitumor effect without systemic autoimmunity.