ライフサイエンスコーパス: antiviral defense

1 alled Cascade (CRISPR-associated complex for antiviral defense).

2 alled Cascade (CRISPR-associated complex for antiviral defense).

3 alled Cascade (CRISPR-associated complex for antiviral defense).

4 d Argonaute 4 (AGO4) in methylation-mediated antiviral defense.

5 ble for cytopathic effects and subversion of antiviral defense.

6 clc prevented autoimmune disease but blocked antiviral defense.

7 w viruses counter this apparently ubiquitous antiviral defense.

8 lindromic repeats (CRISPR) systems mediating antiviral defense.

9 red by the type I interferon is critical for antiviral defense.

10 re a critical component of the first line of antiviral defense.

11 , RNA interference (RNAi) is responsible for antiviral defense.

12 disruption and underlines the role of SGs in antiviral defense.

13 s to airway hyper-responsiveness and reduced antiviral defense.

14 e I IFNs are a cytokine family essential for antiviral defense.

15 infected cells is an important mechanism of antiviral defense.

16 ted the role of caspase-1 in epithelial cell antiviral defense.

17 n essential component of this host intrinsic antiviral defense.

18 s, the role of NbAGO2 might be primarily for antiviral defense.

19 role and mechanism of ISG15 modification in antiviral defense.

20 hagy in the homeostatic regulation of innate antiviral defense.

21 e important effectors in interferon-mediated antiviral defense.

22 sizing a critical role for NK cells in human antiviral defense.

23 kinase R (PKR) is an important component of antiviral defense.

24 atterning, hematopoietic differentiation and antiviral defense.

25 d dendritic cells (pDCs) are key elements of antiviral defense.

26 nding miRNAs are a part of the host's innate antiviral defense.

27 c regulation of gene expression and mount an antiviral defense.

28 highlight the importance of type III IFNs in antiviral defense.

29 Autophagy functions as an intrinsic antiviral defense.

30 by infection and plays a key role in innate antiviral defense.

31 ransgenes, but it is seemingly redundant for antiviral defense.

32 ession of proteins involved in intracellular antiviral defense.

33 -encoded function to block the RNA silencing antiviral defense.

34 sion that play a critical role in the innate antiviral defense.

35 nt RNA polymerases (RdRPs) in N. benthamiana antiviral defense.

36 of a set of cellular genes involved in host antiviral defense.

37 cription (STAT)1, a fundamental component to antiviral defense.

38 of a set of cellular genes involved in host antiviral defense.

39 protective antiviral T cells and to superior antiviral defense.

40 ting a unique role in the later stages of an antiviral defense.

41 epresents a viral adaptation to a novel host antiviral defense.

42 RP activity plays an important role in plant antiviral defense.

43 activated by delivery of antigen to promote antiviral defense.

44 potential shortcut in the activation of its antiviral defense.

45 the possibility that VIP can participate in antiviral defense.

46 e increased, supporting their involvement in antiviral defense.

47 ry but do express many genes associated with antiviral defense.

48 ytosolic DNA sensing plays a pivotal role in antiviral defense.

49 indispensible for interferon production and antiviral defense.

50 st, typified by interferon (IFN), is a major antiviral defense.

51 een studied in a few proteins specialized in antiviral defense.

52 Type I interferon (IFN) is crucial in host antiviral defense.

53 es in CRISPR-Cas9 technology as a eukaryotic antiviral defense.

54 RNA silencing pathway comprises its primary antiviral defense.

55 effector system, which plays a major role in antiviral defense.

56 gene expression and the RNA silencing-based antiviral defense.

57 Three vsRNA pathways are implicated in antiviral defense.

58 ransgenerational RNAi did not have a role in antiviral defense.

59 on response, a powerful branch of the innate antiviral defense.

60 or effector arm of interferon (IFN)-mediated antiviral defense.

61 urvive in infected hosts with a multifaceted antiviral defense.

