ライフサイエンスコーパス: antitumorigenic

1 chidonic acid possibly shifts from producing antitumorigenic 15-LOX-1 and 15-LOX-2 products to produc

2 The antitumorigenic action of GH-RH antagonists could be par

3 ever, the molecular mechanism underlying the antitumorigenic action of p100 remains poorly understood

4 ay a wider role in the antiproliferative and antitumorigenic actions of IGFBP-3.

5 ignant growth of cultured ECs, overcomes the antitumorigenic actions of RA, and is selectively expres

6 N response is required for effective in vivo antitumorigenic actions of the DNMTi 5-azacytidine (AZA)

7 eptor (GPCR) antagonists that have potential antitumorigenic activities, although the mechanism(s) ar

8 nt of ginger, exhibits anti-inflammatory and antitumorigenic activities.

9 clues for explaining their proapoptotic and antitumorigenic activities.

10 at the compound, BMH-21, has wide and potent antitumorigenic activity across NCI60 cancer cell lines

11 Our data suggest that SLPI may possess antitumorigenic activity by virtue of its ability to int

12 to and repress the Smad proteins, while the antitumorigenic activity can be mediated by both Smad-de

13 However, its antitumorigenic activity has not been elucidated in vivo

14 this study provides a new mechanism for the antitumorigenic activity of AHPN.

15 ing a role for this protein in mediating the antitumorigenic activity of DIM-C-pPhCF3 in bladder canc

16 The antitumorigenic activity of nonsteroidal anti-inflammato

17 Similarly, lenalidomide exhibits antitumorigenic activity paralleled by increased miR-181

18 (NAG-(Tg+)) were characterized, and then the antitumorigenic activity was evaluated with 2 colorectal

19 ptor gamma (PPARgamma) agonists that exhibit antitumorigenic activity.

20 ompounds, particularly as anti-infective and antitumorigenic agents, have led to a large body of publ

21 iver X receptor agonists may have utility as antitumorigenic agents.

22 gastrointestinal disorders, as it possesses antitumorigenic, analgesic, anti-inflammatory and antiox

23 etic oleanolic acid derivative that displays antitumorigenic and anti-inflammatory activities, and we

24 cture and as such may be responsible for the antitumorigenic and antiangiogenic activities of ACTIBIN

25 e RNA to 3' mononucleotides and also possess antitumorigenic and antiangiogenic activities.

26 These results establish angiostatin as an antitumorigenic and antiangiogenic agent through a mecha

27 sent report, we review recent studies on the antitumorigenic and antiangiogenic effects of exogenousl

28 finity chromatography and found to have both antitumorigenic and antiangiogenic properties.

29 Thus, Ac-PHSCN-NH2 may be a potent antitumorigenic and antimetastatic agent for postsurgica

30 umorigenic protein in vitro, induced by many antitumorigenic and chemopreventive drugs including cycl

31 hese actions of ursolic acid may mediate its antitumorigenic and chemosensitizing effects.

32 In vivo, MV-Edm was antitumorigenic and inhibited the establishment of myelo

33 -activated gene 1 (NAG-1), a protein with an antitumorigenic and proapoptotic activity that could in

34 These data demonstrate that NAG-1 is an antitumorigenic and proapoptotic protein, and its regula

35 eduction of TR1 levels in malignant cells is antitumorigenic and suggest that the enzyme is a prime t

36 s report, we show that the expression of the antitumorigenic and/or pro-apoptotic gene NAG-1 (nonster

37 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse ski

38 ctor (PEDF) is a multifunctional serpin with antitumorigenic, antimetastatic, and differentiating act

39 mor growth was 50 microg/kg/day, and TAM was antitumorigenic at a dose of 100 microg/kg/day.

40 sema3C may be further developed into a novel antitumorigenic drug.

41 ct on PI3K, LY294002 has been shown to exert antitumorigenic effect in vivo and in vitro.

42 The antitumorigenic effect of downregulation of HSF1 was ass

43 Ormeloxifene potentiated the antitumorigenic effect of gemcitabine by 75% in PDAC xen

44 mature myeloid cells, indicating a potential antitumorigenic effect of histamine.

45 pathway may be, in part, responsible for the antitumorigenic effect of LY294002 in human colorectal c

46 ng MAT1A induction significantly reduced the antitumorigenic effect of miR-495 siRNA, whereas maintai

47 These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in p

48 At the molecular level, the antitumorigenic effect of SOX30 is mediated by directly

49 lecular mechanisms by which they exert their antitumorigenic effects are unknown.

50 of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis.