62 ochondrial apoptosis as a strategy of innate antiviral defense.

63 in eukaryotic cells and be programmed as an antiviral defense.

64 viral M protein, which is a new paradigm in antiviral defense.

65 hat DRB3 is involved in methylation-mediated antiviral defense.

66 as general transcriptional enhancers of the antiviral defense.

67 to facilitate viral replication and inhibit antiviral defenses.

68 interacts with its mammalian hosts to evade antiviral defenses.

69 vivo while avoiding triggering their hosts' antiviral defenses.

70 e developed to counteract these early innate antiviral defenses.

71 tem and DNA methylation are also critical to antiviral defenses.

72 pecific cellular factors to evade the host's antiviral defenses.

73 d make SARS-CoV more susceptible to the host antiviral defenses.

74 s the frontline in the arsenal of the host's antiviral defenses.

75 of the ICP0 protein in countering intrinsic antiviral defenses.

76 d reduction allows poxvirus to overcome host antiviral defenses.

77 the presence of viral molecules and inducing antiviral defenses.

78 ha and -beta]) constitutes the first line of antiviral defenses.

79 his AGO protein has evolved to specialize in antiviral defenses.

80 in HIV-1 and other RNA viruses to evade host antiviral defenses.

81 n, a modification known to mediate host cell antiviral defenses.

82 ly of the Toll pathway and the RNAi-mediated antiviral defenses.

83 d TLR3, which contribute to the induction of antiviral defenses.

84 n and evasion of the host's rapidly deployed antiviral defenses.

85 to disrupt RIG-I signaling and impede innate antiviral defenses.

86 iption factors controlling a multiplicity of antiviral defenses.

87 n response to IFN, potentially to antagonize antiviral defenses.

88 duced signaling pathways activating cellular antiviral defenses.

89 utes to the ability of HCV to control innate antiviral defenses.

90 e functions critical for effective localized antiviral defenses.

91 this suppression and restored intracellular antiviral defenses.

92 with cellular proteins involved in host cell antiviral defenses.

93 equirements for inflammation and delivery of antiviral defenses.

94 d cells with cytolytic activity important to antiviral defenses.

95 tive roles of the IFN mediators in amphibian antiviral defenses.

96 nnate immune signaling and type 1 interferon antiviral defenses.

97 , replication, and suppression of the host's antiviral defenses.

98 gether, our data indicate that RNAi provides antiviral defense against dsDNA viruses in animals.

99 milarity to Arabidopsis AGO2, is involved in antiviral defense against TBSV.

100 In the present study, we examined the innate antiviral defenses against mouse (m) and human (h) CMVs

101 interferons (IFNs), which were discovered as antiviral defense agents but were revealed to be compone

102 cascade that initiates innate intracellular antiviral defenses aimed at restricting the replication

103 nts are detected on Cas proteins involved in antiviral defense, an aspect of Cas biochemistry not con

104 us kinase (JAK) signaling in cardiac myocyte antiviral defense and a negative role of an intrinsic JA

105 ons (IFNs) are important mediators of innate antiviral defense and function by activating a signaling

106 the C. parasitica dicer gene responsible for antiviral defense and generation of virus-derived small

107 FN-alpha and IFN-beta), which are crucial in antiviral defense and immune regulation, signal via the

108 E4 (DCL4) performs dual functions, acting in antiviral defense and in development via the biogenesis

109 n (NS1A) plays a key role in countering host antiviral defense and in virulence.

110 on provides mechanistic insights into innate antiviral defense and potential antiviral prevention str

111 iously unrecognized mechanism for optimizing antiviral defense and set the stage for the discovery of

112 cytokine-mediated NK and T cell-independent antiviral defense and specific cytokine-elicited NK cell

113 are influenced by type 1 interferon-mediated antiviral defenses and by viral countermeasures to these

114 a kinases, which are critically important in antiviral defenses and protection against environmental

115 connect epithelial cells, evading immune and antiviral defenses and provide an explanation for the in

116 stinctly altered immune responses in monocot antiviral defenses and provide insights into monocot vir

117 les the virus to counteract the human innate antiviral defenses and that NSs is one of the major dete

118 s mediated by SNF1 are a component of innate antiviral defenses and that SNF1 inactivation by AL2 and

119 by SNF1 are an important component of innate antiviral defenses and that the inactivation of ADK and

120 N-induced apoptosis, cell growth inhibition, antiviral defense, and chemotaxis.

121 lular events such as cell-growth regulation, antiviral defense, and development of the immune system.

122 Our data identify a role for neutrophils in antiviral defense, and establish a functional link betwe

123 assembly, suppression of RNA silencing-based antiviral defense, and long-distance movement in infecte

124 In plants, it serves as an antiviral defense, and many plant viruses encode suppres

125 iabetes in a host lacking adequate beta-cell antiviral defense, and that incomplete target cell antiv

126 N) response is an important aspect of innate antiviral defense, and the transcription factor IRF3 pla

127 ted that La was required for efficient RNAi, antiviral defense, and transposon silencing in vivo.

128 RNA silencing in plants is a multivalent antiviral defense, and viruses respond by elaborating mu

129 tory tract IgA levels, impaired IgA-mediated antiviral defenses, and increases in the mortality rate

130 nism that viruses use to suppress endogenous antiviral defenses, and provide potential targets for fu

131 hway activation, but their relative roles in antiviral defense are not well understood.

132 Innate cellular antiviral defenses are likely to influence the outcome o

133 rons (IFNs) play an important role in direct antiviral defense as well as linking the innate and adap

134 r characterize the mechanism(s) of honey bee antiviral defense, bees were infected with a model virus

135 interferons (IFNs) are principal elements of antiviral defense but can cause autoimmunity if misregul

136 detection of nucleic acids is important for antiviral defense but is also associated with specific a

137 Intragastric (IG) TPN maintains antiviral defenses but only partially preserves protecti

138 Both STAT1 and STAT2 are important for antiviral defense, but STAT1 has a unique role in protec

139 interferons (IFNs) are critical mediators of antiviral defense, but their elicitation by bacterial pa

140 viral mRNAs and helps combat cellular innate antiviral defenses, but little is known about its struct

141 cture (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition,

142 FNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activitie

143 ic CD4 T cells have the potential to mediate antiviral defense by multiple effector mechanisms in viv

144 oplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of viru

145 ve important implications for DCL4's role in antiviral defense by reducing the selective constraints

146 ) in plants and animals initiates a specific antiviral defense by RNA interference (RNAi).

147 ot enhanced, suggesting prevention of innate antiviral defense by ZIKV.

148 Type 1 interferons (IFN1) elicit antiviral defenses by activating the cognate receptor co

149 ing human cytomegalovirus (HCMV), blunt host antiviral defenses by limiting ISG expression, the overa

150 ode proteins that counteract PML NB-mediated antiviral defenses by multiple mechanisms.

151 st that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establ

152 V has evolved a mechanism to limit host cell antiviral defenses by sequestering NF-kappaB proteins in

153 chia coli, the CRISPR-associated complex for antiviral defense (Cascade) utilizes these RNAs to targe

154 ns that form a CRISPR-associated complex for antiviral defense (Cascade)-like complex are needed for

155 herichia coli "CRISPR-associated complex for antiviral defense" (CASCADE) is central in targeting inv

156 that IL-6, although critical to establishing antiviral defense, contributes to pathogenesis when rele

157 g in insects and adversely affects honey bee antiviral defenses controlled by this transcription fact

158 te MCMV infection to determine whether liver antiviral defense depends on signaling through these mol

159 the hypothesis that interferon (IFN)-induced antiviral defense determines beta-cell survival after in

160 macytoid dendritic cells (pDCs) are vital to antiviral defense, directing immune responses via secret

161 -beta in response to VSV plays a key role in antiviral defense during infection.