51 These apparently antitumorigenic effects can be reversed by a dominant-ne

52 sults demonstrate that miR-34a exerts potent antitumorigenic effects in vitro and in vivo and suggest

53 f genes that may be critical for the in vivo antitumorigenic effects of AhR agonists.

54 , indicating the relative specificity of the antitumorigenic effects of AS gastrin RNA expression.

55 The antitumorigenic effects of FJ9 were pronounced, includin

56 or promoting lung tumorigenesis and that the antitumorigenic effects of PPARgamma are mediated in par

57 ions may contribute to the observed combined antitumorigenic effects of these compounds.

58 our results suggest that NSAIDs exert their antitumorigenic effects, in part, via interference with

59 ce more cancer due to lower CX3CL1-dependent antitumorigenic effects.

60 rimary mechanism by which NSAIDs exert their antitumorigenic effects.

61 C, can be used as a biomarker to predict the antitumorigenic efficacy of patritumab and whether the d

62 ronment is complex, containing both pro- and antitumorigenic elements, and remains to be fully charac

63 ulting in the proteolytic destruction of the antitumorigenic factor thrombospondin-1 (Tsp-1).

64 the EPHB3 tumor suppressor and argue for an antitumorigenic function of Notch signaling in advanced

65 PL's antitumorigenic function was causally linked to its Stat

66 s likely unwise given the protumorigenic and antitumorigenic functions of various family members.

67 lumes and neoangiogenesis and an increase in antitumorigenic GAM infiltrate.

68 veloping malignant lesions are eliminated by antitumorigenic immune cells.

69 that it could be proleukemic in children and antitumorigenic in adults.

70 hway can be both proleukemic in children and antitumorigenic in adults.

71 eroidal anti-inflammatory drugs (NSAIDs) are antitumorigenic in humans as well as in animal models of

72 tic target for future studies to enhance the antitumorigenic inflammatory response in HNSCC and other

73 tive sphingolipid ceramide has emerged as an antitumorigenic lipid, and treatment with short-chain C6

74 st in response to DNA damage is an important antitumorigenic mechanism.

75 NA binding proteins, to rid themselves of an antitumorigenic miRNA.

76 Preclinical studies on antitumorigenic or therapeutic introduction of FHIT were

77 trate, and Nrp1-depleted BMDM adopted a more antitumorigenic phenotype relative to wild-type GAMs wit

78 The reactions exhibited both pro- and antitumorigenic potential and primarily corresponded to

79 These observations led us to examine the antitumorigenic potential of miR-1 in lung cancer cells.

80 with the normal microenvironment to overcome antitumorigenic pressures.

81 gle key splicing event can manifest powerful antitumorigenic properties and validating endogenous spl

82 tion, whereas SRC overexpression rescued the antitumorigenic properties mediated by miR-34a.

83 GR-1 may provide a novel explanation for the antitumorigenic properties of LY294002 in human colorect

84 g a novel mechanism to explain, in part, the antitumorigenic properties of some NSAIDs.

85 pled receptor with potent antiangiogenic and antitumorigenic properties that is mutated in certain ca

86 kinase inhibitor that has antiangiogenic and antitumorigenic properties with potential efficacy for t

87 umor-derived cytokines that suppress initial antitumorigenic properties, causing them to support tumo

88 gnaling and exhibits both antimetastatic and antitumorigenic properties.

89 ral MMPs including MMP-9 exert both pro- and antitumorigenic properties.

90 astatic, neuronotrophic, antiangiogenic, and antitumorigenic properties.

91 AG-1 may provide a novel explanation for the antitumorigenic property of TGZ.

92 ne (NAG-1) was identified as a proapoptotic, antitumorigenic protein in vitro, induced by many antitu

93 lts are consistent with a more than additive antitumorigenic response for the low dose group (25 + 25

94 These data reveal an antitumorigenic role for 5-LO products in the microenvir

95 ormation in Apc(Min)(/+) mice, suggesting an antitumorigenic role for PAF in settings characterized b

96 Thus, in these cells, Ski plays an antitumorigenic role.

97 Thus, SnoN plays both pro-tumorigenic and antitumorigenic roles at different stages of mammalian m

98 mechanistic explanation for the paradoxical antitumorigenic roles of E+P in breast cancer by showing

99 The decorin interactome commands a powerful antitumorigenic signal by potently repressing and attenu

100 tic regulation of the expression of pro- and antitumorigenic target genes.

101 Transition of macrophage phenotype, from antitumorigenic to protumorigenic, occurs before tumorig

102 The (-)-deuterated enantiomer is antitumorigenic, whereas the (+)-deuterated enantiomer h