162 c acid-sensing TLRs in promoting early liver antiviral defense during MCMV infection.

163 NK cell IFN-gamma production and downstream antiviral defenses during innate immune responses.

164 al, nondegradative role in IFNgamma-mediated antiviral defense, establishing that multicellular organ

165 Highlighting its role in antiviral defense, fly Ago2 dissociates so slowly from e

166 the mode of target interference and role in antiviral defense for two CRISPR-Cas systems in Marinomo

167 B activation, attenuating expression of host antiviral defense genes and interrupting an IFN amplific

168 A possible role in C-to-U RNA editing or in antiviral defense has been discussed for other members.

169 cific TRIMs that contribute to TLR3-mediated antiviral defense have not been identified.

170 n development, differentiation and host cell antiviral defenses; however, roles in cancer biology are

171 sive signaling pathways that are involved in antiviral defense, immune response, and cell growth regu

172 piRNA pathway does not play a major role in antiviral defense in adult Drosophila and demonstrates t

173 clease Argonaute 2 (Ago-2), is essential for antiviral defense in adult Drosophila melanogaster.

174 nt to which the piRNA pathway contributes to antiviral defense in adult flies.

175 dings establish RNA silencing as an adaptive antiviral defense in animal cells.

176 topic expression of Lck/Hck/Fgr dampened the antiviral defense in cells and zebrafish.

177 pathways that generate them are also used in antiviral defense in higher eukaryotes, as they are in p

178 be an important early factor for the host's antiviral defense in Lepidoptera.

179 ent antimicrobial mechanism, but its role in antiviral defense in mammals is unclear.

180 er, the importance of the RNAi pathway as an antiviral defense in mammals is unclear.

181 The induction of the intrinsic antiviral defense in mammals relies on the accumulation

182 e, PKR, which plays a major role in cellular antiviral defense in mammals.

183 I interferon response, a major component of antiviral defense in mammals.

184 (piRNA) pathway also has been implicated in antiviral defense in mosquitoes infected with arboviruse

185 raising questions about its importance as an antiviral defense in mosquitoes.

186 RNA silencing is a potent means of antiviral defense in plants and animals.

187 While RNA silencing is a potent antiviral defense in plants, well-adapted plant viruses

188 ting that these proteins might contribute to antiviral defense in prokaryotes.

189 Innate inflammatory events promoting antiviral defense in the liver against murine cytomegalo

190 Antiviral defense in the liver during acute infection wi

191 mbdas therefore constitute the front line of antiviral defense in the lung without compromising host

192 tiviral pathway, plays no detectable role in antiviral defense in the midgut but only protects later

193 al regions in ICP0 involved in altering ND10 antiviral defenses in a cell culture model of HSV-1 infe

194 Here, we examined antiviral defenses in CD4+ cells during virus infection

195 Germ line encoded antiviral defenses in vertebrate cells tend to be either

196 n T lymphocytic cell lines that contain this antiviral defense, including H9.

197 clei of infected cells and inhibits multiple antiviral defenses, including a DNA damage response (DDR

198 earance and expression of genes required for antiviral defenses, including MDA5, RIG-I, TLR3, IRF7/9,

199 During antiviral defense, interferon (IFN) signaling triggers n

200 role played by many in RNA silencing-related antiviral defense is largely unknown, except for reports

201 This intrinsic antiviral defense is normally counteracted by ICP0, whic

202 Another important mechanism of host innate antiviral defense is represented by virus-induced mitoch

203 The major mechanism of antiviral defense is the small, interfering RNA pathway

204 lymphocytes and neutralizing antibodies for antiviral defense is well known, the antiviral mechanism

205 emonstrates that a potent antagonist of host antiviral defenses is encoded by multiple and diverse vi

206 coli, Cascade (CRISPR-associated complex for antiviral defense) is an RNA-guided surveillance complex

207 interferon (IFN-gamma) is a key mediator of antiviral defenses, it is also a mediator of inflammatio

208 ral defense, and that incomplete target cell antiviral defense may enhance susceptibility to diabetes

209 in kinase PKR is a component of the cellular antiviral defense mechanism and phosphorylates Ser-51 on

210 ever, the impact of silencing as a mammalian antiviral defense mechanism and the ability of mammalian

211 ce of RNA interference (RNAi) as a mammalian antiviral defense mechanism has been controversial.

212 In contrast, no general inducible antiviral defense mechanism has been reported in any inv

213 The role of RNA silencing as an antiviral defense mechanism in fungi was examined by tes

214 ted by siRNAs is an evolutionarily conserved antiviral defense mechanism in higher plants and inverte

215 Thus, RNAi is the predominant antiviral defense mechanism in insects that provides pro

216 ed regulatory process that has evolved as an antiviral defense mechanism in plants and animals.

217 RNA interference (RNAi) is an established antiviral defense mechanism in plants and invertebrates.

218 riptional gene silencing (PTGS), which is an antiviral defense mechanism in plants.

219 lly, by reconstituting part of the mammalian antiviral defense mechanism in yeast, we have establishe

220 RNA silencing in plants serves as a potent antiviral defense mechanism through the action of small

221 g with other pathogenic stimuli, triggers an antiviral defense mechanism through the induction of IFN

222 > A hypermutation is an innate antiviral defense mechanism, mediated by host enzymes, w

223 dsRNA and thought to be involved in the host antiviral defense mechanism.

224 Autophagy is a well-known cell-intrinsic antiviral defense mechanism.

225 mechanisms by which viral pathogens activate antiviral defense mechanisms in IECs are largely unknown

226 ssembly, and the ability to inhibit cellular antiviral defense mechanisms play an especially importan

227 ights the important function of Nod2 in host antiviral defense mechanisms.

228 as well as HIV-1 Vif-resistant intracellular antiviral defense mechanisms.

229 ipate in the recruitment of these cells into antiviral defense mechanisms.

230 ests a role for IL-15 as a component of host antiviral defense mechanisms.

231 CV replication, allowing for evasion of host antiviral defense mechanisms.

232 antiviral protein and provide insights into antiviral defense mechanisms.

233 enhance virus replication and to antagonize antiviral defense mechanisms.

234 ceptor-binding protein and a potential novel antiviral defense modulator are derived from dsRNA virus

235 ther viruses, VZV must subvert the intrinsic antiviral defenses of differentiated human cells to prod

236 interferons (IFNs), which are central to the antiviral defenses of other vertebrates.

237 RF-3-dependent signaling pathways and innate antiviral defenses of the host cell.

238 is a means by which adenovirus counters the antiviral defenses of the host.

239 sults further our understanding of honey bee antiviral defense, particularly the role of a non-sequen

240 ly conserved in eukaryotes that serves as an antiviral defense pathway in both plants and Drosophila.

241 protein that inhibits RNA silencing, a major antiviral defense pathway in insects.

242 R (PKR) is a key component of the interferon antiviral defense pathway.

243 KR) is a central component of the interferon antiviral defense pathway.

244 Innate antiviral defense pathways are altered in the asthmatic

245 vivo in recognizing viral RNA and activating antiviral defense pathways has remained controversial.

246 Important antiviral defense pathways that result in type I IFN pro

247 Pancreatic beta-cell antiviral defense plays a critical role in protection fr

248 contributes to the evasion of intracellular antiviral defense programs.

249 st frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for

250 The antiviral defense, raised by beta cells in response to I

251 revious assumptions, tadpoles possess intact antiviral defenses reliant on type III IFNs, which are o

252 as a tumor suppressor gene, but its role in antiviral defense remains unclear.

253 ines, which recruit lymphocytes and initiate antiviral defenses, requires traffic through the host se

254 t functions in suppressing the RNA silencing antiviral defense response and in viral RNA replication,

255 te gene in the induction of an RNA silencing antiviral defense response and the promotion of viral RN

256 bited a striking enrichment in expression of antiviral defense response genes at 37 degrees C relativ

257 share a common pathway to trigger the innate antiviral defense response in human cells, although dsDN

258 er gene dcl2, required for the RNA silencing antiviral defense response in the chestnut blight fungus

259 emperature due, in part, to a less efficient antiviral defense response of infected cells at cool tem

260 We now report that the antiviral defense response requires only one of the four

261 Apoptosis is a potential antiviral defense response that has been shown to be imp

262 riptional gene silencing (PTGS), an adaptive antiviral defense response that limits virus replication

263 tica Dicer gene dcl2-dependent RNA-silencing antiviral defense response.

264 virus burden in the periphery and brain, and antiviral defense responses were analyzed.

265 ther plant- and animal-infecting viruses and antiviral defense responses.

266 In conclusion, suppressed beta-cell antiviral defense reveals the diabetogenic potential of

267 ndent processes are critical for propagating antiviral defense signals during viral infection.

268 RNA-induced silencing is a potent innate antiviral defense strategy in plants, and suppression of

269 cancer while resulting in vitro in deficient antiviral defenses, suggesting that prostate cancer coul

270 , bacteria and archaea have evolved a unique antiviral defense system composed of clustered regularly

271 s to the role of gene silencing as a natural antiviral defense system in plants and offers different

272 We found that pUL103 interacts with cellular antiviral defense systems and proteins involved in organ

273 nteraction between HCV and hepatocyte innate antiviral defense systems is not understood.

274 Here, we describe prokaryotic antiviral defense systems, such as receptor masking or m

275 chanisms also evolved to circumvent the host antiviral defense systems.

276 ore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial s

277 ) of a host organism represents an effective antiviral defense that is frequently manipulated and exp

278 Intrinsic immunity is an aspect of antiviral defense that operates through diverse mechanis

279 interfering RNAs (siRNAs) represents a major antiviral defense that the invading viruses have to over

280 RNA silencing in plants is a form of antiviral defense that was originally discovered from th

281 uclear bodies are part of the cell-intrinsic antiviral defenses that restrict viral gene expression u

282 Based on their crucial role in antiviral defense, these ISGs may play an important role

283 IFN response is a key component to a host's antiviral defenses, this study has investigated the role

284 of VZV genes and to disarm the IFN-dependent antiviral defense through a novel mechanism that prevent

285 RNA (dsRNA) of virus origins mediate potent antiviral defense through a process referred to as RNA i

286 ng elicits interferon production for primary antiviral defense through cascades controlled by protein

287 LH86 cells mount an intact innate antiviral defense through induction of interferon and tr

288 efore, advances the general concept of broad antiviral defense through multihit targeting of a single

289 RNA silencing functions as an antiviral defense through the action of DICER-like (DCL)

290 tributes to homeostatic regulation of innate antiviral defense through the clearance of dysfunctional

291 al infection by inducing IFNs, which trigger antiviral defenses through IFN-stimulated gene (ISG) exp

292 N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3.

293 tion, and egress as well as the avoidance of antiviral defenses through the sequestration of key cell

294 mplex Cascade (CRISPR-associated complex for antiviral defense) uses CRISPR RNA (crRNA) guides to bin

295 ion of host and pathogen shaped the cellular antiviral defenses we know today.

296 of N in eukaryotic hosts having multifaceted antiviral defense, we demonstrate its interaction with N

297 However, qualitatively different antiviral defenses were induced by infusion of unfractio

298 iviral genes and that augmentation of innate antiviral defenses with IFN-alpha is a more effective st

299 m of regulation of TGF-beta signaling by the antiviral defense, with evidence for its role in immune

300 d from the early region E4 act to neutralize antiviral defenses, with a particular focus on DNA damag